LOCUS       NM_001428               1781 bp    mRNA    linear   PRI 24-NOV-2024
DEFINITION  Homo sapiens enolase 1 (ENO1), transcript variant 1, mRNA.
ACCESSION   NM_001428 NM_005945
VERSION     NM_001428.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1781)
  AUTHORS   Li,Y., Liu,L. and Li,B.
  TITLE     Role of ENO1 and its targeted therapy in tumors
  JOURNAL   J Transl Med 22 (1), 1025 (2024)
   PUBMED   39543641
  REMARK    GeneRIF: Role of ENO1 and its targeted therapy in tumors.
            Review article
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1781)
  AUTHORS   Zhu,Q., Li,J., Sun,H., Fan,Z., Hu,J., Chai,S., Lin,B., Wu,L.,
            Qin,W., Wang,Y., Hsieh-Wilson,L.C. and Yi,W.
  TITLE     O-GlcNAcylation of enolase 1 serves as a dual regulator of aerobic
            glycolysis and immune evasion in colorectal cancer
  JOURNAL   Proc Natl Acad Sci U S A 121 (44), e2408354121 (2024)
   PUBMED   39446384
  REMARK    GeneRIF: O-GlcNAcylation of enolase 1 serves as a dual regulator of
            aerobic glycolysis and immune evasion in colorectal cancer.
REFERENCE   3  (bases 1 to 1781)
  AUTHORS   Wang,J., Ren,J., Tu,X., Yuan,H., Ye,Z., Wang,X., Cui,J., Wang,J.,
            Tang,Y., Han,P. and Bai,Y.
  TITLE     ARNTL2 facilitates bladder cancer progression through potentiating
            ENO1-mediated glycolysis in a SLC31A1-independent and -dependent
            manner
  JOURNAL   Life Sci 355, 122974 (2024)
   PUBMED   39147318
  REMARK    GeneRIF: ARNTL2 facilitates bladder cancer progression through
            potentiating ENO1-mediated glycolysis in a SLC31A1-independent and
            -dependent manner.
REFERENCE   4  (bases 1 to 1781)
  AUTHORS   Lung,J., Liu,K.J., Chang,J.Y., Leu,S.J. and Shih,N.Y.
  TITLE     MBP-1 is efficiently encoded by an alternative transcript of the
            ENO1 gene but post-translationally regulated by
            proteasome-dependent protein turnover
  JOURNAL   FEBS J 277 (20), 4308-4321 (2010)
   PUBMED   20849415
  REMARK    GeneRIF: novel transcript was alternatively transcribed from intron
            III of the ENO1 gene and was feasible for MBP-1 production
REFERENCE   5  (bases 1 to 1781)
  AUTHORS   Feo,S., Arcuri,D., Piddini,E., Passantino,R. and Giallongo,A.
  TITLE     ENO1 gene product binds to the c-myc promoter and acts as a
            transcriptional repressor: relationship with Myc promoter-binding
            protein 1 (MBP-1)
  JOURNAL   FEBS Lett 473 (1), 47-52 (2000)
   PUBMED   10802057
REFERENCE   6  (bases 1 to 1781)
  AUTHORS   Subramanian,A. and Miller,D.M.
  TITLE     Structural analysis of alpha-enolase. Mapping the functional
            domains involved in down-regulation of the c-myc protooncogene
  JOURNAL   J Biol Chem 275 (8), 5958-5965 (2000)
   PUBMED   10681589
REFERENCE   7  (bases 1 to 1781)
  AUTHORS   Dawson,S.J. and White,L.A.
  TITLE     Treatment of Haemophilus aphrophilus endocarditis with
            ciprofloxacin
  JOURNAL   J Infect 24 (3), 317-320 (1992)
   PUBMED   1602151
REFERENCE   8  (bases 1 to 1781)
  AUTHORS   Oliva,D., Cali,L., Feo,S. and Giallongo,A.
  TITLE     Complete structure of the human gene encoding neuron-specific
            enolase
  JOURNAL   Genomics 10 (1), 157-165 (1991)
   PUBMED   2045099
REFERENCE   9  (bases 1 to 1781)
  AUTHORS   Ray,R. and Miller,D.M.
  TITLE     Cloning and characterization of a human c-myc promoter-binding
            protein
  JOURNAL   Mol Cell Biol 11 (4), 2154-2161 (1991)
   PUBMED   2005901
REFERENCE   10 (bases 1 to 1781)
  AUTHORS   Wistow,G.J., Lietman,T., Williams,L.A., Stapel,S.O., de Jong,W.W.,
            Horwitz,J. and Piatigorsky,J.
  TITLE     Tau-crystallin/alpha-enolase: one gene encodes both an enzyme and a
            lens structural protein
  JOURNAL   J Cell Biol 107 (6 Pt 2), 2729-2736 (1988)
   PUBMED   2462567
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK309177.1 and BC021166.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 10, 2018 this sequence version replaced NM_001428.4.
