LOCUS       NM_001300942            7049 bp    mRNA    linear   PRI 10-FEB-2025
DEFINITION  Homo sapiens EMSY transcriptional repressor, BRCA2 interacting
            (EMSY), transcript variant 1, mRNA.
ACCESSION   NM_001300942 XM_005274106
VERSION     NM_001300942.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7049)
  AUTHORS   Marzio,A., Kurz,E., Sahni,J.M., Di Feo,G., Puccini,J., Jiang,S.,
            Hirsch,C.A., Arbini,A.A., Wu,W.L., Pass,H.I., Bar-Sagi,D.,
            Papagiannakopoulos,T. and Pagano,M.
  TITLE     EMSY inhibits homologous recombination repair and the interferon
            response, promoting lung cancer immune evasion
  JOURNAL   Cell 185 (1), 169-183 (2022)
   PUBMED   34963055
  REMARK    GeneRIF: EMSY inhibits homologous recombination repair and the
            interferon response, promoting lung cancer immune evasion.
REFERENCE   2  (bases 1 to 7049)
  AUTHORS   Zhang,M., Chen,G., Wang,Y., Wu,S.Q., Sandford,A.J. and He,J.Q.
  TITLE     Polymorphisms in the airway epithelium related genes CDHR3 and EMSY
            are associated with asthma susceptibility
  JOURNAL   BMC Pulm Med 20 (1), 305 (2020)
   PUBMED   33213402
  REMARK    GeneRIF: Polymorphisms in the airway epithelium related genes CDHR3
            and EMSY are associated with asthma susceptibility.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7049)
  AUTHORS   Chen,J., Chen,Q., Wu,C. and Jin,Y.
  TITLE     Genetic variants of the C11orf30-LRRC32 region are associated with
            childhood asthma in the Chinese population
  JOURNAL   Allergol Immunopathol (Madr) 48 (4), 390-394 (2020)
   PUBMED   31812328
  REMARK    GeneRIF: Genetic variants of the C11orf30-LRRC32 region are
            associated with childhood asthma in the Chinese population.
REFERENCE   4  (bases 1 to 7049)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 7049)
  AUTHORS   Elias,M.S., Wright,S.C., Remenyi,J., Abbott,J.C., Bray,S.E.,
            Cole,C., Edwards,S., Gierlinski,M., Glok,M., McGrath,J.A.,
            Nicholson,W.V., Paternoster,L., Prescott,A.R., Have,S.T.,
            Whitfield,P.D., Lamond,A.I. and Brown,S.J.
  TITLE     EMSY expression affects multiple components of the skin barrier
            with relevance to atopic dermatitis
  JOURNAL   J Allergy Clin Immunol 144 (2), 470-481 (2019)
   PUBMED   31158401
  REMARK    GeneRIF: biopsy samples from patients with AD show greater EMSY
            staining in the nucleus, which is consistent with an increased
            functional effect of this transcriptional control protein.
            Erratum:[J Allergy Clin Immunol. 2020 Feb;145(2):723. doi:
            10.1016/j.jaci.2019.11.027.. PMID: 32035608]
REFERENCE   6  (bases 1 to 7049)
  AUTHORS   Chavali,G.B., Ekblad,C.M., Basu,B.P., Brissett,N.C., Veprintsev,D.,
            Hughes-Davies,L., Kouzarides,T., Itzhaki,L.S. and Doherty,A.J.
  TITLE     Crystal structure of the ENT domain of human EMSY
  JOURNAL   J Mol Biol 350 (5), 964-973 (2005)
   PUBMED   15978617
  REMARK    GeneRIF: report the crystal structure of the ENT domain of EMSY;
            dimerisation of EMSY mediated by the ENT domain could provide
            flexibility for it to bind two or more different substrates
            simultaneously
REFERENCE   7  (bases 1 to 7049)
  AUTHORS   Benusiglio,P.R., Lesueur,F., Luccarini,C., McIntosh,J., Luben,R.N.,
            Smith,P., Dunning,A., Easton,D.F., Ponder,B.A. and Pharoah,P.D.
