LOCUS       NM_004901               5803 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens ectonucleoside triphosphate diphosphohydrolase 4
            (ENTPD4), transcript variant 1, mRNA.
ACCESSION   NM_004901
VERSION     NM_004901.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5803)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 5803)
  AUTHORS   Gorelik,A., Labriola,J.M., Illes,K. and Nagar,B.
  TITLE     Crystal structure of the nucleotide-metabolizing enzyme NTPDase4
  JOURNAL   Protein Sci 29 (10), 2054-2061 (2020)
   PUBMED   32767432
  REMARK    GeneRIF: Crystal structure of the nucleotide-metabolizing enzyme
            NTPDase4.
REFERENCE   3  (bases 1 to 5803)
  AUTHORS   Avital-Shacham,M., Sharf,R. and Kleinberger,T.
  TITLE     NTPDASE4 gene products cooperate with the adenovirus E4orf4 protein
            through PP2A-dependent and -independent mechanisms and contribute
            to induction of cell death
  JOURNAL   J Virol 88 (11), 6318-6328 (2014)
   PUBMED   24672025
  REMARK    GeneRIF: NTPDASE4 gene products cooperate with the adenovirus
            E4orf4 protein through PP2A-dependent and -independent mechanisms
            and contribute to induction of cell death.
REFERENCE   4  (bases 1 to 5803)
  AUTHORS   Saito,A., Fujikura-Ouchi,Y., Ito,C., Matsuoka,H., Shimoda,K. and
            Akiyama,K.
  TITLE     An association study on polymorphisms in the PEA15, ENTPD4, and
            GAS2L1 genes and schizophrenia
  JOURNAL   Psychiatry Res 185 (1-2), 9-15 (2011)
   PUBMED   20537721
  REMARK    GeneRIF: The present study fails to provide evidence for the
            contribution of ENTPD4 genes to the etiology of schizophrenia in
            the Japanese population.
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   5  (bases 1 to 5803)
  AUTHORS   Biederbick,A., Rosser,R., Storre,J. and Elsasser,H.P.
  TITLE     The VSFASSQQ motif confers calcium sensitivity to the intracellular
            apyrase LALP70
  JOURNAL   BMC Biochem 5, 8 (2004)
   PUBMED   15200686
  REMARK    GeneRIF: The VSFASSQQ motif confers calcium sensitivity to LALP70
            during UDP cleavage.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5803)
  AUTHORS   Biederbick,A., Kosan,C., Kunz,J. and Elsasser,H.P.
  TITLE     First apyrase splice variants have different enzymatic properties
  JOURNAL   J Biol Chem 275 (25), 19018-19024 (2000)
   PUBMED   10858452
REFERENCE   7  (bases 1 to 5803)
  AUTHORS   Biederbick,A., Rose,S. and Elsasser,H.P.
  TITLE     A human intracellular apyrase-like protein, LALP70, localizes to
            lysosomal/autophagic vacuoles
  JOURNAL   J Cell Sci 112 (Pt 15), 2473-2484 (1999)
   PUBMED   10393803
REFERENCE   8  (bases 1 to 5803)
  AUTHORS   Wang,T.F. and Guidotti,G.
  TITLE     Golgi localization and functional expression of human uridine
            diphosphatase
  JOURNAL   J Biol Chem 273 (18), 11392-11399 (1998)
   PUBMED   9556635
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC341200.1, AJ131358.1,
            CN313716.1, CN313713.1 and AC104561.3.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_004901.4.
            
            Summary: This gene encodes a member of the apyrase protein family.
