LOCUS       NM_173627               2820 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens endonuclease V (ENDOV), transcript variant 1, mRNA.
ACCESSION   NM_173627
VERSION     NM_173627.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2820)
  AUTHORS   Mitsuoka,K., Kim,J.I., Yoshida,A., Matsumoto,A., Aoki-Shioi,N.,
            Iwai,S. and Kuraoka,I.
  TITLE     Base preference for inosine 3'-riboendonuclease activity of human
            endonuclease V: implications for cleavage of poly-A tails
            containing inosine
  JOURNAL   Sci Rep 14 (1), 14973 (2024)
   PUBMED   38951658
  REMARK    GeneRIF: Base preference for inosine 3'-riboendonuclease activity
            of human endonuclease V: implications for cleavage of poly-A tails
            containing inosine.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2820)
  AUTHORS   Berges,N., Nawaz,M.S., Borresdatter Dahl,T., Hagen,L., Bjoras,M.,
            Laerdahl,J.K. and Alseth,I.
  TITLE     Complex alternative splicing of human Endonuclease V mRNA, but
            evidence for only a single protein isoform
  JOURNAL   PLoS One 14 (11), e0225081 (2019)
   PUBMED   31703097
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2820)
  AUTHORS   Kim,J.I., Tohashi,K., Iwai,S. and Kuraoka,I.
  TITLE     Inosine-specific ribonuclease activity of natural variants of human
            endonuclease V
  JOURNAL   FEBS Lett 590 (23), 4354-4360 (2016)
   PUBMED   27800608
  REMARK    GeneRIF: Inosine-specific ribonuclease activity of natural variants
            of human endonuclease V
REFERENCE   4  (bases 1 to 2820)
  AUTHORS   Nawaz,M.S., Vik,E.S., Berges,N., Fladeby,C., Bjoras,M., Dalhus,B.
            and Alseth,I.
  TITLE     Regulation of Human Endonuclease V Activity and Relocalization to
            Cytoplasmic Stress Granules
  JOURNAL   J Biol Chem 291 (41), 21786-21801 (2016)
   PUBMED   27573237
  REMARK    GeneRIF: hEndoV is redistributed to stress granules as a strategy
            to create a local environment low in ATP to permit hEndoV activity.
REFERENCE   5  (bases 1 to 2820)
  AUTHORS   Dalhus,B., Alseth,I. and Bjoras,M.
  TITLE     Structural basis for incision at deaminated adenines in DNA and RNA
            by endonuclease V
  JOURNAL   Prog Biophys Mol Biol 117 (2-3), 134-142 (2015)
   PUBMED   25824682
  REMARK    GeneRIF: Human EndoV appears inactive on DNA, but has been shown to
            incise various RNA substrates containing inosine. [review]
            Review article
REFERENCE   6  (bases 1 to 2820)
  AUTHORS   Vik,E.S., Nawaz,M.S., Strom Andersen,P., Fladeby,C., Bjoras,M.,
            Dalhus,B. and Alseth,I.
  TITLE     Endonuclease V cleaves at inosines in RNA
  JOURNAL   Nat Commun 4, 2271 (2013)
   PUBMED   23912683
  REMARK    GeneRIF: This previously unknown RNA incision activity may suggest
            a role for endonuclease V in normal RNA metabolism.
REFERENCE   7  (bases 1 to 2820)
  AUTHORS   Fladeby,C., Vik,E.S., Laerdahl,J.K., Gran Neurauter,C.,
            Heggelund,J.E., Thorgaard,E., Strom-Andersen,P., Bjoras,M.,
            Dalhus,B. and Alseth,I.
  TITLE     The human homolog of Escherichia coli endonuclease V is a nucleolar
            protein with affinity for branched DNA structures
  JOURNAL   PLoS One 7 (11), e47466 (2012)
   PUBMED   23139746
  REMARK    GeneRIF: ENDOV is localized in the cytoplasm and nucleoli of human
            cells.
REFERENCE   8  (bases 1 to 2820)
  AUTHORS   Zhang,X., Yang,H., Lee,J.J., Kim,E., Lippman,S.M., Khuri,F.R.,
            Spitz,M.R., Lotan,R., Hong,W.K. and Wu,X.
  TITLE     MicroRNA-related genetic variations as predictors for risk of
            second primary tumor and/or recurrence in patients with early-stage
            head and neck cancer
  JOURNAL   Carcinogenesis 31 (12), 2118-2123 (2010)
   PUBMED   20819778
  REMARK    GeneRIF: Observational study of gene-disease association and
            gene-gene interaction. (HuGE Navigator)
REFERENCE   9  (bases 1 to 2820)
  AUTHORS   Moe,A., Ringvoll,J., Nordstrand,L.M., Eide,L., Bjoras,M.,
            Seeberg,E., Rognes,T. and Klungland,A.
