LOCUS       NM_001290072            3845 bp    mRNA    linear   PRI 01-OCT-2024
DEFINITION  Homo sapiens ectonucleotide pyrophosphatase/phosphodiesterase
            family member 5 (ENPP5), transcript variant 1, mRNA.
ACCESSION   NM_001290072 XM_005249259
VERSION     NM_001290072.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3845)
  AUTHORS   Takaya,K. and Kishi,K.
  TITLE     Regulation of ENPP5, a senescence-associated secretory phenotype
            factor, prevents skin aging
  JOURNAL   Biogerontology 25 (3), 529-542 (2024)
   PUBMED   38436793
  REMARK    GeneRIF: Regulation of ENPP5, a senescence-associated secretory
            phenotype factor, prevents skin aging.
REFERENCE   2  (bases 1 to 3845)
  AUTHORS   Lee,K.H., Hwang,H.J., Im,Y.J., Nam,A.R., Lee,J.W. and Cho,J.Y.
  TITLE     New oncogenic functions of LINE1 retroelement as a ceRNA for tumor
            suppressive microRNA miR-126 on ENPP5
  JOURNAL   PLoS One 18 (6), e0286814 (2023)
   PUBMED   37352273
  REMARK    GeneRIF: New oncogenic functions of LINE1 retroelement as a ceRNA
            for tumor suppressive microRNA miR-126 on ENPP5.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3845)
  AUTHORS   Gorelik,A., Randriamihaja,A., Illes,K. and Nagar,B.
  TITLE     A key tyrosine substitution restricts nucleotide hydrolysis by the
            ectoenzyme NPP5
  JOURNAL   FEBS J 284 (21), 3718-3726 (2017)
   PUBMED   28898552
  REMARK    GeneRIF: The ENPP5 is able to cleave nicotinamide adenine
            dinucleotide (NAD), suggesting a potential role of this enzyme in
            NAD-based neurotransmission.
REFERENCE   4  (bases 1 to 3845)
  AUTHORS   Gijsbers,R., Ceulemans,H., Stalmans,W. and Bollen,M.
  TITLE     Structural and catalytic similarities between nucleotide
            pyrophosphatases/phosphodiesterases and alkaline phosphatases
  JOURNAL   J Biol Chem 276 (2), 1361-1368 (2001)
   PUBMED   11027689
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC321540.1, AY358514.1,
            BC027615.2, BX647968.1 and BF593433.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_001290072.1.
            
            Summary: This gene encodes a type-I transmembrane glycoprotein.
            Studies in rat suggest the encoded protein may play a role in
            neuronal cell communications. Alternatively spliced transcript
            variants have been described. [provided by RefSeq, Feb 2014].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer protein (isoform 1). Variants 1
            and 2 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.161434.1,
                                           SRR1660805.215003.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1968189 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000371383.7/ ENSP00000360436.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-27                DC321540.1         31-57
            28-285              AY358514.1         1-258
            286-2106            BC027615.2         154-1974
            2107-3679           BX647968.1         2046-3618
            3680-3845           BF593433.1         14-179              c
FEATURES             Location/Qualifiers
     source          1..3845
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.1"
     gene            1..3845
                     /gene="ENPP5"
                     /gene_synonym="NPP-5; NPP5"
                     /note="ectonucleotide pyrophosphatase/phosphodiesterase
                     family member 5"
                     /db_xref="GeneID:59084"
                     /db_xref="HGNC:HGNC:13717"
                     /db_xref="MIM:617001"
     exon            1..173
                     /gene="ENPP5"
                     /gene_synonym="NPP-5; NPP5"
                     /inference="alignment:Splign:2.1.0"
     exon            174..235
                     /gene="ENPP5"
                     /gene_synonym="NPP-5; NPP5"