            Apyrases are enzymes that catalyze the hydrolysis of nucleotide
            diphosphates and triphosphates in a calcium or magnesium-dependent
            manner. The encoded protein is an endo-apyrase and may play a role
            in salvaging nucleotides from lysosomes. Alternatively spliced
            transcript variants encoding multiple isoforms have been observed
            for this gene, and these isoforms may differ in divalent cation
            dependence and substrate specificity. [provided by RefSeq, Sep
            2011].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7346977.2739600.1, AJ131358.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2158188 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000358689.9/ ENSP00000351520.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-493               DC341200.1         85-577
            494-589             AJ131358.1         475-570
            590-996             CN313716.1         230-636
            997-1804            AJ131358.1         978-1785
            1805-2132           CN313713.1         105-432
            2133-5803           AC104561.3         92431-96101
FEATURES             Location/Qualifiers
     source          1..5803
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p21.3"
     gene            1..5803
                     /gene="ENTPD4"
                     /gene_synonym="LALP70; LAP70; LYSAL1; NTPDase-4; UDPase"
                     /note="ectonucleoside triphosphate diphosphohydrolase 4"
                     /db_xref="GeneID:9583"
                     /db_xref="HGNC:HGNC:14573"
                     /db_xref="MIM:607577"
     exon            1..91
                     /gene="ENTPD4"
                     /gene_synonym="LALP70; LAP70; LYSAL1; NTPDase-4; UDPase"
                     /inference="alignment:Splign:2.1.0"
     exon            92..196
                     /gene="ENTPD4"
                     /gene_synonym="LALP70; LAP70; LYSAL1; NTPDase-4; UDPase"
                     /inference="alignment:Splign:2.1.0"
     CDS             189..2039
                     /gene="ENTPD4"
                     /gene_synonym="LALP70; LAP70; LYSAL1; NTPDase-4; UDPase"
                     /EC_number="3.6.1.6"
                     /EC_number="3.6.1.15"
                     /EC_number="3.6.1.42"
                     /note="isoform a is encoded by transcript variant 1;
                     lysosomal apyrase-like 1; guanosine-diphosphatase like
                     protein; uridine-diphosphatase; lysosomal apyrase-like
                     protein of 70 kDa; golgi luminal UDPase; Golgi UDPase"
                     /codon_start=1
                     /product="ectonucleoside triphosphate diphosphohydrolase 4
                     isoform a"
                     /protein_id="NP_004892.1"
                     /db_xref="CCDS:CCDS6041.1"
                     /db_xref="GeneID:9583"
                     /db_xref="HGNC:HGNC:14573"
                     /db_xref="MIM:607577"
                     /translation="MGRIGISCLFPASWHFSISPVGCPRILNTNLRQIMVISVLAAAV
                     SLLYFSVVIIRNKYGRLTRDKKFQRYLARVTDIEATDTNNPNVNYGIVVDCGSSGSRV
                     FVYCWPRHNGNPHDLLDIRQMRDKNRKPVVMKIKPGISEFATSPEKVSDYISPLLNFA
                     AEHVPRAKHKETPLYILCTAGMRILPESQQKAILEDLLTDIPVHFDFLFSDSHAEVIS
                     GKQEGVYAWIGINFVLGRFEHIEDDDEAVVEVNIPGSESSEAIVRKRTAGILDMGGVS
                     TQIAYEVPKTVSFASSQQEEVAKNLLAEFNLGCDVHQTEHVYRVYVATFLGFGGNAAR
                     QRYEDRIFANTIQKNRLLGKQTGLTPDMPYLDPCLPLDIKDEIQQNGQTIYLRGTGDF
