LOCUS       NM_032140               1565 bp    mRNA    linear   PRI 01-MAR-2025
DEFINITION  Homo sapiens enkurin domain containing 1 (ENKD1), transcript
            variant 1, mRNA.
ACCESSION   NM_032140
VERSION     NM_032140.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1565)
  AUTHORS   Song,T., He,N., Hao,Z. and Yang,Y.
  TITLE     Upregulation of ENKD1 disrupts cellular homeostasis to promote
            lymphoma development
  JOURNAL   J Cell Physiol 238 (6), 1308-1323 (2023)
   PUBMED   36960713
  REMARK    GeneRIF: Upregulation of ENKD1 disrupts cellular homeostasis to
            promote lymphoma development.
REFERENCE   2  (bases 1 to 1565)
  AUTHORS   Zhong,T., Wu,X., Xie,W., Luo,X., Song,T., Sun,S., Luo,Y., Li,D.,
            Liu,M., Xie,S. and Zhou,J.
  TITLE     ENKD1 promotes epidermal stratification by regulating spindle
            orientation in basal keratinocytes
  JOURNAL   Cell Death Differ 29 (9), 1719-1729 (2022)
   PUBMED   35197565
REFERENCE   3  (bases 1 to 1565)
  AUTHORS   Song,T., Yang,Y., Zhou,P., Ran,J., Zhang,L., Wu,X., Xie,W.,
            Zhong,T., Liu,H., Liu,M., Li,D., Zhao,H. and Zhou,J.
  TITLE     ENKD1 promotes CP110 removal through competing with CEP97 to
            initiate ciliogenesis
  JOURNAL   EMBO Rep 23 (5), e54090 (2022)
   PUBMED   35301795
REFERENCE   4  (bases 1 to 1565)
  AUTHORS   Song,T., Zhou,P., Sun,C., He,N., Li,H., Ran,J., Zhou,J., Wu,Y. and
            Liu,M.
  TITLE     Enkurin domain containing 1 (ENKD1) regulates the proliferation,
            migration and invasion of non-small cell lung cancer cells
  JOURNAL   Asia Pac J Clin Oncol 18 (2), e39-e45 (2022)
   PUBMED   33724673
  REMARK    GeneRIF: Enkurin domain containing 1 (ENKD1) regulates the
            proliferation, migration and invasion of non-small cell lung cancer
            cells.
REFERENCE   5  (bases 1 to 1565)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 1565)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   7  (bases 1 to 1565)
  AUTHORS   Sigg,M.A., Menchen,T., Lee,C., Johnson,J., Jungnickel,M.K.,
            Choksi,S.P., Garcia,G. 3rd, Busengdal,H., Dougherty,G.W.,
            Pennekamp,P., Werner,C., Rentzsch,F., Florman,H.M., Krogan,N.,
            Wallingford,J.B., Omran,H. and Reiter,J.F.
  TITLE     Evolutionary Proteomics Uncovers Ancient Associations of Cilia with
            Signaling Pathways
  JOURNAL   Dev Cell 43 (6), 744-762 (2017)
   PUBMED   29257953
REFERENCE   8  (bases 1 to 1565)
  AUTHORS   Hein,M.Y., Hubner,N.C., Poser,I., Cox,J., Nagaraj,N., Toyoda,Y.,
            Gak,I.A., Weisswange,I., Mansfeld,J., Buchholz,F., Hyman,A.A. and
            Mann,M.
  TITLE     A human interactome in three quantitative dimensions organized by
            stoichiometries and abundances
  JOURNAL   Cell 163 (3), 712-723 (2015)
   PUBMED   26496610
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA571420.1, AL136786.1 and CA416982.1.
            
            On Nov 22, 2018 this sequence version replaced NM_032140.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and is the protein-coding variant.
