LOCUS       NM_001423               5913 bp    mRNA    linear   PRI 27-APR-2025
DEFINITION  Homo sapiens epithelial membrane protein 1 (EMP1), mRNA.
ACCESSION   NM_001423
VERSION     NM_001423.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5913)
  AUTHORS   Zhang,J., Yang,J., Li,X., Mao,L., Zhang,Y., Liu,Y. and Bao,Y.
  TITLE     EMP1 correlated with cancer progression and immune characteristics
            in pan-cancer and ovarian cancer
  JOURNAL   Mol Genet Genomics 299 (1), 51 (2024)
   PUBMED   38743077
  REMARK    GeneRIF: EMP1 correlated with cancer progression and immune
            characteristics in pan-cancer and ovarian cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5913)
  AUTHORS   Zhou,T., Chen,H., Wang,Y., Wen,S., Dao,P. and Chen,M.
  TITLE     Key Molecules in Bladder Cancer Affect Patient Prognosis and
            Immunotherapy Efficacy: Further Exploration for CNTN1 and EMP1
  JOURNAL   JCO Precis Oncol 7, e2200630 (2023)
   PUBMED   37437228
  REMARK    GeneRIF: Key Molecules in Bladder Cancer Affect Patient Prognosis
            and Immunotherapy Efficacy: Further Exploration for CNTN1 and EMP1.
REFERENCE   3  (bases 1 to 5913)
  AUTHORS   Zeng,Q., Yi,C., Lu,J., Wang,X., Chen,K. and Hong,L.
  TITLE     Identification of EMP1 as a critical gene for cisplatin resistance
            in ovarian cancer by using integrated bioinformatics analysis
  JOURNAL   Cancer Med 12 (7), 9024-9040 (2023)
   PUBMED   36708070
  REMARK    GeneRIF: Identification of EMP1 as a critical gene for cisplatin
            resistance in ovarian cancer by using integrated bioinformatics
            analysis.
REFERENCE   4  (bases 1 to 5913)
  AUTHORS   Liu,S., Shi,J., Wang,L., Huang,Y., Zhao,B., Ding,H., Liu,Y.,
            Wang,W., Chen,Z. and Yang,J.
  TITLE     Loss of EMP1 promotes the metastasis of human bladder cancer cells
            by promoting migration and conferring resistance to ferroptosis
            through activation of PPAR gamma signaling
  JOURNAL   Free Radic Biol Med 189, 42-57 (2022)
   PUBMED   35850179
  REMARK    GeneRIF: Loss of EMP1 promotes the metastasis of human bladder
            cancer cells by promoting migration and conferring resistance to
            ferroptosis through activation of PPAR gamma signaling.
REFERENCE   5  (bases 1 to 5913)
  AUTHORS   Wang,Y., Zhang,L., Yao,C., Ma,Y. and Liu,Y.
  TITLE     Epithelial Membrane Protein 1 Promotes Sensitivity to RSL3-Induced
            Ferroptosis and Intensifies Gefitinib Resistance in Head and Neck
            Cancer
  JOURNAL   Oxid Med Cell Longev 2022, 4750671 (2022)
   PUBMED   35432717
  REMARK    GeneRIF: Epithelial Membrane Protein 1 Promotes Sensitivity to
            RSL3-Induced Ferroptosis and Intensifies Gefitinib Resistance in
            Head and Neck Cancer.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5913)
  AUTHORS   Chen,Y., Medvedev,A., Ruzanov,P., Marvin,K.W. and Jetten,A.M.
  TITLE     cDNA cloning, genomic structure, and chromosome mapping of the
            human epithelial membrane protein CL-20 gene (EMP1), a member of
            the PMP22 family
  JOURNAL   Genomics 41 (1), 40-48 (1997)
   PUBMED   9126480
REFERENCE   7  (bases 1 to 5913)
  AUTHORS   Ben-Porath,I. and Benvenisty,N.