            
            Summary: This gene encodes alpha-enolase, one of three enolase
            isoenzymes found in mammals. Each isoenzyme is a homodimer composed
            of 2 alpha, 2 gamma, or 2 beta subunits, and functions as a
            glycolytic enzyme. Alpha-enolase in addition, functions as a
            structural lens protein (tau-crystallin) in the monomeric form.
            Alternative splicing of this gene results in a shorter isoform that
            has been shown to bind to the c-myc promoter and function as a
            tumor suppressor. Several pseudogenes have been identified,
            including one on the long arm of chromosome 1. Alpha-enolase has
            also been identified as an autoantigen in Hashimoto encephalopathy.
            [provided by RefSeq, Jan 2011].
            
            Transcript Variant: This variant (1) encodes isoform (1), which is
            localized to the cytosol, and has alpha-enolase activity. It has
            been reported that the monomeric form of this isoform functions as
            a structural lens protein (tau-crystallin), and the dimeric form as
            an enolase (PMID:2462567).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189655.75182.1,
                                           SRR5189658.211206.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2142670
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000234590.10/ ENSP00000234590.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1106              AK309177.1         407-1512
            1107-1776           BC021166.2         482-1151
            1777-1781           BC021166.2         1152-1156
FEATURES             Location/Qualifiers
     source          1..1781
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.23"
     gene            1..1781
                     /gene="ENO1"
                     /gene_synonym="ENO1-IT1; ENO1L1; HEL-S-17; MPB1; NNE; PPH"
                     /note="enolase 1"
                     /db_xref="GeneID:2023"
                     /db_xref="HGNC:HGNC:3350"
                     /db_xref="MIM:172430"
     exon            1..107
                     /gene="ENO1"
                     /gene_synonym="ENO1-IT1; ENO1L1; HEL-S-17; MPB1; NNE; PPH"
                     /inference="alignment:Splign:2.1.0"
     exon            108..201
                     /gene="ENO1"
                     /gene_synonym="ENO1-IT1; ENO1L1; HEL-S-17; MPB1; NNE; PPH"
                     /inference="alignment:Splign:2.1.0"
     CDS             117..1421
                     /gene="ENO1"
                     /gene_synonym="ENO1-IT1; ENO1L1; HEL-S-17; MPB1; NNE; PPH"
                     /EC_number="4.2.1.11"
                     /note="isoform 1 is encoded by transcript variant 1; MYC
                     promoter-binding protein 1; non-neural enolase;
                     2-phospho-D-glycerate hydro-lyase; tau-crystallin; c-myc
                     promoter-binding protein-1; phosphopyruvate hydratase;
                     alpha enolase like 1; plasminogen-binding protein;
                     enolase-alpha; epididymis secretory protein Li 17; enolase
                     1, (alpha); ENO1 intronic transcript 1; ENO1 intronic
                     transcript 1 (non-protein coding)"
                     /codon_start=1
                     /product="alpha-enolase isoform 1"
                     /protein_id="NP_001419.1"
                     /db_xref="CCDS:CCDS97.1"
                     /db_xref="GeneID:2023"
                     /db_xref="HGNC:HGNC:3350"
                     /db_xref="MIM:172430"
                     /translation="MSILKIHAREIFDSRGNPTVEVDLFTSKGLFRAAVPSGASTGIY
                     EALELRDNDKTRYMGKGVSKAVEHINKTIAPALVSKKLNVTEQEKIDKLMIEMDGTEN
                     KSKFGANAILGVSLAVCKAGAVEKGVPLYRHIADLAGNSEVILPVPAFNVINGGSHAG
                     NKLAMQEFMILPVGAANFREAMRIGAEVYHNLKNVIKEKYGKDATNVGDEGGFAPNIL
                     ENKEGLELLKTAIGKAGYTDKVVIGMDVAASEFFRSGKYDLDFKSPDDPSRYISPDQL
                     ADLYKSFIKDYPVVSIEDPFDQDDWGAWQKFTASAGIQVVGDDLTVTNPKRIAKAVNE
                     KSCNCLLLKVNQIGSVTESLQACKLAQANGWGVMVSHRSGETEDTFIADLVVGLCTGQ
                     IKTGAPCRSERLAKYNQLLRIEEELGSKAKFAGRNFRNPLAK"
     exon            202..297
                     /gene="ENO1"
                     /gene_synonym="ENO1-IT1; ENO1L1; HEL-S-17; MPB1; NNE; PPH"
                     /inference="alignment:Splign:2.1.0"
