LOCUS       NM_183387               9771 bp    mRNA    linear   PRI 09-FEB-2024
DEFINITION  Homo sapiens EMAP like 5 (EML5), transcript variant 1, mRNA.
ACCESSION   NM_183387 XM_290624
VERSION     NM_183387.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9771)
  AUTHORS   O'Connor,V., Houtman,S.H., De Zeeuw,C.I., Bliss,T.V. and
            French,P.J.
  TITLE     Eml5, a novel WD40 domain protein expressed in rat brain
  JOURNAL   Gene 336 (1), 127-137 (2004)
   PUBMED   15225882
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL121768.4, BC150639.1, BC032685.1, BC042055.1 and AL162171.4.
            
            On Sep 15, 2018 this sequence version replaced NM_183387.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC150639.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000554922.6/ ENSP00000451998.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-201               AL121768.4         172229-172429       c
            202-420             BC150639.1         1-219
            421-421             BC032685.1         168-168
            422-5666            BC150639.1         221-5465
            5667-7332           BC042055.1         2102-3767
            7333-9771           AL162171.4         32915-35353
FEATURES             Location/Qualifiers
     source          1..9771
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q31.3"
     gene            1..9771
                     /gene="EML5"
                     /gene_synonym="EMAP-2; EMAP-5; FAP16"
                     /note="EMAP like 5"
                     /db_xref="GeneID:161436"
                     /db_xref="HGNC:HGNC:18197"
                     /db_xref="MIM:618119"
     exon            1..647
                     /gene="EML5"
                     /gene_synonym="EMAP-2; EMAP-5; FAP16"
                     /inference="alignment:Splign:2.1.0"
     CDS             451..6384
                     /gene="EML5"
                     /gene_synonym="EMAP-2; EMAP-5; FAP16"
                     /note="isoform 1 is encoded by transcript variant 1;
                     echinoderm microtubule associated protein like 5"
                     /codon_start=1
                     /product="echinoderm microtubule-associated protein-like 5
                     isoform 1"
                     /protein_id="NP_899243.1"
                     /db_xref="CCDS:CCDS45148.1"
                     /db_xref="GeneID:161436"
                     /db_xref="HGNC:HGNC:18197"
                     /db_xref="MIM:618119"
                     /translation="MAARSAPSCHLRLEWVYGYRGHQCRNNLYYTAAKEIVYFVAGVG
                     VVYSPREHRQKFYRGHSDDIISLALHPERVLVATGQVGKEPYICIWDSYTVQTISVLK
                     DVHTHGIACLAFDLDGQRLVSVGLDSKNAVCVWDWKRGKMLSMAPGHTDRIFDISWDL
                     YQPNKLVSCGVKHIKFWSLCGNALTPKRGVFGKTGDLQTILCLACARDELTYSGALNG
                     DIYVWKGINLIRTIQGAHAAGIFSMNACEEGFATGGRDGCIRLWDLTFKPITVIDLRE
                     TDQGYKGLSVRSVCWRGDHILVGTQDSEIFEIVVQERNKPFLIMQGHCEGELWALAVH
                     PTKPLAVTGSDDRSVRIWSLVDHALIARCNMEEPIRCAAVNADGIHLALGMKDGSFTV
                     LRVRDMTEVVHIKDRKEAIHELKYSPDGTYLAVGCNDSSVDIYGVAQRYKKVGECLGS
                     LSFITHLDWSSDSRYLQTNDGNGKRLFYRMPGGKEVTSTEEIKGVHWASWTCVSGLEV
                     NGIWPKYSDINDINSVDGNYIGQVLVTADDYGIIKLFRYPCLRKGAKFRKYIGHSAHV
                     TNVRWSHDYQWVISIGGADHSVFQWKFIPERKLKDAVHIAPQESLADSHSDESDSDLS
                     DVPELDSEIEQETQLTYRRQVYKEDLPQLKEQCKEKQKSATSKRRERAPGNSIRLHFV
                     HGYRGYDCRSNLFYTQIGEIVYHVAAVGVIYNRQQNTQRFYLGHDDDILCLTIHPLKD
                     YVATGQVGRDPSIHIWDTETIKPLSILKGHHQYGVSAVDFSADGKRLASVGIDDSHTV
                     VLWDWKKGEKLSIARGSKDKIFVVKMNPYVPDKLITAGIKHMKFWRKAGGGLIGRKGY
                     IGTLGKNDTMMCAVYGWTEEMAFSGTSTGDVCIWRDIFLVKTVKAHDGPVFSMHALEK
                     GFVTGGKDGIVALWDDSFERCLKTYAIKRAALAPGSKGLLLEDNPSIRAISLGHGHIL
                     VGTKNGEILEVDKSGPITLLVQGHMEGEVWGLATHPYLPICATVSDDKTLRIWDLSPS
                     HCMLAVRKLKKGGRCCCFSPDGKALAVGLNDGSFLMANADTLEDLVSFHHRKDMISDI
                     RFSPGSGKYLAVASHDSFIDIYNVMSSKRVGICKGATSYITHIDWDIRGKLLQVNTGA
                     KEQLFFEAPRGKKQTIPSVEVEKIAWASWTSVLGLCCEGIWPVIGEVTDVTASCLTSD