                     DLCRETIQPFMNKTNETQTSLNGVYQPPIHFQNSEFYGFSEFYYCTEDVLRMGGDYNA
                     AKFTKAAKDYCATKWSILRERFDRGLYASHADLHRLKYQCFKSAWMFEVFHRGFSFPV
                     NYKSLKTALQVYDKEVQWTLGAILYRTRFLPLRDIQQEAFRASHTHWRGVSFVYNHYL
                     FSGCFLVVLLAILLYLLRLRRIHRRTPRSSSAAALWMEEGLPAQNAPGTL"
     exon            197..394
                     /gene="ENTPD4"
                     /gene_synonym="LALP70; LAP70; LYSAL1; NTPDase-4; UDPase"
                     /inference="alignment:Splign:2.1.0"
     exon            395..600
                     /gene="ENTPD4"
                     /gene_synonym="LALP70; LAP70; LYSAL1; NTPDase-4; UDPase"
                     /inference="alignment:Splign:2.1.0"
     exon            601..751
                     /gene="ENTPD4"
                     /gene_synonym="LALP70; LAP70; LYSAL1; NTPDase-4; UDPase"
                     /inference="alignment:Splign:2.1.0"
     exon            752..855
                     /gene="ENTPD4"
                     /gene_synonym="LALP70; LAP70; LYSAL1; NTPDase-4; UDPase"
                     /inference="alignment:Splign:2.1.0"
     exon            856..915
                     /gene="ENTPD4"
                     /gene_synonym="LALP70; LAP70; LYSAL1; NTPDase-4; UDPase"
                     /inference="alignment:Splign:2.1.0"
     exon            916..1070
                     /gene="ENTPD4"
                     /gene_synonym="LALP70; LAP70; LYSAL1; NTPDase-4; UDPase"
                     /inference="alignment:Splign:2.1.0"
     exon            1071..1237
                     /gene="ENTPD4"
                     /gene_synonym="LALP70; LAP70; LYSAL1; NTPDase-4; UDPase"
                     /inference="alignment:Splign:2.1.0"
     exon            1238..1562
                     /gene="ENTPD4"
                     /gene_synonym="LALP70; LAP70; LYSAL1; NTPDase-4; UDPase"
                     /inference="alignment:Splign:2.1.0"
     exon            1563..1648
                     /gene="ENTPD4"
                     /gene_synonym="LALP70; LAP70; LYSAL1; NTPDase-4; UDPase"
                     /inference="alignment:Splign:2.1.0"
     exon            1649..1810
                     /gene="ENTPD4"
                     /gene_synonym="LALP70; LAP70; LYSAL1; NTPDase-4; UDPase"
                     /inference="alignment:Splign:2.1.0"
     exon            1811..5803
                     /gene="ENTPD4"
                     /gene_synonym="LALP70; LAP70; LYSAL1; NTPDase-4; UDPase"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2585..2590
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ENTPD4"
                     /gene_synonym="LALP70; LAP70; LYSAL1; NTPDase-4; UDPase"
                     /note="hexamer: AATAAA"
     polyA_site      2613
                     /gene="ENTPD4"
                     /gene_synonym="LALP70; LAP70; LYSAL1; NTPDase-4; UDPase"
     regulatory      5779..5784
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ENTPD4"
                     /gene_synonym="LALP70; LAP70; LYSAL1; NTPDase-4; UDPase"
                     /note="hexamer: AATAAA"
     polyA_site      5803
                     /gene="ENTPD4"
                     /gene_synonym="LALP70; LAP70; LYSAL1; NTPDase-4; UDPase"
                     /note="major polyA site"
ORIGIN      
        1 aggaaaggag cgcggcctcc aggaagccgg ctggccgtga tgctgcccac tggtggtccc
       61 ccgctcccgg ggtccccggc cggccaagca ggagggctct aactccgtga ggaccccagc
      121 attatttcta taattgtttg tgagaaggac tgaatcccag agcattgcct tgttgctgac
