LOCUS       NM_001347969            3397 bp    mRNA    linear   PRI 06-APR-2024
DEFINITION  Homo sapiens ecto-NOX disulfide-thiol exchanger 1 (ENOX1),
            transcript variant 9, mRNA.
ACCESSION   NM_001347969 XM_005266439
VERSION     NM_001347969.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3397)
  AUTHORS   Zhang,R., Ji,Z., Cai,J., Li,Y. and Ma,G.
  TITLE     Clinical Significance of Serum Kallistatin and ENOX1 Levels in
            Patients with Coronary Heart Disease
  JOURNAL   Med Princ Pract 30 (4), 339-346 (2021)
   PUBMED   32712615
  REMARK    GeneRIF: Clinical Significance of Serum Kallistatin and ENOX1
            Levels in Patients with Coronary Heart Disease.
REFERENCE   2  (bases 1 to 3397)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 3397)
  AUTHORS   Wang,J.L., Tong,C.W., Chang,W.T. and Huang,A.M.
  TITLE     Novel genes FAM134C, C3orf10 and ENOX1 are regulated by NRF-1 and
            differentially regulate neurite outgrowth in neuroblastoma cells
            and hippocampal neurons
  JOURNAL   Gene 529 (1), 7-15 (2013)
   PUBMED   23939472
  REMARK    GeneRIF: We verified that NRF-1 positively regulates FAM134C and
            ENOX1, and negatively regulates C3orf10 in human neuroblastoma
            IMR-32 cells and primary rat cortical neurons.
REFERENCE   4  (bases 1 to 3397)
  AUTHORS   Wang,J., Bansal,A.T., Martin,M., Germer,S., Benayed,R., Essioux,L.,
            Lee,J.S., Begovich,A., Hemmings,A., Kenwright,A., Taylor,K.E.,
            Upmanyu,R., Cutler,P., Harari,O., Marchini,J., Criswell,L.A. and
            Platt,A.
  TITLE     Genome-wide association analysis implicates the involvement of
            eight loci with response to tocilizumab for the treatment of
            rheumatoid arthritis
  JOURNAL   Pharmacogenomics J 13 (3), 235-241 (2013)
   PUBMED   22491018
REFERENCE   5  (bases 1 to 3397)
  CONSRTM   GENDEP Investigators; MARS Investigators; STAR*D Investigators
  TITLE     Common genetic variation and antidepressant efficacy in major
            depressive disorder: a meta-analysis of three genome-wide
            pharmacogenetic studies
  JOURNAL   Am J Psychiatry 170 (2), 207-217 (2013)
   PUBMED   23377640
REFERENCE   6  (bases 1 to 3397)
  AUTHORS   Williams,F.M., Carter,A.M., Hysi,P.G., Surdulescu,G., Hodgkiss,D.,
            Soranzo,N., Traylor,M., Bevan,S., Dichgans,M., Rothwell,P.M.,
            Sudlow,C., Farrall,M., Silander,K., Kaunisto,M., Wagner,P.,
            Saarela,O., Kuulasmaa,K., Virtamo,J., Salomaa,V., Amouyel,P.,
            Arveiler,D., Ferrieres,J., Wiklund,P.G., Ikram,M.A., Hofman,A.,
            Boncoraglio,G.B., Parati,E.A., Helgadottir,A., Gretarsdottir,S.,
            Thorsteinsdottir,U., Thorleifsson,G., Stefansson,K., Seshadri,S.,
            DeStefano,A., Gschwendtner,A., Psaty,B., Longstreth,W.,
            Mitchell,B.D., Cheng,Y.C., Clarke,R., Ferrario,M., Bis,J.C.,
            Levi,C., Attia,J., Holliday,E.G., Scott,R.J., Fornage,M.,
            Sharma,P., Furie,K.L., Rosand,J., Nalls,M., Meschia,J.,
            Mosely,T.H., Evans,A., Palotie,A., Markus,H.S., Grant,P.J. and
            Spector,T.D.
