LOCUS       NM_001249               5261 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens ectonucleoside triphosphate diphosphohydrolase 5
            (inactive) (ENTPD5), transcript variant 1, mRNA.
ACCESSION   NM_001249
VERSION     NM_001249.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5261)
  AUTHORS   Xu,L., Zhou,Y., Wang,G., Bo,L., Jin,B., Dai,L., Lu,Q., Cai,X.,
            Hu,L., Liu,L., Wu,Y., Chang,X., Huang,Y., Song,L., Zhang,T.,
            Wang,Y., Xiao,Y., Zhang,F., Liu,L., Shi,M., Wang,T. and Guo,B.
  TITLE     The UDPase ENTPD5 regulates ER stress-associated renal injury by
            mediating protein N-glycosylation
  JOURNAL   Cell Death Dis 14 (2), 166 (2023)
   PUBMED   36849424
  REMARK    GeneRIF: The UDPase ENTPD5 regulates ER stress-associated renal
            injury by mediating protein N-glycosylation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5261)
  AUTHORS   Arruga,F.
  TITLE     ENTPD5 splice variants: novel players in cancer?
  JOURNAL   Purinergic Signal 17 (3), 317-318 (2021)
   PUBMED   34272651
  REMARK    GeneRIF: ENTPD5 splice variants: novel players in cancer?
            Review article
REFERENCE   3  (bases 1 to 5261)
  AUTHORS   de Campos,R.P., Wink,M.R. and Lenz,G.
  TITLE     ENTPD5: identification of splicing variants and their impact on
            cancer survival
  JOURNAL   Purinergic Signal 17 (3), 467-480 (2021)
   PUBMED   34075526
  REMARK    GeneRIF: ENTPD5: identification of splicing variants and their
            impact on cancer survival.
REFERENCE   4  (bases 1 to 5261)
  AUTHORS   Wang,H., Chen,X., Chen,Y., Cao,Y., Chen,Y., Liu,G. and Huang,L.
  TITLE     [ENTPD5 gene is highly expressed in epithelial ovarian cancer:
            analysis based on Oncomine database and bioinformatics]
  JOURNAL   Nan Fang Yi Ke Da Xue Xue Bao 41 (4), 555-561 (2021)
   PUBMED   33963715
  REMARK    GeneRIF: [ENTPD5 gene is highly expressed in epithelial ovarian
            cancer: analysis based on Oncomine database and bioinformatics].
REFERENCE   5  (bases 1 to 5261)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   6  (bases 1 to 5261)
  AUTHORS   Mulero,J.J., Yeung,G., Nelken,S.T., Bright,J.M., McGowan,D.W. and
            Ford,J.E.
  TITLE     Biochemical characterization of CD39L4
  JOURNAL   Biochemistry 39 (42), 12924-12928 (2000)
   PUBMED   11041857
REFERENCE   7  (bases 1 to 5261)
  AUTHORS   Recio,J.A., Zambrano,N., Pena,Ld., Reig,J.A., Rhoads,A., Rouzaut,A.
            and Notario,V.
  TITLE     The human PCPH proto-oncogene: cDNA identification, primary
            structure, chromosomal mapping, and expression in normal and tumor
            cells
  JOURNAL   Mol Carcinog 27 (3), 229-236 (2000)
   PUBMED   10708485
  REMARK    Erratum:[Mol Carcinog 2000 May;28(1):62]
REFERENCE   8  (bases 1 to 5261)
  AUTHORS   Mulero,J.J., Yeung,G., Nelken,S.T. and Ford,J.E.
  TITLE     CD39-L4 is a secreted human apyrase, specific for the hydrolysis of
            nucleoside diphosphates
  JOURNAL   J Biol Chem 274 (29), 20064-20067 (1999)
   PUBMED   10400613
REFERENCE   9  (bases 1 to 5261)
  AUTHORS   Chadwick,B.P. and Frischauf,A.M.
  TITLE     The CD39-like gene family: identification of three new human
            members (CD39L2, CD39L3, and CD39L4), their murine homologues, and
            a member of the gene family from Drosophila melanogaster
  JOURNAL   Genomics 50 (3), 357-367 (1998)
   PUBMED   9676430
REFERENCE   10 (bases 1 to 5261)
  AUTHORS   Chadwick,B.P. and Frischauf,A.M.
