LOCUS       NM_145010               3378 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens enkurin, TRPC channel interacting protein (ENKUR),
            transcript variant 1, mRNA.
ACCESSION   NM_145010
VERSION     NM_145010.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3378)
  AUTHORS   Seetharam,S.M., Liu,Y., Wu,J., Fechter,L., Murugesan,K.,
            Maecker,H., Gotlib,J., Zehnder,J., Paulmurugan,R. and Krishnan,A.
  TITLE     Enkurin: a novel marker for myeloproliferative neoplasms from
            platelet, megakaryocyte, and whole blood specimens
  JOURNAL   Blood Adv 7 (18), 5433-5445 (2023)
   PUBMED   37315179
  REMARK    GeneRIF: Enkurin: a novel marker for myeloproliferative neoplasms
            from platelet, megakaryocyte, and whole blood specimens.
REFERENCE   2  (bases 1 to 3378)
  AUTHORS   Gui,M., Croft,J.T., Zabeo,D., Acharya,V., Kollman,J.M.,
            Burgoyne,T., Hoog,J.L. and Brown,A.
  TITLE     SPACA9 is a lumenal protein of human ciliary singlet and doublet
            microtubules
  JOURNAL   Proc Natl Acad Sci U S A 119 (41), e2207605119 (2022)
   PUBMED   36191189
REFERENCE   3  (bases 1 to 3378)
  AUTHORS   Hou,R., Li,Y., Luo,X., Zhang,W., Yang,H., Zhang,Y., Liu,J., Liu,S.,
            Han,S., Liu,C., Huang,Y., Liu,Z., Li,A. and Fang,W.
  TITLE     ENKUR expression induced by chemically synthesized cinobufotalin
            suppresses malignant activities of hepatocellular carcinoma by
            modulating beta-catenin/c-Jun/MYH9/USP7/c-Myc axis
  JOURNAL   Int J Biol Sci 18 (6), 2553-2567 (2022)
   PUBMED   35414777
  REMARK    GeneRIF: ENKUR expression induced by chemically synthesized
            cinobufotalin suppresses malignant activities of hepatocellular
            carcinoma by modulating beta-catenin/c-Jun/MYH9/USP7/c-Myc axis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3378)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 3378)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 3378)
  AUTHORS   Ma,Q., Lu,Y. and Gu,Y.
  TITLE     ENKUR Is Involved in the Regulation of Cellular Biology in
            Colorectal Cancer Cells via PI3K/Akt Signaling Pathway
  JOURNAL   Technol Cancer Res Treat 18, 1533033819841433 (2019)
   PUBMED   30947633
  REMARK    GeneRIF: Decreased ENKUR expression is associated with Colorectal
            Cancer.
REFERENCE   7  (bases 1 to 3378)
  AUTHORS   Sigg,M.A., Menchen,T., Lee,C., Johnson,J., Jungnickel,M.K.,
            Choksi,S.P., Garcia,G. 3rd, Busengdal,H., Dougherty,G.W.,
            Pennekamp,P., Werner,C., Rentzsch,F., Florman,H.M., Krogan,N.,
            Wallingford,J.B., Omran,H. and Reiter,J.F.
  TITLE     Evolutionary Proteomics Uncovers Ancient Associations of Cilia with
            Signaling Pathways
  JOURNAL   Dev Cell 43 (6), 744-762 (2017)
   PUBMED   29257953
REFERENCE   8  (bases 1 to 3378)
  AUTHORS   Beech,D.J.
  TITLE     Canonical transient receptor potential 5
  JOURNAL   Handb Exp Pharmacol (179), 109-123 (2007)
   PUBMED   17217053
  REMARK    Review article
REFERENCE   9  (bases 1 to 3378)
  AUTHORS   Sutton,K.A., Jungnickel,M.K., Wang,Y., Cullen,K., Lambert,S. and
            Florman,H.M.
  TITLE     Enkurin is a novel calmodulin and TRPC channel binding protein in
            sperm
  JOURNAL   Dev Biol 274 (2), 426-435 (2004)
   PUBMED   15385169
  REMARK    GeneRIF: Data suggest that enkurin is an adaptor that functions to
            localize a Ca2+ sensitive signal transduction machinery in sperm to
            a Ca2+-permeable ion channel [enkurin]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL512598.11, BC026165.2,
            AK095021.1 and BM979174.1.
            
            On Nov 23, 2018 this sequence version replaced NM_145010.3.