  CONSRTM   EuroCLOT Investigators; Wellcome Trust Case Control Consortium 2;
            MOnica Risk, Genetics, Archiving and Monograph; MetaStroke;
            International Stroke Genetics Consortium
  TITLE     Ischemic stroke is associated with the ABO locus: the EuroCLOT
            study
  JOURNAL   Ann Neurol 73 (1), 16-31 (2013)
   PUBMED   23381943
  REMARK    Erratum:[Ann Neurol. 2014 Jan;75(1):166-7]
REFERENCE   7  (bases 1 to 3397)
  AUTHORS   Landoure,G., Knight,M.A., Stanescu,H., Taye,A.A., Shi,Y.,
            Diallo,O., Johnson,J.O., Hernandez,D., Traynor,B.J.,
            Biesecker,L.G., Elkahloun,A., Rinaldi,C., Vincent,A., Willcox,N.,
            Kleta,R., Fischbeck,K.H. and Burnett,B.G.
  CONSRTM   NIH Intramural Sequencing Center
  TITLE     A candidate gene for autoimmune myasthenia gravis
  JOURNAL   Neurology 79 (4), 342-347 (2012)
   PUBMED   22744667
  REMARK    GeneRIF: These results indicate that this sequence variant in ENOX1
            may contribute to the familial autoimmune myasthenia in these
            patients.
REFERENCE   8  (bases 1 to 3397)
  AUTHORS   Jiang,Z., Gorenstein,N.M., Morre,D.M. and Morre,D.J.
  TITLE     Molecular cloning and characterization of a candidate human
            growth-related and time-keeping constitutive cell surface
            hydroquinone (NADH) oxidase
  JOURNAL   Biochemistry 47 (52), 14028-14038 (2008)
   PUBMED   19055324
  REMARK    GeneRIF: copper-binding capacity, enzymatic activity, and
            time-keeping (clock) properties
REFERENCE   9  (bases 1 to 3397)
  AUTHORS   Scarlett,D.J., Herst,P.M. and Berridge,M.V.
  TITLE     Multiple proteins with single activities or a single protein with
            multiple activities: the conundrum of cell surface NADH
            oxidoreductases
  JOURNAL   Biochim Biophys Acta 1708 (1), 108-119 (2005)
   PUBMED   15882838
REFERENCE   10 (bases 1 to 3397)
  AUTHORS   Sedlak,D., Moore,D.M. and Moore,D.J.
  TITLE     A drug-unresponsive and protease-resistant CNOX protein from human
            sera
  JOURNAL   Arch Biochem Biophys 386 (1), 106-116 (2001)
   PUBMED   11360993
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL162713.19, AL161714.8,
            AL136959.9, AL138823.14, AL607148.8 and AL627430.4.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_001347969.1.
            
            Summary: The protein encoded by this gene is involved in plasma
            membrane electron transport pathways. The encoded protein has both
            a hydroquinone (NADH) oxidase activity and a protein
            disulfide-thiol interchange activity. The two activities cycle with
            a periodicity of 24 minutes, with one activity being at its peak
            when the other is at its lowest. [provided by RefSeq, Dec 2016].
            
            Transcript Variant: This variant (9) differs in the 5' UTR and
            coding sequence compared to variant 10. The resulting isoform (b)
            is shorter at the N-terminus compared to isoform a. Variants 1-9
            all encode the same isoform (b).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.161396.1,
                                           SRR1660809.97687.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000690772.1/ ENSP00000509229.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-321               AL162713.19        110497-110817       c
            322-387             AL161714.8         86790-86855         c
            388-531             AL136959.9         9021-9164           c
            532-675             AL138823.14        112869-113012       c
            676-813             AL138823.14        111940-112077       c
            814-987             AL138823.14        61303-61476         c
            988-1194            AL138823.14        59875-60081         c
