LOCUS       NM_153343               3848 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens ectonucleotide pyrophosphatase/phosphodiesterase 6
            (ENPP6), mRNA.
ACCESSION   NM_153343
VERSION     NM_153343.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3848)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 3848)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   3  (bases 1 to 3848)
  AUTHORS   Sakagami,H., Aoki,J., Natori,Y., Nishikawa,K., Kakehi,Y., Natori,Y.
            and Arai,H.
  TITLE     Biochemical and molecular characterization of a novel
            choline-specific glycerophosphodiester phosphodiesterase belonging
            to the nucleotide pyrophosphatase/phosphodiesterase family
  JOURNAL   J Biol Chem 280 (24), 23084-23093 (2005)
   PUBMED   15788404
  REMARK    GeneRIF: NPP6 has a specific role through the hydrolysis of
            polyunsaturated LPC, glycerophosphorylcholine, or
            sphingosylphosphorylcholine in kidney and brain
REFERENCE   4  (bases 1 to 3848)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC079080.5, BC035035.2 and AC107222.6.
            
            On Nov 22, 2018 this sequence version replaced NM_153343.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            transcript and genomic sequence data to make the sequence
            consistent with the reference genome assembly. The extent of this
            RefSeq transcript is supported by transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC035035.2, SRR1803616.152303.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2158188
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000296741.7/ ENSP00000296741.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-7                 AC079080.5         61789-61795         c
            8-3070              BC035035.2         1-3063
            3071-3848           AC107222.6         42178-42955         c
FEATURES             Location/Qualifiers
     source          1..3848
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q35.1"
     gene            1..3848
                     /gene="ENPP6"
                     /gene_synonym="NPP6"
                     /note="ectonucleotide pyrophosphatase/phosphodiesterase 6"
                     /db_xref="GeneID:133121"
                     /db_xref="HGNC:HGNC:23409"
                     /db_xref="MIM:616983"
     exon            1..295
                     /gene="ENPP6"
                     /gene_synonym="NPP6"
                     /inference="alignment:Splign:2.1.0"
     CDS             55..1377
                     /gene="ENPP6"
                     /gene_synonym="NPP6"
                     /EC_number="3.1.4.38"
                     /note="B830047L21Rik; ectonucleotide
                     pyrophosphatase/phosphodiesterase family member 6; NPP-6;
                     E-NPP 6; choline-specific glycerophosphodiester
                     phosphodiesterase; GPC-Cpde; glycerophosphocholine
                     cholinephosphodiesterase ENPP6"
                     /codon_start=1
                     /product="glycerophosphocholine cholinephosphodiesterase
                     ENPP6 precursor"
                     /protein_id="NP_699174.1"
                     /db_xref="CCDS:CCDS3834.1"
                     /db_xref="GeneID:133121"
                     /db_xref="HGNC:HGNC:23409"
                     /db_xref="MIM:616983"
                     /translation="MAVKLGTLLLALALGLAQPASARRKLLVFLLDGFRSDYISDEAL
