LOCUS       NM_198573               1028 bp    mRNA    linear   PRI 29-OCT-2024
DEFINITION  Homo sapiens energy homeostasis associated (ENHO), mRNA.
ACCESSION   NM_198573 XM_351808
VERSION     NM_198573.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1028)
  AUTHORS   Zheng,L., Wu,Q., Chen,S., Wen,J., Dong,F., Meng,N., Zeng,W.,
            Zhao,C. and Zhong,X.
  TITLE     Development and validation of a new diagnostic prediction model of
            ENHO and NOX4 for early diagnosis of systemic sclerosis
  JOURNAL   Front Immunol 15, 1273559 (2024)
   PUBMED   38348042
  REMARK    GeneRIF: Development and validation of a new diagnostic prediction
            model of ENHO and NOX4 for early diagnosis of systemic sclerosis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1028)
  AUTHORS   Hu,J., Wu,Q., Ding,Q., Wu,W., Li,Q. and Zheng,Z.
  TITLE     High Level of Adropin Promotes the Progression of Pancreatic Ductal
            Adenocarcinoma
  JOURNAL   Curr Cancer Drug Targets 24 (6), 629-641 (2024)
   PUBMED   37990897
  REMARK    GeneRIF: High Level of Adropin Promotes the Progression of
            Pancreatic Ductal Adenocarcinoma.
REFERENCE   3  (bases 1 to 1028)
  AUTHORS   Ding,F., Liu,G., Gao,F., Zheng,Z., Hong,Y., Chen,Y. and Weng,S.
  TITLE     Adropin attenuates pancreatitis-associated lung injury through
            PPARgamma phosphorylation-related macrophage polarization
  JOURNAL   Int J Mol Med 52 (4) (2023)
   PUBMED   37654184
  REMARK    GeneRIF: Adropin attenuates pancreatitis-associated lung injury
            through PPARgamma phosphorylation-related macrophage polarization.
REFERENCE   4  (bases 1 to 1028)
  AUTHORS   Gunraj,R.E., Yang,C., Liu,L., Larochelle,J. and Candelario-Jalil,E.
  TITLE     Protective roles of adropin in neurological disease
  JOURNAL   Am J Physiol Cell Physiol 324 (3), C674-C678 (2023)
   PUBMED   36717106
  REMARK    GeneRIF: Protective roles of adropin in neurological disease.
            Review article
REFERENCE   5  (bases 1 to 1028)
  AUTHORS   Meda,C., Dolce,A., Vegeto,E., Maggi,A. and Della Torre,S.
  TITLE     ERalpha-Dependent Regulation of Adropin Predicts Sex Differences in
            Liver Homeostasis during High-Fat Diet
  JOURNAL   Nutrients 14 (16), 3262 (2022)
   PUBMED   36014766
  REMARK    GeneRIF: ERalpha-Dependent Regulation of Adropin Predicts Sex
            Differences in Liver Homeostasis during High-Fat Diet.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1028)
  AUTHORS   Butler,A.A., Tam,C.S., Stanhope,K.L., Wolfe,B.M., Ali,M.R.,
            O'Keeffe,M., St-Onge,M.P., Ravussin,E. and Havel,P.J.
  TITLE     Low circulating adropin concentrations with obesity and aging
            correlate with risk factors for metabolic disease and increase
            after gastric bypass surgery in humans
  JOURNAL   J Clin Endocrinol Metab 97 (10), 3783-3791 (2012)
   PUBMED   22872690
  REMARK    GeneRIF: Although males exhibit higher adropin levels that are
            reduced by obesity, aging and markers of insulin resistance are
            associated with low plasma adropin irrespective of sex.
            GeneRIF: Plasma adropin levels were examined in 45 men and 85
            woman. Adropin levels are higher in men than woman. Obesity is
            associated with low adropin levels in men. Aging and metabolic risk
            factors are associated with low adropin levels, irrespective of
            sex.
REFERENCE   7  (bases 1 to 1028)
  AUTHORS   Ganesh Kumar,K., Zhang,J., Gao,S., Rossi,J., McGuinness,O.P.,
            Halem,H.H., Culler,M.D., Mynatt,R.L. and Butler,A.A.
  TITLE     Adropin deficiency is associated with increased adiposity and
            insulin resistance
  JOURNAL   Obesity (Silver Spring) 20 (7), 1394-1402 (2012)
   PUBMED   22318315
  REMARK    GeneRIF: Plasma adropin levels are regulated dietary macronutrients
            increasing with dietary fat content. Fasting suppresses plasma
            adropin. Adropin's actions are required for preventing insulin
            resistance, dyslipidemia and impaired glucose tolerance.
REFERENCE   8  (bases 1 to 1028)
  AUTHORS   Lovren,F., Pan,Y., Quan,A., Singh,K.K., Shukla,P.C., Gupta,M.,
            Al-Omran,M., Teoh,H. and Verma,S.
  TITLE     Adropin is a novel regulator of endothelial function
  JOURNAL   Circulation 122 (11 Suppl), S185-S192 (2010)
   PUBMED   20837912
  REMARK    GeneRIF: a potential endothelial protective role of adropin that is
            likely mediated via upregulation of endothelial NO synthase
            expression through the VEGFR2-phosphatidylinositol 3-kinase-Akt and
            VEGFR2-extracellular signal regulated kinase 1/2 pathways.
