LOCUS       NM_020354               8548 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens ectonucleoside triphosphate diphosphohydrolase 7
            (ENTPD7), transcript variant 2, mRNA.
ACCESSION   NM_020354
VERSION     NM_020354.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8548)
  AUTHORS   Tordella,L., Khan,S., Hohmeyer,A., Banito,A., Klotz,S., Raguz,S.,
            Martin,N., Dhamarlingam,G., Carroll,T., Gonzalez Meljem,J.M.,
            Deswal,S., Martinez-Barbera,J.P., Garcia-Escudero,R., Zuber,J.,
            Zender,L. and Gil,J.
  TITLE     SWI/SNF regulates a transcriptional program that induces senescence
            to prevent liver cancer
  JOURNAL   Genes Dev 30 (19), 2187-2198 (2016)
   PUBMED   27737960
REFERENCE   2  (bases 1 to 8548)
  AUTHORS   Yegutkin,G.G.
  TITLE     Enzymes involved in metabolism of extracellular nucleotides and
            nucleosides: functional implications and measurement of activities
  JOURNAL   Crit Rev Biochem Mol Biol 49 (6), 473-497 (2014)
   PUBMED   25418535
  REMARK    Review article
REFERENCE   3  (bases 1 to 8548)
  AUTHORS   Vaughn,B.P., Robson,S.C. and Longhi,M.S.
  TITLE     Purinergic signaling in liver disease
  JOURNAL   Dig Dis 32 (5), 516-524 (2014)
   PUBMED   25034284
  REMARK    Review article
REFERENCE   4  (bases 1 to 8548)
  AUTHORS   Zimmermann,H., Zebisch,M. and Strater,N.
  TITLE     Cellular function and molecular structure of ecto-nucleotidases
  JOURNAL   Purinergic Signal 8 (3), 437-502 (2012)
   PUBMED   22555564
  REMARK    Review article
REFERENCE   5  (bases 1 to 8548)
  AUTHORS   Robson,S.C., Sevigny,J. and Zimmermann,H.
  TITLE     The E-NTPDase family of ectonucleotidases: Structure function
            relationships and pathophysiological significance
  JOURNAL   Purinergic Signal 2 (2), 409-430 (2006)
   PUBMED   18404480
REFERENCE   6  (bases 1 to 8548)
  AUTHORS   Kirley,T.L., Crawford,P.A. and Smith,T.M.
  TITLE     The structure of the nucleoside triphosphate diphosphohydrolases
            (NTPDases) as revealed by mutagenic and computational modeling
            analyses
  JOURNAL   Purinergic Signal 2 (2), 379-389 (2006)
   PUBMED   17710224
REFERENCE   7  (bases 1 to 8548)
  AUTHORS   Shi,J.D., Kukar,T., Wang,C.Y., Li,Q.Z., Cruz,P.E.,
            Davoodi-Semiromi,A., Yang,P., Gu,Y., Lian,W., Wu,D.H. and She,J.X.
  TITLE     Molecular cloning and characterization of a novel mammalian
            endo-apyrase (LALP1)
  JOURNAL   J Biol Chem 276 (20), 17474-17478 (2001)
   PUBMED   11278936
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK055540.1, BC119008.1,
            AL133353.6 and AW629210.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_020354.4.
            
            Summary: This gene encodes a purine-converting ectoenzyme which
            belongs to the ecto-nucleoside triphosphate diphosphohydrolase
            (E-NTPDase) family. The encoded protein hydrolyzes extracellular
            nucleoside triphosphates (UTP, GTP, and CTP) to nucleoside
            monophosphates as part of a purinergic signaling pathway. It
            contains two transmembrane domains at the N- and C-termini and a
            large, hydrophobic catalytic domain located in between. This gene
            affects oxidative stress as well as DNA damage and is a mediator of
            senescence. [provided by RefSeq, Mar 2017].
            
            Transcript Variant: This variant (2) differs in the 5' UTR, lacks
            an alternate exon in the 5' region, and initiates translation at an
            alternate start codon, compared to variant 1. The encoded isoform
            (2) has a shorter and distinct N-terminus, compared to isoform 1.