            
            Summary: This gene encodes a protein that interacts with calmodulin
            and several transient receptor potential canonical cation channel
            proteins. The encoded protein may function as an adaptor to
            localize signal transduction machinery to calcium channels.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Jun 2012].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer protein (isoform 1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK095021.1, SRR1660803.177500.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000331161.9/ ENSP00000331044.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 AL512598.11        75486-75487         c
            3-57                BC026165.2         3-57
            58-428              AK095021.1         1-371
            429-429             AL512598.11        58746-58746         c
            430-3375            AK095021.1         373-3318
            3376-3378           BM979174.1         24-26               c
FEATURES             Location/Qualifiers
     source          1..3378
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10p12.1"
     gene            1..3378
                     /gene="ENKUR"
                     /gene_synonym="C10orf63; CFAP106"
                     /note="enkurin, TRPC channel interacting protein"
                     /db_xref="GeneID:219670"
                     /db_xref="HGNC:HGNC:28388"
                     /db_xref="MIM:611025"
     exon            1..299
                     /gene="ENKUR"
                     /gene_synonym="C10orf63; CFAP106"
                     /inference="alignment:Splign:2.1.0"
     CDS             223..993
                     /gene="ENKUR"
                     /gene_synonym="C10orf63; CFAP106"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="enkurin isoform 1"
                     /protein_id="NP_659447.1"
                     /db_xref="CCDS:CCDS7146.1"
                     /db_xref="GeneID:219670"
                     /db_xref="HGNC:HGNC:28388"
                     /db_xref="MIM:611025"
                     /translation="MDPTCSSECIYNLIPSDLKEPPQPPRYISIFKATVKDDMQKAKT
                     AMKTMGPAKVEVPSPKDFLKKHSKEKTLPPKKNFDRNVPKKPAVPLKTDHPVMGIQSG
                     KNFINTNAADIIMGVAKKPKPIYVDKRTGDKHDLEPSGLVPKYINKKDYGVTPEYICK
                     RNEEIKKAQEDYDRYIQENLKKAAMKRLSDEEREAVLQGLKKNWEEVHKEFQSLSVFI
                     DSIPKKIRKQRLEEEMKQLEHDIGIIEKHKIIYIANNA"
     exon            300..445
                     /gene="ENKUR"
                     /gene_synonym="C10orf63; CFAP106"
                     /inference="alignment:Splign:2.1.0"
     exon            446..669
                     /gene="ENKUR"
                     /gene_synonym="C10orf63; CFAP106"
                     /inference="alignment:Splign:2.1.0"
     exon            670..816
                     /gene="ENKUR"
                     /gene_synonym="C10orf63; CFAP106"
                     /inference="alignment:Splign:2.1.0"
     exon            817..986
                     /gene="ENKUR"
                     /gene_synonym="C10orf63; CFAP106"
                     /inference="alignment:Splign:2.1.0"
     exon            987..3378
                     /gene="ENKUR"
                     /gene_synonym="C10orf63; CFAP106"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3354..3359
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ENKUR"
                     /gene_synonym="C10orf63; CFAP106"
                     /note="hexamer: AATAAA"
     polyA_site      3378
                     /gene="ENKUR"
                     /gene_synonym="C10orf63; CFAP106"
                     /note="major polyA site"
ORIGIN      
        1 acagtcaacg acgcttagca atccggagag aaatagggtg ttttcttccc gagagaggac
       61 tgctaagagg gggttaaagg gggacgatgt gaaggagaga acctgtggtc cttcagaagg
      121 cgaagaagaa agaaagggga agcagtgaag aaagggacgg agatactggg acagggagaa
      181 aaaagttgtg gagagtagct tttaaggagt catttggtgg ccatggatcc aacgtgctct