  TITLE     Incision at hypoxanthine residues in DNA by a mammalian homologue
            of the Escherichia coli antimutator enzyme endonuclease V
  JOURNAL   Nucleic Acids Res 31 (14), 3893-3900 (2003)
   PUBMED   12853604
REFERENCE   10 (bases 1 to 2820)
  AUTHORS   Jay,M.S., Kearns,G.L., Stone,V. and Moss,M.
  TITLE     Toxic pneumonitis in an adolescent following exposure to Snow Storm
            tablets
  JOURNAL   J Adolesc Health Care 9 (5), 431-433 (1988)
   PUBMED   3170309
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK096344.1, AC120024.22, KC877673.1 and BM714470.1.
            
            On Nov 22, 2018 this sequence version replaced NM_173627.4.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK096344.1, SRR1660803.136337.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000518137.6/ ENSP00000429190.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-983               AK096344.1         1-983
            984-1178            AC120024.22        105697-105891       c
            1179-1740           KC877673.1         1-562               c
            1741-2354           AC120024.22        104521-105134       c
            2355-2820           BM714470.1         1-466
FEATURES             Location/Qualifiers
     source          1..2820
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q25.3"
     gene            1..2820
                     /gene="ENDOV"
                     /note="endonuclease V"
                     /db_xref="GeneID:284131"
                     /db_xref="HGNC:HGNC:26640"
                     /db_xref="MIM:619821"
     exon            1..84
                     /gene="ENDOV"
                     /inference="alignment:Splign:2.1.0"
     CDS             29..877
                     /gene="ENDOV"
                     /EC_number="3.1.-.-"
                     /note="isoform 1 is encoded by transcript variant 1;
                     hEndoV; inosine-specific endoribonuclease"
                     /codon_start=1
                     /product="endonuclease V isoform 1"
                     /protein_id="NP_775898.2"
                     /db_xref="CCDS:CCDS54172.1"
                     /db_xref="GeneID:284131"
                     /db_xref="HGNC:HGNC:26640"
                     /db_xref="MIM:619821"
                     /translation="MALEAAGGPPEETLSLWKREQARLKAHVVDRDTEAWQRDPAFSG
                     LQRVGGVDVSFVKGDSVRACASLVVLSFPELEVVYEESRMVSLTAPYVSGFLAFREVP
                     FLLELVQQLREKEPGLMPQVLLVDGNGVLHHRGFGVACHLGVLTDLPCVGVAKKLLQV
                     DGLENNALHKEKIRLLQTRGDSFPLLGDSGTVLGMALRSHDRSTRPLYISVGHRMSLE
                     AAVRLTCCCCRFRIPEPVRQADICSREHIRKSLGLPGPPTPRSPKAQRPVACPKGDSG
                     ESSALC"
     exon            85..256
                     /gene="ENDOV"
                     /inference="alignment:Splign:2.1.0"
     exon            257..391
                     /gene="ENDOV"
                     /inference="alignment:Splign:2.1.0"
     exon            392..431
                     /gene="ENDOV"
                     /inference="alignment:Splign:2.1.0"
     exon            432..544
                     /gene="ENDOV"
                     /inference="alignment:Splign:2.1.0"
     exon            545..613
                     /gene="ENDOV"
                     /inference="alignment:Splign:2.1.0"
     exon            614..742
                     /gene="ENDOV"
                     /inference="alignment:Splign:2.1.0"
     exon            743..807
                     /gene="ENDOV"
                     /inference="alignment:Splign:2.1.0"
     exon            808..866
                     /gene="ENDOV"
                     /inference="alignment:Splign:2.1.0"
     exon            867..2820
                     /gene="ENDOV"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2794..2799