            1195-1428           AL138823.14        55943-56176         c
            1429-1641           AL138823.14        44562-44774         c
            1642-1748           AL138823.14        26443-26549         c
            1749-1866           AL138823.14        22408-22525         c
            1867-2051           AL607148.8         78218-78402         c
            2052-2159           AL607148.8         49342-49449         c
            2160-2216           AL607148.8         45270-45326         c
            2217-2319           AL607148.8         16508-16610         c
            2320-2405           AL607148.8         3925-4010           c
            2406-3397           AL627430.4         3413-4404           c
FEATURES             Location/Qualifiers
     source          1..3397
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q14.11"
     gene            1..3397
                     /gene="ENOX1"
                     /gene_synonym="bA64J21.1; cCNOX; CNOX; PIG38"
                     /note="ecto-NOX disulfide-thiol exchanger 1"
                     /db_xref="GeneID:55068"
                     /db_xref="HGNC:HGNC:25474"
                     /db_xref="MIM:610914"
     exon            1..321
                     /gene="ENOX1"
                     /gene_synonym="bA64J21.1; cCNOX; CNOX; PIG38"
                     /inference="alignment:Splign:2.1.0"
     exon            322..387
                     /gene="ENOX1"
                     /gene_synonym="bA64J21.1; cCNOX; CNOX; PIG38"
                     /inference="alignment:Splign:2.1.0"
     exon            388..531
                     /gene="ENOX1"
                     /gene_synonym="bA64J21.1; cCNOX; CNOX; PIG38"
                     /inference="alignment:Splign:2.1.0"
     exon            532..675
                     /gene="ENOX1"
                     /gene_synonym="bA64J21.1; cCNOX; CNOX; PIG38"
                     /inference="alignment:Splign:2.1.0"
     CDS             606..2537
                     /gene="ENOX1"
                     /gene_synonym="bA64J21.1; cCNOX; CNOX; PIG38"
                     /note="isoform b is encoded by transcript variant 9;
                     candidate growth-related and time keeping constitutive
                     hydroquinone (NADH) oxidase; constitutive Ecto-NOX; cell
                     proliferation-inducing gene 38 protein; candidate
                     growth-related and time keeping constitutive hydroquinone
                     [NADH] oxidase; ecto-NADPH oxidase disulfide-thiol
                     exchanger 1"
                     /codon_start=1
                     /product="ecto-NOX disulfide-thiol exchanger 1 isoform b"
                     /protein_id="NP_001334898.1"
                     /db_xref="CCDS:CCDS9389.1"
                     /db_xref="GeneID:55068"
                     /db_xref="HGNC:HGNC:25474"
                     /db_xref="MIM:610914"
                     /translation="MVDAGGVENITQLPQELPQMMAAAADGLGSIAIDTTQLNMSVTD
                     PTAWATAMNNLGMVPVGLPGQQLVSDSICVPGFDPSLNMMTGITPINPMIPGLGLVPP
                     PPPTEVAVVKEIIHCKSCTLFPQNPNLPPPSTRERPPGCKTVFVGGLPENATEEIIQE
                     VFEQCGDITAIRKSKKNFCHIRFAEEFMVDKAIYLSGYRMRLGSSTDKKDSGRLHVDF
                     AQARDDFYEWECKQRMRAREERHRRKLEEDRLRPPSPPAIMHYSEHEAALLAEKLKDD
                     SKFSEAITVLLSWIERGEVNRRSANQFYSMVQSANSHVRRLMNEKATHEQEMEEAKEN
                     FKNALTGILTQFEQIVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELRNAQSEQLM
                     GIRREEEMEMSDDENCDSPTKKMRVDESALAAQAYALKEENDSLRWQLDAYRNEVELL
                     KQEKEQLFRTEENLTKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKEEQSHT
                     QALLKVLQEQLKGTKELVETNGHSHEDSNEINVLTVALVNQDRENNIEKRSQGLKSEK