            Both variants 2 and 3 encode the same isoform (2).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.189723.1,
                                           SRR1803615.10665.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000370489.5/ ENSP00000359520.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-31                AK055540.1         4-34
            32-2341             BC119008.1         1-2310
            2342-8416           AL133353.6         53597-59671
            8417-8548           AW629210.1         14-145              c
FEATURES             Location/Qualifiers
     source          1..8548
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q24.2"
     gene            1..8548
                     /gene="ENTPD7"
                     /gene_synonym="LALP1"
                     /note="ectonucleoside triphosphate diphosphohydrolase 7"
                     /db_xref="GeneID:57089"
                     /db_xref="HGNC:HGNC:19745"
                     /db_xref="MIM:616753"
     exon            1..80
                     /gene="ENTPD7"
                     /gene_synonym="LALP1"
                     /inference="alignment:Splign:2.1.0"
     exon            81..183
                     /gene="ENTPD7"
                     /gene_synonym="LALP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             176..1990
                     /gene="ENTPD7"
                     /gene_synonym="LALP1"
                     /EC_number="3.6.1.15"
                     /note="isoform 2 is encoded by transcript variant 2;
                     lysosomal apyrase-like protein 1; NTPDase 7"
                     /codon_start=1
                     /product="ectonucleoside triphosphate diphosphohydrolase 7
                     isoform 2"
                     /protein_id="NP_065087.1"
                     /db_xref="CCDS:CCDS7480.1"
                     /db_xref="GeneID:57089"
                     /db_xref="HGNC:HGNC:19745"
                     /db_xref="MIM:616753"
                     /translation="MARISFSYLCPASWYFTVPTVSPFLRQRVAFLGLFFISCLLLLM
                     LIIDFRHWSASLPRDRQYERYLARVGELEATDTEDPNLNYGLVVDCGSSGSRIFVYFW
                     PRHNGNPHDLLDIKQMRDRNSQPVVKKIKPGISAMADTPEHASDYLRPLLSFAAAHVP
                     VKKHKETPLYILCTAGMRLLPERKQLAILADLVKDLPLEFDFLFSQSQAEVISGKQEG
                     VYAWIGINFVLGRFDHEDESDAEATQELAAGRRRTVGILDMGGASLQIAYEVPTSTSV
                     LPAKQEEAAKILLAEFNLGCDVQHTEHVYRVYVTTFLGFGGNFARQRYEDLVLNETLN
                     KNRLLGQKTGLSPDNPFLDPCLPVGLTDVVERNSQVLHVRGRGDWVSCGAMLSPLLAR
                     SNTSQASLNGIYQSPIDFNNSEFYGFSEFFYCTEDVLRIGGRYHGPTFAKAAQDYCGM
                     AWSVLTQRFKNGLFSSHADEHRLKYQCFKSAWMYQVLHEGFHFPYDYPNLRTAQLVYD
                     REVQWTLGAILYKTRFLPLRDLRQEGVRQAHGSWFRLSFVYNHYLFFACILVVLLAIF
                     LYLLRLRRIHHRQTRASAPLDLLWLEEVVPMMGVQVGP"
     exon            184..366
                     /gene="ENTPD7"
                     /gene_synonym="LALP1"
                     /inference="alignment:Splign:2.1.0"
     exon            367..572
                     /gene="ENTPD7"
                     /gene_synonym="LALP1"
                     /inference="alignment:Splign:2.1.0"
     exon            573..723
                     /gene="ENTPD7"
