LOCUS       NM_003633               4821 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens ectodermal-neural cortex 1 (ENC1), transcript variant
            1, mRNA.
ACCESSION   NM_003633
VERSION     NM_003633.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4821)
  AUTHORS   Cao,Z., Zhu,J., Wang,Z., Peng,Y. and Zeng,L.
  TITLE     Comprehensive pan-cancer analysis reveals ENC1 as a promising
            prognostic biomarker for tumor microenvironment and therapeutic
            responses
  JOURNAL   Sci Rep 14 (1), 25331 (2024)
   PUBMED   39455818
  REMARK    GeneRIF: Comprehensive pan-cancer analysis reveals ENC1 as a
            promising prognostic biomarker for tumor microenvironment and
            therapeutic responses.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4821)
  AUTHORS   He,L., Zhang,C., He,W. and Xu,M.
  TITLE     The emerging role of ectodermal neural cortex 1 in cancer
  JOURNAL   Sci Rep 14 (1), 513 (2024)
   PUBMED   38177640
  REMARK    GeneRIF: The emerging role of ectodermal neural cortex 1 in cancer.
            Review article
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4821)
  AUTHORS   Zhang,P., Zhao,F., Jia,K. and Liu,X.
  TITLE     The LOXL1 antisense RNA 1 (LOXL1-AS1)/microRNA-423-5p
            (miR-423-5p)/ectodermal-neural cortex 1 (ENC1) axis promotes
            cervical cancer through the mitogen-activated protein kinase
            (MEK)/extracellular signal-regulated kinase (ERK) pathway
  JOURNAL   Bioengineered 13 (2), 2567-2584 (2022)
   PUBMED   35015607
  REMARK    GeneRIF: The LOXL1 antisense RNA 1 (LOXL1-AS1)/microRNA-423-5p
            (miR-423-5p)/ectodermal-neural cortex 1 (ENC1) axis promotes
            cervical cancer through the mitogen-activated protein kinase
            (MEK)/extracellular signal-regulated kinase (ERK) pathway.
REFERENCE   4  (bases 1 to 4821)
  AUTHORS   Fujita,M., Furukawa,Y., Tsunoda,T., Tanaka,T., Ogawa,M. and
            Nakamura,Y.
  TITLE     Up-regulation of the ectodermal-neural cortex 1 (ENC1) gene, a
            downstream target of the beta-catenin/T-cell factor complex, in
            colorectal carcinomas
  JOURNAL   Cancer Res 61 (21), 7722-7726 (2001)
   PUBMED   11691783
REFERENCE   5  (bases 1 to 4821)
  AUTHORS   Kim,T.A., Ota,S., Jiang,S., Pasztor,L.M., White,R.A. and Avraham,S.
  TITLE     Genomic organization, chromosomal localization and regulation of
            expression of the neuronal nuclear matrix protein NRP/B in human
            brain tumors
  JOURNAL   Gene 255 (1), 105-116 (2000)
   PUBMED   10974570
REFERENCE   6  (bases 1 to 4821)
  AUTHORS   Zhao,L., Gregoire,F. and Sul,H.S.
  TITLE     Transient induction of ENC-1, a Kelch-related actin-binding
            protein, is required for adipocyte differentiation
  JOURNAL   J Biol Chem 275 (22), 16845-16850 (2000)
   PUBMED   10828068
REFERENCE   7  (bases 1 to 4821)
  AUTHORS   Hernandez,M.C., Andres-Barquin,P.J., Kuo,W.L. and Israel,M.A.
  TITLE     Assignment of the ectodermal-neural cortex 1 gene (ENC1) to human
            chromosome band 5q13 by in situ hybridization
  JOURNAL   Cytogenet Cell Genet 87 (1-2), 89-90 (1999)
   PUBMED   10640818
REFERENCE   8  (bases 1 to 4821)
  AUTHORS   Hernandez,M.C., Andres-Barquin,P.J., Holt,I. and Israel,M.A.
  TITLE     Cloning of human ENC-1 and evaluation of its expression and
            regulation in nervous system tumors
  JOURNAL   Exp Cell Res 242 (2), 470-477 (1998)
   PUBMED   9683534
REFERENCE   9  (bases 1 to 4821)
  AUTHORS   Kim,T.A., Lim,J., Ota,S., Raja,S., Rogers,R., Rivnay,B., Avraham,H.
            and Avraham,S.
  TITLE     NRP/B, a novel nuclear matrix protein, associates with p110(RB) and
            is involved in neuronal differentiation
  JOURNAL   J Cell Biol 141 (3), 553-566 (1998)
   PUBMED   9566959
REFERENCE   10 (bases 1 to 4821)
  AUTHORS   Polyak,K., Xia,Y., Zweier,J.L., Kinzler,K.W. and Vogelstein,B.