  TITLE     Characterization of a tumor-associated gene, a member of a novel
            family of genes encoding membrane glycoproteins
  JOURNAL   Gene 183 (1-2), 69-75 (1996)
   PUBMED   8996089
REFERENCE   8  (bases 1 to 5913)
  AUTHORS   Lobsiger,C.S., Magyar,J.P., Taylor,V., Wulf,P., Welcher,A.A.,
            Program,A.E. and Suter,U.
  TITLE     Identification and characterization of a cDNA and the structural
            gene encoding the mouse epithelial membrane protein-1
  JOURNAL   Genomics 36 (3), 379-387 (1996)
   PUBMED   8884260
REFERENCE   9  (bases 1 to 5913)
  AUTHORS   Ruegg,C.L., Wu,H.Y., Fagnoni,F.F., Engleman,E.G. and Laus,R.
  TITLE     B4B, a novel growth-arrest gene, is expressed by a subset of
            progenitor/pre-B lymphocytes negative for cytoplasmic mu-chain
  JOURNAL   J Immunol 157 (1), 72-80 (1996)
   PUBMED   8683158
REFERENCE   10 (bases 1 to 5913)
  AUTHORS   Marvin,K.W., Fujimoto,W. and Jetten,A.M.
  TITLE     Identification and characterization of a novel squamous
            cell-associated gene related to PMP22
  JOURNAL   J Biol Chem 270 (48), 28910-28916 (1995)
   PUBMED   7499420
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            U77085.1, BC047300.1 and AC022276.35.
            
            On Nov 23, 2018 this sequence version replaced NM_001423.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DA008831.1, Y07909.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000256951.10/ ENSP00000256951.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2742              U77085.1           28-2769
            2743-2746           BC047300.1         2726-2729
            2747-5913           AC022276.35        7770-10936
FEATURES             Location/Qualifiers
     source          1..5913
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p13.1"
     gene            1..5913
                     /gene="EMP1"
                     /gene_synonym="CL-20; EMP-1; TMP"
                     /note="epithelial membrane protein 1"
                     /db_xref="GeneID:2012"
                     /db_xref="HGNC:HGNC:3333"
                     /db_xref="MIM:602333"
     exon            1..147
                     /gene="EMP1"
                     /gene_synonym="CL-20; EMP-1; TMP"
                     /inference="alignment:Splign:2.1.0"
     exon            148..267
                     /gene="EMP1"
                     /gene_synonym="CL-20; EMP-1; TMP"
                     /inference="alignment:Splign:2.1.0"
     CDS             190..663
                     /gene="EMP1"
                     /gene_synonym="CL-20; EMP-1; TMP"
                     /note="tumor-associated membrane protein"
                     /codon_start=1
                     /product="epithelial membrane protein 1"
                     /protein_id="NP_001414.1"
                     /db_xref="CCDS:CCDS8660.1"
                     /db_xref="GeneID:2012"
                     /db_xref="HGNC:HGNC:3333"
                     /db_xref="MIM:602333"
                     /translation="MLVLLAGIFVVHIATVIMLFVSTIANVWLVSNTVDASVGLWKNC
                     TNISCSDSLSYASEDALKTVQAFMILSIIFCVIALLVFVFQLFTMEKGNRFFLSGATT