  TITLE     Cloning and mapping of a human and mouse gene with homology to
            ecto-ATPase genes
  JOURNAL   Mamm Genome 8 (9), 668-672 (1997)
   PUBMED   9271669
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC005484.2 and AC005480.3.
            
            On Apr 23, 2020 this sequence version replaced NM_001249.4.
            
            Summary: The protein encoded by this gene is similar to E-type
            nucleotidases (NTPases)/ecto-ATPase/apyrases. NTPases, such as
            CD39, mediate catabolism of extracellular nucleotides. ENTPD5
            contains 4 apyrase-conserved regions which is characteristic of
            NTPases. [provided by RefSeq, Jan 2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.93128.1,
                                           SRR1803613.208124.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000334696.11/ ENSP00000335246.6
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-39                AC005484.2         121802-121840
            40-146              AC005484.2         125160-125266
            147-206             AC005484.2         129940-129999
            207-493             AC005480.3         21175-21461
            494-573             AC005480.3         22454-22533
            574-717             AC005480.3         26186-26329
            718-793             AC005480.3         31973-32048
            794-829             AC005480.3         32288-32323
            830-918             AC005480.3         32935-33023
            919-998             AC005480.3         33332-33411
            999-1060            AC005480.3         34362-34423
            1061-1162           AC005480.3         35369-35470
            1163-1303           AC005480.3         36323-36463
            1304-1360           AC005480.3         37439-37495
            1361-1476           AC005480.3         39222-39337
            1477-5261           AC005480.3         42333-46117
FEATURES             Location/Qualifiers
     source          1..5261
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q24.3"
     gene            1..5261
                     /gene="ENTPD5"
                     /gene_synonym="CD39L4; NTPDase-5; PCPH"
                     /note="ectonucleoside triphosphate diphosphohydrolase 5
                     (inactive)"
                     /db_xref="GeneID:957"
                     /db_xref="HGNC:HGNC:3367"
                     /db_xref="MIM:603162"
     exon            1..39
                     /gene="ENTPD5"
                     /gene_synonym="CD39L4; NTPDase-5; PCPH"
                     /inference="alignment:Splign:2.1.0"
     exon            40..146
                     /gene="ENTPD5"
                     /gene_synonym="CD39L4; NTPDase-5; PCPH"
                     /inference="alignment:Splign:2.1.0"
     exon            147..206
                     /gene="ENTPD5"
                     /gene_synonym="CD39L4; NTPDase-5; PCPH"
                     /inference="alignment:Splign:2.1.0"
     exon            207..493
                     /gene="ENTPD5"
                     /gene_synonym="CD39L4; NTPDase-5; PCPH"
                     /inference="alignment:Splign:2.1.0"
     CDS             277..1563
                     /gene="ENTPD5"
                     /gene_synonym="CD39L4; NTPDase-5; PCPH"
                     /EC_number="3.6.1.6"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; proto-oncogene CPH; CD39-like 4; Pcph
                     proto-oncogene protein; ER-UDPase; NTPDase 5; CD39
