LOCUS       NM_001425                649 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens epithelial membrane protein 3 (MAM blood group)
            (EMP3), transcript variant 1, mRNA.
ACCESSION   NM_001425
VERSION     NM_001425.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 649)
  AUTHORS   Li,L., Xia,S., Zhao,Z., Deng,L., Wang,H., Yang,D., Hu,Y., Ji,J.,
            Huang,D. and Xin,T.
  TITLE     EMP3 as a prognostic biomarker correlates with EMT in GBM
  JOURNAL   BMC Cancer 24 (1), 89 (2024)
   PUBMED   38229014
  REMARK    GeneRIF: EMP3 as a prognostic biomarker correlates with EMT in GBM.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 649)
  AUTHORS   Martija,A.A., Krauss,A., Bachle,N., Doth,L., Christians,A.,
            Krunic,D., Schneider,M., Helm,D., Will,R., Hartmann,C.,
            Herold-Mende,C., von Deimling,A. and Pusch,S.
  TITLE     EMP3 sustains oncogenic EGFR/CDK2 signaling by restricting receptor
            degradation in glioblastoma
  JOURNAL   Acta Neuropathol Commun 11 (1), 177 (2023)
   PUBMED   37936247
  REMARK    GeneRIF: EMP3 sustains oncogenic EGFR/CDK2 signaling by restricting
            receptor degradation in glioblastoma.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 649)
  AUTHORS   Ilsley,M.D., Storry,J.R. and Olsson,M.L.
  TITLE     Yes, MAM: how the cancer-related EMP3 protein became a regulator of
            erythropoiesis and the key protein underlying a new blood group
            system
  JOURNAL   Immunohematology 38 (4), 130-136 (2022)
   PUBMED   36789459
  REMARK    GeneRIF: Yes, MAM: how the cancer-related EMP3 protein became a
            regulator of erythropoiesis and the key protein underlying a new
            blood group system.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 649)
  AUTHORS   Kim,E.K. and Koo,J.S.
  TITLE     Expression of epithelial membrane protein (EMP) 1, EMP 2, and EMP 3
            in thyroid cancer
  JOURNAL   Histol Histopathol 37 (1), 51-61 (2022)
   PUBMED   34617578
  REMARK    GeneRIF: Expression of epithelial membrane protein (EMP) 1, EMP 2,
            and EMP 3 in thyroid cancer.
REFERENCE   5  (bases 1 to 649)
  AUTHORS   Lv,Q., Xiao,W., Xiong,Z., Shi,J., Miao,D., Meng,X., Yuan,H.,
            Yang,H. and Zhang,X.
  TITLE     Identification of candidate biomarker EMP3 and its prognostic
            potential in clear cell renal cell carcinoma
  JOURNAL   Front Biosci (Landmark Ed) 26 (11), 1176-1190 (2021)
   PUBMED   34856762
  REMARK    GeneRIF: Identification of candidate biomarker EMP3 and its
            prognostic potential in clear cell renal cell carcinoma.
REFERENCE   6  (bases 1 to 649)
  AUTHORS   Liehr,T., Kuhlenbaumer,G., Wulf,P., Taylor,V., Suter,U., Van
            Broeckhoven,C., Lupski,J.R., Claussen,U. and Rautenstrauss,B.
  TITLE     Regional localization of the human epithelial membrane protein
            genes 1, 2, and 3 (EMP1, EMP2, EMP3) to 12p12.3, 16p13.2, and
            19q13.3
  JOURNAL   Genomics 58 (1), 106-108 (1999)
   PUBMED   10331954
REFERENCE   7  (bases 1 to 649)
  AUTHORS   Bolin,L.M., McNeil,T., Lucian,L.A., DeVaux,B., Franz-Bacon,K.,
            Gorman,D.M., Zurawski,S., Murray,R. and McClanahan,T.K.
  TITLE     HNMP-1: a novel hematopoietic and neural membrane protein
            differentially regulated in neural development and injury
  JOURNAL   J Neurosci 17 (14), 5493-5502 (1997)
   PUBMED   9204931
REFERENCE   8  (bases 1 to 649)
  AUTHORS   Ben-Porath,I. and Benvenisty,N.
  TITLE     Characterization of a tumor-associated gene, a member of a novel
            family of genes encoding membrane glycoproteins
  JOURNAL   Gene 183 (1-2), 69-75 (1996)
   PUBMED   8996089
REFERENCE   9  (bases 1 to 649)
  AUTHORS   Taylor,V. and Suter,U.
