LOCUS       NM_001172439            2378 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens endonuclease, poly(U) specific (ENDOU), transcript
            variant 1, mRNA.
ACCESSION   NM_001172439
VERSION     NM_001172439.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2378)
  AUTHORS   Malard,F., Karginov,F.V. and Campagne,S.
  TITLE     1H, 13C and 15N backbone resonance assignment of the
            calcium-activated EndoU endoribonuclease
  JOURNAL   Biomol NMR Assign 18 (2), 263-267 (2024)
   PUBMED   39249657
  REMARK    GeneRIF: [1]H, [13]C and [15]N backbone resonance assignment of the
            calcium-activated EndoU endoribonuclease.
REFERENCE   2  (bases 1 to 2378)
  AUTHORS   Sun,X., Shen,J., Perrimon,N., Kong,X. and Wang,D.
  TITLE     The endoribonuclease Arlr is required to maintain lipid homeostasis
            by downregulating lipolytic genes during aging
  JOURNAL   Nat Commun 14 (1), 6254 (2023)
   PUBMED   37803019
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2378)
  AUTHORS   Lee,H.C., Fu,C.Y., Lin,C.Y., Hu,J.R., Huang,T.Y., Lo,K.Y.,
            Tsai,H.Y., Sheu,J.C. and Tsai,H.J.
  TITLE     Poly(U)-specific endoribonuclease ENDOU promotes translation of
            human CHOP mRNA by releasing uORF element-mediated inhibition
  JOURNAL   EMBO J 40 (11), e104123 (2021)
   PUBMED   33511665
  REMARK    GeneRIF: Poly(U)-specific endoribonuclease ENDOU promotes
            translation of human CHOP mRNA by releasing uORF element-mediated
            inhibition.
REFERENCE   4  (bases 1 to 2378)
  AUTHORS   Jing,H., Ackerman,W.E. 4th, Zhao,G., El Helou,Y., Buhimschi,C.S.
            and Buhimschi,I.A.
  TITLE     Connecting the dots on vertical transmission of SARS-CoV-2 using
            protein-protein interaction network analysis - Potential roles of
            placental ACE2 and ENDOU
  JOURNAL   Placenta 104, 16-19 (2021)
   PUBMED   33197855
  REMARK    GeneRIF: Connecting the dots on vertical transmission of SARS-CoV-2
            using protein-protein interaction network analysis - Potential
            roles of placental ACE2 and ENDOU.
REFERENCE   5  (bases 1 to 2378)
  AUTHORS   Laneve,P., Gioia,U., Ragno,R., Altieri,F., Di Franco,C.,
            Santini,T., Arceci,M., Bozzoni,I. and Caffarelli,E.
  TITLE     The tumor marker human placental protein 11 is an endoribonuclease
  JOURNAL   J Biol Chem 283 (50), 34712-34719 (2008)
   PUBMED   18936097
  REMARK    GeneRIF: human placental protein 11 is an endoribonuclease
REFERENCE   6  (bases 1 to 2378)
  AUTHORS   Gioia,U., Laneve,P., Dlakic,M., Arceci,M., Bozzoni,I. and
            Caffarelli,E.
  TITLE     Functional characterization of XendoU, the endoribonuclease
            involved in small nucleolar RNA biosynthesis
  JOURNAL   J Biol Chem 280 (19), 18996-19002 (2005)
   PUBMED   15755742
REFERENCE   7  (bases 1 to 2378)
  AUTHORS   Jenne,D.
  TITLE     Homology of placental protein 11 and pea seed albumin 2 with
            vitronectin
  JOURNAL   Biochem Biophys Res Commun 176 (3), 1000-1006 (1991)
   PUBMED   1710108
REFERENCE   8  (bases 1 to 2378)
  AUTHORS   Grundmann,U., Romisch,J., Siebold,B., Bohn,H. and Amann,E.
  TITLE     Cloning and expression of a cDNA encoding human placental protein
            11, a putative serine protease with diagnostic significance as a
            tumor marker
  JOURNAL   DNA Cell Biol 9 (4), 243-250 (1990)
   PUBMED   2350438
REFERENCE   9  (bases 1 to 2378)
  AUTHORS   Inaba,N., Ishige,H., Ijichi,M., Satoh,N., Ohkawa,R., Sekiya,S.,
            Shirotake,S., Takamizawa,H., Renk,T. and Bohn,H.
  TITLE     Immunohistochemical detection of pregnancy-specific protein (SP1)
            and placenta-specific tissue proteins (PP5, PP10, PP11 and PP12) in
            ovarian adenocarcinomas
  JOURNAL   Oncodev Biol Med 3 (5-6), 379-389 (1982)
   PUBMED   6755403
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK075446.1, BC069698.1 and
            AI039727.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001172439.1.