                     antigen-like 4; nucleoside diphosphatase; GDPase ENTPD5;
                     UDPase ENTPD5; uridine-diphosphatase ENTPD5;
                     guanosine-diphosphatase ENTPD5; inosine diphosphate
                     phosphatase ENTPD5; nucleoside diphosphate phosphatase
                     ENTPD5"
                     /codon_start=1
                     /product="nucleoside diphosphate phosphatase ENTPD5
                     isoform 1 precursor"
                     /protein_id="NP_001240.1"
                     /db_xref="CCDS:CCDS9825.1"
                     /db_xref="GeneID:957"
                     /db_xref="HGNC:HGNC:3367"
                     /db_xref="MIM:603162"
                     /translation="MATSWGTVFFMLVVSCVCSAVSHRNQQTWFEGIFLSSMCPINVS
                     ASTLYGIMFDAGSTGTRIHVYTFVQKMPGQLPILEGEVFDSVKPGLSAFVDQPKQGAE
                     TVQGLLEVAKDSIPRSHWKKTPVVLKATAGLRLLPEHKAKALLFEVKEIFRKSPFLVP
                     KGSVSIMDGSDEGILAWVTVNFLTGQLHGHRQETVGTLDLGGASTQITFLPQFEKTLE
                     QTPRGYLTSFEMFNSTYKLYTHSYLGFGLKAARLATLGALETEGTDGHTFRSACLPRW
                     LEAEWIFGGVKYQYGGNQEGEVGFEPCYAEVLRVVRGKLHQPEEVQRGSFYAFSYYYD
                     RAVDTDMIDYEKGGILKVEDFERKAREVCDNLENFTSGSPFLCMDLSYITALLKDGFG
                     FADSTVLQLTKKVNNIETGWALGATFHLLQSLGISH"
     exon            494..573
                     /gene="ENTPD5"
                     /gene_synonym="CD39L4; NTPDase-5; PCPH"
                     /inference="alignment:Splign:2.1.0"
     exon            574..717
                     /gene="ENTPD5"
                     /gene_synonym="CD39L4; NTPDase-5; PCPH"
                     /inference="alignment:Splign:2.1.0"
     exon            718..793
                     /gene="ENTPD5"
                     /gene_synonym="CD39L4; NTPDase-5; PCPH"
                     /inference="alignment:Splign:2.1.0"
     exon            794..829
                     /gene="ENTPD5"
                     /gene_synonym="CD39L4; NTPDase-5; PCPH"
                     /inference="alignment:Splign:2.1.0"
     exon            830..918
                     /gene="ENTPD5"
                     /gene_synonym="CD39L4; NTPDase-5; PCPH"
                     /inference="alignment:Splign:2.1.0"
     exon            919..998
                     /gene="ENTPD5"
                     /gene_synonym="CD39L4; NTPDase-5; PCPH"
                     /inference="alignment:Splign:2.1.0"
     exon            999..1060
                     /gene="ENTPD5"
                     /gene_synonym="CD39L4; NTPDase-5; PCPH"
                     /inference="alignment:Splign:2.1.0"
     exon            1061..1162
                     /gene="ENTPD5"
                     /gene_synonym="CD39L4; NTPDase-5; PCPH"
                     /inference="alignment:Splign:2.1.0"
     exon            1163..1303
                     /gene="ENTPD5"
                     /gene_synonym="CD39L4; NTPDase-5; PCPH"
                     /inference="alignment:Splign:2.1.0"
     exon            1304..1360
                     /gene="ENTPD5"
                     /gene_synonym="CD39L4; NTPDase-5; PCPH"
                     /inference="alignment:Splign:2.1.0"
     exon            1361..1476
                     /gene="ENTPD5"
                     /gene_synonym="CD39L4; NTPDase-5; PCPH"
                     /inference="alignment:Splign:2.1.0"
     exon            1477..5261
                     /gene="ENTPD5"
                     /gene_synonym="CD39L4; NTPDase-5; PCPH"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5238..5243
