LOCUS       NM_001776              12493 bp    mRNA    linear   PRI 09-OCT-2024
DEFINITION  Homo sapiens ectonucleoside triphosphate diphosphohydrolase 1
            (ENTPD1), transcript variant 1, mRNA.
ACCESSION   NM_001776
VERSION     NM_001776.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 12493)
  AUTHORS   Isaacs,J.F., Degefu,H.N., Chen,T., Kleist,S.A., Musial,S.C.,
            Ford,M.A., Searles,T.G., Lin,C.C., Skorput,A.G.J., Shirai,K.,
            Turk,M.J., Zanazzi,G.J. and Rosato,P.C.
  TITLE     CD39 Is Expressed on Functional Effector and Tissue-resident Memory
            CD8+ T Cells
  JOURNAL   J Immunol 213 (5), 588-599 (2024)
   PUBMED   38975728
  REMARK    GeneRIF: CD39 Is Expressed on Functional Effector and
            Tissue-resident Memory CD8+ T Cells.
REFERENCE   2  (bases 1 to 12493)
  AUTHORS   Ortiz,M.A., Diaz-Torne,C., De Agustin,J.J., Estrada,P., Reina,D.,
            Hernandez,M.V., Sang,H., Zamora,C., Canto,E., Corominas,H. and
            Vidal,S.
  TITLE     Altered CD39 and CD73 Expression in Rheumatoid Arthritis:
            Implications for Disease Activity and Treatment Response
  JOURNAL   Biomolecules 14 (1), 1 (2023)
   PUBMED   38275742
  REMARK    GeneRIF: Altered CD39 and CD73 Expression in Rheumatoid Arthritis:
            Implications for Disease Activity and Treatment Response.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 12493)
  AUTHORS   Elsaghir,A., El-Sabaa,E.M.W., Zahran,A.M., Mandour,S.A.,
            Salama,E.H., Aboulfotuh,S., El-Morshedy,R.M., Tocci,S.,
            Mandour,A.M., Ali,W.E., Abdel-Wahid,L., Sayed,I.M. and
            El-Mokhtar,M.A.
  TITLE     Elevated CD39+T-Regulatory Cells and Reduced Levels of Adenosine
            Indicate a Role for Tolerogenic Signals in the Progression from
            Moderate to Severe COVID-19
  JOURNAL   Int J Mol Sci 24 (24), 17614 (2023)
   PUBMED   38139439
  REMARK    GeneRIF: Elevated CD39+T-Regulatory Cells and Reduced Levels of
            Adenosine Indicate a Role for Tolerogenic Signals in the
            Progression from Moderate to Severe COVID-19.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 12493)
  AUTHORS   Wang,Y., Liu,M., Zhang,L., Liu,X., Ji,H., Wang,Y., Gui,J., Yue,Y.
            and Wen,Z.
  TITLE     Cancer CD39 drives metabolic adaption and mal-differentiation of
            CD4+ T cells in patients with non-small-cell lung cancer
  JOURNAL   Cell Death Dis 14 (12), 804 (2023)
   PUBMED   38062068
  REMARK    GeneRIF: Cancer CD39 drives metabolic adaption and
            mal-differentiation of CD4[+] T cells in patients with
            non-small-cell lung cancer.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 12493)
  AUTHORS   Kaczmarek,E., Koziak,K., Sevigny,J., Siegel,J.B., Anrather,J.,
            Beaudoin,A.R., Bach,F.H. and Robson,S.C.
  TITLE     Identification and characterization of CD39/vascular ATP
            diphosphohydrolase
  JOURNAL   J Biol Chem 271 (51), 33116-33122 (1996)
   PUBMED   8955160
REFERENCE   6  (bases 1 to 12493)
  AUTHORS   Wang,T.F. and Guidotti,G.
  TITLE     CD39 is an ecto-(Ca2+,Mg2+)-apyrase
  JOURNAL   J Biol Chem 271 (17), 9898-9901 (1996)
   PUBMED   8626624
REFERENCE   7  (bases 1 to 12493)
  AUTHORS   Christoforidis,S., Papamarcaki,T., Galaris,D., Kellner,R. and
            Tsolas,O.
  TITLE     Purification and properties of human placental ATP
            diphosphohydrolase
  JOURNAL   Eur J Biochem 234 (1), 66-74 (1995)
   PUBMED   8529670
REFERENCE   8  (bases 1 to 12493)
  AUTHORS   Maliszewski,C.R., Delespesse,G.J., Schoenborn,M.A., Armitage,R.J.,
            Fanslow,W.C., Nakajima,T., Baker,E., Sutherland,G.R.,
            Poindexter,K., Birks,C. et al.