                     KMVLATGDDLGFVKLFRYPTKGKFGKFKRYVAHSTHVTNVRWTYDDSMLVTLGGTDMS
                     LMVWTNEMEGYREKRPCDSEESDIDSEEDGGYDSDVTRENEISYTIRALSTNIRPMLG
                     IKPHLQQKEPSIDERQGVVRGSRPPVSRAPPQPEKLQTNNVGKKKRPIEDLVLELIFG
                     YRGRDCRNNVHYLNDGDDIIYHTASVGILHNVATGSQSFYQEHNDDILCLTVNQHPKF
                     INIVATGQVGDSADMSATAPSIHIWDAMNKQTLSILRCYHSKGVCSVSFSATGKLLLS
                     VGLDPEHTITIWRWQEGAKIASRAGHNQRIFVAEFRPDSDTQFVSVGVKHVKFWTLAG
                     RALLSKKGLLSTLEDARMQTMLAIAFGANNLTFTGTISGDVCVWKDHILCRIVARAHN
                     GPVFAMYTTLRDGLIVTGGKERPSKEGGAVKLWDQELRRCRAFRLETGQATDCVRSVC
                     RGKGKILVGTRNAEIIEVGEKNAACNILVNGHVDGPIWGLATHPSRDFFLSAAEDGTV
                     RLWDIADKKMLNKVNLGHAARTVCYSPEGDMVAIGMKNGEFIILLVSSLKIWGKKRDR
                     RCAIHDIRFSPDSRYLAVGSSENSVDFYDLTLGPTLNRISYCKDIPSFVIQMDFSADS
                     SYLQVSSGCYKRHVYEVPSGKHLMDHAAIDRITWATWTSILGDEVLGIWSRHAEKADV
                     NCACVSHSGISLVTGDDFGMVKLFDFPCPEKFAKHKRFLGHSPHVTNIRFTSGDRHVV
                     SAGGDDCSLFVWKCVHTPH"
     exon            648..807
                     /gene="EML5"
                     /gene_synonym="EMAP-2; EMAP-5; FAP16"
                     /inference="alignment:Splign:2.1.0"
     exon            808..906
                     /gene="EML5"
                     /gene_synonym="EMAP-2; EMAP-5; FAP16"
                     /inference="alignment:Splign:2.1.0"
     exon            907..975
                     /gene="EML5"
                     /gene_synonym="EMAP-2; EMAP-5; FAP16"
                     /inference="alignment:Splign:2.1.0"
     exon            976..1161
                     /gene="EML5"
                     /gene_synonym="EMAP-2; EMAP-5; FAP16"
                     /inference="alignment:Splign:2.1.0"
     exon            1162..1297
                     /gene="EML5"
                     /gene_synonym="EMAP-2; EMAP-5; FAP16"
                     /inference="alignment:Splign:2.1.0"
     exon            1298..1499
                     /gene="EML5"
                     /gene_synonym="EMAP-2; EMAP-5; FAP16"
                     /inference="alignment:Splign:2.1.0"
     exon            1500..1637
                     /gene="EML5"
                     /gene_synonym="EMAP-2; EMAP-5; FAP16"
                     /inference="alignment:Splign:2.1.0"
     exon            1638..1894
                     /gene="EML5"
                     /gene_synonym="EMAP-2; EMAP-5; FAP16"
                     /inference="alignment:Splign:2.1.0"
     exon            1895..2107
                     /gene="EML5"
                     /gene_synonym="EMAP-2; EMAP-5; FAP16"
                     /inference="alignment:Splign:2.1.0"
     exon            2108..2275
                     /gene="EML5"
                     /gene_synonym="EMAP-2; EMAP-5; FAP16"
                     /inference="alignment:Splign:2.1.0"
     exon            2276..2382
                     /gene="EML5"
                     /gene_synonym="EMAP-2; EMAP-5; FAP16"
                     /inference="alignment:Splign:2.1.0"
     exon            2383..2501
                     /gene="EML5"
                     /gene_synonym="EMAP-2; EMAP-5; FAP16"
                     /inference="alignment:Splign:2.1.0"
     exon            2502..2688
                     /gene="EML5"
                     /gene_synonym="EMAP-2; EMAP-5; FAP16"
                     /inference="alignment:Splign:2.1.0"
     exon            2689..2794
                     /gene="EML5"
                     /gene_synonym="EMAP-2; EMAP-5; FAP16"
                     /inference="alignment:Splign:2.1.0"
     exon            2795..2888
                     /gene="EML5"
                     /gene_synonym="EMAP-2; EMAP-5; FAP16"
                     /inference="alignment:Splign:2.1.0"
     exon            2889..2989
                     /gene="EML5"
                     /gene_synonym="EMAP-2; EMAP-5; FAP16"
                     /inference="alignment:Splign:2.1.0"
     exon            2990..3192
                     /gene="EML5"
                     /gene_synonym="EMAP-2; EMAP-5; FAP16"
                     /inference="alignment:Splign:2.1.0"
     exon            3193..3304