                     ESLPGFKEIVSRGVKVDYLTPDFPSLSYPNYYTLMTGRHCEVHQMIGNYMWDPTTNKS
                     FDIGVNKDSLMPLWWNGSEPLWVTLTKAKRKVYMYYWPGCEVEILGVRPTYCLEYKNV
                     PTDINFANAVSDALDSFKSGRADLAAIYHERIDVEGHHYGPASPQRKDALKAVDTVLK
                     YMTKWIQERGLQDRLNVIIFSDHGMTDIFWMDKVIELNKYISLNDLQQVKDRGPVVSL
                     WPAPGKHSEIYNKLSTVEHMTVYEKEAIPSRFYYKKGKFVSPLTLVADEGWFITENRE
                     MLPFWMNSTGRREGWQRGWHGYDNELMDMRGIFLAFGPDFKSNFRAAPIRSVDVYNVM
                     CNVVGITPLPNNGSWSRVMCMLKGRASTAPPVWPSHCALALILLFLLA"
     exon            296..475
                     /gene="ENPP6"
                     /gene_synonym="NPP6"
                     /inference="alignment:Splign:2.1.0"
     exon            476..587
                     /gene="ENPP6"
                     /gene_synonym="NPP6"
                     /inference="alignment:Splign:2.1.0"
     exon            588..729
                     /gene="ENPP6"
                     /gene_synonym="NPP6"
                     /inference="alignment:Splign:2.1.0"
     exon            730..909
                     /gene="ENPP6"
                     /gene_synonym="NPP6"
                     /inference="alignment:Splign:2.1.0"
     exon            910..1047
                     /gene="ENPP6"
                     /gene_synonym="NPP6"
                     /inference="alignment:Splign:2.1.0"
     exon            1048..1171
                     /gene="ENPP6"
                     /gene_synonym="NPP6"
                     /inference="alignment:Splign:2.1.0"
     exon            1172..3848
                     /gene="ENPP6"
                     /gene_synonym="NPP6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3822..3827
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ENPP6"
                     /gene_synonym="NPP6"
                     /note="hexamer: AATAAA"
     polyA_site      3848
                     /gene="ENPP6"
                     /gene_synonym="NPP6"
                     /note="major polyA site"
ORIGIN      
        1 agtctttgca aggcgacagc tgtgccagcc gggctctggc aggctcctgg cagcatggca
       61 gtgaagcttg ggaccctcct gctggccctt gccctgggcc tggcccagcc agcctctgcc
      121 cgccggaagc tgctggtgtt tctgctggat ggttttcgct cagactacat cagtgatgag
      181 gcgctggagt cattgcctgg tttcaaagag attgtgagca ggggagtaaa agtggattac
      241 ttgactccag acttccctag tctctcgtat cccaattatt ataccctaat gactggccgc
      301 cattgtgaag tccatcagat gatcgggaac tacatgtggg accccaccac caacaagtcc
      361 tttgacattg gcgtcaacaa agacagccta atgcctctct ggtggaatgg atcagaacct
      421 ctgtgggtca ctctgaccaa ggccaaaagg aaggtctaca tgtactactg gccaggctgt
      481 gaggttgaga ttctgggtgt cagacccacc tactgcctag aatataaaaa tgtcccaacg
      541 gatatcaatt ttgccaatgc agtcagcgat gctcttgact ccttcaagag tggccgggcc
      601 gacctggcag ccatatacca tgagcgcatt gacgtggaag gccaccacta cgggcctgca
      661 tctccgcaga ggaaagatgc cctcaaggct gtagacactg tcctgaagta catgaccaag
      721 tggatccagg agcggggcct gcaggaccgc ctgaacgtca ttattttctc ggatcacgga
      781 atgaccgaca ttttctggat ggacaaagtg attgagctga ataagtacat cagcctgaat
      841 gacctgcagc aagtgaagga ccgcgggcct gttgtgagcc tttggccggc ccctgggaaa
      901 cactctgaga tatataacaa actgagcaca gtggaacaca tgactgtcta cgagaaagaa
      961 gccatcccaa gcaggttcta ttacaagaaa ggaaagtttg tctctccttt gactttagtg
     1021 gctgatgaag gctggttcat aactgagaat cgagagatgc ttccgttttg gatgaacagc
     1081 accggcaggc gggaaggttg gcagcgtgga tggcacggct acgacaacga gctcatggac