  TITLE     The CD39 lymphoid cell activation antigen. Molecular cloning and
            structural characterization
  JOURNAL   J Immunol 153 (8), 3574-3583 (1994)
   PUBMED   7930580
REFERENCE   9  (bases 1 to 12493)
  AUTHORS   Calame,D. and Herman,I.
  TITLE     ENTPD1-Related Neurodevelopmental Disorder
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   37262206
REFERENCE   10 (bases 1 to 12493)
  AUTHORS   Hedera,P.
  TITLE     Hereditary Spastic Paraplegia Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301682
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK304018.1 and AL365273.25.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_001776.5.
            
            Summary: The protein encoded by this gene is a plasma membrane
            protein that hydrolyzes extracellular ATP and ADP to AMP.
            Inhibition of this protein's activity may confer anticancer
            benefits. Several transcript variants encoding different isoforms
            have been found for this gene. [provided by RefSeq, Aug 2015].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.206162.1,
                                           SRR1660803.74136.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000371205.5/ ENSP00000360248.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2016              AK304018.1         9-2024
            2017-12493          AL365273.25        139292-149768
FEATURES             Location/Qualifiers
     source          1..12493
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q24.1"
     gene            1..12493
                     /gene="ENTPD1"
                     /gene_synonym="ATP-DPH; ATPDase; CD39; NTPDase-1; SPG64"
                     /note="ectonucleoside triphosphate diphosphohydrolase 1"
                     /db_xref="GeneID:953"
                     /db_xref="HGNC:HGNC:3363"
                     /db_xref="MIM:601752"
     exon            1..93
                     /gene="ENTPD1"
                     /gene_synonym="ATP-DPH; ATPDase; CD39; NTPDase-1; SPG64"
                     /inference="alignment:Splign:2.1.0"
     CDS             78..1610
                     /gene="ENTPD1"
                     /gene_synonym="ATP-DPH; ATPDase; CD39; NTPDase-1; SPG64"
                     /EC_number="3.6.1.5"
                     /note="isoform 1 is encoded by transcript variant 1; CD39
                     antigen; lymphoid cell activation antigen; ecto-apyrase;
                     ecto-ATPase 1; ecto-ATPDase 1; ecto-ATP diphosphohydrolase
                     1; NTPDase1; nucleoside triphosphate diphosphohydrolase 1"
                     /codon_start=1
                     /product="ectonucleoside triphosphate diphosphohydrolase 1
                     isoform 1"
                     /protein_id="NP_001767.3"
                     /db_xref="CCDS:CCDS7444.1"
                     /db_xref="GeneID:953"
                     /db_xref="HGNC:HGNC:3363"
                     /db_xref="MIM:601752"
                     /translation="MEDTKESNVKTFCSKNILAILGFSSIIAVIALLAVGLTQNKALP
                     ENVKYGIVLDAGSSHTSLYIYKWPAEKENDTGVVHQVEECRVKGPGISKFVQKVNEIG
                     IYLTDCMERAREVIPRSQHQETPVYLGATAGMRLLRMESEELADRVLDVVERSLSNYP
                     FDFQGARIITGQEEGAYGWITINYLLGKFSQKTRWFSIVPYETNNQETFGALDLGGAS