  TITLE     Common variation in EMSY and risk of breast and ovarian cancer: a
            case-control study using HapMap tagging SNPs
  JOURNAL   BMC Cancer 5, 81 (2005)
   PUBMED   16029503
  REMARK    GeneRIF: common genetic variation in EMSY does not appear to have a
            role in development of breast or ovarian cancer
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 7049)
  AUTHORS   Ekblad,C.M., Chavali,G.B., Basu,B.P., Freund,S.M., Veprintsev,D.,
            Hughes-Davies,L., Kouzarides,T., Doherty,A.J. and Itzhaki,L.S.
  TITLE     Binding of EMSY to HP1beta: implications for recruitment of HP1beta
            and BS69
  JOURNAL   EMBO Rep 6 (7), 675-680 (2005)
   PUBMED   15947784
  REMARK    GeneRIF: The crystal structure of residues 1-108 of EMSY at 2.0 A
            resolution is reported; the structure contains both the ENT domain
            and the HP1beta/BS69-binding motif.
REFERENCE   9  (bases 1 to 7049)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (33), 12130-12135 (2004)
   PUBMED   15302935
REFERENCE   10 (bases 1 to 7049)
  AUTHORS   Hughes-Davies,L., Huntsman,D., Ruas,M., Fuks,F., Bye,J., Chin,S.F.,
            Milner,J., Brown,L.A., Hsu,F., Gilks,B., Nielsen,T., Schulzer,M.,
            Chia,S., Ragaz,J., Cahn,A., Linger,L., Ozdag,H., Cattaneo,E.,
            Jordanova,E.S., Schuuring,E., Yu,D.S., Venkitaraman,A., Ponder,B.,
            Doherty,A., Aparicio,S., Bentley,D., Theillet,C., Ponting,C.P.,
            Caldas,C. and Kouzarides,T.
  TITLE     EMSY links the BRCA2 pathway to sporadic breast and ovarian cancer
  JOURNAL   Cell 115 (5), 523-535 (2003)
   PUBMED   14651845
  REMARK    GeneRIF: The remarkable clinical overlap between sporadic EMSY
            amplification and familial BRCA2 deletion implicates a BRCA2
            pathway in sporadic breast and ovarian cancer.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP002360.4, BC033404.1, BC143374.1, AP003165.2 and AI275430.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001300942.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: BC143374.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMEA1965299, SAMEA1968189 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000695367.1/ ENSP00000511840.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-7                 AP002360.4         160636-160642
            8-111               BC033404.1         1-104
            112-4227            BC143374.1         1-4116
            4228-6827           AP003165.2         99491-102090
            6828-6917           AI275430.1         7-96                c
            6918-7049           AP003165.2         102181-102312
FEATURES             Location/Qualifiers
     source          1..7049
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.5"
     gene            1..7049
                     /gene="EMSY"
                     /gene_synonym="C11orf30; GL002"
                     /note="EMSY transcriptional repressor, BRCA2 interacting"
                     /db_xref="GeneID:56946"
                     /db_xref="HGNC:HGNC:18071"
                     /db_xref="MIM:608574"
     exon            1..111
                     /gene="EMSY"
                     /gene_synonym="C11orf30; GL002"
                     /inference="alignment:Splign:2.1.0"
     exon            112..220