  TITLE     A model for p53-induced apoptosis
  JOURNAL   Nature 389 (6648), 300-305 (1997)
   PUBMED   9305847
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC026405.5 and BC000418.2.
            
            On Aug 11, 2020 this sequence version replaced NM_003633.3.
            
            Summary: This gene encodes a member of the kelch-related family of
            actin-binding proteins. The encoded protein plays a role in the
            oxidative stress response as a regulator of the transcription
            factor Nrf2, and expression of this gene may play a role in
            malignant transformation. Alternatively spliced transcript variants
            encoding multiple isoforms have been observed for this gene.
            [provided by RefSeq, Feb 2012].
            
            Transcript Variant: This variant (1) represents the most abundant
            transcript. Variants 1, 2, and 3 encode the same isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF059611.1, SRR11853564.22144.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743, SAMEA2153733
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000302351.9/ ENSP00000306356.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-34                AC026405.5         99393-99426         c
            35-2310             BC000418.2         1-2276
            2311-4821           AC026405.5         86107-88617         c
FEATURES             Location/Qualifiers
     source          1..4821
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q13.3"
     gene            1..4821
                     /gene="ENC1"
                     /gene_synonym="CCL28; ENC-1; KLHL35; KLHL37; NRPB; PIG10;
                     TP53I10"
                     /note="ectodermal-neural cortex 1"
                     /db_xref="GeneID:8507"
                     /db_xref="HGNC:HGNC:3345"
                     /db_xref="MIM:605173"
     exon            1..422
                     /gene="ENC1"
                     /gene_synonym="CCL28; ENC-1; KLHL35; KLHL37; NRPB; PIG10;
                     TP53I10"
                     /inference="alignment:Splign:2.1.0"
     exon            423..2237
                     /gene="ENC1"
                     /gene_synonym="CCL28; ENC-1; KLHL35; KLHL37; NRPB; PIG10;
                     TP53I10"
                     /inference="alignment:Splign:2.1.0"
     CDS             436..2205
                     /gene="ENC1"
                     /gene_synonym="CCL28; ENC-1; KLHL35; KLHL37; NRPB; PIG10;
                     TP53I10"
                     /note="isoform 1 is encoded by transcript variant 1;
                     nuclear restricted protein, BTB domain-like (brain); tumor
                     protein p53 inducible protein 10; kelch-like 35;
                     ectoderm-neural cortex protein 1; kelch-like protein 37;
                     p53-induced gene 10 protein; nuclear matrix protein NRP/B;
                     ectodermal-neural cortex 1 (with BTB-like domain);
                     kelch-like family member 37; ectodermal-neural cortex 1
                     (with BTB domain)"
                     /codon_start=1
                     /product="ectoderm-neural cortex protein 1 isoform 1"
                     /protein_id="NP_003624.1"
                     /db_xref="CCDS:CCDS4021.1"
                     /db_xref="GeneID:8507"
                     /db_xref="HGNC:HGNC:3345"
                     /db_xref="MIM:605173"
                     /translation="MSVSVHENRKSRASSGSINIYLFHKSSYADSVLTHLNLLRQQRL
                     FTDVLLHAGNRTFPCHRAVLAACSRYFEAMFSGGLKESQDSEVNFDNSIHPEVLELLL
                     DYAYSSRVIINEENAESLLEAGDMLEFQDIRDACAEFLEKNLHPTNCLGMLLLSDAHQ