                     /gene_synonym="LALP1"
                     /inference="alignment:Splign:2.1.0"
     exon            724..827
                     /gene="ENTPD7"
                     /gene_synonym="LALP1"
                     /inference="alignment:Splign:2.1.0"
     exon            828..884
                     /gene="ENTPD7"
                     /gene_synonym="LALP1"
                     /inference="alignment:Splign:2.1.0"
     exon            885..1018
                     /gene="ENTPD7"
                     /gene_synonym="LALP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1019..1185
                     /gene="ENTPD7"
                     /gene_synonym="LALP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1186..1510
                     /gene="ENTPD7"
                     /gene_synonym="LALP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1511..1596
                     /gene="ENTPD7"
                     /gene_synonym="LALP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1597..1758
                     /gene="ENTPD7"
                     /gene_synonym="LALP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1759..8548
                     /gene="ENTPD7"
                     /gene_synonym="LALP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4440..4445
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ENTPD7"
                     /gene_synonym="LALP1"
                     /note="hexamer: AATATA"
     polyA_site      4464
                     /gene="ENTPD7"
                     /gene_synonym="LALP1"
                     /note="major polyA site"
     regulatory      8516..8521
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ENTPD7"
                     /gene_synonym="LALP1"
                     /note="hexamer: AAGAAA"
     regulatory      8527..8532
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ENTPD7"
                     /gene_synonym="LALP1"
                     /note="hexamer: AGTAAA"
     polyA_site      8533
                     /gene="ENTPD7"
                     /gene_synonym="LALP1"
     polyA_site      8548
                     /gene="ENTPD7"
                     /gene_synonym="LALP1"
                     /note="major polyA site"
ORIGIN      
        1 ccggctgggc aaggggccgc ggggagcagc tcgggactga accgagaggt gccgaaggaa
       61 ccggcgggcc gcttgatccc gctgcagacg taggagatgc ctgggacaag gaggccacct
      121 tctcagggca aaagaaaaag aaggtgacag gcgttgagac caccgaaggg aacccatggc
      181 taggatcagt ttttcctacc tctgcccagc ctcctggtac ttcactgtgc ccacagtgag
      241 tccatttctc cgtcagcggg tggcattcct gggactcttc ttcatatcct gtctcctttt
      301 acttatgtta atcatagact ttcgacattg gagtgcttca ttaccacgag ataggcaata
      361 cgaaaggtat ttggctcgag taggggagct tgaagctact gacactgaag acccaaatct
      421 gaattatgga cttgttgttg actgtggcag cagtggttcc cggatttttg tttatttctg
      481 gccaagacat aatgggaacc cccatgactt gctggacatc aaacagatga gagaccgcaa
      541 cagccaacca gtggttaaaa aaatcaagcc aggaatctct gcaatggcag acactccaga
      601 acatgccagt gattaccttc gtcctctgct gagctttgct gctgctcatg tgcctgtgaa
      661 gaagcacaag gagacccctc tttacatcct ctgcacagca ggcatgaggc ttctccctga
      721 gaggaagcag ttggctatct tggctgacct agtgaaagat ttaccactgg agtttgactt
      781 cctcttttca cagtctcaag cagaagtgat ctctgggaag caggaagggg tttatgcatg
