LOCUS       NM_001382258            1735 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens ectonucleoside triphosphate diphosphohydrolase 5
            (inactive) (ENTPD5), transcript variant 10, mRNA.
ACCESSION   NM_001382258
VERSION     NM_001382258.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1735)
  AUTHORS   Xu,L., Zhou,Y., Wang,G., Bo,L., Jin,B., Dai,L., Lu,Q., Cai,X.,
            Hu,L., Liu,L., Wu,Y., Chang,X., Huang,Y., Song,L., Zhang,T.,
            Wang,Y., Xiao,Y., Zhang,F., Liu,L., Shi,M., Wang,T. and Guo,B.
  TITLE     The UDPase ENTPD5 regulates ER stress-associated renal injury by
            mediating protein N-glycosylation
  JOURNAL   Cell Death Dis 14 (2), 166 (2023)
   PUBMED   36849424
  REMARK    GeneRIF: The UDPase ENTPD5 regulates ER stress-associated renal
            injury by mediating protein N-glycosylation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1735)
  AUTHORS   Arruga,F.
  TITLE     ENTPD5 splice variants: novel players in cancer?
  JOURNAL   Purinergic Signal 17 (3), 317-318 (2021)
   PUBMED   34272651
  REMARK    GeneRIF: ENTPD5 splice variants: novel players in cancer?
            Review article
REFERENCE   3  (bases 1 to 1735)
  AUTHORS   de Campos,R.P., Wink,M.R. and Lenz,G.
  TITLE     ENTPD5: identification of splicing variants and their impact on
            cancer survival
  JOURNAL   Purinergic Signal 17 (3), 467-480 (2021)
   PUBMED   34075526
  REMARK    GeneRIF: ENTPD5: identification of splicing variants and their
            impact on cancer survival.
REFERENCE   4  (bases 1 to 1735)
  AUTHORS   Wang,H., Chen,X., Chen,Y., Cao,Y., Chen,Y., Liu,G. and Huang,L.
  TITLE     [ENTPD5 gene is highly expressed in epithelial ovarian cancer:
            analysis based on Oncomine database and bioinformatics]
  JOURNAL   Nan Fang Yi Ke Da Xue Xue Bao 41 (4), 555-561 (2021)
   PUBMED   33963715
  REMARK    GeneRIF: [ENTPD5 gene is highly expressed in epithelial ovarian
            cancer: analysis based on Oncomine database and bioinformatics].
REFERENCE   5  (bases 1 to 1735)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   6  (bases 1 to 1735)
  AUTHORS   Mulero,J.J., Yeung,G., Nelken,S.T., Bright,J.M., McGowan,D.W. and
            Ford,J.E.
  TITLE     Biochemical characterization of CD39L4
  JOURNAL   Biochemistry 39 (42), 12924-12928 (2000)
   PUBMED   11041857
REFERENCE   7  (bases 1 to 1735)
  AUTHORS   Recio,J.A., Zambrano,N., Pena,Ld., Reig,J.A., Rhoads,A., Rouzaut,A.
            and Notario,V.
  TITLE     The human PCPH proto-oncogene: cDNA identification, primary
            structure, chromosomal mapping, and expression in normal and tumor
            cells
  JOURNAL   Mol Carcinog 27 (3), 229-236 (2000)
   PUBMED   10708485
  REMARK    Erratum:[Mol Carcinog 2000 May;28(1):62]
REFERENCE   8  (bases 1 to 1735)
  AUTHORS   Mulero,J.J., Yeung,G., Nelken,S.T. and Ford,J.E.
  TITLE     CD39-L4 is a secreted human apyrase, specific for the hydrolysis of
            nucleoside diphosphates
  JOURNAL   J Biol Chem 274 (29), 20064-20067 (1999)
   PUBMED   10400613
REFERENCE   9  (bases 1 to 1735)
  AUTHORS   Chadwick,B.P. and Frischauf,A.M.
  TITLE     The CD39-like gene family: identification of three new human
            members (CD39L2, CD39L3, and CD39L4), their murine homologues, and
            a member of the gene family from Drosophila melanogaster
  JOURNAL   Genomics 50 (3), 357-367 (1998)
   PUBMED   9676430
REFERENCE   10 (bases 1 to 1735)
  AUTHORS   Chadwick,B.P. and Frischauf,A.M.
  TITLE     Cloning and mapping of a human and mouse gene with homology to
            ecto-ATPase genes
  JOURNAL   Mamm Genome 8 (9), 668-672 (1997)
   PUBMED   9271669
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC005484.2 and AC005480.3.