                     LVCWLCILVGVSIYTSHYANRDGTQYHHGYSYILGWICFCFSFIIGVLYLVLRKK"
     exon            268..364
                     /gene="EMP1"
                     /gene_synonym="CL-20; EMP-1; TMP"
                     /inference="alignment:Splign:2.1.0"
     exon            365..505
                     /gene="EMP1"
                     /gene_synonym="CL-20; EMP-1; TMP"
                     /inference="alignment:Splign:2.1.0"
     exon            506..5913
                     /gene="EMP1"
                     /gene_synonym="CL-20; EMP-1; TMP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2720..2725
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EMP1"
                     /gene_synonym="CL-20; EMP-1; TMP"
                     /note="hexamer: TATAAA"
     polyA_site      2746
                     /gene="EMP1"
                     /gene_synonym="CL-20; EMP-1; TMP"
                     /note="major polyA site"
     regulatory      3797..3802
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EMP1"
                     /gene_synonym="CL-20; EMP-1; TMP"
                     /note="hexamer: AATAAA"
     regulatory      3803..3808
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EMP1"
                     /gene_synonym="CL-20; EMP-1; TMP"
                     /note="hexamer: AATATA"
     polyA_site      3818
                     /gene="EMP1"
                     /gene_synonym="CL-20; EMP-1; TMP"
                     /note="major polyA site"
     polyA_site      3822
                     /gene="EMP1"
                     /gene_synonym="CL-20; EMP-1; TMP"
     regulatory      5892..5897
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EMP1"
                     /gene_synonym="CL-20; EMP-1; TMP"
                     /note="hexamer: ATTAAA"
     polyA_site      5913
                     /gene="EMP1"
                     /gene_synonym="CL-20; EMP-1; TMP"
ORIGIN      
        1 acacacccca gtacaccagc agaggaaact tataacctcg ggaggcaggt ccttcccctc
       61 agtgcggtca catacttcca gaagagcgga ccagggctgc tgccagcacc tgccactcag
      121 agcgcctctg tcgctgggac ccttcagaac tctctttgct cacaagttac caaaaaaaaa
      181 agagccaaca tgttggtatt gctggctggt atctttgtgg tccacatcgc tactgttatt
      241 atgctatttg ttagcaccat tgccaatgtc tggttggttt ccaatacggt agatgcatca
      301 gtaggtcttt ggaaaaactg taccaacatt agctgcagtg acagcctgtc atatgccagt
      361 gaagatgccc tcaagacagt gcaggccttc atgattctct ctatcatctt ctgtgtcatt
      421 gccctcctgg tcttcgtgtt ccagctcttc accatggaga agggaaaccg gttcttcctc
      481 tcaggggcca ccacactggt gtgctggctg tgcattcttg tgggggtgtc catctacact
      541 agtcattatg cgaatcgtga tggaacgcag tatcaccacg gctattccta catcctgggc
      601 tggatctgct tctgcttcag cttcatcatc ggcgttctct atctggtcct gagaaagaaa
      661 taaggccgga cgagttcatg gggatctggg gggtggggag gaggaagccg ttgaatctgg
      721 gagggaagtg gaggttgctg tacaggaaaa accgagatag gggagggggg agggggaagc
      781 aaagggggga ggtcaaatcc caaaccatta ctgaggggat tctctactgc caagcccctg
      841 ccctggggag aaagtagttg gctagtactt tgatgctccc ttgatggggt ccagagagcc
      901 tccctgcagc caccagactt ggcctccagc tgttcttagt gacacacact gtctggggcc
