LOCUS       NM_001247               4104 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens ectonucleoside triphosphate diphosphohydrolase 6
            (ENTPD6), transcript variant 1, mRNA.
ACCESSION   NM_001247
VERSION     NM_001247.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4104)
  AUTHORS   Ramasamy,A., Curjuric,I., Coin,L.J., Kumar,A., McArdle,W.L.,
            Imboden,M., Leynaert,B., Kogevinas,M., Schmid-Grendelmeier,P.,
            Pekkanen,J., Wjst,M., Bircher,A.J., Sovio,U., Rochat,T.,
            Hartikainen,A.L., Balding,D.J., Jarvelin,M.R., Probst-Hensch,N.,
            Strachan,D.P. and Jarvis,D.L.
  TITLE     A genome-wide meta-analysis of genetic variants associated with
            allergic rhinitis and grass sensitization and their interaction
            with birth order
  JOURNAL   J Allergy Clin Immunol 128 (5), 996-1005 (2011)
   PUBMED   22036096
REFERENCE   2  (bases 1 to 4104)
  AUTHORS   Bailey,S.D., Xie,C., Do,R., Montpetit,A., Diaz,R., Mohan,V.,
            Keavney,B., Yusuf,S., Gerstein,H.C., Engert,J.C. and Anand,S.
  CONSRTM   DREAM investigators
  TITLE     Variation at the NFATC2 locus increases the risk of
            thiazolidinedione-induced edema in the Diabetes REduction
            Assessment with ramipril and rosiglitazone Medication (DREAM) study
  JOURNAL   Diabetes Care 33 (10), 2250-2253 (2010)
   PUBMED   20628086
  REMARK    GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
REFERENCE   3  (bases 1 to 4104)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am J Hum Genet 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   4  (bases 1 to 4104)
  AUTHORS   Lim,J., Hao,T., Shaw,C., Patel,A.J., Szabo,G., Rual,J.F.,
            Fisk,C.J., Li,N., Smolyar,A., Hill,D.E., Barabasi,A.L., Vidal,M.
            and Zoghbi,H.Y.
  TITLE     A protein-protein interaction network for human inherited ataxias
            and disorders of Purkinje cell degeneration
  JOURNAL   Cell 125 (4), 801-814 (2006)
   PUBMED   16713569
REFERENCE   5  (bases 1 to 4104)
  AUTHORS   Ivanenkov,V.V., Murphy-Piedmonte,D.M. and Kirley,T.L.
  TITLE     Bacterial expression, characterization, and disulfide bond
            determination of soluble human NTPDase6 (CD39L2) nucleotidase:
            implications for structure and function
  JOURNAL   Biochemistry 42 (40), 11726-11735 (2003)
   PUBMED   14529283
  REMARK    GeneRIF: A secondary structural model of NTPDase-6 is proposed
            based on disulfide architecture (four conserved cysteine residues
            Cys249-Cys280 and Cys340-Cys354, circular dichroism data, and
            regions of conservation among all NTPDases.