            
            ##Evidence-Data-START##
            Transcript exon combination :: ERR279858.819.1, AL136786.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2146411 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000243878.9/ ENSP00000243878.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-25                DA571420.1         7-31
            26-1563             AL136786.1         1-1538
            1564-1565           CA416982.1         18-19               c
FEATURES             Location/Qualifiers
     source          1..1565
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q22.1"
     gene            1..1565
                     /gene="ENKD1"
                     /gene_synonym="C16orf48; DAKV6410; FBB11"
                     /note="enkurin domain containing 1"
                     /db_xref="GeneID:84080"
                     /db_xref="HGNC:HGNC:25246"
                     /db_xref="MIM:621119"
     exon            1..393
                     /gene="ENKD1"
                     /gene_synonym="C16orf48; DAKV6410; FBB11"
                     /inference="alignment:Splign:2.1.0"
     CDS             309..1349
                     /gene="ENKD1"
                     /gene_synonym="C16orf48; DAKV6410; FBB11"
                     /codon_start=1
                     /product="enkurin domain-containing protein 1"
                     /protein_id="NP_115516.1"
                     /db_xref="CCDS:CCDS10844.1"
                     /db_xref="GeneID:84080"
                     /db_xref="HGNC:HGNC:25246"
                     /db_xref="MIM:621119"
                     /translation="MCEGPSRISGPIPPDPTLCPDNYRRPTSAQGRLEGNALKLDLLT
                     SDRALDTTAPRGPCIGPGAGEILERGQRGVGDVLLQLEGISLGPGASLKRKDPKDHEK
                     ENLRRIREIQKRFREQERSREQGQPRPLKALWRSPKYDKVESRVKAQLQEPGPASGTE
                     SAHFLRAHSRCGPGLPPPHVSSPQPTPPGPEAKEPGLGVDFIRHNARAAKRAPRRHSC
                     SLQVLAQVLEQQRQAQEHYNATQKGHVPHYLLERRDLWRREAEARKQSQPDPAMPPGH
                     TRMPENQRLETLTKLLQSQSQLLRELVLLPAGADSLRAQSHRAELDRKLVQVEEAIKI
                     FSRPKVFVKMDD"
     exon            394..588
                     /gene="ENKD1"
                     /gene_synonym="C16orf48; DAKV6410; FBB11"
                     /inference="alignment:Splign:2.1.0"
     exon            589..761
                     /gene="ENKD1"
                     /gene_synonym="C16orf48; DAKV6410; FBB11"
                     /inference="alignment:Splign:2.1.0"
     exon            762..887
                     /gene="ENKD1"
                     /gene_synonym="C16orf48; DAKV6410; FBB11"
                     /inference="alignment:Splign:2.1.0"
     exon            888..1051
                     /gene="ENKD1"
                     /gene_synonym="C16orf48; DAKV6410; FBB11"
                     /inference="alignment:Splign:2.1.0"
     exon            1052..1188
                     /gene="ENKD1"
                     /gene_synonym="C16orf48; DAKV6410; FBB11"
                     /inference="alignment:Splign:2.1.0"
     exon            1189..1565
                     /gene="ENKD1"
                     /gene_synonym="C16orf48; DAKV6410; FBB11"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1544..1549
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ENKD1"
                     /gene_synonym="C16orf48; DAKV6410; FBB11"
                     /note="hexamer: ATTAAA"
     polyA_site      1565
                     /gene="ENKD1"
                     /gene_synonym="C16orf48; DAKV6410; FBB11"
                     /note="major polyA site"
ORIGIN      
        1 gcccggcaac aacaagtccc gtcgggtggc agcggctggc ggcaaaacct ctcgagtgag
       61 cccctgcccg agtgccgcgg gggagaggcc gcgagcggga ccgagaagtg ggctgggagc
      121 agaggtcgcg gaggtggcga gcgaggccgg ggcccaggcg gggaccggca ggggcccggg
      181 agtggcgggc acgccagggt cagggtgccg ggcgagggag ggggcccggg gttggggaag
      241 ggggcccggg gagggaggta aacagccctg caggcctcgg ggcaccgttg ctgggcggcg
      301 ccggcggcat gtgcgagggc ccgtcccgca tctcggggcc catcccccca gacccgacgc
      361 tctgtcctga caactacagg cggccgacct cggctcaagg gcgcctcgag ggaaacgcgc
      421 tgaagctgga cttgctgact tccgaccggg ccctggacac caccgctccc cgtggcccct
      481 gcatcggtcc cggtgccgga gagatcctgg agcgcggcca gcgcggcgtc ggggacgtgc
      541 tgttgcaact cgaggggatc tccctaggtc ctggggcctc tctcaagagg aaggacccta
      601 aggaccatga gaaggagaac ctgaggcgga tcagggagat tcagaagcgc ttcagagaac
      661 aggagcgcag ccgggagcag ggccagccca ggcccctgaa agctctgtgg cgctcaccca
      721 agtacgacaa ggtggagtcc cgggtcaagg cccagctcca ggagcctggc cctgcctctg
      781 ggacagagtc tgcccacttc ctgcgggcgc actcccgctg cggccctggc ctcccaccac
      841 cccatgtatc tagtccccag ccaaccccac caggtcccga agctaaggag ccaggcctgg
      901 gggtggactt cattcgtcac aatgcacgag ctgccaagag agccccccgg aggcattcct
      961 gctcactgca ggtcctggca caagtgctag agcagcagcg gcaggcccag gagcactaca
     1021 atgccacgca gaagggccat gtgccacatt acttgttgga gcgcagggac ctgtggcggc
     1081 gggaggccga ggcccgcaag cagagccagc cggaccctgc catgccccca ggccacacgc
     1141 gcatgcctga gaaccagcgg ctggaaacac tgaccaagct gctccagagc cagagccagc
     1201 tgctgcgtga gctggtactg ctgcctgctg gggcagactc actgagagcc cagagccacc
     1261 gtgctgagct ggaccggaag ctggtgcagg tagaggaggc catcaagatc ttttctcggc
     1321 ccaaagtctt cgtgaagatg gacgactgag cccctttggg ggacagtggc aaggagctcc
     1381 atgctgagga tcgccacatg gctgcaaagg acagggttgg acccaatccc agagcagagg
     1441 tctgaagaca ggagcagggg ggtggccagt gtccctagag cactcttccc agtcaccagt
     1501 ggctgcagaa gggccaccct agccttttaa ctgctttgtc aaaattaaac attttgtaca
     1561 cagga
//