                     /gene="EMSY"
                     /gene_synonym="C11orf30; GL002"
                     /inference="alignment:Splign:2.1.0"
     CDS             151..4164
                     /gene="EMSY"
                     /gene_synonym="C11orf30; GL002"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein EMSY; BRCA2-interacting transcriptional repressor
                     EMSY; EMSY, BRCA2 interacting transcriptional repressor"
                     /codon_start=1
                     /product="BRCA2-interacting transcriptional repressor EMSY
                     isoform 1"
                     /protein_id="NP_001287871.1"
                     /db_xref="CCDS:CCDS73349.1"
                     /db_xref="GeneID:56946"
                     /db_xref="HGNC:HGNC:18071"
                     /db_xref="MIM:608574"
                     /translation="MPVVWPTLLDLSRDECKRILRKLELEAYAGVISALRAQGDLTKE
                     KKDLLGELSKVLSISTERHRAEVRRAVNDERLTTIAHKMNLSLYLGERPSYSMSGPNS
                     SSEWSIEGRRLVPLMPRLVPQTAFTVTANAVANAAIQHNASLPVPAETGSKEVVVCYS
                     YTSTTSTPTSTPVPSGSIATVKSPRPASPASNVVVLPSGSTVYVKSVSCSDEDEKPRK
                     RRRTNSSSSSPVVLKEVPKAVVPVSKTITVPVSGSPKMSNIMQSIANSLPPHMSPVKI
                     TFTKPSTQTTNTTTQKVIIVTTSPSSTFVPNILSKSHNYAAVTKLVPTSVIASTTQKP
                     PVVITASQSSLVSNSSSGSSSSTPSPIPNTVAVTAVVSSTPSVVMSTVAQGVSTSAIK
                     MASTRLPSPKSLVSAPTQILAQFPKQHQQSPKQQLYQVQQQTQQQVAQPSPVSHQQQP
                     QQSPLPPGIKPTIQIKQESGVKIITQQVQPSKILPKPVTATLPTSSNSPIMVVSSNGA
                     IMTTKLVTTPTGTQATYTRPTVSPSIGRMAATPGAATYVKTTSGSIITVVPKSLATLG
                     GKIISSNIVSGTTTKITTIPMTSKPNVIVVQKTTGKGTTIQGLPGKNVVTTLLNAGGE
                     KTIQTVPTGAKPAILTATRPITKMIVTQPKGIGSTVQPAAKIIPTKIVYGQQGKTQVL
                     IKPKPVTFQATVVSEQTRQLVTETLQQASRVAEAGNSSIQEGKEEPQNYTDSSSSSTE
                     SSQSSQDSQPVVHVIASRRQDWSEHEIAMETSPTIIYQDVSSESQSATSTIKALLELQ
                     QTTVKEKLESKPRQPTIDLSQMAVPIQMTQEKRHSPESPSIAVVESELVAEYITTERT
                     DEGTEVAFPLLVSHRSQPQQPSQPQRTLLQHVAQSQTATQTSVVVKSIPASSPGAITH
                     IMQQALSSHTAFTKHSEELGTEEGEVEEMDTLDPQTGLFYRSALTQSQSAKQQKLSQP
                     PLEQTQLQVKTLQCFQTKQKQTIHLQADQLQHKLPQMPQLSIRHQKLTPLQQEQAQPK
                     PDVQHTQHPMVAKDRQLPTLMAQPPQTVVQVLAVKTTQQLPKLQQAPNQPKIYVQPQT
                     PQSQMSLPASSEKQTASQVEQPIITQGSSVTKITFEGRQPPTVTKITGGSSVPKLTSP
                     VTSISPIQASEKTAVSDILKMSLMEAQIDTNVEHMIVDPPKKALATSMLTGEAGSLPS
                     THMVVAGMANSTPQQQKCRESCSSPSTVGSSLTTRKIDPPAVPATGQFMRIQNVGQKK
                     AEESPAEIIIQAIPQYAIPCHSSSNVVVEPSGLLELNNFTSQQLDDEETAMEQDIDSS
                     TEDGTEPSPSQSSAERS"
     exon            221..320
                     /gene="EMSY"
                     /gene_synonym="C11orf30; GL002"
                     /inference="alignment:Splign:2.1.0"
     exon            321..395
                     /gene="EMSY"
                     /gene_synonym="C11orf30; GL002"
                     /inference="alignment:Splign:2.1.0"
     exon            396..437
                     /gene="EMSY"
                     /gene_synonym="C11orf30; GL002"
                     /inference="alignment:Splign:2.1.0"
     exon            438..613
                     /gene="EMSY"
                     /gene_synonym="C11orf30; GL002"