      181 ctttcagtat ggggaggatt ggcatctcct gtctttttcc tgcttcttgg cattttagca
      241 tatctccagt agggtgtcct cgaattctga ataccaattt acgccaaatt atggtcatta
      301 gtgtcctggc tgctgctgtt tcacttttat atttttctgt tgtcataatc cgaaataagt
      361 atgggcgact aaccagagac aagaaatttc aaaggtacct ggcacgagtt accgacattg
      421 aagctacaga caccaataac cccaatgtga actatgggat cgtggtggac tgtggtagca
      481 gtgggtctcg agtatttgtt tactgctggc caaggcataa tggcaatcca catgatctgt
      541 tggatatcag gcaaatgagg gataaaaacc gaaagccagt ggtcatgaag ataaaaccgg
      601 gcatttcaga atttgctacc tctccagaga aagtcagtga ttacatttct ccacttttga
      661 actttgctgc agagcatgtg ccacgggcaa aacacaaaga gacacctctc tacattctct
      721 gcacggctgg aatgagaatc ctccccgaaa gccagcagaa agctattctg gaagaccttc
      781 tgaccgatat ccccgtgcac tttgactttc tgttttctga ctctcatgca gaagtaattt
      841 ctgggaaaca agaaggtgtg tatgcttgga ttggcattaa ttttgtcctt ggacgatttg
      901 agcatattga agatgatgat gaggccgttg tggaagttaa cattcctgga agtgaaagca
      961 gcgaagccat tgtccgtaaa aggacagcgg gcattctcga catgggcggc gtgtcgactc
     1021 agatagcgta cgaagtcccc aaaactgtaa gctttgcgtc ctcacagcag gaagaagtag
     1081 ctaaaaactt gttagctgaa tttaacttgg gatgtgatgt tcaccaaact gagcatgtgt
     1141 atcgagtcta tgtggccacg tttcttgggt ttggtggcaa tgctgctcga cagagatacg
     1201 aagacagaat atttgccaac accattcaaa agaacaggct cctgggtaaa cagactggtc
     1261 tgactcctga tatgccgtac ttggacccct gcctacccct agacattaaa gatgaaatcc
     1321 agcaaaatgg acaaaccata tacctacgag ggactggaga ctttgacctg tgtcgagaga
     1381 ctatccagcc tttcatgaat aaaacaaacg agacccagac ttccctcaat ggggtctacc
     1441 agcccccaat tcacttccag aacagtgaat tctatggctt ctccgaattc tactactgca
     1501 ccgaggatgt gttacgaatg gggggagact acaatgctgc taaatttact aaagctgcaa
     1561 aggattattg tgcaacaaag tggtccattt tgcgggaacg ctttgaccga ggactgtacg
     1621 cctctcatgc tgacctccac aggcttaagt atcagtgctt caaatcggcc tggatgtttg
     1681 aggtgtttca taggggcttt tcgtttcctg tcaactataa aagcttaaag actgccttgc
     1741 aagtttacga caaggaggtt cagtggaccc ttggagccat cctctacagg acccgctttc
     1801 taccattaag agacatccag caggaggcct tccgagccag tcacacccac tggcggggcg
     1861 tttcctttgt ctacaaccac tacctgttct ctggctgctt cctggtggtg ctgctggcca
     1921 tcctgctgta cctgctgcgg ctgcggcgca tccacaggcg cactccccgg agcagctcgg
     1981 ccgccgccct ctggatggag gagggccttc ccgcccagaa tgccccgggg accttgtgat
     2041 ccagctcaca gctccacgaa gactcaaaag gaaaagccat ttttgcctca gggtttctcc
     2101 tctttatttt cctgtggttt tgttttttct ttcccttttt tgttcctcca aacaaaaaca
     2161 aaatgcaggc cgagcgcggt ggctcacgcc tgtaatccca gcactttggg aggccgaggc
     2221 gggcggatca tgaggtcagg agatcgagac catcctggct aacacggtga aaccccgtct
     2281 ctactaaaaa tacaaaaaat tagctgggtg tggtggcggg cgcccgtagt cccagctact
     2341 caggaggctg aggcaggaga atggcatgaa cctgggaggc agagcttgca gtgagccgag
     2401 atcacaccac tgcactccag cctgggcgac agagtgagac tccgtctcaa aaaaaaaaaa
     2461 tgcattgttt ataagccctg ctgtctagaa gtattgcgtt tagccatttt gagtacagca
     2521 ttaaattgag gagtggggaa gagggaaatt cacttgattt ttgctgcaca ggatatctgc
     2581 caaaaataaa tgagatttct ggggtttctc taaggaatgt taaatttaaa cacatgcact
     2641 ttgatactgg agggaggtgg aaagatgcat tctgtcagtg gagaggggac tgaatagtga
     2701 tgctttcata gaaccaaaaa acttactgcc tgaaatgata atcctctttt ttctctatct
     2761 tgaaagctct aacctgaaga gggtgatttt tttttttatt tattgttcag gtctgttact
     2821 gtatatgttt tctttgcaaa tttaaatttt ttaaaccatt tatatccaaa acagagaaac
     2881 atgggcacca ggagataacc atttataaaa gtgatagtga actatcgact acagctttgt
     2941 gcgagtgtgt gaaaaatccc aagaaaccag cgtgagggga ggcaatgctg gttctttaaa