                     TQVTFVPQNQTIESPDNALQFRLYGKDYNVYTHSFLCYGKDQALWQKLAKDIQVASNE
                     ILRDPCFHPGYKKVVNVSDLYKTPCTKRFEMTLPFQQFEIQGIGNYQQCHQSILELFN
                     TSYCPYSQCAFNGIFLPPLQGDFGAFSAFYFVMKFLNLTSEKVSQEKVTEMMKKFCAQ
                     PWEEIKTSYAGVKEKYLSEYCFSGTYILSLLLQGYHFTADSWEHIHFIGKIQGSDAGW
                     TLGYMLNLTNMIPAEQPLSTPLSHSTYVFLMVLFSLVLFTVAIIGLLIFHKPSYFWKD
                     MV"
     exon            94..221
                     /gene="ENTPD1"
                     /gene_synonym="ATP-DPH; ATPDase; CD39; NTPDase-1; SPG64"
                     /inference="alignment:Splign:2.1.0"
     exon            222..339
                     /gene="ENTPD1"
                     /gene_synonym="ATP-DPH; ATPDase; CD39; NTPDase-1; SPG64"
                     /inference="alignment:Splign:2.1.0"
     exon            340..490
                     /gene="ENTPD1"
                     /gene_synonym="ATP-DPH; ATPDase; CD39; NTPDase-1; SPG64"
                     /inference="alignment:Splign:2.1.0"
     exon            491..650
                     /gene="ENTPD1"
                     /gene_synonym="ATP-DPH; ATPDase; CD39; NTPDase-1; SPG64"
                     /inference="alignment:Splign:2.1.0"
     exon            651..890
                     /gene="ENTPD1"
                     /gene_synonym="ATP-DPH; ATPDase; CD39; NTPDase-1; SPG64"
                     /inference="alignment:Splign:2.1.0"
     exon            891..1151
                     /gene="ENTPD1"
                     /gene_synonym="ATP-DPH; ATPDase; CD39; NTPDase-1; SPG64"
                     /inference="alignment:Splign:2.1.0"
     exon            1152..1265
                     /gene="ENTPD1"
                     /gene_synonym="ATP-DPH; ATPDase; CD39; NTPDase-1; SPG64"
                     /inference="alignment:Splign:2.1.0"
     exon            1266..1403
                     /gene="ENTPD1"
                     /gene_synonym="ATP-DPH; ATPDase; CD39; NTPDase-1; SPG64"
                     /inference="alignment:Splign:2.1.0"
     exon            1404..12493
                     /gene="ENTPD1"
                     /gene_synonym="ATP-DPH; ATPDase; CD39; NTPDase-1; SPG64"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1906..1911
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ENTPD1"
                     /gene_synonym="ATP-DPH; ATPDase; CD39; NTPDase-1; SPG64"
                     /note="hexamer: TATAAA"
     polyA_site      1936
                     /gene="ENTPD1"
                     /gene_synonym="ATP-DPH; ATPDase; CD39; NTPDase-1; SPG64"
                     /note="major polyA site"
     regulatory      3120..3125
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ENTPD1"
                     /gene_synonym="ATP-DPH; ATPDase; CD39; NTPDase-1; SPG64"
                     /note="hexamer: AATAAA"
     polyA_site      3139
                     /gene="ENTPD1"
                     /gene_synonym="ATP-DPH; ATPDase; CD39; NTPDase-1; SPG64"
                     /note="major polyA site"
     regulatory      3745..3750
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ENTPD1"
                     /gene_synonym="ATP-DPH; ATPDase; CD39; NTPDase-1; SPG64"
                     /note="hexamer: AATAAA"