                     /inference="alignment:Splign:2.1.0"
     exon            614..766
                     /gene="EMSY"
                     /gene_synonym="C11orf30; GL002"
                     /inference="alignment:Splign:2.1.0"
     exon            767..1026
                     /gene="EMSY"
                     /gene_synonym="C11orf30; GL002"
                     /inference="alignment:Splign:2.1.0"
     exon            1027..1303
                     /gene="EMSY"
                     /gene_synonym="C11orf30; GL002"
                     /inference="alignment:Splign:2.1.0"
     exon            1304..1558
                     /gene="EMSY"
                     /gene_synonym="C11orf30; GL002"
                     /inference="alignment:Splign:2.1.0"
     exon            1559..1708
                     /gene="EMSY"
                     /gene_synonym="C11orf30; GL002"
                     /inference="alignment:Splign:2.1.0"
     exon            1709..1879
                     /gene="EMSY"
                     /gene_synonym="C11orf30; GL002"
                     /inference="alignment:Splign:2.1.0"
     exon            1880..2016
                     /gene="EMSY"
                     /gene_synonym="C11orf30; GL002"
                     /inference="alignment:Splign:2.1.0"
     exon            2017..2190
                     /gene="EMSY"
                     /gene_synonym="C11orf30; GL002"
                     /inference="alignment:Splign:2.1.0"
     exon            2191..2389
                     /gene="EMSY"
                     /gene_synonym="C11orf30; GL002"
                     /inference="alignment:Splign:2.1.0"
     exon            2390..2554
                     /gene="EMSY"
                     /gene_synonym="C11orf30; GL002"
                     /inference="alignment:Splign:2.1.0"
     exon            2555..2710
                     /gene="EMSY"
                     /gene_synonym="C11orf30; GL002"
                     /inference="alignment:Splign:2.1.0"
     exon            2711..2752
                     /gene="EMSY"
                     /gene_synonym="C11orf30; GL002"
                     /inference="alignment:Splign:2.1.0"
     exon            2753..2904
                     /gene="EMSY"
                     /gene_synonym="C11orf30; GL002"
                     /inference="alignment:Splign:2.1.0"
     exon            2905..3468
                     /gene="EMSY"
                     /gene_synonym="C11orf30; GL002"
                     /inference="alignment:Splign:2.1.0"
     exon            3469..3969
                     /gene="EMSY"
                     /gene_synonym="C11orf30; GL002"
                     /inference="alignment:Splign:2.1.0"
     exon            3970..7049
                     /gene="EMSY"
                     /gene_synonym="C11orf30; GL002"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5541..5546
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EMSY"
                     /gene_synonym="C11orf30; GL002"
                     /note="hexamer: AATAAA"
     polyA_site      5576
                     /gene="EMSY"
                     /gene_synonym="C11orf30; GL002"
                     /note="major polyA site"
     regulatory      5975..5980
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EMSY"
                     /gene_synonym="C11orf30; GL002"