            
            Summary: The protein encoded by this gene is similar to E-type
            nucleotidases (NTPases)/ecto-ATPase/apyrases. NTPases, such as
            CD39, mediate catabolism of extracellular nucleotides. ENTPD5
            contains 4 apyrase-conserved regions which is characteristic of
            NTPases. [provided by RefSeq, Jan 2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.157880.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-39                AC005484.2         121802-121840
            40-146              AC005484.2         125160-125266
            147-206             AC005484.2         129940-129999
            207-493             AC005480.3         21175-21461
            494-573             AC005480.3         22454-22533
            574-717             AC005480.3         26186-26329
            718-793             AC005480.3         31973-32048
            794-829             AC005480.3         32288-32323
            830-918             AC005480.3         32935-33023
            919-998             AC005480.3         33332-33411
            999-1060            AC005480.3         34362-34423
            1061-1162           AC005480.3         35369-35470
            1163-1303           AC005480.3         36323-36463
            1304-1360           AC005480.3         37439-37495
            1361-1476           AC005480.3         39222-39337
            1477-1735           AC005480.3         53760-54018
FEATURES             Location/Qualifiers
     source          1..1735
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q24.3"
     gene            1..1735
                     /gene="ENTPD5"
                     /gene_synonym="CD39L4; NTPDase-5; PCPH"
                     /note="ectonucleoside triphosphate diphosphohydrolase 5
                     (inactive)"
                     /db_xref="GeneID:957"
                     /db_xref="HGNC:HGNC:3367"
                     /db_xref="MIM:603162"
     exon            1..39
                     /gene="ENTPD5"
                     /gene_synonym="CD39L4; NTPDase-5; PCPH"
                     /inference="alignment:Splign:2.1.0"
     exon            40..146
                     /gene="ENTPD5"
                     /gene_synonym="CD39L4; NTPDase-5; PCPH"
                     /inference="alignment:Splign:2.1.0"
     exon            147..206
                     /gene="ENTPD5"
                     /gene_synonym="CD39L4; NTPDase-5; PCPH"
                     /inference="alignment:Splign:2.1.0"
     exon            207..493
                     /gene="ENTPD5"
                     /gene_synonym="CD39L4; NTPDase-5; PCPH"
                     /inference="alignment:Splign:2.1.0"
     CDS             277..1509
                     /gene="ENTPD5"
                     /gene_synonym="CD39L4; NTPDase-5; PCPH"
                     /EC_number="3.6.1.6"
                     /note="isoform 4 precursor is encoded by transcript
                     variant 10; proto-oncogene CPH; CD39-like 4; Pcph
                     proto-oncogene protein; ER-UDPase; NTPDase 5; CD39
                     antigen-like 4; nucleoside diphosphatase; GDPase ENTPD5;
                     UDPase ENTPD5; uridine-diphosphatase ENTPD5;
                     guanosine-diphosphatase ENTPD5; inosine diphosphate
                     phosphatase ENTPD5; nucleoside diphosphate phosphatase
                     ENTPD5"
                     /codon_start=1
                     /product="nucleoside diphosphate phosphatase ENTPD5
                     isoform 4 precursor"
                     /protein_id="NP_001369187.1"
                     /db_xref="GeneID:957"
                     /db_xref="HGNC:HGNC:3367"
                     /db_xref="MIM:603162"
                     /translation="MATSWGTVFFMLVVSCVCSAVSHRNQQTWFEGIFLSSMCPINVS
                     ASTLYGIMFDAGSTGTRIHVYTFVQKMPGQLPILEGEVFDSVKPGLSAFVDQPKQGAE
                     TVQGLLEVAKDSIPRSHWKKTPVVLKATAGLRLLPEHKAKALLFEVKEIFRKSPFLVP
                     KGSVSIMDGSDEGILAWVTVNFLTGQLHGHRQETVGTLDLGGASTQITFLPQFEKTLE
                     QTPRGYLTSFEMFNSTYKLYTHSYLGFGLKAARLATLGALETEGTDGHTFRSACLPRW
                     LEAEWIFGGVKYQYGGNQEGEVGFEPCYAEVLRVVRGKLHQPEEVQRGSFYAFSYYYD
                     RAVDTDMIDYEKGGILKVEDFERKAREVCDNLENFTSGSPFLCMDLSYITALLKDGFG
                     FADSTVLQNTWRKWTPIS"
     exon            494..573
                     /gene="ENTPD5"
                     /gene_synonym="CD39L4; NTPDase-5; PCPH"
                     /inference="alignment:Splign:2.1.0"
     exon            574..717