     polyA_site      3770
                     /gene="ENTPD1"
                     /gene_synonym="ATP-DPH; ATPDase; CD39; NTPDase-1; SPG64"
     regulatory      12472..12477
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ENTPD1"
                     /gene_synonym="ATP-DPH; ATPDase; CD39; NTPDase-1; SPG64"
                     /note="hexamer: AATAAA"
     polyA_site      12493
                     /gene="ENTPD1"
                     /gene_synonym="ATP-DPH; ATPDase; CD39; NTPDase-1; SPG64"
ORIGIN      
        1 acggagacgg accacagcaa gcagaggctg ggggggggaa agacgaggaa agaggaggaa
       61 aacaaaagct gctacttatg gaagatacaa aggagtctaa cgtgaagaca ttttgctcca
      121 agaatatcct agccatcctt ggcttctcct ctatcatagc tgtgatagct ttgcttgctg
      181 tggggttgac ccagaacaaa gcattgccag aaaacgttaa gtatgggatt gtgctggatg
      241 cgggttcttc tcacacaagt ttatacatct ataagtggcc agcagaaaag gagaatgaca
      301 caggcgtggt gcatcaagta gaagaatgca gggttaaagg tcctggaatc tcaaaatttg
      361 ttcagaaagt aaatgaaata ggcatttacc tgactgattg catggaaaga gctagggaag
      421 tgattccaag gtcccagcac caagagacac ccgtttacct gggagccacg gcaggcatgc
      481 ggttgctcag gatggaaagt gaagagttgg cagacagggt tctggatgtg gtggagagga
      541 gcctcagcaa ctaccccttt gacttccagg gtgccaggat cattactggc caagaggaag
      601 gtgcctatgg ctggattact atcaactatc tgctgggcaa attcagtcag aaaacaaggt
      661 ggttcagcat agtcccatat gaaaccaata atcaggaaac ctttggagct ttggaccttg
      721 ggggagcctc tacacaagtc acttttgtac cccaaaacca gactatcgag tccccagata
      781 atgctctgca atttcgcctc tatggcaagg actacaatgt ctacacacat agcttcttgt
      841 gctatgggaa ggatcaggca ctctggcaga aactggccaa ggacattcag gttgcaagta
      901 atgaaattct cagggaccca tgctttcatc ctggatataa gaaggtagtg aacgtaagtg
      961 acctttacaa gaccccctgc accaagagat ttgagatgac tcttccattc cagcagtttg
     1021 aaatccaggg tattggaaac tatcaacaat gccatcaaag catcctggag ctcttcaaca
     1081 ccagttactg cccttactcc cagtgtgcct tcaatgggat tttcttgcca ccactccagg
     1141 gggattttgg ggcattttca gctttttact ttgtgatgaa gtttttaaac ttgacatcag
     1201 agaaagtctc tcaggaaaag gtgactgaga tgatgaaaaa gttctgtgct cagccttggg
     1261 aggagataaa aacatcttac gctggagtaa aggagaagta cctgagtgaa tactgctttt
     1321 ctggtaccta cattctctcc ctccttctgc aaggctatca tttcacagct gattcctggg
     1381 agcacatcca tttcattggc aagatccagg gcagcgacgc cggctggact ttgggctaca
     1441 tgctgaacct gaccaacatg atcccagctg agcaaccatt gtccacacct ctctcccact
     1501 ccacctatgt cttcctcatg gttctattct ccctggtcct tttcacagtg gccatcatag
     1561 gcttgcttat ctttcacaag ccttcatatt tctggaaaga tatggtatag caaaagcagc
     1621 tgaaatatgc tggctggagt gaggaaaaaa atcgtccagg gagcattttc ctccatcgca
     1681 gtgttcaagg ccatccttcc ctgtctgcca gggccagtct tgacgagtgt gaagcttcct
     1741 tggcttttac tgaagccttt cttttggagg tattcaatat cctttgcctc aaggacttcg
     1801 gcagatactg tctctttcat gagtttttcc cagctacacc tttctccttt gtactttgtg
     1861 cttgtatagg ttttaaagac ctgacacctt tcataatctt tgctttataa aagaacaata
     1921 ttgactttgt ctagaagaac tgagagtctt gagtcctgtg ataggaggct gagctggctg
     1981 aaagaagaat ctcaggaact ggttcagttg tactctttaa gaaccccttt ctctctcctg
     2041 tttgccatcc attaagaaag ccatatgatg cctttggaga aggcagacac acattccatt
     2101 cccagcctgc tctgtgggta ggagaatttt ctacagtagg caaatatgtg ctaaagccaa