     1141 atgcggggca tcttcctggc cttcggacct gatttcaaat ccaacttcag agctgctcct
     1201 atcaggtcgg tggacgtcta caatgtcatg tgcaatgtgg tgggcatcac cccgctgccc
     1261 aacaacggat cctggtccag ggtgatgtgc atgctgaagg gccgcgccag cactgccccg
     1321 cctgtctggc ccagccactg tgccctggca ctgattcttc tcttcctgct tgcataactg
     1381 atcatattgc ttgtctcaga aaaaaacacc atcagcaaag tgggcctcca aagccagatg
     1441 attttcattt tatgtgtgaa taatagcttc attaacacaa tcaagaccat gcacattgta
     1501 aatacattat tcttggataa ttctatacat aaaagttcct acttgttaaa aaagatacaa
     1561 accttgtttt tccagaaggt aggaaaatcc tagctttcca tttgtgcagt tatatgtcat
     1621 tttctccttt cttttcacgt tactcaggat gaactctctg agcagggacc tgctcctgca
     1681 gcaaccaaac ttggagtggt tattgcagac agacgtggct ctgggcccct ctctgtccca
     1741 ccttgcacaa aggaccccct cagaccaggc ccttgtctgt gccctgtcca cacccaggag
     1801 ccatcctcag tgtctgtggc cacaatcctg tactgttcct tccatccctg ataaaaggag
     1861 gtctacatga aagcaaaagc tactgtctat ttctgaccca gctcatggaa ttttttcatc
     1921 ttatactgag ctccagaaag gacgtaactt agcatggatc accaatcaat caaaaaataa
     1981 ataaatcact aaggattgga gaactcatag aacaaggtga aagacatgag tgccctccca
     2041 aagtctgagt gcacgaaaat ttctctcttg ccttgaggag cagaaaagct tctgatggac
     2101 atgggcttct gtgagactta tcacacatag tgtatcgtgg catgaagccc ggcacatagc
     2161 aggccctgca tattgatgga caaatggatg gcctgcctgc cttccctgtc cgttcacctg
     2221 tgcaaaggct tcctcagaca tgccactctg tggctcccaa tatagggtgc agacaagagc
     2281 aatccctgac atgacattat agcctgggaa agggctggct cactgatgag aatgtggagg
     2341 catcagcaag gatctcggtg ggttgctcag agaggtgatg cactaagcct taatcctgga
     2401 caccagtacc cctgcagcat ggcttgctca acaacagtct ttgagtggca tagaattcca
     2461 aagaaaatgg tgctgggtgg agaatggaga gagcatgatg gagcagagtc ccagtcactg
     2521 accaactaac tggtcgtttg attaggaaac agtttggcca aagtaccacc tttgagacct
     2581 aagttctttt gatacctttg agaagagcca ctgagcctga gttgaaatat ttttagctta
     2641 gtcatctgtg tttgctatag gagaaattgt aacacaagaa ataactcctt tttacatgat
     2701 catttatatc tatatacata tatatacttg catacactat cactgcatta aaaaatgagt
     2761 ttgggctggg catggtggct cacacctata atcccaacac tttcggaggc caaggaggga
     2821 caaacgaacc cttgaggcca ggagttccag actaacttgg gcaacacagg gcgaccccca
     2881 tctctacaaa acataaaaga tttttaaaaa attagccagg catggtggca catgcctgtg
     2941 gtctcagcta cttgggaggc tgaggcagga gaatcatttg agcccaggag gtcaaggctg
     3001 cagtgagctt tgatcacacc actgcactcc agcctgggca acagagcaag accccatcct
     3061 ccaccccccc caaaaaatag aaagaaaaaa aaagtttgca ctaattgagg tacatctgca
     3121 agtgagactt tttgtcagga aaaggcaata tatcaggtct cctcaggacg atggaggcct
     3181 tatatggtgt gttaccttga aaactgaata tcaacgttca ccttgattca ggaaagctgg
     3241 gtgctgtctc catgccatga atcatgagag caaaggatca ctgcttaaaa atactgaatt
     3301 taccttcaca aaagatttct aaagatttat gtaatgtgtt ttaaaagcgc cagtaaacca
     3361 tcggatcaat tggaaagaag gcaactcttc agcctttgtt atctagctga aaacaaatga
     3421 caactttcaa aacattggca gtagttgttg aaaaagacgt ctattgttca aagtttcttt
     3481 ctccttaaag gacggtgttc caatgaattc agtagagccc actttcctcc actgtggagg
     3541 aagaatccct aagagatact caaatgatta aattaaaatt ggatcatcaa actcaagaga
     3601 ggcataaact tagacacagt cttgcatttt tgtctttcct gaactcttct gccattttcc
     3661 tccttcactc gtcctgaaaa tctgcaagtt acataataaa actttagata tttgtctgac
     3721 aaagtgtaat tactcaactg aataaatgac tgagaacaag ttacaaaagg aatcatgaat
     3781 cctggtaaac aataaagaag attcagacac tgagggaaaa aaataaagct ttttacttaa
     3841 ataatgca
//