                     /note="hexamer: AATAAA"
     polyA_site      5995
                     /gene="EMSY"
                     /gene_synonym="C11orf30; GL002"
                     /note="major polyA site"
     regulatory      6066..6071
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EMSY"
                     /gene_synonym="C11orf30; GL002"
                     /note="hexamer: AATAAA"
     polyA_site      6085
                     /gene="EMSY"
                     /gene_synonym="C11orf30; GL002"
     regulatory      6899..6904
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EMSY"
                     /gene_synonym="C11orf30; GL002"
                     /note="hexamer: TATAAA"
     polyA_site      6919
                     /gene="EMSY"
                     /gene_synonym="C11orf30; GL002"
     regulatory      7024..7029
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EMSY"
                     /gene_synonym="C11orf30; GL002"
                     /note="hexamer: AATATA"
     polyA_site      7049
                     /gene="EMSY"
                     /gene_synonym="C11orf30; GL002"
ORIGIN      
        1 gttacctgtc gccatcttgc cccttcagag gcaccgcaaa caaacccaat tcctggtgtc
       61 ccctagtctt ggcggaggag ccttttagat gagccccgaa aggccgggca gggaggacaa
      121 gctctttggg gctaccaaac agaagcagca atgcctgttg tgtggccaac ccttctggat
      181 ctcagcaggg atgaatgcaa aagaattctt cgaaaattgg aattggaggc atatgctgga
      241 gttatcagtg cacttcgggc acagggggat ctcaccaagg aaaagaaaga tcttcttgga
      301 gaactatcaa aagttcttag catctcaaca gaacgccacc gtgctgaagt tcggagagca
      361 gtaaacgatg aacggttaac aacaattgca cataaaatga atttatcctt atatttgggt
      421 gaaagaccaa gttacagtat gtctggacct aatagctctt cagaatggtc cattgaaggt
      481 cgtcgattgg taccactgat gccccggctc gttccccaaa ccgcctttac tgtaacagct
      541 aatgctgttg ctaatgcagc tatccagcat aatgcatctc ttccagtgcc tgcagaaaca
      601 ggaagcaagg aagtagtggt ttgctattcc tacacaagta ccacgtcaac cccaacctct
      661 acccctgttc caagtggcag catagcaacg gttaagtctc caagacctgc cagtcctgcc
      721 tccaatgtag ttgtcttgcc aagtggaagt actgtttatg tcaaaagtgt aagctgttca
      781 gatgaagatg aaaaacccag aaaacgaagg cgaacaaact cttccagctc ctctcctgtt
      841 gttctaaagg aagttccaaa ggccgttgtt ccagtctcaa agacgatcac tgtgcctgtg
      901 agtggtagtc ccaagatgag caacatcatg cagagcattg ccaactcctt accaccccac
      961 atgtctcctg taaaaataac cttcactaaa ccatcaacac agacaacaaa cacaacaaca
     1021 cagaaggtta ttatagtcac cacatcacca agctcaacct tcgtgcccaa cattctctcc
     1081 aaatcccata actatgcagc agtcactaag cttgtaccaa cgtcagtcat tgcttctaca
     1141 acccagaagc caccagttgt tataactgct tcacagtcct ctctggtcag taatagcagc
     1201 agtggcagca gcagttctac accatcacct attcctaata cagttgcagt aacagctgtg
     1261 gtgtcctcta caccatctgt ggtcatgtca acagtagcac aaggtgtatc tacatcagca
     1321 atcaaaatgg catcaaccag acttccttcc cccaaaagct tagtgagtgc cccaactcag
     1381 attcttgcac agttccctaa acaacatcaa cagtctccta agcagcagtt atatcaagtg
     1441 caacagcaga cacagcaaca agtggcccag ccttctccag tatctcatca gcaacagcct
     1501 cagcagtctc ctttgccacc tggtattaaa cctaccatcc aaatcaaaca ggagtcaggt
     1561 gttaaaatca tcacacaaca ggttcaacca agtaaaatct tacccaaacc agtgacagca
     1621 actctaccca ccagtagcaa ttcccctatt atggtggtta gcagtaatgg tgcaattatg
     1681 acaactaaac tggtaaccac tcctactggc acacaagcaa cctatacccg gccaacagtg
     1741 agcccatcca ttggtcggat ggctgcaacc cctggagctg caacctatgt gaaaactacg