     2161 agagttttat aaggaaatat atgtgctcat gcagtcaata cagttctcaa tcccacccaa
     2221 agcaggtatg tcaataaatc acatattcct aggtgatacc caaatgctac agagtggaac
     2281 actcagacct gagatttgca aaaagcagat gtaaatatat gcattcaaac atcagggctt
     2341 actatgaggt aggtggtata tacatgtcac aaataaaaat acagttacaa ctcagggtca
     2401 caaaaaatgc atcttccaat gcatattttt attatggtaa aatatacata aatataattc
     2461 accattttaa catttaattc atattaaata cgtacaaatc agtgacattt agtacattca
     2521 cagtgttgtg ccaccatcac cactatttag ttccagaaca tttgcatcat caatacattg
     2581 tctagagaca agactatcct gggtaggcag aaaccataga tcttttgtgt ttacagctat
     2641 ggaaaccaac tgtaccataa agatagttca ctgagtttta aagccaagcc acatcttatt
     2701 tttccaaggt ttaatttagt gagagggcag cattagtgtg gagtggcatg cttttgccct
     2761 atcgtggaat ttacacatca gaatgtgcag gatccaagtc tgaaagtgtt gccacccgtc
     2821 acacaacatg ggctttgttt gcttattcca tgaagcagca gctatagacc ttaccatgga
     2881 aacatgaaga gaccctgcac ccctttcctt aaggattgct gcaagagtta cctgttgagc
     2941 aggattgact ggtgatgttt cattctgacc ttgtcccaag ctctccatct ctagatctgg
     3001 ggactgactg ttgagctgat ggggaaagaa aagctctcac acaaaccgga agccaaatgt
     3061 cccctatctc ttgaatgatc aagtcacttt tgacaacatc caggtgaata taaaaactta
     3121 ataaagctgt ggaaaggaac tcttaatctt cttttctgct acttaggtta aattcactag
     3181 atcttgatta ggaatcaaaa ttcgaattgg gacatgttca aattctttct tgtggtagtt
     3241 gcctatactg tcatcgctgc tgttggttga gcatttgtgg tgtaccacgc tgtgtgctca
     3301 agggtattac attcatcttc tcatttaatc ctcacaacaa tctgaagaag gtaggtatta
     3361 caattcccac ttcatagaaa cagaaactga ggttcagaga ggttaagtca tttgcccaaa
     3421 tggctgagcc aaagcctacc atgtacctaa cctttatttt ctttcccgaa cataccaggc
     3481 tgtctcctca taacttccaa gcatgcactt aaaactccac atgaatacaa ggttcatggg
     3541 acttggtatt catagaaagg gaggcagaaa gctggtctgt tcctgatagg cttgtaattt
     3601 aatatcattc tgttcatgtg ctttggatgg aagcacatct ggcatatgat gctaatcagt
     3661 ggttcccata cccctggctt cctaatttta atgtttgctc acagcatagt agattgacat
     3721 caaatagtgg ccgatgatga tgaaaataaa ggtcaaataa gttgagccaa taacagccgc
     3781 ttttttcctt ctgtctgcgt atacaaagca ctgtcatgca cacaatctat tctgaccctc
     3841 acaacaaccc ataagggtgt aaatagtatt tccattttac aaatgaggat cacacaaact
     3901 actacatggc agagcagata ctccaactca tgtcttctgg ttgaagccta ttgctttttc
     3961 ttttctaaac actttccctc agcaagttgg aattagactt cacaagtctc cttcagagaa
     4021 cacaaatctt ttcttattcc attcctgttt ggttgcctac gtccaatctc cccctcccca
     4081 gagatgccaa aaaaaaaatc ctttaaggta tttgggagcc aaactcaact tgttaaaatc
     4141 tcaaattatg gagacaatca gcagacacaa cctaacccca attattttgg caggaaggtt
     4201 ggtttagagg cagatccagc aatctgcttt gggccactct gggtggggta ggtgaaataa
     4261 gattggtcac tgttaactaa ttttaatatt ggattggcca ttggttatca ctgattacca
     4321 ttctcccctg gattttcacc caggactcaa aacttggttc tgctaaccct gttcctttat
     4381 gaggaacctt ttaaagattc ctttataagg tgggagtttt ttttctatga acctataggg
     4441 gagaaaaaag atcagcagaa gtcattactt tttttttttt tttttttttt ttttgagaga
     4501 gagtctcact ccattgccca ggctggagtg cagtggtgct atctcggctc actgcaacct
     4561 ccgcctcctg ggttcaagca attctcctgc ctcagcctcc cgagtagctg ggattgcagg
     4621 tgcccaccac cacacccggc taatttttgt atttttagta aagacagggt ttcaccatgt
     4681 tggccaggct ggtctccaac tcccaatctc aggtgatcct attgcctcgg gctcccaaag