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ENDOV"
                     /note="hexamer: AATAAA"
     polyA_site      2820
                     /gene="ENDOV"
                     /note="major polyA site"
ORIGIN      
        1 gtgcggaagg ggtgcccggg acgaagccat ggccctggag gcggcgggag ggccgccgga
       61 ggaaacgctg tcactgtgga aacgggagca agctcggctg aaggcccacg tcgtagaccg
      121 ggacaccgag gcgtggcagc gagaccccgc cttctcgggt ctgcagaggg tcgggggcgt
      181 tgacgtgtcc ttcgtgaaag gggacagtgt ccgcgcttgt gcttccctgg tggtgctcag
      241 cttccctgag ctcgaggtgg tgtatgagga gagccgcatg gtcagcctca cagcccccta
      301 cgtgtcgggc ttcctggcct tccgagaggt gcccttcttg ctggagctgg tgcagcagct
      361 gcgggagaag gagccgggcc tcatgcccca ggtccttctt gtggatggaa acggggtact
      421 ccaccaccga ggctttgggg tggcctgcca ccttggcgtc cttacagacc tgccgtgtgt
      481 tggggtggcc aagaaacttc tgcaggtgga tgggctggag aacaacgccc tgcacaagga
      541 gaagatccga ctcctgcaga ctcgaggaga ctcattccct ctgctgggag actctgggac
      601 tgtcctggga atggccctga ggagccacga ccgcagcacc aggcccctct acatctccgt
      661 gggccacagg atgagcctgg aggccgctgt gcgcctgact tgctgctgct gcaggttccg
      721 gatcccagag cccgtgcgcc aggctgacat ctgctcccga gagcacatcc gcaagtcgct
      781 gggactcccc gggccaccca caccgaggag cccgaaggcg cagaggccag tggcatgccc
      841 caaaggagac tccggagagt cctcagcact ttgttgaacg tggtggtgag agcacacgtc
      901 ctcgtctcat tcctgatcga acgcggtggt gagagcacac gtcctcgtct cgttcctgat
      961 cgaacgcggt ggtgagagca cacatcctcg tctcgttcct gatcgaacgc ggtggtgaga
     1021 gcacacgtcc tcgtctcgtt cctgatcgaa cgtggtggtg agagcacacg tccttgtctt
     1081 gttcctgatc ttaagggaac gtttgcagtc tttcaccact agatgtgatg tgagctgtta
     1141 gattttcaag gatgctcttc atccagctga agacggtccc ttctagtcct aatttgttaa
     1201 gtgtttttat ccttaaaggg tactggattt tgtcaaatgc ttttctggcc tctattgaaa
     1261 agatcctgtg ttcttctgtg aatatgaggt gttacattga ttgattttca tatgttgagc
     1321 cagtttccat ttgtggaata catctaactc ggtcatggtg tataatccat ttactctgct
     1381 gctgaatgtg atttgcttgt attttggtgc ggatttttac atctgtattt ataagggata
     1441 ttggtctggt gttttcttat gatgtcttcc tttggttttg atatcaggat aatattagcc
     1501 tcatagattg ggttaggaaa tgttctctcc tccgtttttt ttggaagaga gagattggtg
     1561 ttaattcttg ctagaacctt tggtagaatt tgccagtaag cctatctggt cttgggtctt
     1621 tgggaggatt ttgattcgat tcaatctatg tatttgttat agatcgttcg gattgtccat
     1681 ccttgagtca gttgctagct tgtgtgtttc ttggagtttt tccgtttcgt ccatgttatc
     1741 tcatctgttg gcataccgtc gttcacggga ttttattgat gtgtgtgagg tctctgagaa
     1801 cgtccctgcc ttcactcctg cttttagtca ctggcatctt cttttaactt gggccatctg
     1861 gccgtgcatg gttttgggag agtcctcctt gactctgcag atgctgagca gtgatctggc
     1921 tgggaaaggg gaccaggagt gcagggcacc tgctgaggac tcacctaagc ccaagagtca
     1981 gagagtcgga gctccaacca catctgcctg catgcctttc ccaggctctc cccaggcgga
     2041 cagccagcac cccctcccca aagaccgggc agttcctgac cagcacccca ccaagtcctc
     2101 agtaaggcct gtctttgggg gagcagggtt tcaggaggac agtgggggtg gtgtagaact
     2161 catggctggc ggttccgggc ctctcaggaa gctttgccac tgggcttggg gttaagtggg
     2221 tgtggggctc cgaaccctaa atgggtgaga gttgaaatga aagcggcacc tgtagtccgt
     2281 ttggggtgca ggtgtgtgcc aggggtcttc agccccggct gatggccaca tgaaccacat
     2341 gaggagaggc agggcgtgtc agcagcaaac ctaagtgtgt gctcatttct gtgggccctt
     2401 actctgtgac actgcagctc tccagagaga cgctttgaaa acaaaacagg aaagaacaca
     2461 cggccccgcg tctgttgcct gagtcactgt attccttaaa aggtgaagga ccctggtcct
     2521 tggcttttcg tgcacatgag aaaatgttgg ccaaggttag cgattatgct tctgtaatct
     2581 gtaaccagaa gtgctcttat gcccaaacct tgatgtgatt ctgctgtaat gtaacttcgg
     2641 agccagctgg atggatgtga ctgtgcaggt cctgagcccc ggcccccgta accaagcagt
     2701 gggccgagac actgagccgg gcagtcaaac aggagctctc taaggctgct cccgggctgg
     2761 gacctgggtc taggattctc agtaagacct ttgaataaaa ctaacttgaa ttcttcaaaa
//