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ENTPD5"
                     /gene_synonym="CD39L4; NTPDase-5; PCPH"
                     /note="hexamer: AATAAA"
     polyA_site      5261
                     /gene="ENTPD5"
                     /gene_synonym="CD39L4; NTPDase-5; PCPH"
                     /note="major polyA site"
ORIGIN      
        1 gagggcggcg ggctgccgcg caagggtggc gcgcgcgcgt tttccttgtt cctggtcaac
       61 aaagaaatgt ggagtgtctt ggctgaatcc tcatacagac aagatcatta tggtgctgtt
      121 aggtaggact tgtatccaga tgtaaggttg aaaaagtgat ataataaagg aaccaaggag
      181 aaaattcaga aggaaagaaa aaattgcctc tgcaggtgtg cgagcaggat tgcttctgca
      241 acaaaagcct ccacccagcc acatcttggg aaaagaatgg ccacttcttg gggcacagtc
      301 tttttcatgc tggtggtatc ctgtgtttgc agcgctgtct cccacaggaa ccagcagact
      361 tggtttgagg gtatcttcct gtcttccatg tgccccatca atgtcagcgc cagcaccttg
      421 tatggaatta tgtttgatgc agggagcact ggaactcgaa ttcatgttta cacctttgtg
      481 cagaaaatgc caggacagct tccaattcta gaaggggaag tttttgattc tgtgaagcca
      541 ggactttctg cttttgtaga tcaacctaag cagggtgctg agaccgttca agggctctta
      601 gaggtggcca aagactcaat cccccgaagt cactggaaaa agaccccagt ggtcctaaag
      661 gcaacagcag gactacgctt actgccagaa cacaaagcca aggctctgct ctttgaggta
      721 aaggagatct tcaggaagtc acctttcctg gtaccaaagg gcagtgttag catcatggat
      781 ggatccgacg aaggcatatt agcttgggtt actgtgaatt ttctgacagg tcagctgcat
      841 ggccacagac aggagactgt ggggaccttg gacctagggg gagcctccac ccaaatcacg
      901 ttcctgcccc agtttgagaa aactctggaa caaactccta ggggctacct cacttccttt
      961 gagatgttta acagcactta taagctctat acacatagtt acctgggatt tggattgaaa
     1021 gctgcaagac tagcaaccct gggagccctg gagacagaag ggactgatgg gcacactttc
     1081 cggagtgcct gtttaccgag atggttggaa gcagagtgga tctttggggg tgtgaaatac
     1141 cagtatggtg gcaaccaaga aggggaggtg ggctttgagc cctgctatgc cgaagtgctg
     1201 agggtggtac gaggaaaact tcaccagcca gaggaggtcc agagaggttc cttctatgct
     1261 ttctcttact attatgaccg agctgttgac acagacatga ttgattatga aaaggggggt
     1321 attttaaaag ttgaagattt tgaaagaaaa gccagggaag tgtgtgataa cttggaaaac
     1381 ttcacctcag gcagtccttt cctgtgcatg gatctcagct acatcacagc cctgttaaag
     1441 gatggctttg gctttgcaga cagcacagtc ttacagctca caaagaaagt gaacaacata
     1501 gagacgggct gggccttggg ggccaccttt cacctgttgc agtctctggg catctcccat
     1561 tgaggccacg tacttccttg gagacctgca tttgccaaca cctttttaag gggaggagag
     1621 agcacttagt ttctgaacta gtctggggac atcctggact tgagcctaga gatttaggtt
     1681 taattaattt tacacatcta atgtgaactg ctgcctaacc actcaagagt acacagctgg
     1741 caccagagca tcacagagag ccctgtgagc caaaaagtat agttttggaa cttaaccttg
     1801 gagtgagagc ccagggacag gtccctggaa accaaagaaa aatcgcattt caaccctttg
     1861 agtgcctcat tccactgaat atttaaattt tcctcttaaa tggtaaactg acttattgca
     1921 atcccaagac ccatcaatat cagtattttt ttcctcccta tacagtgccc tgcccaccct
     1981 tatctgcacc cacctcccct gaaaaagaga gaaaaaaaaa aacctggttt tgctttccat
     2041 gtataattca acaacgcaaa atgggaccat gtcagaatct gtatgatcct attctgtgtt
     2101 agctccaatc agccagctga gagccatcct aaatattaat aggatgagag agtaactcct
     2161 aactgtgcat aaattacagc cttaagaaag aaggccaccc ggtctctggg gacatgtttt
     2221 gggagggtgt ggctgcctca tatagcctac ctttgcttta atcagcattt tatcagtcaa
     2281 ctctgggatt aatgaacata tccgacttta tgggtatgtg tatattcagt gccagtacca
     2341 cctcccaggc taatgtgtta acagtgtttt ctatgattct aaacttgttt tctttgtatt
     2401 tctaagaaat acaactaggc cctaactttt ggtctgtggt cagaggtcag tgtctgtgct