     4741 tgctgggatt acaggagtga gccaccatgc ctggccagaa gtggttactt ctgtagacaa
     4801 aagaataatg ctacttaatc aggctttctg tgtgacaaga aagagaaaga aaataaagaa
     4861 gtttcaattc atccaattct taataagaaa tatgtaaata aaatttttta aaattacact
     4921 tcattttaat gttgtatcag tcaaggtccc tgcaagagat ggatggtatg gtacactcaa
     4981 actgggtaac acaggagagt tttcagaaag caactaaatc caaaatacta tcaaggaatc
     5041 aatataaaaa ttgttaatat ttttctcata ctaaattttc aaaatatttt gtgtctatta
     5101 catttacagc acatcttaat taggactagc tgtgtgttca cctcacatgt ggcttgtagc
     5161 taccatactg gacagcacat gtccaaaaaa atacacgtaa agttaaagtt taaaagacac
     5221 aggaactaag ccctcattgt ctttcccttg ggaggtagtt taaagagcta tagatgctgt
     5281 aacattcttg ctattattta ttatatatga cattattcct aaaaaagctt ttgagatcct
     5341 aggttgtatt cctcaggttt tgttgccttc ccatgaagat gtgaaggcag ggatgcctgt
     5401 tattcagtcc aagatgcatg acaagagacc ttgggaaagt ttcatctgga tttaaagatt
     5461 aattcttgat gcttacattc catactcaaa atgtaaattt gaatattaaa ataaagatga
     5521 tttttttttt ggagctagtc ttgctctgtt gcccaggctg gaatgcagtg gcatgatcat
     5581 ggctcactgc agcctcgacc tcccaagctc aagcaaggct acaggtgtgc acctaagtag
     5641 ctaggactac aggtgtgcac caccatgtct agctattttt ttttctgtag agacagggtt
     5701 ttcctatgtt gtccaggctg gtctcgaact cctgccctca agcaatcctc ctgccttggc
     5761 ctcccaaagt gttgagatta caggcgtaag ccactgcacc tggccaagat gaatatttta
     5821 atagctcaca gaacaaagtt tgccacataa tgataaaatt actatgaaaa tatattccct
     5881 ttattgtcag tttaaaagat gaactgagtt tcacccaaac tggtctggcc cctctctgat
     5941 tcaaatacca atagttgctc tgattcaaat tccaactgtt agaacatgac agctgctcat
     6001 aactagcttt gcttactaac catgtttctt tccatttgta ttaggtcctt tactttttat
     6061 aacagcctca aagtttcatg aattgctgca gtaaacattg attttcatgt ttgtgagtct
     6121 gcaagccagc tgggcagctc tacttcaggt ggtaagggtg gatcagacct attccatata
     6181 cctcttgttc tccttgtcca gtggtttcta gggatatgtt ctcatgatga accccgcaga
     6241 ggctcgtgaa agtgagagga aactaggatg cctcttaagg tcttggtcag gatggggtct
     6301 cctgtcactt ctgtcacagg ctattgtaag tcatatgagc aagctcaata aaatataaac
     6361 aagtcagata aacagtggga ggaatggcaa agtcatatgg ccaaggccat gagtgattaa
     6421 ttttaacaca ggaaaaaagt aaagcattaa atgcgattat ttaatataca atgtcttatt
     6481 aactgaaata taaaatgtgt ttactgtaaa atataatctg tttatctcac caaagaaata
     6541 ttatctttaa aaaatgtcat tacttctaag acatcatcag tctgcaactt ctttccatag
     6601 ccttaatcag gatgctgtgg cagctcccac attagcctcg cattctaaac tggtagatgt
     6661 cctaggaaac catacatcta tgtatttttc ttattttata cgtttaggac aatgtatagc
     6721 taattaccca actttttatt tgcatacaaa tctaatacaa ctgaacacaa tcagttttat
     6781 cacaggtata atggattttt caatagtgag gaggtgcctc catgagcctt ctctttagaa
     6841 aagtggcatt caagactctt catttgaagt gaagattgct atgtcttttg cattgctcta
     6901 ttttacataa attaagttat aaattgacac tataatcaac tgacaccatg atcagtgatg
     6961 atgatcaccc tcatcagcac tagagttgac ttgtttttat aacccctttg catgtatgtt
     7021 gaatagcaaa gttcatcaga gaacatgtat tagtcaatgg taagtaagat actctcatct
     7081 aagaaataac atcacctctt ctaatgaagt tctaagaaga gagggaagaa aaagtcttgg
     7141 gagctagtca gggaatagtg tgtatttgca attacctaaa ctgaactcta ccattactcc
     7201 taacccagtt cctcctcctg tgttttacat gattaatgcc acccctgcct caatgaacca
     7261 agatcagctc catcactggg acctccccat tctgcctgtg caatattttt cttttttatt