                     EALLIGIISTFLHVHPFGANIEYLWSYMQQLDSKISANEIEMLLMRLPRMFKQEFTGV
                     GATLEKRWKLCAFEGIKTT"
     exon            676..813
                     /gene="ENOX1"
                     /gene_synonym="bA64J21.1; cCNOX; CNOX; PIG38"
                     /inference="alignment:Splign:2.1.0"
     exon            814..987
                     /gene="ENOX1"
                     /gene_synonym="bA64J21.1; cCNOX; CNOX; PIG38"
                     /inference="alignment:Splign:2.1.0"
     exon            988..1194
                     /gene="ENOX1"
                     /gene_synonym="bA64J21.1; cCNOX; CNOX; PIG38"
                     /inference="alignment:Splign:2.1.0"
     exon            1195..1428
                     /gene="ENOX1"
                     /gene_synonym="bA64J21.1; cCNOX; CNOX; PIG38"
                     /inference="alignment:Splign:2.1.0"
     exon            1429..1641
                     /gene="ENOX1"
                     /gene_synonym="bA64J21.1; cCNOX; CNOX; PIG38"
                     /inference="alignment:Splign:2.1.0"
     exon            1642..1748
                     /gene="ENOX1"
                     /gene_synonym="bA64J21.1; cCNOX; CNOX; PIG38"
                     /inference="alignment:Splign:2.1.0"
     exon            1749..1866
                     /gene="ENOX1"
                     /gene_synonym="bA64J21.1; cCNOX; CNOX; PIG38"
                     /inference="alignment:Splign:2.1.0"
     exon            1867..2051
                     /gene="ENOX1"
                     /gene_synonym="bA64J21.1; cCNOX; CNOX; PIG38"
                     /inference="alignment:Splign:2.1.0"
     exon            2052..2159
                     /gene="ENOX1"
                     /gene_synonym="bA64J21.1; cCNOX; CNOX; PIG38"
                     /inference="alignment:Splign:2.1.0"
     exon            2160..2216
                     /gene="ENOX1"
                     /gene_synonym="bA64J21.1; cCNOX; CNOX; PIG38"
                     /inference="alignment:Splign:2.1.0"
     exon            2217..2319
                     /gene="ENOX1"
                     /gene_synonym="bA64J21.1; cCNOX; CNOX; PIG38"
                     /inference="alignment:Splign:2.1.0"
     exon            2320..2405
                     /gene="ENOX1"
                     /gene_synonym="bA64J21.1; cCNOX; CNOX; PIG38"
                     /inference="alignment:Splign:2.1.0"
     exon            2406..3397
                     /gene="ENOX1"
                     /gene_synonym="bA64J21.1; cCNOX; CNOX; PIG38"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2723..2728
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ENOX1"
                     /gene_synonym="bA64J21.1; cCNOX; CNOX; PIG38"
                     /note="hexamer: AATAAA"
     polyA_site      2746
                     /gene="ENOX1"
                     /gene_synonym="bA64J21.1; cCNOX; CNOX; PIG38"
                     /note="major polyA site"
     regulatory      3376..3381
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ENOX1"
                     /gene_synonym="bA64J21.1; cCNOX; CNOX; PIG38"
                     /note="hexamer: AATAAA"
     polyA_site      3397
                     /gene="ENOX1"
                     /gene_synonym="bA64J21.1; cCNOX; CNOX; PIG38"
                     /note="major polyA site"
ORIGIN      
        1 acactcgcag gcgcgcgtgc gcacgcccgc gcgcctccag ccgcggagtc tccagcgccc
       61 ctcagcagat ccccgctctc ccgggcgccg ctactcacac aggcttccag ccgccacggg
      121 gcgtcctctg tctgctgcag cggcggcggc agcagaggga acggcgactg cagcccggcc
      181 gcgtctccca gctccgtgcc cgggacagag tccgggagaa gcaaaggagg aggaggacgc
      241 cgaggctagg aggagccgcg ccgcgcccgg cgccccactc cgcgcagcgg gttgcctccg
      301 ctccccatac ggcggcccca ggtcctttgc tgccagcatg atgtcgtatt tataatatgt
      361 ggaggagaga gagctcacca tgctcagaag cctctgatat gtcagaacca tgctgtcttc
