LOCUS       NM_015036               4651 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens endonuclease domain containing 1 (ENDOD1), mRNA.
ACCESSION   NM_015036 XM_290546 XM_937098
VERSION     NM_015036.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4651)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 4651)
  AUTHORS   Qiu,J., Peng,S., Si-Tu,J., Hu,C., Huang,W., Mao,Y., Qiu,W., Li,K.
            and Wang,D.
  TITLE     Identification of endonuclease domain-containing 1 as a novel tumor
            suppressor in prostate cancer
  JOURNAL   BMC Cancer 17 (1), 360 (2017)
   PUBMED   28532481
  REMARK    GeneRIF: Overexpression of ENDOD1 suppressed cell proliferation,
            induced G0/G1 cell cycle arrest and inhibited cell migration and
            invasion.
            Erratum:[BMC Cancer. 2017 Aug 24;17(1):569. doi:
            10.1186/s12885-017-3517-9.. PMID: 28836942]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4651)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   4  (bases 1 to 4651)
  AUTHORS   O'Neill,E.E., Brock,C.J., von Kriegsheim,A.F., Pearce,A.C.,
            Dwek,R.A., Watson,S.P. and Hebestreit,H.F.
  TITLE     Towards complete analysis of the platelet proteome
  JOURNAL   Proteomics 2 (3), 288-305 (2002)
   PUBMED   11921445
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA050413.1, BC071171.1 and AP000787.5.
            
            On Nov 23, 2018 this sequence version replaced NM_015036.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DA843823.1, SRR1660803.76686.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000278505.5/ ENSP00000278505.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                DA050413.1         37-49
            14-2037             BC071171.1         1-2024
            2038-4651           AP000787.5         10578-13191
FEATURES             Location/Qualifiers
     source          1..4651
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q21"
     gene            1..4651
                     /gene="ENDOD1"
                     /note="endonuclease domain containing 1"
                     /db_xref="GeneID:23052"
                     /db_xref="HGNC:HGNC:29129"
                     /db_xref="MIM:619568"
     exon            1..382
                     /gene="ENDOD1"
                     /inference="alignment:Splign:2.1.0"
     CDS             83..1585
                     /gene="ENDOD1"
                     /note="endonuclease domain-containing 1 protein"
                     /codon_start=1
                     /product="endonuclease domain-containing 1 protein
                     precursor"
                     /protein_id="NP_055851.1"
                     /db_xref="CCDS:CCDS41699.1"
                     /db_xref="GeneID:23052"
                     /db_xref="HGNC:HGNC:29129"
                     /db_xref="MIM:619568"
                     /translation="MGTARWLALGSLFALAGLLEGRLVGEEEAGFGECDKFFYAGTPP
                     AGLAADSHVKICQRAEGAERFATLYSTRDRIPVYSAFRAPRPAPGGAEQRWLVEPQID
                     DPNSNLEEAINEAEAITSVNSLGSKQALNTDYLDSDYQRGQLYPFSLSSDVQVATFTL
                     TNSAPMTQSFQERWYVNLHSLMDRALTPQCGSGEDLYILTGTVPSDYRVKDKVAVPEF
                     VWLAACCAVPGGGWAMGFVKHTRDSDIIEDVMVKDLQKLLPFNPQLFQNNCGETEQDT