REFERENCE   6  (bases 1 to 4104)
  AUTHORS   Deloukas,P., Matthews,L.H., Ashurst,J., Burton,J., Gilbert,J.G.,
            Jones,M., Stavrides,G., Almeida,J.P., Babbage,A.K., Bagguley,C.L.,
            Bailey,J., Barlow,K.F., Bates,K.N., Beard,L.M., Beare,D.M.,
            Beasley,O.P., Bird,C.P., Blakey,S.E., Bridgeman,A.M., Brown,A.J.,
            Buck,D., Burrill,W., Butler,A.P., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M., Clark,G., Clark,L.N., Clark,S.Y.,
            Clee,C.M., Clegg,S., Cobley,V.E., Collier,R.E., Connor,R.,
            Corby,N.R., Coulson,A., Coville,G.J., Deadman,R., Dhami,P.,
            Dunn,M., Ellington,A.G., Frankland,J.A., Fraser,A., French,L.,
            Garner,P., Grafham,D.V., Griffiths,C., Griffiths,M.N., Gwilliam,R.,
            Hall,R.E., Hammond,S., Harley,J.L., Heath,P.D., Ho,S., Holden,J.L.,
            Howden,P.J., Huckle,E., Hunt,A.R., Hunt,S.E., Jekosch,K.,
            Johnson,C.M., Johnson,D., Kay,M.P., Kimberley,A.M., King,A.,
            Knights,A., Laird,G.K., Lawlor,S., Lehvaslaiho,M.H., Leversha,M.,
            Lloyd,C., Lloyd,D.M., Lovell,J.D., Marsh,V.L., Martin,S.L.,
            McConnachie,L.J., McLay,K., McMurray,A.A., Milne,S., Mistry,D.,
            Moore,M.J., Mullikin,J.C., Nickerson,T., Oliver,K., Parker,A.,
            Patel,R., Pearce,T.A., Peck,A.I., Phillimore,B.J.,
            Prathalingam,S.R., Plumb,R.W., Ramsay,H., Rice,C.M., Ross,M.T.,
            Scott,C.E., Sehra,H.K., Shownkeen,R., Sims,S., Skuce,C.D.,
            Smith,M.L., Soderlund,C., Steward,C.A., Sulston,J.E., Swann,M.,
            Sycamore,N., Taylor,R., Tee,L., Thomas,D.W., Thorpe,A., Tracey,A.,
            Tromans,A.C., Vaudin,M., Wall,M., Wallis,J.M., Whitehead,S.L.,
            Whittaker,P., Willey,D.L., Williams,L., Williams,S.A., Wilming,L.,
            Wray,P.W., Hubbard,T., Durbin,R.M., Bentley,D.R., Beck,S. and
            Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 20
  JOURNAL   Nature 414 (6866), 865-871 (2001)
   PUBMED   11780052
REFERENCE   7  (bases 1 to 4104)
  AUTHORS   Hicks-Berger,C.A., Chadwick,B.P., Frischauf,A.M. and Kirley,T.L.
  TITLE     Expression and characterization of soluble and membrane-bound human
            nucleoside triphosphate diphosphohydrolase 6 (CD39L2)
  JOURNAL   J Biol Chem 275 (44), 34041-34045 (2000)
   PUBMED   10948193
REFERENCE   8  (bases 1 to 4104)
  AUTHORS   Yeung,G., Mulero,J.J., McGowan,D.W., Bajwa,S.S. and Ford,J.E.
  TITLE     CD39L2, a gene encoding a human nucleoside diphosphatase,
            predominantly expressed in the heart
  JOURNAL   Biochemistry 39 (42), 12916-12923 (2000)
   PUBMED   11041856
REFERENCE   9  (bases 1 to 4104)
  AUTHORS   Chadwick,B.P. and Frischauf,A.M.
  TITLE     The CD39-like gene family: identification of three new human
            members (CD39L2, CD39L3, and CD39L4), their murine homologues, and
            a member of the gene family from Drosophila melanogaster
  JOURNAL   Genomics 50 (3), 357-367 (1998)
   PUBMED   9676430
REFERENCE   10 (bases 1 to 4104)
  AUTHORS   Chadwick,B.P. and Frischauf,A.M.
  TITLE     Cloning and mapping of a human and mouse gene with homology to
            ecto-ATPase genes
  JOURNAL   Mamm Genome 8 (9), 668-672 (1997)
   PUBMED   9271669
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL035252.5.
            
            On May 17, 2019 this sequence version replaced NM_001247.4.
            
            Summary: ENTPD6 is similar to E-type nucleotidases (NTPases).