      421 catgagactt cctttgtgaa gagcatccat ttaaaagact tttatgaata catggtttca
      481 atcaagtccc cagagaacac atttgtcttc tgagctgctg gcagttttga gaatctgatg
      541 acctccgagg ggaccctgca ctcagccatc aaagtgttcc tgcccctctg gacactcata
      601 attcaatggt agatgcaggt ggagttgaga acatcaccca gcttccccag gagcttcctc
      661 agatgatggc tgcagcagcc gatggtttgg ggagtatagc gatagacacg acccagctca
      721 acatgtccgt gacagatccc acagcctggg ctacagccat gaataacctg ggcatggttc
      781 ccgtagggtt gcctggacag cagctcgtgt ctgactcaat ctgtgtccca ggctttgatc
      841 caagcctcaa catgatgact ggaatcaccc ccattaaccc aatgatacca ggccttggac
      901 tggtacctcc cccaccacca acagaagtgg ctgttgtcaa agaaataatc cactgcaaaa
      961 gctgtactct ttttcctcaa aatccaaatc ttccacctcc ttccacaaga gaacgacctc
     1021 ctgggtgtaa gaccgtgttt gtcggaggat taccagaaaa tgctactgag gaaattattc
     1081 aagaagtctt tgaacagtgc ggtgatatta cagcaattcg gaaaagcaag aagaattttt
     1141 gtcacattcg ctttgcagag gaattcatgg ttgataaagc catttacctt tctggttata
     1201 ggatgcgatt agggtctagc accgacaaaa aggattcagg ccgccttcat gtggactttg
     1261 cccaggccag ggatgacttc tatgagtggg aatgcaagca gaggatgcgt gcccgggagg
     1321 agcggcaccg gcgcaagctg gaggaggacc ggctcaggcc cccatccccg cctgccataa
     1381 tgcactactc ggagcacgaa gccgctctgc tggctgaaaa gctgaaagat gatagcaagt
     1441 tttcagaggc tatcacagtg ctgctttcct ggattgaacg aggggaagtg aatcggcgct
     1501 ctgcaaacca gttctattcc atggtgcagt cggccaacag ccacgtccgc cggctaatga
     1561 atgaaaaagc cacccatgag caagagatgg aggaagccaa ggagaatttt aaaaatgcct
     1621 taactgggat tctcactcaa tttgagcaga ttgtggccgt tttcaacgct tctaccagac
     1681 aaaaagcttg ggaccatttc tcgaaagccc agcgcaagaa catagacatt tggcgaaagc
     1741 attctgagga gctccggaat gctcaaagtg agcagctcat gggcatccgc cgcgaagaag
     1801 aaatggaaat gtctgatgat gagaactgtg acagccctac aaagaaaatg agagtcgatg
     1861 aatcagccct ggctgcccag gcctacgctc tgaaagagga gaatgacagt ctccgctggc
     1921 agctggatgc ctacaggaat gaggtggagc tgctgaaaca agaaaaagaa cagcttttcc
     1981 gaacagaaga aaacctcacc aaggaccagc aactgcagtt tctgcagcaa accatgcaag
     2041 gcatgcagca gcaattgcta accatccagg aggagttaaa caacaaaaag tcagaattgg
     2101 aacaagcaaa ggaagagcag tcccatacac aagcgttact aaaagtcctg caggaacaat
     2161 taaaaggtac caaggaattg gtcgagacca atggccacag ccatgaggat tcaaatgaaa
     2221 tcaatgtgtt gacagttgca ttagtcaacc aagaccgaga gaacaatatt gagaaaagaa
     2281 gccaaggctt aaaatcagag aaagaagctc tgctaatagg tatcatatca acgtttcttc
     2341 acgtccatcc ttttggagcc aacatagaat atctttggtc atacatgcag cagctggact
     2401 ccaagatatc tgcaaatgaa atagaaatgc ttttgatgag gctgccacgc atgttcaaac
     2461 aggaattcac gggtgtggga gccacgctgg aaaaaagatg gaagctgtgt gcctttgaag
     2521 gaattaaaac tacctaactg cgaagagcaa agcatctctg gaaatgaaac catgtgaacc
     2581 tggccagggc ggtgcgacgg ggaagcagga ggtgtggggt tggtccagca cgcaaccttt
     2641 gtggagccat cgaagcctgc ctttagttat atctgtggcg ttctcttgta agtggaaatg
     2701 taattgtgta ccagtttctt aaaataaaca aagcttcata ctgtgacaga tctgtttcct
     2761 atgaaaacca aacaatgatt ccacagtcat aatgatggca aaatcttaaa atgtgctaca
     2821 tttgagaata gctcaccaag caaaatattt aaagttaatg atggtgtagc aatgattgtt
     2881 gctaggctac agagttgtat atgtaatgta tagctgaaat cattaaatga cattttcctg
     2941 aaagtctttc tgttttagta aaaaaaaaaa aaaaaaaaaa aagaaaaaga aaaagaaaaa
     3001 aagaaaaaag aaaaagtttt acagtgaggg aaaagcatac caaaagaaaa cttgaatatg
     3061 tgtctaaaca gttattgtat tttgtaaatt aagttatatg ctgttccagg gacttttgcc
     3121 ttattgaaga ggcagaaaat atgattggac acattgagaa tgctttatca agaatattat
     3181 ttttctaatg taacaattct ccatcataag ttcttttaac atggactgca taacagtttt
     3241 cataaagtgt aaataaagga aaaactagtg ttattgtctt gtacttggta tgtaacattc
     3301 aggtttatgc atcaaaataa acattcagta aatattcctg ttacaaattt tatagcaaag
     3361 atattaattt ttttcaataa atatgacttc taccata
//