     3001 aacacacact tcagaattta ctggtacatt ttatttagaa aaatcctcgt tactgttatc
     3061 ttttcctgac cgcaggtaat tacgctcctt attccatatt tcagtggcat tagaacactg
     3121 tggttttgaa agaattggaa attcctagtt tcaccagttt cggttttatt ggaactagag
     3181 cacatgccca cttcttgctc agtattcctc agtgtttctg cttaatcgtg cctcagtttc
     3241 ttccagcttc caattggtgt ttcccccacc ccccttaatt aaaagtcatc tcagctttta
     3301 atcgtactgg gagaccccat gcacagcctg ccgagtcctc ttcctaaccg cattgactga
     3361 ggctgttgct ggcagcacca ctgtaaatcc agaagggaag agtctgcatc caatacagga
     3421 aataaattca cattttgaag gaaaaaattc gacaatttaa gccaaaatct aaaaaggaca
     3481 attggattgg catatgtgag attggtgttt tttcacctat ttatttagtt gagaagtttg
     3541 gggaattctc gtacagtttt tttaggtgga gtttgttttg tgcgagtgtc tgtgtgtgct
     3601 gttccctaac tccagaacag ttaaattcct gtagttggta gcagattagt acccagaagt
     3661 ggggttgttg ctataacaga taactgagga tattataaaa gtggctttgg aactaggtac
     3721 tgggcagagg ctgggagagt ttggagaaac aggagagaaa aggcctgtat tgccatgaac
     3781 tgagcattag gggcagttct gctgagggat cagaagagaa gaccaaggga attctgtccc
     3841 agttgtggct caaactgcct caggtgcagc ttaacctgcg tctctggaag gtaaaatgca
     3901 tctgatcctt gaggcaagag ctgtgggggc atggctccct cacctggatt tcaaagcgtg
     3961 ttaccagcag cctggggacc caggctctgc ctctggattt acctgcatcg tatttgcgct
     4021 tcgtggtcaa agttgttaag aaaggggtga gcttctggct acctaataag ttggtcttgg
     4081 ccacctgcct gcgacacttc ctggaggagc catggattat tggtggaggc tgcagggagc
     4141 tggcgatgga gccactggtg tcagcagcag agagggaaga aaggaaagga aggggccaca
     4201 aatggttgaa gtgggcaggt gggcacccag ggagttaggg gaccccgcct tccagctctg
     4261 ggcatagaag agttagtcac atacctgagg atcctgaaac aagggctgag aaaacctcat
     4321 tgctccagct gagaggtagt agtggatttg ccatttttaa acagttgcct aagaaaaaac
     4381 gttgaagaat atgcagcaga cactatatgt ggcctgtaaa gcctagaata tttactaaaa
     4441 tatttacaga aaaagtttgc tggtccttgt gagaacaatg cagttcaaaa aaggatacag
     4501 acagaagcat cctcttaaat caggaatgta gtttccattt gtgggcacga aaagatggac
     4561 aagagaagta accaaacttc aatcttaaaa tatttgttgc accagaattt cacttcggat
     4621 ttttccgtct agattatttt caagatgagt tttgaaacaa accaagaaac ctgcccctca
     4681 cccaaaattg tttaaaaaga gaccactcaa gggagttcat tatgccgtat ggagatgtct
     4741 gcagtcgcag caaatcacat tccagagaag gtctcgcgta ggtgaagaca gccaggtgct
     4801 ttctctaaga gatacagggt gggtgagaga caagccaggg aggatcttaa ttcaagagaa
     4861 gaattcatac caagagctga ccaagaaggc agtaaattct gtgtacttgt agcagaagaa
     4921 attggactag gaacttgccc aaagctttat caaagaaaag cattgtgttc aatcttggta
     4981 gaaacatgcc agcaataagt gcttatgttc catagccata tcatgggctt ctcactttta
     5041 aacctcctcc aggggatgtt ctcagacatt tcacaatccc tctggggaca ttacagtaga
     5101 agagaaacac atggaactgt accagtgctt tttgcccatg ttcatcctaa gctccggctt
     5161 taggcagtgc tttctgacct gggcggagtg aagacgctgc tggtggctga ggccagtaac
     5221 atggggcccc tgcccagcca ccctgaaggc tgggtaggtc cctcttttca ccaccagttt
     5281 tccacatctg tgtactctag attaacaaac tctggataaa cagatattta cattttaaac
     5341 tcaggcctac acagagtagt tttccttata aggagcatgt atcacttagc aagaaactaa
     5401 aaatggcaaa tgagtttttc atcctttaag aaaaaaatca gctttagaat tctctgcggt
     5461 cagttgtgtg caatgcaaca aaactacctt tcagtaaatt acttagttat ttatttcagt
     5521 gttttgtttc ttttgatact aagtttccct ttcaataatg aatgatgtga ccaaccaagg
     5581 agaatttgtt tgttctgtac taaaattata ttttacagtt aggaattata aaaagcaagg
     5641 gagcatcttt aaatgttttt tgtttaagcg atgtcttcca tccaaagtaa gaataatact
     5701 ctcggaaggt ccttttggtg tcatgtcact tgctgtatgt ggcagcctta cagtgccaca
     5761 cttgggtact gaaaaatcaa taaaacgaaa gttcatcatc cca
//