                     /inference="alignment:Splign:2.1.0"
     exon            236..1099
                     /gene="ENPP5"
                     /gene_synonym="NPP-5; NPP5"
                     /inference="alignment:Splign:2.1.0"
     CDS             271..1704
                     /gene="ENPP5"
                     /gene_synonym="NPP-5; NPP5"
                     /EC_number="3.6.1.29"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; E-NPP 5; ectonucleotide
                     pyrophosphatase/phosphodiesterase 5 (putative)"
                     /codon_start=1
                     /product="ectonucleotide pyrophosphatase/phosphodiesterase
                     family member 5 isoform 1 precursor"
                     /protein_id="NP_001277001.1"
                     /db_xref="CCDS:CCDS4915.1"
                     /db_xref="GeneID:59084"
                     /db_xref="HGNC:HGNC:13717"
                     /db_xref="MIM:617001"
                     /translation="MTSKFLLVSFILAALSLSTTFSLQPDQQKVLLVSFDGFRWDYLY
                     KVPTPHFHYIMKYGVHVKQVTNVFITKTYPNHYTLVTGLFAENHGIVANDMFDPIRNK
                     SFSLDHMNIYDSKFWEEATPIWITNQRAGHTSGAAMWPGTDVKIHKRFPTHYMPYNES
                     VSFEDRVAKIIEWFTSKEPINLGLLYWEDPDDMGHHLGPDSPLMGPVISDIDKKLGYL
                     IQMLKKAKLWNTLNLIITSDHGMTQCSEERLIELDQYLDKDHYTLIDQSPVAAILPKE
                     GKFDEVYEALTHAHPNLTVYKKEDVPERWHYKYNSRIQPIIAVADEGWHILQNKSDDF
                     LLGNHGYDNALADMHPIFLAHGPAFRKNFSKEAMNSTDLYPLLCHLLNITAMPHNGSF
                     WNVQDLLNSAMPRVVPYTQSTILLPGSVKPAEYDQEGSYPYFIGVSLGSIIVIVFFVI
                     FIKHLIHSQIPALQDMHAEIAQPLLQA"
     exon            1100..1276
                     /gene="ENPP5"
                     /gene_synonym="NPP-5; NPP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1277..3845
                     /gene="ENPP5"
                     /gene_synonym="NPP-5; NPP5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2591..2596
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ENPP5"
                     /gene_synonym="NPP-5; NPP5"
                     /note="hexamer: ATTAAA"
     regulatory      2611..2616
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ENPP5"
                     /gene_synonym="NPP-5; NPP5"
                     /note="hexamer: ATTAAA"
     polyA_site      2618
                     /gene="ENPP5"
                     /gene_synonym="NPP-5; NPP5"
     polyA_site      2633
                     /gene="ENPP5"
                     /gene_synonym="NPP-5; NPP5"
                     /note="major polyA site"
     regulatory      3818..3823
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ENPP5"
                     /gene_synonym="NPP-5; NPP5"
                     /note="hexamer: AATAAA"
     polyA_site      3845
                     /gene="ENPP5"
                     /gene_synonym="NPP-5; NPP5"
                     /note="major polyA site"
ORIGIN      
        1 ggcgcggtca ggtgctccgc tccagagttg agcgcaggtg agctcctgcg cgttccgggg
       61 gcgttcctcc agtcaccctc ccgccgttac ccgcggcgcg cccgagggag tctcctccag
      121 accctccctc ccgttgctcc aaactaatac ggactgaacg gatcgctgcg agggtgggag
      181 agaaaattag ggggagaaag gacagagaga gcaactacca tccatagcca gatagattat
      241 cttacactga actgatcaag tactttgaaa atgacttcga aatttctctt ggtgtccttc
      301 atacttgctg cactgagtct ttcaaccacc ttttctctcc aaccagacca gcaaaaggtt
      361 ctactagttt cttttgatgg attccgttgg gattacttat ataaagttcc aacgccccat
      421 tttcattata ttatgaaata tggtgttcac gtgaagcaag ttactaatgt ttttattaca
      481 aaaacctacc ctaaccatta tactttggta actggcctct ttgcagagaa tcatgggatt
      541 gttgcaaatg atatgtttga tcctattcgg aacaaatctt tctccttgga tcacatgaat
      601 atttatgatt ccaagttttg ggaagaagcg acaccaatat ggatcacaaa ccagagggca
      661 ggacatacta gtggtgcagc catgtggccc ggaacagatg taaaaataca taagcgcttt
      721 cctactcatt acatgcctta caatgagtca gtttcatttg aagatagagt tgccaaaatt