            
            Summary: This gene encodes a protein with endoribonuclease activity
            that binds polyuridine-enriched single-stranded RNA. This gene was
            initially characterized based on its high expression in placenta
            but was mischaracterized as a serine protease. In mouse, this gene
            promotes tolerance to self-antigens by regulating B cell
            activation-induced cell death (AICD). The protein may be useful as
            a tumor marker. Multiple alternatively spliced transcript variants
            encoding distinct protein isoforms have been found for this gene.
            [provided by RefSeq, Jul 2020].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest protein (isoform 1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK075446.1, BC069698.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145893, SAMEA2147596
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000422538.8/ ENSP00000397679.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1198              AK075446.1         47-1244
            1199-2064           BC069698.1         1160-2025
            2065-2367           AK075446.1         2111-2413
            2368-2378           AI039727.1         15-25               c
FEATURES             Location/Qualifiers
     source          1..2378
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.11"
     gene            1..2378
                     /gene="ENDOU"
                     /gene_synonym="P11; PP11; PRSS26"
                     /note="endonuclease, poly(U) specific"
                     /db_xref="GeneID:8909"
                     /db_xref="HGNC:HGNC:14369"
                     /db_xref="MIM:606720"
     exon            1..132
                     /gene="ENDOU"
                     /gene_synonym="P11; PP11; PRSS26"
                     /inference="alignment:Splign:2.1.0"
     CDS             78..1310
                     /gene="ENDOU"
                     /gene_synonym="P11; PP11; PRSS26"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; 26 serine protease; 22 serine protease;
                     placental protein 11; poly(U)-specific endoribonuclease;
                     protein endoU; uridylate-specific endoribonuclease;
                     endonuclease, polyU-specific"
                     /codon_start=1
                     /product="uridylate-specific endoribonuclease isoform 1
                     precursor"
                     /protein_id="NP_001165910.1"
                     /db_xref="CCDS:CCDS53785.1"
                     /db_xref="GeneID:8909"
                     /db_xref="HGNC:HGNC:14369"
                     /db_xref="MIM:606720"
                     /translation="MRACISLVLAVLCGLAWAGKIESCASRCNEKFNRDAACQCDRRC
                     LWHGNCCEDYEHLCTEDHKESEPLPQLEEETEEALASNLYSAPTSCQGRCYEAFDKHH
                     QCHCNARCQEFGNCCKDFESLCSDHEVSHSSDAITKEEIQSISEKIYRADTNKAQKED
                     IVLNSQNCISPSETRNQVDRCPKPLFTYVNEKLFSKPTYAAFINLLNNYQRATGHGEH
                     FSAQELAEQDAFLREIMKTAVMKELYSFLHHQNRYGSEQEFVDDLKNMWFGLYSRGNE
                     EGDSSGFEHVFSGEVKKGKVTGFHNWIRFYLEEKEGLVDYYSHIYDGPWDSYPDVLAM
                     QFNWDGYYKEVGSAFIGSSPEFEFALYSLCFIARPGKVCQLSLGGYPLAVRTYTWDKS
                     TYGNGKKYIATAYIVSST"
     exon            133..255
                     /gene="ENDOU"
                     /gene_synonym="P11; PP11; PRSS26"
                     /inference="alignment:Splign:2.1.0"
     exon            256..321
                     /gene="ENDOU"
                     /gene_synonym="P11; PP11; PRSS26"
                     /inference="alignment:Splign:2.1.0"
     exon            322..459
                     /gene="ENDOU"
                     /gene_synonym="P11; PP11; PRSS26"
                     /inference="alignment:Splign:2.1.0"
     exon            460..628
                     /gene="ENDOU"
                     /gene_synonym="P11; PP11; PRSS26"
                     /inference="alignment:Splign:2.1.0"
     exon            629..828
                     /gene="ENDOU"
                     /gene_synonym="P11; PP11; PRSS26"