            GeneRIF: Adropin has an endothelial protective function mediated
            via upregulation of eNOS expression through the VEGFR2-PI3K-Akt and
            VEGFR2-ERK1/2 pathways. Adropin therapy may thus be useful for
            limiting diseases characterized by endothelial dysfunction.
REFERENCE   9  (bases 1 to 1028)
  AUTHORS   Kumar,K.G., Trevaskis,J.L., Lam,D.D., Sutton,G.M., Koza,R.A.,
            Chouljenko,V.N., Kousoulas,K.G., Rogers,P.M., Kesterson,R.A.,
            Thearle,M., Ferrante,A.W. Jr., Mynatt,R.L., Burris,T.P., Dong,J.Z.,
            Halem,H.A., Culler,M.D., Heisler,L.K., Stephens,J.M. and
            Butler,A.A.
  TITLE     Identification of adropin as a secreted factor linking dietary
            macronutrient intake with energy homeostasis and lipid metabolism
  JOURNAL   Cell Metab 8 (6), 468-481 (2008)
   PUBMED   19041763
  REMARK    GeneRIF: Adropin is the name given to the secreted peptide encoded
            by the ORF in C9orf165. In mice, it is abundant in liver where it
            is regulated by dietary macronutrients. Adropin regulates
            expression of genes involved in lipogenesis and adipogenesis.
REFERENCE   10 (bases 1 to 1028)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL160270.19.
            
            On Nov 23, 2018 this sequence version replaced NM_198573.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: ERR279849.676.1, ERR279872.1272.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000399775.3/ ENSP00000382675.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-214               AL160270.19        107430-107643       c
            215-1028            AL160270.19        105696-106509       c
FEATURES             Location/Qualifiers
     source          1..1028
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9p13.3"
     gene            1..1028
                     /gene="ENHO"
                     /gene_synonym="C9orf165; UNQ470"
                     /note="energy homeostasis associated"
                     /db_xref="GeneID:375704"
                     /db_xref="HGNC:HGNC:24838"
                     /db_xref="MIM:618556"
     exon            1..214
                     /gene="ENHO"
                     /gene_synonym="C9orf165; UNQ470"
                     /inference="alignment:Splign:2.1.0"
     exon            215..1028
                     /gene="ENHO"
                     /gene_synonym="C9orf165; UNQ470"
                     /inference="alignment:Splign:2.1.0"
     CDS             376..606
                     /gene="ENHO"
                     /gene_synonym="C9orf165; UNQ470"
                     /note="adropin; energy homeostasis-associated protein;
                     GAAI470"
                     /codon_start=1
                     /product="adropin precursor"
                     /protein_id="NP_940975.2"
                     /db_xref="CCDS:CCDS43795.1"
                     /db_xref="GeneID:375704"
                     /db_xref="HGNC:HGNC:24838"
                     /db_xref="MIM:618556"
                     /translation="MGAAISQGALIAIVCNGLVGFLLLLLWVILCWACHSRSADVDSL
                     SESSPNSSPGPCPEKAPPPQKPSHEGSYLLQP"
     regulatory      1007..1012
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ENHO"
                     /gene_synonym="C9orf165; UNQ470"
                     /note="hexamer: AATAAA"
     polyA_site      1028
                     /gene="ENHO"
                     /gene_synonym="C9orf165; UNQ470"
                     /note="major polyA site"
ORIGIN      
        1 agaccgcccg cggcagaggc cgccccggtc gcgccgcggc gggagcggcc ggtggaggct
       61 gcgcggccga gggggagggc cgggggagcg gacgtcgcct ctgctggtct cccacctccc
      121 gccgcccccc gcccgcaggc tcccaagcct tagtcggcgc cgagcatccc gctgccccgg
      181 accctcccgc gggcgcgcac caggctcaac tcaggctcag gactgcaggt agacatctcc
      241 actgcccagg aatcactgag cgtgcagaca gcacagcctc ctctgaaggc cggccatacc
      301 agagtcctgc ctcggcatgg gcctcaccat tgaggcagct ccactgtctg tgctggtctg
      361 agggtgctgc ctgtcatggg ggcagccatc tcccaggggg ccctcatcgc catcgtctgc
      421 aacggtctcg tgggcttctt gctgctgctg ctctgggtca tcctctgctg ggcctgccat
      481 tctcgctctg ccgacgttga ctctctctct gaatccagtc ccaactccag ccctggcccc
      541 tgtcctgaga aggccccacc accccagaag cccagccatg aaggcagcta cctgctgcag
      601 ccctgaaggc ccctggccta gcctggagcc caggacctaa gtccacctca cctagagcct
      661 ggaattagga tcccagagtt cagccagcct ggggtccaga actcaagagt ccgcctgctt
      721 ggagctggac ccagcggccc agagtctagc cagcttggct ccaataggag ctcagtggcc
      781 ctaaggagat gggcctgggg tgggggctta tgagttggtg ctagagccag ggccatctgg
      841 actatgctcc atcccaaggg ccaagggtca ggggccgggt ccactctttc cctaggctga
      901 gcacctctag gccctctagg ctggggaagc aaactggaac ccatggcaat aataggaggg
      961 tgtccaggct gggcccctcc cctggtcctc ccagtgtttg ctggataata aatggaacta
     1021 tggctcta
//