     1801 agtggtagca tcattacagt agtacccaaa tcattagcta ccttgggggg caagataatt
     1861 agcagtaata tagtttctgg aacgactacc aaaatcacta caatcccaat gacttccaag
     1921 cccaacgtga ttgttgtaca aaagactaca ggaaaaggaa cgaccattca aggcctcccg
     1981 ggcaaaaatg ttgtcacaac gttgctaaat gctggaggag aaaagactat tcagacagtg
     2041 ccaacaggag caaagccagc tatccttact gctacaagac ccatcaccaa aatgattgta
     2101 acgcagccaa aaggaatagg ttctacagtt caaccagcag ctaaaatcat cccaacaaaa
     2161 attgtttatg ggcagcaagg gaaaacgcag gttcttatta aacccaaacc agtgactttt
     2221 caagcgacag ttgttagtga acaaacaaga cagctagtaa cagaaacatt acagcaagca
     2281 tccagggtag cagaggctgg taattcatct attcaggaag gaaaagaaga accacagaat
     2341 tatacagata gtagttcctc ttctacagag tcctcccaga gttcccaaga ttcccagcct
     2401 gtagttcatg taattgcttc ccggcgtcag gattggtcag aacatgagat tgcaatggag
     2461 actagcccta ccataattta tcaggatgta tccagtgaat cacaatcagc tacttcaaca
     2521 atcaaagctc tgttagaact ccaacagaca acagtaaagg aaaaattgga atctaaacca
     2581 agacaaccca ctattgacct gagtcaaatg gcagtgccta ttcagatgac ccaggaaaag
     2641 agacattctc ctgagagtcc atcaattgct gtggtagagt cagaactagt agctgaatac
     2701 atcactactg aacgcactga tgaggggaca gaggttgctt ttccccttct agtcagccat
     2761 cgctcccagc cccaacagcc ttcccagccc cagcggaccc tgctccagca tgtggctcag
     2821 tcacagaccg caacacagac ttcggtggtg gtgaagtcca tcccagcatc ttcccctgga
     2881 gcaatcaccc acattatgca gcaggcatta agcagtcaca ctgcttttac caaacacagc
     2941 gaggaacttg gaactgagga gggcgaggtt gaagagatgg acactttaga ccctcagaca
     3001 ggtctgtttt accgatctgc cctgactcag tcacagtcag ctaaacagca gaaacttagc
     3061 cagcccccgc tggaacagac tcagctgcaa gtgaaaactc tgcagtgctt ccagactaaa
     3121 cagaagcaga ccatccacct gcaggcagac cagctccagc acaaactccc gcaaatgccc
     3181 cagctttcca tcaggcatca aaaactcacc cctctccagc aagaacaagc acagcccaag
     3241 ccagatgtac agcacacaca gcatcccatg gtggccaaag acaggcagct tcctacctta
     3301 atggcacagc ccccgcaaac tgtagtacag gtgcttgcag tgaaaaccac gcagcagctc
     3361 cctaaactgc agcaggctcc gaaccaacca aaaatctacg tgcaacccca aaccccccag
     3421 agccaaatgt cgctcccagc ttcttcagag aaacagacgg caagccaggt ggagcagcca
     3481 attataaccc aaggatcctc tgttacaaag ataacttttg aggggcgcca gcctcccaca
     3541 gttacaaaga taactggtgg cagttctgtg cctaagctga catcaccagt tacaagcata
     3601 tctcccattc aggcctctga gaagacagca gtgtctgaca ttttgaaaat gtctttgatg
     3661 gaagctcaga ttgatacaaa tgtagaacat atgatagtgg atcccccaaa gaaggctctt
     3721 gccactagca tgctcactgg tgaagcagga tcattaccct ccacccacat ggtggtggca
     3781 gggatggcga attccactcc ccagcaacag aaatgtagag agtcctgttc gagtccatcc
     3841 actgttggct cttccctaac gacaaggaaa attgatccac cagcagtgcc tgcgacaggc
     3901 cagttcatgc gtattcagaa tgtaggccaa aagaaagctg aagagagtcc agcagaaatt
     3961 atcatccagg ctattcctca gtatgctatt ccttgtcact ccagctccaa tgtggtggtg
     4021 gagcccagtg ggcttcttga gctaaacaac ttcactagtc aacagctgga tgatgaggag
     4081 acagcaatgg agcaggacat agacagtagc acggaggatg gaactgaacc cagcccttct
     4141 cagagctctg ctgaacggtc ctagtgtttg gacacaatag tgcactttaa aacctgcttg
     4201 gttaccaagt gtccagggaa acccttgtat tttgatgact aaaaagagca ctttgcccgt
     4261 acttaggctg tggaccctaa aacagcagtg tttcaacaag atgttgctgc aggagcagct
     4321 ttttaaaaca agataaaact cacaggggaa tgtacttttt taaaaaaaaa tgaaaaagaa
     4381 aaaaaaagct gcacatttac agtgacttaa gacctggtct tctttctctg ttggatcatg