     7321 tctccttcta atattactgt tattgctcca gtaaagagct gtaatatatt ttacctggac
     7381 tgataccagg aatggtggtg ttgcttccaa tctgttgctg ctagattaat ctttgcaaag
     7441 cacaggctta atttcattgc tgctcaacta aaaccactgg tggctttcca ttgcctacaa
     7501 aataaagtca acctccccat cagacattca aggctttcaa tgatccatgg ccgccagctc
     7561 tctccaggct catatcccac tccactcctc tgatgtttcc tacactacac tacactatac
     7621 tacactacag ccaggtagaa tgactgttca cccaacacca ctcaggttgt cttctcaact
     7681 tggaatactc ttgcaccttc aaagctcatt tcaaatgccc cttcatttgt gaagccttct
     7741 ccaaatttcc aagtcagaat gtctcttcct tgtgctacca caacccttta actgagcctc
     7801 cattagtgca ctgagaccat tctgttcagt gtctgggtga agcttcctgg tgaaaaatat
     7861 gttacctatt tctttctgaa aagttggatt cagggatatt atcacggacc taaggtaata
     7921 gttctagcca acctccctgt ccactgccag gccgactaca aacccttctg ttgctggcga
     7981 gctggtccgc accactagtt ctgcttcact ctatttatct cttgatgtaa ccatcttctt
     8041 tctccaggtt ttaagaacca gcccaactcc tggttccctg atgaagcttt tattccccta
     8101 gccacatgga acttttcctt tttggaacat gcctttagtt tctgtgtagt ttgccatgca
     8161 gcacttcatt gtacacatta ttaaaacaga attttaagga ttagaatgaa ccttaaaaga
     8221 tcatgcatct caaaatttaa tgtacataca aattacccag ggattttgtt gaaataaaaa
     8281 ttatttaatt ttaattaata taaataattc agtaggtctg gggtgaggcc tgaggtttta
     8341 catttccaac aagctgccag gtaaagccaa tacatctgtc caggaatcac actttgcgta
     8401 tcaaaggtct agatgacatt atcattccaa agagtttctt ttacaggctc tcagatcagt
     8461 gttcatccac tacctgacta ctgtcattca caggcattct gttccacagc aggccagcta
     8521 acgtggtatt tacaaagctc actcctctta tacaacaatc caagtgtttc ttttgtcagt
     8581 tgtctgtgcc ccaggagatc cctctctgcc ttgccttgcc ctctgccttt ggagaccagc
     8641 acctcatact cagtgaaggc ctggagtgct taagagggat ttcttccagc tctcttgccc
     8701 tggtcttcag tgtattagat gtattacctc catgctctca gtagaggccc ataggaaaga
     8761 gtaggtaggt tatgccagct cacacgcatc ctttaaaaat ggtttagaag tttagctggt
     8821 ttcttattac tcctgtctat ggatgtttcc ttctgtcact ctactaggga tgaaacagct
     8881 aatcatgttc aatagttaca tttagattgg tttttaaaaa ctatgattgt attagttcgt
     8941 ttccatgctg ctgataaaga catatctgag actggaaaca aaaagggttt aattggactt
     9001 acagttccac atggctgggg aggcctcaaa atcaggtggg aggcaaaagg tacttcttac
     9061 gtggtggcat caagagcaaa atgaggaaga agcaaaagca gaaactcttc ataaacccac
     9121 cagatcttgt gggacttatt atcacgagaa tagcacagaa aagactggcc tccatgattc
     9181 aattacctcc cactgcgtcc ctcccacaac atgtgggaat tctgggagat acaattcaag
     9241 ttgagatttg ggtggggaca cagccaaacc atatcattcc tccctgggct cctccaaatt
     9301 tcataatcct cacatttcaa aaccaatcat tccttcccaa cagttcccca aagtcttaac
     9361 tcatttcagc attaacccaa aagtccacag tccaaagtct catctgagac aaggcaagtc
     9421 ccttccactt acaagcctgt aaaagcaagc tagttacctc ctagatacaa tggggggtac
     9481 aggtattggg taaatacagc tgttccaaat gagagaaatt ggccaaaaca aaggggttac
     9541 agggtccatg caagtctgaa atccagtggg gcagtcaaat tttaaagctc cataatgatc
     9601 tcctttgact ccatgtctca cattcaggtc atgctgatgc aagagatagg ttcccatggt
     9661 cttgtgcagc tccgcccctg tggctttgca gagtacagcc tccctcctgg ctgctttctc
     9721 aggctgatgt tgagtgtctg tagcttttcc aggcacaaga tgcaagttgg tggttgatct
     9781 accattctgg ggtctaccat tctggggtct accgttctgg gactgtggcc ttcttctcac
     9841 agctccacta ggcagtgccc caacagggac tctgtgtggg ggctctgccc cacatttccc