      961 ccatcagctg ccacaacacc agccccactt ctgggtcatg cactgaggtc cacagaccta
     1021 ctgcactgag ttaaaatagc ggtacaagtt ctggcaagag cagatactgt ctttgtgctg
     1081 aatacgctaa gcctggaagc catcctgccc ttctgaccca aagcaaaaca tcacattcca
     1141 gtctgaagtg cctactgggg ggctttggcc tgtgagccat tgtccctctt tggaacagat
     1201 atttagctct gtggaattca gtgacaaaat gggaggagga aagagagttt gtaaggtcat
     1261 gctggtgggt tagctaaacc aagaaggaga ccttttcaca atggaaaacc tgggggatgg
     1321 tcagagccca gtcgagacct cacacacggc tgtccctcat ggagacctca tgccatggtc
     1381 tttgctaggc ctcttgctga aagccaaggc agctcttctg gagtttctct aaagtcacta
     1441 gtgaacaatt cggtggtaaa agtaccacac aaactatggg atccaagggg cagtcttgca
     1501 acagtgccat gttagggtta tgtttttagg attcccctca atgcagtcag tgtttctttt
     1561 aagtatacaa caggagagag atggacatgg ctcattgtag cacaatccta ttactcttcc
     1621 tctaacattt ttgaggaagt tttgtctaat tatcaatatt gaggatcagg gctcctaggc
     1681 tcagtggtag ctctggctta gacaccacct ggagtgatca cctcttgggg accctgccta
     1741 tcccacttca caggtgaggc atggcaattc tggaagctga ttaaaacaca cataaaccaa
     1801 aaccaaacaa caggcccttg ggtgaaaggt gctatataat tgtgaagtat taagcctacc
     1861 gtatttcagc catgataaga acagagtgcc tgcattccca ggaaaatacg aaaatcccat
     1921 gagataaata aaaatatagg tgatgggcag atcttttctt taaaataaaa aagcaaaaac
     1981 tcttgtggta cctagtcaga tggtagacga gctgtctgct gccgcaggag cacctctata
     2041 caggacttag aagtagtatg ttattcctgg ttaagcaggc attgctttgc cctggagcag
     2101 ctattttaag ccatctcaga ttctgtctaa aggggttttt tgggaagacg ttttctttat
     2161 cgccctgaga agatctaccc cagggagaat ctgagacatc ttgcctactt ttctttatta
     2221 gctttctcct catccatttc ttttatacct ttcctttttg gggagttgtt atgccatgat
     2281 ttttggtatt tatgtaaaag gattattact aattctattt ctctatgttt attctagtta
     2341 aggaaatgtt gagggcaagc caccaaatta cctaggctga ggttagagag attggccagc
     2401 aaaaactgtg ggaagatgaa ctttgtcatt atgatttcat tatcacatga ttatagaagg
     2461 ctgtcttagt gcaaaaaaca tacttacatt tcagacatat ccaaagggaa tactcacatt
     2521 ttgttaagaa gttgaactat gactggagta aaccatgtat tcccttatct tttacttttt
     2581 ttctgtgaca tttatgtctc atgtaatttg cattactctg gtggattgtt ctagtactgt
     2641 attgggcttc ttcgttaata gattatttca tatactataa ttgtaaatat tttgatacaa
     2701 atgtttataa ctctagggat ataaaaacag attctgattc ccttcattgt gtgaatgttt
     2761 ttttctaaaa aaaatgtgga gaaatatgga taattatgac atttatccct cattaagctg
     2821 cctatcagtt tgatttggac aacttgacat ttatttgaga cattaagcta ctttctggta
     2881 atatattagg catttctgca atagctcttt caggtaactg aatattatta agcatagttt
     2941 tatcttgctt tgattaaacc tcttaggcaa aaaatggaac ttcataagct aatacattag
     3001 aaaggggtta tgattataaa tcagaaatgc ttgtgacatt aagaaatgag gcacttgtga
     3061 aatttctttg aaatagccag ctcctctaat gtgtcttcaa aatataaagt gattcacaaa
     3121 ggcatgcatc acacctattt gtagcagccc attcattaca taaaccaggg catacctgtg
     3181 tgggctctgt gagtgaaggg aggcttcact actttctgtg agcagtaagg actggtatct
     3241 ttctgtgagc aataaggact ggataaagac tgcatatcct tgtgtcgtgt cagcaccaat
     3301 acaataagga gggttttaat gtgaagcagg caatcttcca gccccttctg gtcttggatg
     3361 aaatagttgc acagagtatt gcaccaaaaa tacacaatgg aggctgaaaa gttcaacata