                     EKMKKILEVVNQIQDEERMVQSQKSSSPLSSTRSKRSTLLPPEASEGSSSFLGKLMGF
                     IATPFIKLFQLIYYLVVAILKNIVYFLWCVTKQVINGIESCLYRLGSATISYFMAIGE
                     ELVSIPWKVLKVVAKVIRALLRILCCLLKAICRVLSIPVRVLVDVATFPVYTMGAIPI
                     VCKDIALGLGGTVSLLFDTAFGTLGGLFQVVFSVCKRIGYKVTFDNSGEL"
     exon            383..4651
                     /gene="ENDOD1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4632..4637
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ENDOD1"
                     /note="hexamer: AATAAA"
     polyA_site      4651
                     /gene="ENDOD1"
                     /note="major polyA site"
ORIGIN      
        1 gtagtgcgct ccccgcccag cctgcagagc tcgcgccgcg gcagcccagc cgctcggccc
       61 cgccgcgctc gcagaggccg ccatgggcac cgcgcgctgg ctcgcgctgg gcagcctctt
      121 cgccctggct gggctgctgg aaggccggct cgtgggcgag gaggaagccg gctttggcga
      181 atgtgacaag ttcttctacg ccgggacccc gcctgcgggg ctggcggccg attcccacgt
      241 gaagatctgt cagcgcgcgg agggtgctga gcgcttcgcc accctctaca gcacccggga
      301 ccgcatcccc gtgtactccg cgttccgcgc cccgcgccct gcgcccggcg gcgccgagca
      361 gcgatggctg gtggagccgc agatcgatga ccccaacagc aaccttgagg aggcgattaa
      421 tgaggcagag gccatcacct ctgtgaacag cctgggaagc aagcaagcct tgaatacaga
      481 ttaccttgat tctgattacc aaagaggaca gctttaccca ttctccctta gcagtgatgt
      541 ccaggtggcc acatttactc tcacaaattc agccccaatg actcagtcct tccaggaacg
      601 gtggtatgtg aatctccaca gcctaatgga ccgggctttg accccacagt gtggcagtgg
      661 ggaagaccta tatatcctca caggcacagt gccctcagac tacagagtta aagacaaagt
      721 ggcagtccct gagtttgttt ggctggcagc ctgttgtgct gtccctggag gaggctgggc
      781 catgggcttt gtcaagcaca cccgggacag tgacatcata gaagatgtga tggtaaaaga
      841 tcttcagaaa ctgcttccat ttaaccctca gctgtttcag aacaactgtg gtgaaactga
      901 gcaagacaca gagaaaatga aaaaaatcct ggaagtggtt aaccaaatcc aggatgaaga
      961 acgaatggta caatctcaaa agagttctag tcccctttct agcaccagga gcaagaggtc
     1021 tactctgttg cctccagagg catctgaggg aagtagtagc tttttgggaa aactcatggg
     1081 cttcattgct accccattca tcaagctttt tcaattaatt tattaccttg tggtagcaat
     1141 cctgaagaac attgtctatt tcctgtggtg tgttaccaag caggtgatta atggcataga
     1201 aagttgcctt taccgcctgg gctcagccac catctcatac ttcatggcca ttggggaaga
     1261 gttggtgagc attccctgga aggtgctcaa ggtcgtggcc aaagtcatca gggctctcct
     1321 ccggatcctt tgttgtctgc tgaaggccat ttgccgagtt ctgagcatcc ctgtccgtgt
     1381 ccttgtggat gtggccactt tccctgtgta caccatgggc gctattccaa ttgtttgcaa
     1441 ggacattgca ctgggccttg gtggcactgt ctcactgctc tttgacactg cttttggtac
     1501 cctgggtggc ctatttcagg tggtttttag tgtctgcaag cggattggct acaaggttac
     1561 ttttgacaat tctggggagt tataaactca aaaaactaat agtatccagt cacagtgaat
     1621 ttgaaagctg gaatagtttg tctttacaat gggtttctgt tcactgtcag ttatcattat
     1681 attttggcct ttggtgggga tgtctgcttg tttttgcaaa agaagatggc agaatttaga
     1741 cttgacagag gagaaatgct cagggtgaga ttaggtgtag taatctgctg tttacctcca
     1801 gttatatgtg caaactccca agccactaat aacttcagtt atgcactcta acacagacga
     1861 ccacctgaaa tgcactggta tttatttctg ataattaaaa attacagggg agggaagaac
     1921 tagaaaaaga acaactttag accaaaggtg tctgagaaaa ggagaaaggg agcttgttct
     1981 tcccattgct ctttgtgatt taaggcaaaa cagattaaaa aaaaaatctg cagccaattt