     4441 gccggtgaaa cagttttgtc ttgcagtgga aagagacttc ctgtgaatgt ttctcaactg
     4501 gtttctactg agcaaaatac catctaaaag gagaatgtga atagttgtat tttgaaatga
     4561 tgtgtcagga aaagtttttt aaaaacttgt atgtttttgc aaatccctgg aagtgttgaa
     4621 ttggttaaaa ttttacattt tctcagttca taattagttt ataaacacct agaataatac
     4681 tggcattaaa gaatccttgt tggatggtag aaatcagatc cctaaccagt gggaggtact
     4741 ttttgggtgg cttgtgcatt cttatcagtt gtgtgctaat ttattgtatt gttcctttgt
     4801 gctctaagca gcacacttgc cttctattta tttaagtgta aacatttcaa agcaggccgt
     4861 actccttctg acaaatttct tgtaaaccag gattgcctac gctttccact gtcgtcgtct
     4921 ccccactttc cctcttcctt taagaaaact tactaaaaaa tgtttcattg cgaagcagag
     4981 gaaaagaaac gttttcagac ctaaaggaaa tgtttggtca tgttaagaaa acaaattatt
     5041 cattcatatg atgctttctt aacgttgaaa ttgcacattc acattggact gagactttga
     5101 aaataacttt tacatacttt tgtttaagcc cctttgaaat gtataaaaag ttcatttaca
     5161 gttctaaatg taatgttttt aagccttcta tctttttagg acacagtttg tttaagcaat
     5221 atgttttggt cttgtgatca ctgtctgtca caagtagagt gaaaggggta agggggtggg
     5281 agggtaagag ttttgacaag ttgtggcaaa ggaaactata cttttcattt ttaaaaatgt
     5341 aaatagaaaa gtttttaacg gttttatata gatttcacta taaataagca ttttaagact
     5401 gacaaatgtt gaactgtaca tacatttatc agcataactg cccagttttt ttggtgctga
     5461 agtactgtaa gtagaattca tcaacggtct cctaattttt gcatctacat ctggggggaa
     5521 aaagctgtga tactatagtt aataaattcc cactagagtg acactgaaga tttaaacaca
     5581 agcattcata agatgcgctg atctctggtg gttgtcacta gttctgctag gtgataatga
     5641 tttacccata gatggagctg ttggatatta ttttattgta caaattcatg tttaaaaaac
     5701 tttgtgactg tttctagtta agtaattttt taacctttct tgggtcatag acttctttgg
     5761 taaactatga actctcacca aaaagataca catgcaacat gttaaataca tgttagactt
     5821 tgcatacaat tttaggggct catgggcctc taagcctatc catgtattcc aggttaagcc
     5881 ctctgttatg atcaatccat tacttacaga ttaagttttt ataaaataaa gtatctttta
     5941 aatattcatg gatcaagtaa caagagcaaa cttgaataaa gttatgttct acatattttg
     6001 gcagcatagc atacctgtgt cccttgagaa tttagccttc atatgtttct gcaattggaa
     6061 tggcaaataa aagtgctatc atctacattt ttttaaagaa ttacaaatat taagaaatta
     6121 tcaagtgaaa tttaaaattt ttcttttaaa ggtgttaatt ccaaatagag catgcattca
     6181 tttatttatt caacaaatat taattgagca tcttctgtat gacaagtagt attctgtgca
     6241 ctggggatac catagtgaac aaacaggaaa tcctatcctt atgaagttta taaacagggc
     6301 ttcctgctca tgaaatggat acaaggaatg aagacaggag aaaataagaa caatacttag
     6361 gtttttttat aaagtggata gatgatgatg ccatatatgg attttcagac atccctttac
     6421 tgaaagtctt agcattatat ctattagtat tccacattta agtacataat ttaaaagtaa
     6481 tttaaagtca tctctttgaa ggatattaac aaattacaat gcaaatgcta cagaattttt
     6541 agaatcctaa caactattag gcagtgataa gaaaaatcca tttggcttaa agtaaacttt
     6601 aataagtgcc tagtattgca gatgcagttt atggtgaact tagaggatta aaaaccaaag
     6661 ggggcttcat tgagatattc acatgccata aactctccca tttaaagtat accgtttaat
     6721 ggttttagta tatccacaga gttgggcaag ccattaccac aatcaatttg agaacatttt
     6781 cattaatcac aaaagaaatc ctgaaatgaa accaccacca ccatcgctcc agccctgggt
     6841 ggccactcct ctactttctg cctcttatgg atgtgccata agaaatgtgg acatttcata
     6901 taaatgagat tatataatat gtggtctttt gtgacttctt tcacttagcg tattttcaag
     6961 gttcatccgt gttgtagaat gtgtcagtac tacatttctt tttatggcca ttccattgtg
     7021 tgaaatatat cacattttgt ttacccgtt
//