     2461 attccaggat ctattatttc agtttgccct tttattctct ccgtttgtaa cagtaccttc
     2521 ctgtcctggt ccctgatcac tttagctaat atcctttgaa ttatttatct agttcagagt
     2581 ttccaatacc gttcctgaca aaaccccact tggatttggt tggctctctc agcccacatc
     2641 agtacagtgg accaacattt ccagggagaa ccatatttaa tgtccctcat gctctctttt
     2701 tgaatccaag tgctcagagc tcttgactgt gaattattta ccccaaattc attatcttgc
     2761 actttttttt gagatggagt cttgctctgt tgctcaggct agagtggagt ggcgcaatct
     2821 cagctcactg caacctccgc ccccaggttc aagcgattct tgttctcagc ctcctgaaga
     2881 gctgggatta caggtgccca ccaccattcc tggctaattt ttgtatttgt agtagagatg
     2941 gggtttcacc atgttggcca ggctggtttc caactcctga tctcaattga tccacccgct
     3001 tcccaaagtg ctgggattac aggcatgaga caccgcgcct ggccttatct tgcactttca
     3061 acataatcat ccctgcttct catctgccct gcagtgctct tggacctgga agatctccct
     3121 gtggtctggc ccctttgcct tggttgttaa cctccagctt ctttgcagga gtgtatttcc
     3181 ccaaaacttg tggctttcac agtagactcc gtttccatcc tctctctcac aaaggatgtt
     3241 aagtatgcct ggccctcaca cagtccatgg gaaaccttat ttttaacatt actccattga
     3301 gtcaataaat atttaccatc tgctgtgtgc aagttactag gcaaatttct gtatccttgt
     3361 ccctaaaatt cttgtcttta aattcattgt ggaatttctt tagacttcac actgactttt
     3421 attactaagg tcacctttat accaactgcc ttcctcaaaa tgcttataat gaaataacag
     3481 aatcttgagt tggaaacagc ccaaagaaat aatccaatgt tgtactcagt gcagaattcc
     3541 ctagaatttc taacaggttg tcattcagct tctgctaagc catgttcaaa cagcttattc
     3601 catttggaac tgcactgata ttaaaaaaaa ttccttatat tgagctgaaa tctacctatc
     3661 ttctaagtgg tcttagttct gctctaatct ctccttccaa aatctttgga tcttttgaaa
     3721 aaagttcctc ccaagttctt ttataagtga catgactttt agaccccttc ccatctttgt
     3781 caacaaaagt agggtgccag accagtcaca gaacactaaa tgtcatccat gtttccttca
     3841 gtagaaacca gcagttttaa aagaggtaag ctgtgttcac taaagactgt tccagcttga
     3901 caaatgcaga gatataagtc tctggtcttt aatcactgtg ggggccattt tgtaaaacac
     3961 acatactgtc cagcagactc ctttggtcat cccaaatacc tctgaactcc agggaagatg
     4021 cattctaact ccacgaactt acctattttg ttaaccttga ttagaccttc tggagaagta
     4081 accaatttgt ccatcttagg agcaatttgg aatgagagtt tttatttttt tctgtaacgc
     4141 ccatcctgcc tgcagtagac cctttgggct taagaggtcc tacagattct aatagtttcc
     4201 tctttgtaga tgtgttaaca tatttaaaat acttaggaca tggcctggta cgtgacagat
     4261 ggtgtttaac atcattgtca tatgaagaac actctctgtg ggccaatgga ggtgtgcctt
     4321 aaaattcttc atcttgcctg attttgtttg cataacttct ggagagtctg tgtcctcctc
     4381 atctaggcca cctttccatt ttttgtgaaa gatgaccttg tccctgcagt ctccgccagg
     4441 agtcacacag cttttcacag cagctgccat ctttaattct ttttcctgag attccagcaa
     4501 ggttgtgaca ttgtcacttt tttgttctag actcttttaa attttctgca tttgcctgaa
     4561 aagcacccct gtaagaatag atttctcatg gctctaaaaa ttattcccaa gaatacctta
     4621 cttggttcaa aagcagactg tttctcttca tttcatctca aatcagactt ctgggcaaga
     4681 tgttctttag agtaagcaaa cctacaacct aaaaatctct tcaagaggca tctctggtct
     4741 tgtgacgaga cctcttcaaa aacccacagt aaaactcccc tccctccagt tggccaccag
     4801 tctgccacca aacatgaaca aattctgctg ctaatcggtt tcccttgtga tctggttcct
     4861 gaggtcttcg gatctgtgca atgaattatt tattgtttta ttaaaccgac agtggtgtcc
     4921 cagagaggaa ccataaataa aatggaaatc tggtgctgtg ataaagtaat aactagcatt
     4981 aatgagacct ggttttcctt tcagaaagtc cagtatacct gtaacaaagg ttaaagcaat
     5041 ttatatttaa tttgcattct gatgttaaca tttaaacagc aattctaaca aaaatgcatc
     5101 gagtctaatt cttacctcta tcaaaaaaca actgtataaa tttatgacca acattaaaac
     5161 aaaaacaaaa tgtaaatttt ctctttagaa atgattaact ggaaatgagt gagacagcac
     5221 cttgtgggtt ttttagtaat aaaaagctct tttcaaccaa a
//