     2041 cttggcattt gcttctcttt ctcctcaact cgactgacct tggtggaatg cagataatgc
     2101 ctctttgttg aaataacttt gtgggaatgt acaattttct atatctctta gctttccgtg
     2161 gttctcaagg atatgtacag ttttcatttt cctccaaagt tgaattttgc tacatttttc
     2221 ttttaggtaa tgataagcat tttttaaaaa atcattttta ggtaatggta agcattttat
     2281 gccaaatgtg gcataacaga gtttgaattg aagggcaaag ttttcttttc tttttttttt
     2341 gggccccttg aatggtataa tacagtcctc tccggtggaa agaagagaag agaaggtgga
     2401 cagccctgct cttagtaggt gctgcagatc caaggacatc ttttgtccag cttggattaa
     2461 cttgacgtgt atccctgcct gacaaggttg aactgaaaga tctatatgtt aagctaacat
     2521 gaaaattcat attctgcaac atagtagatt tttctaatgc atgaaataag tacccagcac
     2581 agtaaaaata ctctgactta tgtccctaaa tggttgtttt gatacaacta tatagaaaag
     2641 agccacaaaa taaagataaa agttattgtg gccatctctg aaaaaaatat ataaaatatt
     2701 taagaataat tatatcttag gaaattattt ttacagtgtg tttgaggcta caaacataac
     2761 tcccccatta atacaaatta aatgtgagag ctcattctca aaattttttt gatcaagcac
     2821 ttgtcatttt aaatcttgca ctaaaaaatg gtaacaagag ggaccaaact ttgcttccca
     2881 caattgggat ggaatcacct ggatttttct gaatgtttta aagaattgct gagaggtaga
     2941 aacagccaag tatgaaatac tgatcttggg gctaccgccc aggatcaatc agaaagttat
     3001 atgcaaaaat tcggggtccc aacaaggaga gaacaatatg tcaaccattt gcatggggtc
     3061 gatggatgag aaacatgagc gtagcaagag ttacattttg cagaaaaata gcggaggcac
     3121 acccagagta gaacagcagc cagcaagctg ccatcctgat caatttgtga tgcaaggtta
     3181 gggagtatga gcaccgcatg ggtccatgct agggagatgt gcaccaggct tagctaagaa
     3241 acttaaagca gtattttacc aactcttgtc ttagggagca taaagtttgg atgtcccttt
     3301 atttcagcag tgtgaaggta aatggaaggg tgagggtttg acttggtact gattggtcaa
     3361 gaatcctgct ggataaagaa aaggaatttt agaagtgacc agagggacag tccagccaaa
     3421 ctattatttg ataaggaacc caaggccctg ggaggcaaca ggctagccct tagtttcatg
     3481 gctagctgag agcagattag gagccaacgt tgtttgcaca tgtcccatca cacctgagat
     3541 gtcagacatg ggaagttcgt gctattattc agttgcctct ctggaccatg gcaagatttc
     3601 ctcattcatc aaacagactc caggccctga caaagcagtt ggatttggca tgtgtgatga
     3661 aaacaattag ccatccatgt acaacattat gcttactgca tcccatggaa acttaattcc
     3721 ctcctagcac atatttgcat actgaaaggt ccgaaaaggg catccacggc agcttgagcc
     3781 ccttagcacc atgtaaggag cacagcatcc aaacggcttc ttgagaacca ttggggaatg
     3841 tctttctttt tcacatccaa ttgtttagtg tctatttatt cttgggtggc cagttttgaa
     3901 acctaaaaag ggacaataaa gcaaaaagta tcagtaagga taggtggctg agacccactg
     3961 ccctgagcta ctagtgtggc tgtgcctgtg ggtctctaga accatctgca ttggacgtga
     4021 agccacagca ggtggctgga ctgctggcct gttcctaatg agctacgctg ggctttgagg
     4081 tagaggttgg ggtttatgaa ccccaactct ggcttaaaga tcttgctgtg gctctgttat
     4141 gttctgaggc cttgggatta gcctcttcct cattatggag ctgattttct agtctgtgga
     4201 tcagctatgc ctttggacac ttctcttttc cattgtgcct tttgaatgtt gtcttctcac
     4261 tcagcatcag cacttcgatc taaatgcaga ctaggtagtt gggaggagga accaaagtga
     4321 accatccttc atttattcag tcattcgttc atctgtcaaa cacgtatttg gacatcaagg
     4381 ttgcagagat gaacaatgca tggatttcat ctttgaggag ttcaaaacct agtggagaga
     4441 acacatggta caatcgtaac acatgaagga caagtaagtg ctgcagtaaa ggtactaata
     4501 acatgttcct tggaacagag gaagaaaaac cacgaaacca tggaaattag ggaagccttt
     4561 acagagggtg tgacaaaact caatttgaca ttttcaagct atgtacaatg atgtgcacct
     4621 tgcagatgct caataaagta attactgaca a
//