      841 gattggaatc aactttgttt tgggaagatt cgaccacgag gatgaatcag atgctgaggc
      901 tacccaggaa ttggcagcag gacggagaag gacagtaggg atactggata tgggaggagc
      961 ctctctccaa attgcttatg aagttcctac ctcaacctct gtccttcctg caaagcagga
     1021 agaagctgcc aagatcctgc tggctgagtt caacctgggc tgtgatgtgc aacacactga
     1081 acacgtgtac agggtttatg tcacaacttt tctgggtttc ggaggcaact ttgcccggca
     1141 gcgctacgaa gaccttgttc tgaatgaaac tcttaacaaa aacagattgc ttggtcagaa
     1201 gacaggtctg agtcccgaca atccatttct ggatccctgc ctgccagtgg gactcacaga
     1261 tgtggtggag aggaacagcc aagtcttaca tgtccgagga agaggagact gggtgtcttg
     1321 tggggcaatg ctgagccccc tgctggctcg ctccaacacc agccaggcct cactcaatgg
     1381 catatatcaa tcgcctattg acttcaacaa cagcgagttc tacggcttct ctgagttttt
     1441 ttattgtaca gaggatgtgt tgcgcattgg tggccgctac catgggccaa catttgccaa
     1501 ggctgctcag gattactgtg gcatggcttg gtcggtacta actcagagat tcaagaatgg
     1561 cctcttttca tcacatgcag atgagcatcg actcaaatat cagtgtttta aatcggcttg
     1621 gatgtaccaa gtcttacatg aaggattcca ctttccctat gactacccaa acctgcggac
     1681 agcccagctg gtgtatgacc gagaggttca gtggacgctg ggagccattc tatataaaac
     1741 acgattctta ccactcaggg atcttcggca ggaaggtgtc cgacaagccc atggtagctg
     1801 gttccgtctc tcctttgtat acaaccacta tctcttcttt gcctgtatcc tggtggtgct
     1861 actggccatc ttcctatacc ttctgcggct acgccgaatt caccaccgac aaacacgagc
     1921 ctcagctcca ttggacttgc tgtggcttga agaggtggtg cccatgatgg gagtacaggt
     1981 ggggccgtga ggctggacca ggactagaga agcttgagca cccccgagtt gctgctcatt
     2041 gaattcctcc actttcttat atagcctcag atgctgtgat gtctgacctt gtggatattt
     2101 gcccttggaa tttctacttt actttctacc gtaattcctt ctccgtaccc aggtcttctc
     2161 tgagagaagc tataatttaa tctgtgagga actaaatgac aggagattgg tgctaatacg
     2221 ggggaccaag ctttgtccaa gtgaagcagg cttcgactcc ttctgagagg tctggtgtgt
     2281 tcctagaatc tcaccttttc ttcccttgct aaagcatgaa gtttggcatt tggcacactg
     2341 gaagcctggt tgaaatgaaa tttgtagcat ctgatacaaa gccagagaca ttctagcaag
     2401 tgcagcagcc ccttctttct ctgtaacaga gatatcattt atgtggagat ccacaacctt
     2461 taacagggat ccaagatctt tgcagttcaa tcgaccacat aggaatttcc aggcaccaaa
     2521 atgatataac ttccttgctt ccttgacaaa gaagccatca tgggtgtgat ccaagatccc
     2581 tgtcgtagtg ttgatgatgt tagtacatga ttttaaaggt tagaacccct tctaaatgaa
     2641 tggtctgtgg aagattttag tatcttatct gatgcctggt atgatgagga tagaaaattt
     2701 ttccattttt atgtgcctca caggctgttt gggcattaat tttgcttttt gagccttaag
     2761 tgtgttagta ggatggagaa actgtgatgg ggactgggaa cctggatttg tctgatttta
     2821 ggtcactgtt ccctgggcct gtttttgtga gcccttacac aggaagatat aaagagagtt
     2881 ctttcatttc actgctaaaa tcagtatgta gtatggggaa tgtatttggg ttgtttttaa
     2941 agaaaagggg aacagaatca ggagagtggg caaaggcaat aaaatcaaag ttcttattaa
     3001 ttatttctga gaaatagaag tttctcaatt tatgactctt ggaatgtctg aaagggagca
     3061 aatttggaat agatcaatct gttaataagc catctggcaa ctttcagaac ctctattaag
     3121 agactgctga gtcacaaaca gcacttccat taatgaagcg agaggaaaag ccataataat
     3181 tacatcttca cccactaccc ttccagagct ttgcttctcc tccacattta gccattaaat
     3241 tgcatgagga tttctcttca tcagggtccg catggaatct ttcttatatt ttaccctttc
     3301 ctacatgtag ccttgaatgt cctttccacg aatatgctcc cacggctggg agcattttct
     3361 tttcttttcg tcacctttga tttttgggat tagattaata ggggaaaaag tccctggctt