      241 tctgagtgca tttataacct catacccagt gacttgaagg agcctcccca gcctcctagg
      301 tacatatcca tttttaaggc aactgtaaaa gatgacatgc aaaaagctaa aactgcaatg
      361 aaaactatgg gaccagcaaa agttgaagta ccttctccaa aggatttcct aaagaaacat
      421 tcaaaggaaa aaactctacc acccaaaaaa aactttgatc ggaacgtgcc caaaaagcct
      481 gctgtgccat tgaagactga tcatcctgtc atgggaatac agagtggaaa aaattttata
      541 aatacaaatg cagctgatat catcatggga gtggctaaaa agcctaaacc aatttatgtt
      601 gataaaagaa ctggagacaa gcatgatctt gagccttcag gactagttcc aaagtacatc
      661 aataaaaagg attatggtgt cacacctgaa tacatatgta agcgaaacga ggaaataaag
      721 aaagcccaag aagactatga tcgttatatc caggaaaacc ttaagaaagc agctatgaaa
      781 aggctctccg atgaagaaag ggaggcagtt ttgcaggggc tgaaaaagaa ctgggaagag
      841 gtgcataaag aattccagtc cctctcggtc tttatagatt ctataccaaa gaagatccgc
      901 aagcagaggc tggaagaaga aatgaaacaa ctagaacacg acattggcat aattgaaaag
      961 cacaagatta tttatattgc caataacgca tgataccaac agcacaactt tgaaaactgt
     1021 taagtatttt gaactggaaa tagtaacacg tgccttcttg ctactctaaa ctgtctccaa
     1081 cacattgttt ctgagctcca caaatgcaaa agatgtattt tcctgtggcc catgacattt
     1141 gcagttattc ccagtgagaa atattttcag tattcgtaac actgtatatg atgaaaggct
     1201 tctatttgga ggaagaaaaa ttaagaagac aacttacaaa atcaagatga caacttataa
     1261 aggcatcatt gaggatgatt aaggagaata gcctcctttc tagcatacca acctcgatac
     1321 tcttatttta ttccacaact cactatgcat atcttattta aatgtttttt tccttttggt
     1381 cctttctact tatctatttt gtgaattcta aagttacatt tgtaagatta cataatctat
     1441 taagcaataa gtttatgtta gtagagctgt tttcaaccca aaaataagaa aaaatagctc
     1501 taaatatcta aaaggaaaag gttattttat gaaattttaa attagaaaaa tttggtaaaa
     1561 tatatgcaac tataaaatat cagagaaata acaatttcta ctgcttacac tggtttttat
     1621 cctctggaca acataaaaaa caaaatatgg gagtctttca ggcttttttc acaaacacag
     1681 aatttggaag ccttatagaa aagcttattt tggttactta aagaaaagta gtttatatac
     1741 aattattttt tgaaaattca cttgaaactt gtccatatga gtatctttat tcctttatta
     1801 acttagggca gatataaaat aaaggataat atatgacaaa ttctcactta ccaagaatgg
     1861 ttggttgcta tttagggtag gctaacagct gtgacagtac actccaaaat gtataattac
     1921 gtaaacacat attcaattct tgctaacata gcagtacttt gctgtgagca ggtcagcagg
     1981 aacccttttc tgcagtcact cagggaccca gacttacaga gtgggtagga tgcatctgat
     2041 ccagagttag ggagaggcac gtacaggcca ggcctagaaa tgatgcatat cattcccgtt
     2101 tgcatcgcta agtaagcaac ttaagttgct ttaacaaact aactccaaat ctcagtttcc
     2161 tgataaagat acatttttca tttacatcac tgtgcaatgt gactaagggt aggggtataa
     2221 gtctgttcca tgcagtcact cagggaccca gtctcctttt gtctggtgac tctgttgatc
     2281 caggcagtct ttctctgcca attcaggatg agatgtttag gtaagtattt tatttgtgaa
     2341 atgattgcta tacatactca tttttaaata attcaaaatc agtagcaatg caaaaatatt
     2401 ctgattactt tagccttatg gatattatgc tttgaagtca tgagtgggag ttgccttaaa
     2461 tgttaaaatg aaaactttgt ggttttaaca gctaattctt ttgctttctg taaatgtcta
     2521 ctaaagaatc tagacttttc tctatggtct acagtgttgt cctagatgaa cattgttgcc
     2581 tttctttcac agagccttca gagggaaaca ttcccatcca ttgttcctgg aaaggtgatc
     2641 cctaccacgg gatcccaaac ttggatagag ccagttcaac ctcccccaat ccatacacat
     2701 acatacctag gtcatcctat cacccaaaag agggacaaac atctgacttg gacagctgac
     2761 cagtgactga tcagattctc tctctcttga gagcatgaat taagagacat ggagactgca
     2821 gtcacttggg agtagacacc tgaaactaaa aagtcaaact tcattatgca gctagtttga
     2881 cttggtttct cttcctgttc aaaggaagaa tgggtagaat aaagatttga tgtggtctgg
     2941 ccccttgtct atgatctttt tagcttgatt tcttgaaatg ctgcttcttc cctacccact
     3001 gtaactggca ttcccatagt actgaggtac tagagacctc tgagatctgc acacatggtt
     3061 ccctccaccc agaaaactgc ccttttcttt ctctcatcct acatagctgc ctggcaaatc
     3121 cctagtcttc atcagctcac atcacatttc catgacaatc ccctttgatt cctcagaatc
     3181 tggccttcct ttatagcact ggtcatattg tattgtgcat atctggttat ttgcctgttt
     3241 tccatgaaca tttcaagctt atgggggaga agacactgta tacattttca tctgcattcc
     3301 ttagaatctg cataacagct ggtatagaga aggtactcaa aaaatcctta atgaataaag
     3361 taatggatcg tacccaaa
//