            NTPases, such as CD39, mediate catabolism of extracellular
            nucleotides. ENTPD6 contains 4 apyrase-conserved regions which are
            characteristic of NTPases. Alternative splicing results in multiple
            transcript variants encoding different isoforms. [provided by
            RefSeq, Dec 2015].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.254771.1,
                                           SRR1803617.195033.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000376652.9/ ENSP00000365840.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-156               AL035252.5         73477-73632
            157-225             AL035252.5         84287-84355
            226-547             AL035252.5         84841-85162
            548-624             AL035252.5         87614-87690
            625-768             AL035252.5         91028-91171
            769-844             AL035252.5         92632-92707
            845-880             AL035252.5         93441-93476
            881-969             AL035252.5         94413-94501
            970-1049            AL035252.5         95267-95346
            1050-1114           AL035252.5         96315-96379
            1115-1216           AL035252.5         98997-99098
            1217-1357           AL035252.5         100603-100743
            1358-1414           AL035252.5         101866-101922
            1415-1527           AL035252.5         102970-103082
            1528-4104           AL035252.5         103264-105840
FEATURES             Location/Qualifiers
     source          1..4104
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20p11.21"
     gene            1..4104
                     /gene="ENTPD6"
                     /gene_synonym="CD39L2; dJ738P15.3; IL-6SAG; IL6ST2;
                     NTPDase-6"
                     /note="ectonucleoside triphosphate diphosphohydrolase 6"
                     /db_xref="GeneID:955"
                     /db_xref="HGNC:HGNC:3368"
                     /db_xref="MIM:603160"
     exon            1..156
                     /gene="ENTPD6"
                     /gene_synonym="CD39L2; dJ738P15.3; IL-6SAG; IL6ST2;
                     NTPDase-6"
                     /inference="alignment:Splign:2.1.0"
     exon            157..225
                     /gene="ENTPD6"
                     /gene_synonym="CD39L2; dJ738P15.3; IL-6SAG; IL6ST2;
                     NTPDase-6"
                     /inference="alignment:Splign:2.1.0"
     CDS             172..1626
                     /gene="ENTPD6"
                     /gene_synonym="CD39L2; dJ738P15.3; IL-6SAG; IL6ST2;
                     NTPDase-6"
                     /EC_number="3.6.1.6"
                     /note="isoform 1 is encoded by transcript variant 1;
                     interleukin 6 signal transducer-2; NTPDase 6; CD39
                     antigen-like 2; ectonucleoside triphosphate
                     diphosphohydrolase 6 (putative)"
                     /codon_start=1
                     /product="ectonucleoside triphosphate diphosphohydrolase 6
                     isoform 1"
                     /protein_id="NP_001238.3"