     3421 taaagaaaac aaaagtagaa ttcttcaaaa ataaatttca tactgggaac agaaaggaac
     3481 taaatgcttc ataaaacagg gaaaaagaaa ttaagatcat cctagaaata aactaagata
     3541 aaaataagta tactgaccct tggttggtag ataaaaagat gaccagtctt gtattgtttt
     3601 aaaattagat aaacatggat taagcatgca aagactctgt tccttttttt ttttcttgga
     3661 gacagggcct cacgctgtca cccaggctgg agtgcagttg tgcaacatca tggctcaccg
     3721 cagcctcaac ctcctgggct caaacagtcc tcccaactca gactccagag tagctgggac
     3781 tacaggtgtg cgccaccaca ctcagctaat tttttatttt atttttttag agatggagtc
     3841 tgtgttgtcc aggctggtct caaactcttg ggctcaagca atcctcccac ctcagcctcc
     3901 caaagtgctg ggattacaag catgagctac tgcacctgcc ctctgtttcc tttggaaatc
     3961 tcttaccttt cattagggtt tctttcatag caatttcctt tggtttttaa gacttctaca
     4021 ttgctttttc ttttattatc tgtgctccgt gaaccttatg aatgctgctt aaaaataatg
     4081 tcaaaatatg ttttagctgc ctactcaggt aacgttttct tttgctctca tcttggtttc
     4141 catatactat ttttggtttt ttgtgagatc taatcaatga tctagtcaga agctacttca
     4201 ctggctaaca gtgatcatgt tcatgtgcta aaaatgaact tgaaacacgg aagtagtggt
     4261 tggtccagtt tgaaagctct tattagtatt cttcatcctg gctgtaataa tagccattat
     4321 ttgttatgcc tttgttatgt agcagacact cttaaggatt ttatgtgtat tattcaaatt
     4381 gctattactg ttctttttat agttgagaat ctcaggatac ctacatttat cactttttca
     4441 atatatatgt atttcttatt cttattttgt cttggagtgt ttaatgtgtt atttcctgtt
     4501 cattacttta atattatggt atctaggctt gtctttatta ccatgagcaa ggtctccagg
     4561 agttccacag tactgaagga aaattttgtc atatccctca gaagaactga atatttatta
     4621 ttggtatggg ctcctttgtt tattctcttc tcccaattaa tagattttaa atgaaatctt
     4681 attagctaga aacaaaagcc acttactcct tgctgagagc caattactta aatatatttc
     4741 ttccttataa taaaataatt tgcttctagg agcagaaatc tatcttgcca taccctttgg
     4801 tttttaaaga tttctcttct atttgcattt ctgcactttg gtggttctcc catgaagata
     4861 attatggtgt cataaaattc acattccact ggttcctttg aatcttacca accactcttg
     4921 ttaacagaga caatgaacct gaactgtttt aggactcttg ttattactga gacaggtcac
     4981 aaacatcaaa ataggagtcc gtggcttgta gtgatgcttt ttagtcttgt gatagcacaa
     5041 tccatcactt tccccaaaat tcttgtcata gaacataatg aaaaatatgt aaaataccca
     5101 tttatgtggc atttcattca cttaagttgc agttaactct aagccaaatt ataccatttt
     5161 ttctctctgt actttagctc cttgaatttc cttaatctgg gaaacttttg ttcccacacc
     5221 aaggaacaaa ttcagggggt acaagtgcag gtttgttaca tgagtatatt gagtgatgct
     5281 gaggtttggg gtacagatcc catcaccagg tggtgagcat agtacctaac agatagttct
     5341 ttaatccatg ccctcctctc tccctccctg ctctagtagt ccacagtgtc tattctggtc
     5401 tgggaaattt tcatcacttt ccaccaatct tctatttatt ctccaaatgt cttccaaagt
     5461 atcctgcccc accccctcct catcctaaga gattccttta acttcaagat catatccagt
     5521 gattgctgaa aaatgtctgc catgcacttg ctaagctagt gtttttaggc attaacattt
     5581 attatcacat ccatatttat atttttgaaa taatttatac ttctcactga tatcatctaa
     5641 acagatgctt ctcacagttt tatgttttgt tttttgtcag ggatgaaaga caagtgagtg
     5701 gtatcactta agggaaagaa cagtaggctt aacgaatagc agacctggat tctagttctg
     5761 gctttgtcat ttactagctc tggtacccca ggccagtcac ttaccatctc tggttcggtt
     5821 ctcatctatc aaacaaagag gctagacaag attagaaact aaaggcagaa gacaaggtag
     5881 aaaaatcata tgattttggg aagagcattt tgtcctttgg tttagaagac caggctgccc
     5941 aaaagagcct cctattttat ccataacccc tgatgataag gttggtggga acagagtttc