     exon            298..356
                     /gene="ENO1"
                     /gene_synonym="ENO1-IT1; ENO1L1; HEL-S-17; MPB1; NNE; PPH"
                     /inference="alignment:Splign:2.1.0"
     exon            357..426
                     /gene="ENO1"
                     /gene_synonym="ENO1-IT1; ENO1L1; HEL-S-17; MPB1; NNE; PPH"
                     /inference="alignment:Splign:2.1.0"
     exon            427..560
                     /gene="ENO1"
                     /gene_synonym="ENO1-IT1; ENO1L1; HEL-S-17; MPB1; NNE; PPH"
                     /inference="alignment:Splign:2.1.0"
     exon            561..783
                     /gene="ENO1"
                     /gene_synonym="ENO1-IT1; ENO1L1; HEL-S-17; MPB1; NNE; PPH"
                     /inference="alignment:Splign:2.1.0"
     exon            784..981
                     /gene="ENO1"
                     /gene_synonym="ENO1-IT1; ENO1L1; HEL-S-17; MPB1; NNE; PPH"
                     /inference="alignment:Splign:2.1.0"
     exon            982..1183
                     /gene="ENO1"
                     /gene_synonym="ENO1-IT1; ENO1L1; HEL-S-17; MPB1; NNE; PPH"
                     /inference="alignment:Splign:2.1.0"
     exon            1184..1292
                     /gene="ENO1"
                     /gene_synonym="ENO1-IT1; ENO1L1; HEL-S-17; MPB1; NNE; PPH"
                     /inference="alignment:Splign:2.1.0"
     exon            1293..1351
                     /gene="ENO1"
                     /gene_synonym="ENO1-IT1; ENO1L1; HEL-S-17; MPB1; NNE; PPH"
                     /inference="alignment:Splign:2.1.0"
     exon            1352..1781
                     /gene="ENO1"
                     /gene_synonym="ENO1-IT1; ENO1L1; HEL-S-17; MPB1; NNE; PPH"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1752..1757
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ENO1"
                     /gene_synonym="ENO1-IT1; ENO1L1; HEL-S-17; MPB1; NNE; PPH"
                     /note="hexamer: AATAAA"
     polyA_site      1779
                     /gene="ENO1"
                     /gene_synonym="ENO1-IT1; ENO1L1; HEL-S-17; MPB1; NNE; PPH"
                     /note="major polyA site"
ORIGIN      
        1 agtatctgtg ggtacccgga gcacggagat ctcgccggct ttacgttcac ctcggtgtct
       61 gcagcaccct ccgcttcctc tcctaggcga cgagacccag tggctagaag ttcaccatgt
      121 ctattctcaa gatccatgcc agggagatct ttgactctcg cgggaatccc actgttgagg
      181 ttgatctctt cacctcaaaa ggtctcttca gagctgctgt gcccagtggt gcttcaactg
      241 gtatctatga ggccctagag ctccgggaca atgataagac tcgctatatg gggaagggtg
      301 tctcaaaggc tgttgagcac atcaataaaa ctattgcgcc tgccctggtt agcaagaaac
      361 tgaacgtcac agaacaagag aagattgaca aactgatgat cgagatggat ggaacagaaa
      421 ataaatctaa gtttggtgcg aacgccattc tgggggtgtc ccttgccgtc tgcaaagctg
      481 gtgccgttga gaagggggtc cccctgtacc gccacatcgc tgacttggct ggcaactctg
      541 aagtcatcct gccagtcccg gcgttcaatg tcatcaatgg cggttctcat gctggcaaca
      601 agctggccat gcaggagttc atgatcctcc cagtcggtgc agcaaacttc agggaagcca
      661 tgcgcattgg agcagaggtt taccacaacc tgaagaatgt catcaaggag aaatatggga
      721 aagatgccac caatgtgggg gatgaaggcg ggtttgctcc caacatcctg gagaataaag
      781 aaggcctgga gctgctgaag actgctattg ggaaagctgg ctacactgat aaggtggtca
      841 tcggcatgga cgtagcggcc tccgagttct tcaggtctgg gaagtatgac ctggacttca
      901 agtctcccga tgaccccagc aggtacatct cgcctgacca gctggctgac ctgtacaagt
      961 ccttcatcaa ggactaccca gtggtgtcta tcgaagatcc ctttgaccag gatgactggg
     1021 gagcttggca gaagttcaca gccagtgcag gaatccaggt agtgggggat gatctcacag
     1081 tgaccaaccc aaagaggatc gccaaggccg tgaacgagaa gtcctgcaac tgcctcctgc
     1141 tcaaagtcaa ccagattggc tccgtgaccg agtctcttca ggcgtgcaag ctggcccagg
     1201 ccaatggttg gggcgtcatg gtgtctcatc gttcggggga gactgaagat accttcatcg
     1261 ctgacctggt tgtggggctg tgcactgggc agatcaagac tggtgcccct tgccgatctg
     1321 agcgcttggc caagtacaac cagctcctca gaattgaaga ggagctgggc agcaaggcta
     1381 agtttgccgg caggaacttc agaaacccct tggccaagta agctgtgggc aggcaagccc
     1441 ttcggtcacc tgttggctac acagacccct cccctcgtgt cagctcaggc agctcgaggc
     1501 ccccgaccaa cacttgcagg ggtccctgct agttagcgcc ccaccgccgt ggagttcgta
     1561 ccgcttcctt agaacttcta cagaagccaa gctccctgga gccctgttgg cagctctagc
     1621 tttgcagtcg tgtaattggc ccaagtcatt gtttttctcg cctcactttc caccaagtgt
     1681 ctagagtcat gtgagcctcg tgtcatctcc ggggtggcca caggctagat ccccggtggt
     1741 tttgtgctca aaataaaaag cctcagtgac ccatgagaat a
//