                     /db_xref="CCDS:CCDS13170.1"
                     /db_xref="GeneID:955"
                     /db_xref="HGNC:HGNC:3368"
                     /db_xref="MIM:603160"
                     /translation="MKKGIRYETSRKTSYIFQQPQHGPWQTRMRKISNHGSLRVAKVA
                     YPLGLCVGVFIYVAYIKWHRATATQAFFSITRAAPGARWGQQAHSPLGTAADGHEVFY
                     GIMFDAGSTGTRVHVFQFTRPPRETPTLTHETFKALKPGLSAYADDVEKSAQGIRELL
                     DVAKQDIPFDFWKATPLVLKATAGLRLLPGEKAQKLLQKVKKVFKASPFLVGDDCVSI
                     MNGTDEGVSAWITINFLTGSLKTPGGSSVGMLDLGGGSTQIAFLPRVEGTLQASPPGY
                     LTALRMFNRTYKLYSYSYLGLGLMSARLAILGGVEGQPAKDGKELVSPCLSPSFKGEW
                     EHAEVTYRVSGQKAAASLHELCAARVSEVLQNRVHRTEEVKHVDFYAFSYYYDLAAGV
                     GLIDAEKGGSLVVGDFEIAAKYVCRTLETQPQSSPFSCMDLTYVSLLLQEFGFPRSKV
                     LKLTRKIDNVETSWALGAIFHYIDSLNRQKSPAS"
     exon            226..547
                     /gene="ENTPD6"
                     /gene_synonym="CD39L2; dJ738P15.3; IL-6SAG; IL6ST2;
                     NTPDase-6"
                     /inference="alignment:Splign:2.1.0"
     exon            548..624
                     /gene="ENTPD6"
                     /gene_synonym="CD39L2; dJ738P15.3; IL-6SAG; IL6ST2;
                     NTPDase-6"
                     /inference="alignment:Splign:2.1.0"
     exon            625..768
                     /gene="ENTPD6"
                     /gene_synonym="CD39L2; dJ738P15.3; IL-6SAG; IL6ST2;
                     NTPDase-6"
                     /inference="alignment:Splign:2.1.0"
     exon            769..844
                     /gene="ENTPD6"
                     /gene_synonym="CD39L2; dJ738P15.3; IL-6SAG; IL6ST2;
                     NTPDase-6"
                     /inference="alignment:Splign:2.1.0"
     exon            845..880
                     /gene="ENTPD6"
                     /gene_synonym="CD39L2; dJ738P15.3; IL-6SAG; IL6ST2;
                     NTPDase-6"
                     /inference="alignment:Splign:2.1.0"
     exon            881..969
                     /gene="ENTPD6"
                     /gene_synonym="CD39L2; dJ738P15.3; IL-6SAG; IL6ST2;
                     NTPDase-6"
                     /inference="alignment:Splign:2.1.0"
     exon            970..1049
                     /gene="ENTPD6"
                     /gene_synonym="CD39L2; dJ738P15.3; IL-6SAG; IL6ST2;
                     NTPDase-6"
                     /inference="alignment:Splign:2.1.0"
     exon            1050..1114
                     /gene="ENTPD6"
                     /gene_synonym="CD39L2; dJ738P15.3; IL-6SAG; IL6ST2;
                     NTPDase-6"
                     /inference="alignment:Splign:2.1.0"
     exon            1115..1216
                     /gene="ENTPD6"
                     /gene_synonym="CD39L2; dJ738P15.3; IL-6SAG; IL6ST2;
                     NTPDase-6"
                     /inference="alignment:Splign:2.1.0"
     exon            1217..1357
                     /gene="ENTPD6"
                     /gene_synonym="CD39L2; dJ738P15.3; IL-6SAG; IL6ST2;
                     NTPDase-6"
                     /inference="alignment:Splign:2.1.0"