     6001 taatagtaat cataataaat ttcagaagag ttttaaagct tctggtcaac ccccttgatt
     6061 tatatgggtg ataaaactga ggcctagagc agttgtaata tgtgcaaagt catagtgact
     6121 ggcctcctag cccaactact ttgtcagcta caatgaaatg ctcattaaca gaatctttct
     6181 gcaagtataa acagaatcta ttttttataa aacagctggc cacaactaac catgccccat
     6241 ctttacaact gcttctgaca ttcatttatg actgctttgc tcacatttag gaataaactt
     6301 tgaaaaaaat actttgtcag aaatagtgcc aagttttcac tacatctatt cttgttcctg
     6361 tatttctttt cgtactttta aattttatac atctttttaa aacaatttta tacaatttcc
     6421 tttactacaa catccaagca attcattaga tgactacagc ctagatgaag gtataaatgc
     6481 ctattacatc tacctcatta aagaacttcg ttgtaattct tgggcagttt ccagactctg
     6541 ttacagaaac agagggctgt ttctttttgt tgtctttaaa cttttcaaat taattcaaaa
     6601 ctagtatcta attgtccttt ttgctgtggt atgtggtgta atgttgattg ggaataagaa
     6661 ttatggtaga aatagcagat gtttcaaatt ctcccatatt agtctcttag ggacgctagc
     6721 tccagattcc agcccctggg gcaataactt gtgaggattt tcctggtgtt acaaaaaata
     6781 ttgctgttaa aaaactaaga ctcaaaacca aaagttgtga ttaataataa caggattatt
     6841 agtcaataat attttgatta atactataga atagcaacag tgaatatacc tcaaattgaa
     6901 aacttttagg ttgtgttctt ggctcattct ctcataacct ggatctaagt tggaaagctg
     6961 tggcaccctg tttgggtgtc ccatctaccc tgttttctgt ttctgcagat ggcttgttca
     7021 agcttcattt taagcctgct ctgtctactt atcttcctta tatcctaata gacttctctt
     7081 gtgttattac acatttctct tttgctctaa tatttcatta ttttccagtt tgtcagtacc
     7141 gttatcagag ggacgaggaa ggaataacac accagttgac cattttgttt ctctgaaaat
     7201 ctgagcaata cggagatcct tttattagta aaactgaatc attactcata ctacaagggc
     7261 tttcactttt aaaatgtaat ccatcattgc ttgccatttt tatgaaaacc aaagttgaaa
     7321 agtcttctga atcacaggct atgtatagcc acacatgcat gacttcaggc tagcataaag
     7381 acatgtctgc tcctgagcct cttcttttaa agggcaacca cttgtatacc ctctggtggc
     7441 cactcctcct tctccactcc aaggcagccc tggtactttc ctaagtggcc cctcctacag
     7501 agcacttgcc ggcatttggc ctgctgctgg tgaagacgcc ccttactagc ttcataaatg
     7561 tttttctgca agcagggatc ccagacacat actttggttt ctagtgtttc agttactatg
     7621 ttgtatttga aattctcatt ccacaattac cctttagttg aagtcctgaa gtacatgcca
     7681 tgtactcccc ctttatttct accttgatca atggcctctg cggagtgtag tgaaagacat
     7741 ctttttatta tgatctacac tttaaaaaac caaaggctgc ctgtattaca ttgctttggg
     7801 gagttgttaa gactctgttt tttctactgc ttcacattaa acaataattt tgttgaattt
     7861 tgaattctta aaattctcac tgacaaacat tttaggtcag tgttgaggaa aatgtgtgat
     7921 gcatgttaga gaggtgatgc attctccctt atgcagggac atgggtatat gtgttacata
     7981 tgctgatata taacccacca ttcatcccag gaccacaagg gtagctgtag ataaactggt
     8041 tatcctaaaa tcatgattat cagtgttgat ctctgcaacc aacattgctt tagggagttg
     8101 ctagtcatta cccctgctac aatagatagt atttgtcagt ctaagttaca gacaaaaaat
     8161 tctaggttga ctgattaaga aagccatgtg ttttaatttc cttcatgttt taaaaacaat
     8221 ggacgtaagt gcagagagac ctttgaaaat attaagggaa atctatttaa tcctataggt
     8281 atgtgatgac ttgttttttt ggaaaaaggt atttggaaca tcaatctgta attatccatt
     8341 ttccattcat gcattcacta attcaatatt tgatatgtgt ctgggagtgc tgggaataac
     8401 ataaatacaa aaaaaaccct aagataatca ttcaccagaa gctcatagat ataatacagt
     8461 tatatagcta aatgcaacca gttgtttttc caaatgtact catcatctgt aataaaagaa
     8521 aaatgaagta aaacatctga aaccttaa
//