     9901 ttccacactg ccctaggaga ggttccccat gagggctctg cccctgcagc aaacttttgc
     9961 ctggacatcc aggtgtttcc atatatattc tgaaatctag gcagaggttc ccaaatctca
    10021 attcttgaca tctctgcacc cacaggctca acatcacatg gaagctgcca atgcttgggg
    10081 cctctaccct ctgaagccac agcccaagct ctatgttggc tcctttcagc catggctgga
    10141 gcagctggga cacagggcac caagtcccta ggctgcacac agcacagaga ccctgggccc
    10201 agcccacaaa accacttttt cctcctgggc ctctgggcct gtgatgggag gggctgccat
    10261 gaaggtctct gacatgacct ggagacattt tccccatggt cttggggatt aacattaggc
    10321 tccttgctgc ttatgcaaat ttctgcagcc agcttgaatt tctccttaaa aaaaatgggt
    10381 ttttcttttc tactgcatca tcaggctgca gattttccac atttatgctc ttgtttccct
    10441 tttaaaacag aatgttttta acagcaccca agtcaccttt tgaatgcttt gctgcttaga
    10501 aatttattcc accagatacc ctaagtcatc tctctcaagc tctaagttcc acaaatctct
    10561 agggcaaggg tgaaatgctg ccagtctcct tgctaaaaca taacaagggt cacctttact
    10621 tcagttccca acaaggtctt catctccatc tgagaccacc tcagcctgga ccttattgtt
    10681 catatcacta tcagtatttt tgtcaatgcc attcacagtc tctaggaggt tccaaacttt
    10741 cctacatttt cctatcttct tctgagccct ccagattatt tcaacaccca gttccaaagt
    10801 tgcttccaca ttttcgggta tcttttcagc aatgccccac tctactggta ctattagtcc
    10861 attttcatgc tgctgataaa gacatacctg agactgggaa caaaaagagg tttaattgga
    10921 cttatagttc cacctggctg gggaggcctc agaatcatgg caggaggtga aaggcatttc
    10981 ttacacggca gcagcaagag aaaaatgaag aagcagcaaa agcagaaacc cctgataaaa
    11041 ccatcagatc tcgtgagact tattcactat cacaagaata gcatgggaaa gaccagcccc
    11101 cttgattcaa ttacctcccc ctgggtcctg tgggaattct ggaaggtaca attcaagttg
    11161 agatttgggt ggggacacag ccaaaccata tcaatgattt tgtactttaa ccagctgaat
    11221 ggaagtacaa tctcttgcta tatgacacaa taattatttg caaaatgagt aaacatatca
    11281 taaggaaatt atttttacaa ggtttgaaac ctgaaatgca gtctattatc atacataact
    11341 aaaaatagag cctcaataaa cagattccca gttttgaaaa tgcaacattt gtactccaca
    11401 ttgtcagttt tcttaggtat atttataaat actcctataa aaatgtaaag aaacacataa
    11461 tgtagattgc taattttata ataacacaag ttgattttga catccaactt attaattatg
    11521 aaatgacttt tggcctagta acaatgaaaa tgggggcaaa tacagataaa tggtaattct
    11581 tagaatgaac tactcagcac caattctaag tttttcttga tggtaaatca taatgttccc
    11641 tttctcctcg gttctgcaat ctataggcat accataattg taatcaatag cttaaaaata
    11701 tgtctctctg tcctattctg tatctgtatc tcttggattt ttacctttgc aatagtcaac
    11761 tgaaccatct tcttggagta ctcatgaaga tggaagtcta catggagaat acaggatgaa
    11821 tccactctgt ctcctgcagt gaagtctgtt tgaaggatgt atttggctgt cttctggaca
    11881 ggccattcta ataacagaaa caaacaagtt attttaaaac ttattggaat attcaaatat
    11941 taaccaaagt agaaaaatat aatacacatc catgtgccca tcacagaact tcactgatta
    12001 tcatcattta gccagtcttg aagaagcaag tgctaattac aatcacaaat gaaacaagat
    12061 tcagacttca tgaagagcac tgcgctataa taaaagaaga aatgagcaca tacattcttt
    12121 tactgacagt caaatggtga aggtgggcag aatcattatg tgatgcaaca tggcaaaagt
    12181 atacagacag tgcatccaga ggaaggcacc ttgctgaatg actagaatgg aagtaggaga
    12241 cattttgcag gcccccttca tcctgcaggg agaaccagaa ccacagcagc tctatttgcc
    12301 tattcctctt taaattacaa agttaaaatt tgggagtagt agaaaatcaa ttggttatct
    12361 tatagagtct cctagaatat ttcattggca ttgagaaggt ggaaaatgca aattatatac
    12421 tttaaaatgt aatttttgct tttcacatat gcttaaagcc taaaacctct taataaactt
    12481 cttctgaaat ata
//