     exon            1358..1414
                     /gene="ENTPD6"
                     /gene_synonym="CD39L2; dJ738P15.3; IL-6SAG; IL6ST2;
                     NTPDase-6"
                     /inference="alignment:Splign:2.1.0"
     exon            1415..1527
                     /gene="ENTPD6"
                     /gene_synonym="CD39L2; dJ738P15.3; IL-6SAG; IL6ST2;
                     NTPDase-6"
                     /inference="alignment:Splign:2.1.0"
     exon            1528..4104
                     /gene="ENTPD6"
                     /gene_synonym="CD39L2; dJ738P15.3; IL-6SAG; IL6ST2;
                     NTPDase-6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2725..2730
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ENTPD6"
                     /gene_synonym="CD39L2; dJ738P15.3; IL-6SAG; IL6ST2;
                     NTPDase-6"
                     /note="hexamer: AATAAA"
     polyA_site      2742
                     /gene="ENTPD6"
                     /gene_synonym="CD39L2; dJ738P15.3; IL-6SAG; IL6ST2;
                     NTPDase-6"
                     /note="major polyA site"
ORIGIN      
        1 gcggagccca ggccctaggg aatcgtgggg tcgtatcccg cgggtggagg ccggggtggc
       61 gccggccggg gcgggggagc ccaaaagacc ggctgccgcc tgctccccgg aaaagggcac
      121 tcgtctccgt gggtgtggcg gagcgcgcgg tgcatggaat gggctatgtg aatgaaaaaa
      181 ggtatccgtt atgaaacttc cagaaaaacg agctacattt ttcagcagcc gcagcacggt
      241 ccttggcaaa caaggatgag aaaaatatcc aaccacggga gcctgcgggt ggcgaaggtg
      301 gcataccccc tggggctgtg tgtgggcgtg ttcatctatg ttgcctacat caagtggcac
      361 cgggccaccg ccacccaggc cttcttcagc atcaccaggg cagccccggg ggcccggtgg
      421 ggtcagcagg cccacagccc cctggggaca gctgcagacg ggcacgaggt cttctacggg
      481 atcatgtttg atgcaggaag cactggcacc cgagtacacg tcttccagtt cacccggccc
      541 cccagagaaa ctcccacgtt aacccacgaa accttcaaag cactgaagcc aggtctttct
      601 gcctatgctg atgatgttga aaagagcgct cagggaatcc gggaactact ggatgttgct
      661 aaacaggaca ttccgttcga cttctggaag gccacccctc tggtcctcaa ggccacagct
      721 ggcttacgcc tgttacctgg agaaaaggcc cagaagttac tgcagaaggt gaaaaaagta
      781 tttaaagcat cgcctttcct tgtaggggat gactgtgttt ccatcatgaa cggaacagat
      841 gaaggcgttt cggcgtggat caccatcaac ttcctgacag gcagcttgaa aactccagga
      901 gggagcagcg tgggcatgct ggacttgggc ggaggatcca ctcagatcgc cttcctgcca
      961 cgcgtggagg gcaccctgca ggcctcccca cccggctacc tgacggcact gcggatgttt
     1021 aacaggacct acaagctcta ttcctacagc tacctcgggc tcgggctgat gtcggcacgc
     1081 ctggcgatcc tgggcggcgt ggaggggcag cctgctaagg atggaaagga gttggtcagc
     1141 ccttgcttgt ctcccagttt caaaggagag tgggaacacg cagaagtcac gtacagggtt
     1201 tcagggcaga aagcagcggc aagcctgcac gagctgtgtg ctgccagagt gtcagaggtc
     1261 cttcaaaaca gagtgcacag gacggaggaa gtgaagcatg tggacttcta tgctttctcc
     1321 tactattacg accttgcagc tggtgtgggc ctcatagatg cggagaaggg aggcagcctg
     1381 gtggtggggg acttcgagat cgcagccaag tacgtgtgtc ggaccctgga gacacagccg
     1441 cagagcagcc ccttctcatg catggacctc acctacgtca gcctgctact ccaggagttc
     1501 ggctttccca ggagcaaagt gctgaagctc actcggaaaa ttgacaatgt tgagaccagc
     1561 tgggctctgg gggccatttt tcattacatc gactccctga acagacagaa gagtccagcc