  TITLE     Epithelial membrane protein-2 and epithelial membrane protein-3:
            two novel members of the peripheral myelin protein 22 gene family
  JOURNAL   Gene 175 (1-2), 115-120 (1996)
   PUBMED   8917086
REFERENCE   10 (bases 1 to 649)
  AUTHORS   Lobsiger,C.S., Magyar,J.P., Taylor,V., Wulf,P., Welcher,A.A.,
            Program,A.E. and Suter,U.
  TITLE     Identification and characterization of a cDNA and the structural
            gene encoding the mouse epithelial membrane protein-1
  JOURNAL   Genomics 36 (3), 379-387 (1996)
   PUBMED   8884260
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL541088.3 and BC009718.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001425.2.
            
            Summary: The protein encoded by this gene belongs to the
            PMP-22/EMP/MP20 family of proteins. The protein contains four
            transmembrane domains and two N-linked glycosylation sites. It is
            thought to be involved in cell proliferation, cell-cell
            interactions and function as a tumor suppressor. Alternative
            splicing results in multiple transcript variants. [provided by
            RefSeq, Sep 2015].
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163658.570470.1, BQ017062.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000270221.11/ ENSP00000270221.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-568               AL541088.3         181-748
            569-649             BC009718.1         556-636
FEATURES             Location/Qualifiers
     source          1..649
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.33"
     gene            1..649
                     /gene="EMP3"
                     /gene_synonym="YMP"
                     /note="epithelial membrane protein 3 (MAM blood group)"
                     /db_xref="GeneID:2014"
                     /db_xref="HGNC:HGNC:3335"
                     /db_xref="MIM:602335"
     exon            1..59
                     /gene="EMP3"
                     /gene_synonym="YMP"
                     /inference="alignment:Splign:2.1.0"
     exon            60..152
                     /gene="EMP3"
                     /gene_synonym="YMP"
                     /inference="alignment:Splign:2.1.0"
     CDS             75..566
                     /gene="EMP3"
                     /gene_synonym="YMP"
                     /note="EMP-3; HNMP-1; hematopoietic neural membrane
                     protein 1"
                     /codon_start=1
                     /product="epithelial membrane protein 3"
                     /protein_id="NP_001416.1"
                     /db_xref="CCDS:CCDS12715.1"
                     /db_xref="GeneID:2014"
                     /db_xref="HGNC:HGNC:3335"
                     /db_xref="MIM:602335"
                     /translation="MSLLLLVVSALHILILILLFVATLDKSWWTLPGKESLNLWYDCT
                     WNNDTKTWACSNVSENGWLKAVQVLMVLSLILCCLSFILFMFQLYTMRRGGLFYATGL
                     CQLCTSVAVFTGALIYAIHAEEILEKHPRGGSFGYCFALAWVAFPLALVSGIIYIHLR
                     KRE"
     exon            153..255
                     /gene="EMP3"
                     /gene_synonym="YMP"
                     /inference="alignment:Splign:2.1.0"
     exon            256..396
                     /gene="EMP3"
                     /gene_synonym="YMP"
                     /inference="alignment:Splign:2.1.0"
     exon            397..649
                     /gene="EMP3"
                     /gene_synonym="YMP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      631..636
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EMP3"
                     /gene_synonym="YMP"
                     /note="hexamer: AATAAA"
     polyA_site      649
                     /gene="EMP3"
                     /gene_synonym="YMP"
                     /note="major polyA site"
ORIGIN      
        1 ggaggcccga gcgagggaca agactccgac tccagctctg acttttttcg cggctctcgg
       61 cttccactgc agccatgtca ctcctcttgc tggtggtctc agcccttcac atcctcattc
      121 ttatactgct tttcgtggcc actttggaca agtcctggtg gactctccct gggaaagagt
      181 ccctgaatct ctggtacgac tgcacgtgga acaacgacac caaaacatgg gcctgcagta
      241 atgtcagcga gaatggctgg ctgaaggcgg tgcaggtcct catggtgctc tccctcattc
      301 tctgctgtct ctccttcatc ctgttcatgt tccagctcta caccatgcga cgaggaggtc
      361 tcttctatgc caccggcctc tgccagcttt gcaccagcgt ggcggtgttt actggcgcct
      421 tgatctatgc cattcacgcc gaggagatcc tggagaagca cccgcgaggg ggcagcttcg
      481 gatactgctt cgccctggcc tgggtggcct tccccctcgc cctggtcagc ggcatcatct
      541 acatccacct acggaagcgg gagtgagcgc cccgcctcgc tcggctgccc ccgccccttc
      601 ccggcccccc tcgccgcgcg tcctccaaaa aataaaacct taaccgcgg
//