                     /gene="ENTPD5"
                     /gene_synonym="CD39L4; NTPDase-5; PCPH"
                     /inference="alignment:Splign:2.1.0"
     exon            718..793
                     /gene="ENTPD5"
                     /gene_synonym="CD39L4; NTPDase-5; PCPH"
                     /inference="alignment:Splign:2.1.0"
     exon            794..829
                     /gene="ENTPD5"
                     /gene_synonym="CD39L4; NTPDase-5; PCPH"
                     /inference="alignment:Splign:2.1.0"
     exon            830..918
                     /gene="ENTPD5"
                     /gene_synonym="CD39L4; NTPDase-5; PCPH"
                     /inference="alignment:Splign:2.1.0"
     exon            919..998
                     /gene="ENTPD5"
                     /gene_synonym="CD39L4; NTPDase-5; PCPH"
                     /inference="alignment:Splign:2.1.0"
     exon            999..1060
                     /gene="ENTPD5"
                     /gene_synonym="CD39L4; NTPDase-5; PCPH"
                     /inference="alignment:Splign:2.1.0"
     exon            1061..1162
                     /gene="ENTPD5"
                     /gene_synonym="CD39L4; NTPDase-5; PCPH"
                     /inference="alignment:Splign:2.1.0"
     exon            1163..1303
                     /gene="ENTPD5"
                     /gene_synonym="CD39L4; NTPDase-5; PCPH"
                     /inference="alignment:Splign:2.1.0"
     exon            1304..1360
                     /gene="ENTPD5"
                     /gene_synonym="CD39L4; NTPDase-5; PCPH"
                     /inference="alignment:Splign:2.1.0"
     exon            1361..1476
                     /gene="ENTPD5"
                     /gene_synonym="CD39L4; NTPDase-5; PCPH"
                     /inference="alignment:Splign:2.1.0"
     exon            1477..1735
                     /gene="ENTPD5"
                     /gene_synonym="CD39L4; NTPDase-5; PCPH"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1716..1721
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ENTPD5"
                     /gene_synonym="CD39L4; NTPDase-5; PCPH"
                     /note="hexamer: AATAAT"
     polyA_site      1735
                     /gene="ENTPD5"
                     /gene_synonym="CD39L4; NTPDase-5; PCPH"
                     /note="major polyA site"
ORIGIN      
        1 gagggcggcg ggctgccgcg caagggtggc gcgcgcgcgt tttccttgtt cctggtcaac
       61 aaagaaatgt ggagtgtctt ggctgaatcc tcatacagac aagatcatta tggtgctgtt
      121 aggtaggact tgtatccaga tgtaaggttg aaaaagtgat ataataaagg aaccaaggag
      181 aaaattcaga aggaaagaaa aaattgcctc tgcaggtgtg cgagcaggat tgcttctgca
      241 acaaaagcct ccacccagcc acatcttggg aaaagaatgg ccacttcttg gggcacagtc
      301 tttttcatgc tggtggtatc ctgtgtttgc agcgctgtct cccacaggaa ccagcagact
      361 tggtttgagg gtatcttcct gtcttccatg tgccccatca atgtcagcgc cagcaccttg
      421 tatggaatta tgtttgatgc agggagcact ggaactcgaa ttcatgttta cacctttgtg
      481 cagaaaatgc caggacagct tccaattcta gaaggggaag tttttgattc tgtgaagcca
      541 ggactttctg cttttgtaga tcaacctaag cagggtgctg agaccgttca agggctctta
      601 gaggtggcca aagactcaat cccccgaagt cactggaaaa agaccccagt ggtcctaaag
      661 gcaacagcag gactacgctt actgccagaa cacaaagcca aggctctgct ctttgaggta
      721 aaggagatct tcaggaagtc acctttcctg gtaccaaagg gcagtgttag catcatggat
      781 ggatccgacg aaggcatatt agcttgggtt actgtgaatt ttctgacagg tcagctgcat
      841 ggccacagac aggagactgt ggggaccttg gacctagggg gagcctccac ccaaatcacg
      901 ttcctgcccc agtttgagaa aactctggaa caaactccta ggggctacct cacttccttt
      961 gagatgttta acagcactta taagctctat acacatagtt acctgggatt tggattgaaa
     1021 gctgcaagac tagcaaccct gggagccctg gagacagaag ggactgatgg gcacactttc
     1081 cggagtgcct gtttaccgag atggttggaa gcagagtgga tctttggggg tgtgaaatac
     1141 cagtatggtg gcaaccaaga aggggaggtg ggctttgagc cctgctatgc cgaagtgctg
     1201 agggtggtac gaggaaaact tcaccagcca gaggaggtcc agagaggttc cttctatgct
     1261 ttctcttact attatgaccg agctgttgac acagacatga ttgattatga aaaggggggt
     1321 attttaaaag ttgaagattt tgaaagaaaa gccagggaag tgtgtgataa cttggaaaac
     1381 ttcacctcag gcagtccttt cctgtgcatg gatctcagct acatcacagc cctgttaaag
     1441 gatggctttg gctttgcaga cagcacagtc ttacagaaca cttggagaaa gtggactccg
     1501 atatcttaag acagaccaag acatcttgac aaaattgaaa agataaaggg gcacctgcat
     1561 tcgccgaaag gctctgtatc tcatgttgca gatatggtcc caggcaccaa aacctacaaa
     1621 agaaaggatc tatagaccag agtgacttca caaggacctg ggctccccct tgtccctcca
     1681 tcctgttacg taagaggttg ttttcagtgt tcttcaataa tactctccac ttcta
//