     1621 tcatagtggc cgagccatcc ctgtccccgt cagcagtgtc tgtgtgtctg cataaaccct
     1681 cctgtcctgg acgtgacttc atcctgagga gccacagcac aggccgtgct ggcactttct
     1741 gcacactggc tctgggactt gcagaaggcc tggtgctgcc ctggcatcag cctcttccag
     1801 tcacatctgg ccagagggct gtctggacct gggccctgct caatgccacc tgtctgcctg
     1861 ggctccaagt gggcaggacc aggacagaac cacaggcaca cactgagggg gcagtgtggc
     1921 tccctgcctg tcccatcccc atgccccgtc cgcggggctg tggctgctgc tgtgcatgtc
     1981 cctgcgatgg gagtcttgtc tcccagcctg tcagtttcct ccccagggca gagctcccct
     2041 tcctgcaaga gtctgggagg cggtgcaggc tgtcctggct gctctgggga agccgaggga
     2101 cagccataac acccccggga cagtaggtct gggcggcacc actgggaact ctggacttga
     2161 gtgtgtttgc ctcttccttg ggtatgaatg tgtgagttca cccagaggcc tgctctcctc
     2221 acacattgtg tggtttgggg ttaatgatgg agggagacac ctcctcatag acggcaggtg
     2281 cccacctttc agggagtctc ccagcatggg cggatgccgg gcatgagctg ctgtaaacta
     2341 tttgtggctg tgctgcttga gtgacgtctc tgtcgtgtgg gtgccaagtg cttgtgtaga
     2401 aactgtgttc tgagccccct tttctggaca ccaactgtgt cctgtgaatg tatcgctact
     2461 gtgagctgtt cccgcctagc cagggccatg tcttaggtgc agctgtgcca cgggtcagct
     2521 gagccacagt cccagaacca agctctcggt gtctcgggcc accatccgcc cacctcgggc
     2581 tgaccccacc tcctccatgg acagtgtgag ccccgggccg tgcatcctgc tcagtgtggc
     2641 gtcagtgtcg gggctgagcc ccttgagctg cttcagtgaa tgtacagtgc ccggcacgag
     2701 ctgaacctca tgtgttccac tcccaataaa aggttgacag gggcttctcc ttctctggga
     2761 ttcctctcgt tgagcgacag tagcatttgc ccacctggca cctgagatcc ctgtttacta
     2821 aaccttagaa aagctgccaa agggggtggc gtatttccag tcctgtcgac atccctctcg
     2881 aggacacagc agtggagggc ccctgggggc tggggctggt gaagggtctg gctggtggcc
     2941 ccggccctcc cagcgtctgt tgagcacagc tcctcctgtg ccaggccagc agcccacagc
     3001 acggccaggt gaggcctggg cacataacct cgagtgagct gcaagtcccc atgtcattct
     3061 gttcagcaag gatctggttt tggtctggaa gcgtcccaaa ggtgtcgcat gccagggaaa
     3121 ctgcagacca gcccacatcc cgagtgcttg tgcctgaagc cccccccaac caactgtcac
     3181 aggaggacag gatctggccc tagggcctcc cagggctgca gcgaatgctg atggagccac
     3241 gtggtggagg cctgcacaga gcaggaaagg acaaaagaca aaaagaggaa cagtttcctc
     3301 cctcccgcct gggctgggtc cccaccagcg cctttacttc cataatatcc accagcttaa
     3361 atatttaaag aactccggag gctgagaatc agacgcatga aggtaaagcc aaaatcaatt
     3421 tggtccattt aaagaaggtc ggtgacctca tgcctgaaaa aggcaaacaa ctggaagttt
     3481 tccaaaagtg caccaaataa gtcatggaat atttctgggc ccggcaaagt atgcaagtca
     3541 tttctctctg agtgtctttt gtgataatga agtaggctct catttgtcaa aaatagctac
     3601 acgtgcacat cgtaaaagaa gcaaactagg gttgcttgaa aattctgttc cctcaggatg
     3661 tgtgcattga caagctcaga caggtctcac acgccccaca tgccacccca gcccgcgtac
     3721 cccacatcac ttagcaccca ttgctgccca ctgagctgcc tcagtcctgc agtccccgtg
     3781 tttggatggc aggatcccag ggcagtgagt ttcagggcat aagcagacgt tgccacgttg
     3841 ccttcaatcc tactggacaa gcatcggtgc tggcctcccc catgtcctaa cagctacagc
     3901 cagtttaatc tttgccattc tggcagattt aaaaaaatga taactggtag ttttaatatg
     3961 catggatcta attcatcggg tatatctaag ttgtatttcc gtgaaacatc tgttcatatc
     4021 ccttgccgat tttctataag attgtcatca tttttttgtt aattgtagat ctttatttat
     4081 taaggaaatt atcccattat gata
//