     3421 ttttaagtca attaatcaaa ttgcattgat tcttgatgct ttcttagagg cctacatgat
     3481 ttcttagatt gctctgataa actatcataa ggggtccacc tcccctcatt tagctccccc
     3541 agggatttct tttcccccat gtcatacacc cagtcctaaa tcaaccccca aggctatcct
     3601 tccatccctt ctgcagaggg aacttttgtc agactctgca acaaactcct agctctatcc
     3661 agagtgtcct ctgctgctaa gattggtatc tttctcctca aaagcctgga tggtgaatgg
     3721 gggtgcatta gtcagaattc tccagagaaa cagaaaaaat aagattcgcg tgtgtgtgca
     3781 aacatatata taaataaata aaaatatatt tattttaagg aattgactca catgattttg
     3841 aaggcaggca agcccaaagt ctgcaagggg tgggccagca gagagctggt gctacagtgc
     3901 gggtctgaaa gttgccagag tcccttttat agagaagctt aaaaaatatt tgttgaatta
     3961 aatgtcttag gtagagacaa attgaattaa agtggttaag taaatactct taggtgaaat
     4021 ttgtgcaaat tatgagtata aagagggtga gctacagaac tctccatgac cactcaagaa
     4081 tgggacccaa aggcaaatga taacttattc attcatcaag ggataaactt gagttatcaa
     4141 atggttaata gataaagatc ccactctgcc ttggatttag ccatcgcagt ccctgtgtaa
     4201 aaccccaccg gctttcaggc atggaaaaaa atttcacaaa ggccttgaaa gaaggcatat
     4261 gaagaccaaa aggatattga gcagggttcc atacttgaat aaaggaagaa actcccttca
     4321 atgtttacta agaaatagtt agaatatagc atatcctgta tagatgaaat gtcctagcga
     4381 aaatgtttaa atgtatttaa agaagagcta gattttgtgg ggggagagaa gggaatagga
     4441 taggctggtg ggaggaagaa tgaaaagaag aaaacttgtt ggaaattttg gagtagattg
     4501 tgaggagggg tgactcactt taaagatgta tcatttggag gtagacacga ttttcagagc
     4561 acaaaacaga taaggaaaga tgtatgctga ttgtgtggag cccaagggaa ggcggggttt
     4621 tggagtctta cgtggctttg tttctgaaag ggagacatgt gaagcctact cctgaggcgg
     4681 gaggctgggg acatgaccat caagacctat aattgataaa caactagggg ctgggtgctg
     4741 cacctacatg ctggggaaat agaaaatgaa gcagacatgt gtcccatctt cttccagctt
     4801 tcagtctagc ttggaaataa atctcatacc tagagaaaat ggaggatctg tgggatgtag
     4861 atgaggtggg agcatgaatg cctagggagg gaagaagaaa gattttcagt tcttcagctt
     4921 ttcctcatga ccctatctca tgccatgagc aattgtctgg catctcctgt gggttggacc
     4981 actgctgcat ttcttacttg ccaacatcac tttgtcccaa atgccattcc tttgttccag
     5041 ggcctccttg tcttccatct ggggaactgg aggtgagaag cattataata gcctctctgc
     5101 ctttatctac aatctctcca acctgtgctt tatgctgatg tcaggatggg cgttgatgga
     5161 tgcttctatc actgtcgggg cagggagggc cagaacacta gcataagatg tcaatatgtc
     5221 tatccatatg tcaggtccat actcaactca agcttctggt taactgctga tctattggca
     5281 actccagttc ccaataagtt cctcatctcc ttctgagacc acctcagtgt ggacttaatc
     5341 gtccacatca ctgtcagcat tttggttaaa accattcaac aagtctccag gaagctccaa
     5401 actttccttc atcttcctgt cttcttctga gccctccaaa ctcttccaac ctctacccgt
     5461 tacccagttc caaaggtgct tccacacttt caagtatctt tatagcaatg ccccactcct
     5521 ggtaccaaat tcctgtatta gtctgttttc acactgctat gaagacatac ttgagactcg
     5581 gtaatttata tagaaaagag gtttaattga caaaaaagct aacaaagtga gccctgattc
     5641 aaaaatgact gtctacactt ggcacatgag ggactttatg atattaagag attaattaaa
     5701 caacagtgga tggggaggaa gaacagactt ttgagctctt cccaatatag gaatgtgtta
     5761 gttctaaaaa ttttcttaag ttgtttgctt ggaactcaga gtatattttt ccatacgaaa
     5821 aattcagaac tattttattt atgatatggg ctaaaaagac ttctgtaatc tagcttggaa
     5881 acttaataat cattaaactt attttcaatg aga
//