                     CTKLYELSWRMCLSNFQTIRKNEDFLQLPQDMVVQLLSSEELETEDERLVYESAINWI
                     SYDLKKRYCYLPELLQTVRLALLPAIYLMENVAMEELITKQRKSKEIVEEAIRCKLKI
                     LQNDGVVTSLCARPRKTGHALFLLGGQTFMCDKLYLVDQKAKEIIPKADIPSPRKEFS
                     ACAIGCKVYITGGRGSENGVSKDVWVYDTLHEEWSKAAPMLVARFGHGSAELKHCLYV
                     VGGHTAATGCLPASPSVSLKQVEHYDPTINKWTMVAPLREGVSNAAVVSAKLKLFAFG
                     GTSVSHDKLPKVQCYDQCENRWTVPATCPQPWRYTAAAVLGNQIFIMGGDTEFSACSA
                     YKFNSETYQWTKVGDVTAKRMSCHAVASGNKLYVVGGYFGIQRCKTLDCYDPTLDVWN
                     SITTVPYSLIPTAFVSTWKHLPS"
     exon            2238..4821
                     /gene="ENC1"
                     /gene_synonym="CCL28; ENC-1; KLHL35; KLHL37; NRPB; PIG10;
                     TP53I10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4795..4800
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ENC1"
                     /gene_synonym="CCL28; ENC-1; KLHL35; KLHL37; NRPB; PIG10;
                     TP53I10"
                     /note="hexamer: AATAAA"
     polyA_site      4821
                     /gene="ENC1"
                     /gene_synonym="CCL28; ENC-1; KLHL35; KLHL37; NRPB; PIG10;
                     TP53I10"
                     /note="major polyA site"
ORIGIN      
        1 gcagactgct ctggcagccg gagaggaggc ggtgcggcgg tggcgctgcg gagacccggt
       61 ccagacgcct ggcggccgcc ggcacacaag gcgctttcta gctccctccc ccgagcgcac
      121 agcccgcctc cttccgcggc gcctgcagtg gcaggcttgc tctgccctac cgtgacgcgc
      181 tccggagacg ctctgcgggt cctggacacc gggtccgcgg cgtggggacg acagacggag
      241 gcgaacgcca tcggtagccg gtccgcgagc catcgttcgg ggcgcagtcc tctccccggc
      301 tggccctcct ttctccgggg cattcgccac cgcttccctg ggctgagacg accggttcgt
      361 cgcctccttg cccgtgaccg tcgctagaac tcagttgtgc gttgcggcca gtcgccactg
      421 ctgagtggaa acaaaatgtc agtcagtgtg catgagaacc gcaagtccag ggccagcagc
      481 ggctccatta acatctatct gtttcacaag tcctcctacg ctgacagcgt cctcactcac
      541 ctgaatcttt tacgccagca gcgtctcttc actgacgtcc ttctccatgc cggaaatagg
      601 accttccctt gccaccgggc agtgctggct gcatgcagtc gctactttga ggccatgttc
      661 agtggtggcc tgaaagagag ccaggacagt gaggtcaact ttgacaattc catccaccca
      721 gaagtcttgg agctgctgct tgactatgcg tactcctccc gggtcatcat caatgaagaa
      781 aatgcagaat cgctcctgga agctggtgac atgctggagt ttcaagacat ccgggatgca
      841 tgtgcagagt tcctggaaaa gaacctgcat cccaccaact gcctgggcat gctgctgctg
      901 tctgatgcac accagtgcac caagctgtac gaactatctt ggagaatgtg tctcagcaac
      961 ttccaaacca tcaggaagaa tgaagatttc ctccagctgc cccaggacat ggtagtgcaa
     1021 ctcttgtcca gtgaagagct ggagacagag gatgaaaggc ttgtgtacga gtctgcaatt
     1081 aactggatca gctatgacct gaagaagcgc tattgctacc tcccagaact gttgcagaca
     1141 gtaaggctgg cacttctgcc agccatctat ctcatggaga atgtggccat ggaggaactc
     1201 atcaccaagc agagaaagag taaggaaatt gtggaagagg ccatcaggtg caaactgaaa
     1261 atcctgcaga atgacggtgt ggtaaccagc ctctgtgccc gacctcggaa aactggccat
     1321 gccctcttcc ttctgggagg acagactttc atgtgtgaca agttgtatct ggtagaccag
     1381 aaggccaaag aaatcattcc caaggctgac attcccagcc caagaaaaga gtttagtgca
     1441 tgtgcgattg gctgcaaagt gtacattact ggggggcggg ggtctgaaaa tggggtctca
     1501 aaagatgtct gggtttatga taccctgcac gaggagtggt ccaaggctgc ccccatgctg
     1561 gtggccaggt ttggccatgg ctctgctgaa ctgaagcact gcctgtatgt ggttgggggg
     1621 cacacggccg caactggctg cctcccggcc tccccctcag tctctctaaa gcaggtagaa
     1681 cattatgacc ccacaatcaa caaatggacc atggtggccc cactccgaga aggcgttagc
     1741 aacgccgcag tagtgagtgc caaacttaag ttatttgctt tcggaggtac cagtgtcagt
     1801 catgacaagc tccccaaagt tcagtgttac gatcagtgtg aaaacaggtg gactgtaccg
     1861 gccacctgtc cccagccctg gcgttacaca gcagcagctg tgctggggaa ccagattttt