                     /inference="alignment:Splign:2.1.0"
     exon            829..942
                     /gene="ENDOU"
                     /gene_synonym="P11; PP11; PRSS26"
                     /inference="alignment:Splign:2.1.0"
     exon            943..1049
                     /gene="ENDOU"
                     /gene_synonym="P11; PP11; PRSS26"
                     /inference="alignment:Splign:2.1.0"
     exon            1050..1192
                     /gene="ENDOU"
                     /gene_synonym="P11; PP11; PRSS26"
                     /inference="alignment:Splign:2.1.0"
     exon            1193..2378
                     /gene="ENDOU"
                     /gene_synonym="P11; PP11; PRSS26"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2352..2357
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ENDOU"
                     /gene_synonym="P11; PP11; PRSS26"
                     /note="hexamer: ATTAAA"
     polyA_site      2378
                     /gene="ENDOU"
                     /gene_synonym="P11; PP11; PRSS26"
                     /note="major polyA site"
ORIGIN      
        1 gtctgagagc tgtgacattc atctgactct agtgaaagtc caacagccac tccctttttg
       61 gcctccaact gggcaccatg agggcctgca tctccctggt attggccgtg ctgtgtggcc
      121 tggcctgggc tggaaaaata gaatcctgtg catctcgatg taatgagaaa tttaaccggg
      181 acgctgcctg ccagtgtgac cgccggtgtc tctggcatgg gaactgctgt gaagactatg
      241 aacatctgtg tactgaggac cacaaagagt cagagccatt gccacagctg gaggaagaga
      301 cagaagaggc cctcgccagc aacttgtact cggcacccac ctcctgccag ggccgctgct
      361 acgaagcctt tgacaagcac caccaatgtc actgcaatgc ccgctgccaa gagtttggga
      421 actgctgcaa ggattttgag agcctgtgta gtgaccacga ggtctcccac agcagtgatg
      481 ccataacaaa agaggagatt cagagcatct ctgagaagat ctacagggca gacaccaaca
      541 aagcccagaa ggaagacatc gttctcaata gccaaaactg catctccccg tcagagacca
      601 gaaaccaagt ggatcgctgc ccaaagccac tcttcactta tgtcaatgag aagctgttct
      661 ccaagcccac ctatgcagcc ttcatcaacc tcctcaacaa ctaccagcgg gcaacaggcc
      721 atggggagca cttcagtgcc caggagctgg ccgagcagga cgccttcctc agagagatca
      781 tgaagacagc agtcatgaag gagctctaca gcttcctcca tcaccagaat cgctatggct
      841 cagagcaaga gtttgtcgat gacttgaaga acatgtggtt tgggctctat tcaagaggca
      901 atgaagaggg ggactcgagt ggctttgaac atgtcttctc aggtgaggta aaaaaaggca
      961 aggttactgg cttccataac tggatccgct tctacctgga ggagaaggag ggtctggttg
     1021 actattacag tcacatctac gatgggcctt gggattctta ccccgatgtg ctggcaatgc
     1081 agttcaactg ggacggctac tataaggaag tgggctctgc tttcatcggc agcagccctg
     1141 agtttgagtt tgcactctac tccctgtgct tcatcgccag gccaggcaaa gtgtgccagt
     1201 taagcctggg aggatatccc ttagctgtcc ggacatatac ctgggacaag tccacctatg
     1261 ggaatggcaa gaagtacatc gccacagcct acatagtgtc ttccacctaa tagaacttcg
     1321 agccagaaag gggcatgagg gctcttgcga gactgaagtg ctatcttctc tggactagag
     1381 agaagaggga gaggactgga agggatcacc aaatctcaaa gcaatgagaa gcattcctaa
     1441 atcccaaagt gcccacatgg gaaagagata aaatgtacaa attagaaaaa tgtggataaa
     1501 cagtcaaacc tttatcctct agaattttgg caatgttgac taagaaacag agtccaagca
     1561 gagaaggtag gaaccctcca tagctctctg ccctgatgtg tgggggaact aggaagaagt
     1621 cctttgacct caccaggcct catgcttccc tttaatgtaa agggaagggg tttgcccact
     1681 ttcctctttt tggggttggt gagagggcaa accctgatat ttttactgtg aaggtgtttt
     1741 cagttgttct taggaagaac agctgataga aattcaagat tactataatg gctgttatta
     1801 tacacagctc tgtaaactac cactcagccc tgtgttgggg tcctcaaaga agtaaggcca
     1861 cagtaatcaa gcaagggcct ttggtttttt ccagagttag atcctctcag aacagagtct
     1921 gggagaactc caatgctgaa tggagaaggg taataggttg gtgcagtgaa tgggctgggg
     1981 gtggggtggc cttctccagg cctgagtgtt tttgtgtcca gctcagtatc tgcaacaaga
     2041 agtttcccac ttgtggatgt ttagtgcagc cacagacttg tattttgatc cccaattttt
     2101 ttttgaaaga gttctcctca taggaggatg attcagcatc agaagaagaa ggaacccata
     2161 gcttggtgtc attaacataa ttattttaag ccttatccag cagccataat ttgaataact
     2221 ctacgagacc agagagactg tagttcccta ttttaacctc aattatgcat ttgtccccca
     2281 accccactga gaactaaatg ctgtaccaca gagccgggtg tgaactatgg tttagaaggt
     2341 tcaagtttcc aattaaagtc attgaagaaa acttgaaa
//