      781 attgaatggt ttacgtcaaa agagcccata aatcttggtc ttctctattg ggaagaccct
      841 gatgacatgg gccaccattt gggacctgac agtccgctca tggggcctgt catttcagat
      901 attgacaaga agttaggata tctcatacaa atgctgaaaa aggcaaagtt gtggaacact
      961 ctgaacctaa tcatcacaag tgatcatgga atgacgcagt gctctgagga aaggttaata
     1021 gaacttgacc agtacctgga taaagaccac tataccctga ttgatcaatc tccagtagca
     1081 gccatcttgc caaaagaagg taaatttgat gaagtctatg aagcactaac tcacgctcat
     1141 cctaatctta ctgtttacaa aaaagaagac gttccagaaa ggtggcatta caaatacaac
     1201 agtcgaattc aaccaatcat agcagtggct gatgaagggt ggcacatttt acagaataag
     1261 tcagatgact ttctgttagg caaccacggt tacgataatg cgttagcaga tatgcatcca
     1321 atatttttag cccatggtcc tgccttcaga aagaatttct caaaagaagc catgaactcc
     1381 acagatttgt acccactact atgccacctc ctcaatatca ccgccatgcc acacaatgga
     1441 tcattctgga atgtccagga tctgctcaat tcagcaatgc caagggtggt cccttataca
     1501 cagagtacta tactcctccc tggtagtgtt aaaccagcag aatatgacca agaggggtca
     1561 tacccttatt tcataggggt ctctcttggc agcattatag tgattgtatt ttttgtaatt
     1621 ttcattaagc atttaattca cagtcaaata cctgccttac aagatatgca tgctgaaata
     1681 gctcaaccat tattacaagc ctaatgttac tttgaagtgg atttgcatat tgaagtggag
     1741 attccataat tatgtcagtg tttaaaggtt tcaaattctg ggaaaccagt tccaaacatt
     1801 tgcagaaacc attaagcagt tacatattta ggtatacaca cacacacaca cacacataca
     1861 cacacacgga ccaaaatact tacacctgca aaggaataaa gatgtgagag tatgtctcca
     1921 ttgttcactg tagcataggg atagataaga tcctgcttta tttggacttg gcgcagataa
     1981 tgtatatatt tagcaacttt gcactatgta aagtacctta tgtattgcac tttaaatttc
     2041 tctcctgatg ggtactttaa tttgaaatgc actttatgca cagttatgtc ttataacttg
     2101 attgaaaatg acaacttttt gcacccatgt cacagaatac ttgttacgca ttgttcaaac
     2161 tgaaggaaat ttctaataat cccgaataat gaacgtagaa atctatctcc ataaattgag
     2221 agaagaagaa ggtgataagt gttgaaaatt aaatgtgata acctttgaac cttgaatttt
     2281 ggagatgtat tcccaacagc agaatgcaac tgtgggcatt tcttgtctta tttctttcca
     2341 gagaacgtgg ttttcattta tttttccctc aaaagagagt caaatactga cagattcgtt
     2401 ctaaatatat tgtttctgtc ataaaattat tgtgatttcc tgatgagtca tattactgtg
     2461 attttcataa taatgaagac accatgaata tacttttttt ctatatagtt cagcaatggc
     2521 ctgaatagaa gcaaccaggc accatctcag caatgttttc tcttgtttgt aattatttgc
     2581 tcctttgaaa attaaatcac tattaattac attaaaaatc aaattggata aaacaatgtt
     2641 ttctttctgg tagcgcataa taacagagca caagcatctt ttagatttga gcatttgaag
     2701 attcaaagtt gcgaaagagc acaaaccata ttaggtaaaa tattggccac tcgatccttg
     2761 aaaagaactg tgtggagcct ggaaaaaaaa attaggacca catgtgagat gtttacaaga
     2821 cacccagaac agtggtaaag tgtgcatact agaaaaagca gcaaaataac tctttgtggt
     2881 aacaggtatc aaaacacggg agccgagatg atatagctct gtttcaagaa atatgtgaat
     2941 acccacctac caggtgctca gtggaatcaa agatgaatcc aagttcacaa atagacttct
     3001 acttccaagg tagtactttt gacctgcctg gtcatctcag tcttttccat tccaacaacc
     3061 taaggctgtg ctttagattt ctaagtaatc aagaagtttg ggagaggcat agtattacat
     3121 gtggcttctt agaggaaaga ggaagccctg aaaagaaaga ctttccttga agaaaatagc
     3181 attttacaga cacatggata gtactgtgat ttcatgtata tatatgtacc aattggctaa
     3241 tgagtaggta aaattgtatt actattccag aaagaaagga caaatgggat gtgaagaact
     3301 aaagtgacat agttaaaaat ttaaccaaat ttaagtgctt cctaaaattt ggtgaatgtc
     3361 ttatttttta aaatgataat accaataagg aatgttggca cataattccc atttcattat
     3421 aaaacctctt aatagaatag aatcaaataa ttggaaatgg cctatagatt aaaaagctga
     3481 gaaagtatat ggtaggtagc aaactcccca gaagtatgaa ctctggatta gacatctcag
     3541 aatacatgag cactcatgtt ggcttgcttt gtagctatga acttaccctg tattattgaa
     3601 atgtcagcat aatgactgga aggtgaaatt ggtccatttt agagcattac tattatgcta
     3661 tctgtccatt taaattaata attgcattaa attcatttta gaaggtgcta ttacattagt
     3721 agtaagaaag taaattcata tataaatatt tgattatcag atggtttact tacagatact
     3781 tattttcctg taaaatagga gagtttacct gaagaaaaat aaaactttta acttttctgg
     3841 gaaaa
//