     1921 attatggggg gtgatacaga attctctgcc tgctctgctt ataaattcaa cagtgagact
     1981 taccagtgga ccaaggtggg agatgtgaca gcaaagcgca tgagctgcca tgctgtggcc
     2041 tctggaaaca aactctacgt ggttggagga tactttggca ttcagcgatg caagactttg
     2101 gactgctacg atccaacatt agacgtgtgg aacagcatca ccactgtccc gtactcgctg
     2161 attcctactg catttgtcag cacctggaaa catctgcctt cttaaatgca gtacattcta
     2221 aagagagtga gcatgagctc actccatcac tcgatgagat aatatgagat ttctacttcg
     2281 gagaggccaa gtctaatgaa gagaaaaaaa ggaaaagaag ttgcaagact cgaataaaat
     2341 ctgctgcacc ttgtaaatgc tctaactgga catgaaggaa aggggcgagg gaggggggtg
     2401 ggatttttgg tgcaagtagc acatggttta aatatgaatg aacaaacctg tgatctagtc
     2461 cttgtcttgt aattgtggat taatgtcaat gttaatcagc ccctcaaagg gagagaaaag
     2521 ctggaccttt tcccttgctg taccatattc agcatttgat ttccatgggc cccaccattt
     2581 atgtgtagaa tttgaaatgg ttgtcacctc tctctgagga cagagcttga agcctccaca
     2641 ccagctgctg ctggagattc aaagcccaac tgtgggtccg agagggaagc tggctgggct
     2701 ggctgaagaa tgaagaccac tggactctcc gttaatctct aaggggtctg ctccccagga
     2761 acgtttctga acaatgggga ctttgttggt agccatttgg tagatgttct tttctattta
     2821 taagtgactt taaactttcc cttggctgtt aagaagtttg ttatagattt agctatttat
     2881 tgttcgatgc ctgcatgctg aaacaatgcc tacagctgtc ttcacatgta tggacgtgtg
     2941 tgaatggttg tacgttttgc acattttgtg gctgttgaga tgtgctttgc tgcacaaaca
     3001 tgaaaatttt tgagttacaa tttggagcat aactggaggg tgggttgggg aggggtggat
     3061 ttttaaaatg tcaagacagg gaaggatgac aaaatggaaa tttaaatgac atcctagagg
     3121 tagagaaacc gtggagatcg cttttctcag actcaccaac ttttaatggg atttcatggg
     3181 gtttggttgt gctgataggg taaggggagg ctgctttctg cccttctccc cactcccatc
     3241 tgatttactt aattcagtct cagctgctga aatttggaaa ggaccaaatt gctttacagt
     3301 ttttttcttt gtgtagtatc ttgaaatcct ggaaaattct atggaatagt tctgtatata
     3361 gggcacaagt aaaggcattg tccaaagttt atttatttat ttattaccct aagaatgctt
     3421 tgccataacc acatttaatg ggaaaaacgg cagtatcaca gatgtaaatt aactcaccag
     3481 atttactggg cctgaactca ttctcttctt gctatatgat ttagcaagtt ctagaaggtc
     3541 tccaagacaa taattacatt ggcacaatgt atacttcagt gctcacccgt aggcaaatct
     3601 ctttttaaaa aactctttgg tgcacaagta acacatttgg ccacaaaaca ccaaagaatt
     3661 gtaggcagtg gcccctattg agaagttttc cggtagagtt ggaaatcagt tgtgaataca
     3721 ttctttgcta gttggagtgc ttgtttacta agcatgtgcc gtcgtaggta ttagtgctag
     3781 tctcagatag gtgcttcccc tgaggtgcag gggaagacca aagtttgcaa ctcgaactgc
     3841 tttcgtccat gtttctcaca ttgctgtatt ttagaaaata ggggttaaga ctgataacaa
     3901 ccttttacat tgtgactgtg tttgcattgt ctaatgacag ataaatcctt aacatttctc
     3961 tccaccttag tactttagac taattgtgtt tgtccgtcca tgccatgaat gagtgggctg
     4021 tagttgggcc taaataaatg agctgttgga agaaaagaat cacagtactt tccagcagtc
     4081 agtccctggt tcctagatgt gttctaagca atgcaaatgt ctaattgtcc cccagtgggc
     4141 atagtcagtg tcgtttatat tgtagcagtt acagctctgt agtttatgat gcaaatctgc
     4201 caagagagat gtatgtgtca ctgcatggct tctgaaagca ggatgaattt tctgcagctg
     4261 tttcaaagtt ggggtctgtt cttgaatcct ctattaatta ctgtgtgtga gccagaggga
     4321 gctgtggtaa gggttgggcc cccagcctgt agggaacttt ctggactccc actctttgaa
     4381 tcgatatagg catttggtct cactacttga ccattctcac cctgtgaaac gtcccacact
     4441 ttgaagcaaa tacaattcac agcacagtac acacaaaaac cttggcataa gacagagaag
     4501 gttcttctta ttttgtgggc tggttgctgt agaaacacat aacaaagggc agccctccac
     4561 ttctggtata attgtgtagc cccttttctt tgggcttgac acctgtcttg aataagagtg
     4621 attagagctg cataatgtcc ctctcttggc tattgaccat gtggttcacg tacaaaactc
     4681 tgtataagtt gaaggaaaat gttcatgttc atatgtactt gtttgctatg actacatttt
     4741 gaggttttgt aaaactgtta tttttttttt tttcacaatg tgaaactgaa ggtcaataaa
     4801 ttattagaga ttttctcttc a
//