                     /gene="EML5"
                     /gene_synonym="EMAP-2; EMAP-5; FAP16"
                     /inference="alignment:Splign:2.1.0"
     exon            3305..3432
                     /gene="EML5"
                     /gene_synonym="EMAP-2; EMAP-5; FAP16"
                     /inference="alignment:Splign:2.1.0"
     exon            3433..3574
                     /gene="EML5"
                     /gene_synonym="EMAP-2; EMAP-5; FAP16"
                     /inference="alignment:Splign:2.1.0"
     exon            3575..3727
                     /gene="EML5"
                     /gene_synonym="EMAP-2; EMAP-5; FAP16"
                     /inference="alignment:Splign:2.1.0"
     exon            3728..3859
                     /gene="EML5"
                     /gene_synonym="EMAP-2; EMAP-5; FAP16"
                     /inference="alignment:Splign:2.1.0"
     exon            3860..3948
                     /gene="EML5"
                     /gene_synonym="EMAP-2; EMAP-5; FAP16"
                     /inference="alignment:Splign:2.1.0"
     exon            3949..4125
                     /gene="EML5"
                     /gene_synonym="EMAP-2; EMAP-5; FAP16"
                     /inference="alignment:Splign:2.1.0"
     exon            4126..4327
                     /gene="EML5"
                     /gene_synonym="EMAP-2; EMAP-5; FAP16"
                     /inference="alignment:Splign:2.1.0"
     exon            4328..4454
                     /gene="EML5"
                     /gene_synonym="EMAP-2; EMAP-5; FAP16"
                     /inference="alignment:Splign:2.1.0"
     exon            4455..4469
                     /gene="EML5"
                     /gene_synonym="EMAP-2; EMAP-5; FAP16"
                     /inference="alignment:Splign:2.1.0"
     exon            4470..4478
                     /gene="EML5"
                     /gene_synonym="EMAP-2; EMAP-5; FAP16"
                     /inference="alignment:Splign:2.1.0"
     exon            4479..4557
                     /gene="EML5"
                     /gene_synonym="EMAP-2; EMAP-5; FAP16"
                     /inference="alignment:Splign:2.1.0"
     exon            4558..4687
                     /gene="EML5"
                     /gene_synonym="EMAP-2; EMAP-5; FAP16"
                     /inference="alignment:Splign:2.1.0"
     exon            4688..4786
                     /gene="EML5"
                     /gene_synonym="EMAP-2; EMAP-5; FAP16"
                     /inference="alignment:Splign:2.1.0"
     exon            4787..4807
                     /gene="EML5"
                     /gene_synonym="EMAP-2; EMAP-5; FAP16"
                     /inference="alignment:Splign:2.1.0"
     exon            4808..4981
                     /gene="EML5"
                     /gene_synonym="EMAP-2; EMAP-5; FAP16"
                     /inference="alignment:Splign:2.1.0"
     exon            4982..5190
                     /gene="EML5"
                     /gene_synonym="EMAP-2; EMAP-5; FAP16"
                     /inference="alignment:Splign:2.1.0"
     exon            5191..5348
                     /gene="EML5"
                     /gene_synonym="EMAP-2; EMAP-5; FAP16"
                     /inference="alignment:Splign:2.1.0"
     exon            5349..5463
                     /gene="EML5"
                     /gene_synonym="EMAP-2; EMAP-5; FAP16"
                     /inference="alignment:Splign:2.1.0"
     exon            5464..5652
                     /gene="EML5"
                     /gene_synonym="EMAP-2; EMAP-5; FAP16"
                     /inference="alignment:Splign:2.1.0"
     exon            5653..5825
                     /gene="EML5"
                     /gene_synonym="EMAP-2; EMAP-5; FAP16"
                     /inference="alignment:Splign:2.1.0"
     exon            5826..5988
                     /gene="EML5"
                     /gene_synonym="EMAP-2; EMAP-5; FAP16"
                     /inference="alignment:Splign:2.1.0"
     exon            5989..6092
                     /gene="EML5"
                     /gene_synonym="EMAP-2; EMAP-5; FAP16"
                     /inference="alignment:Splign:2.1.0"
     exon            6093..6246
                     /gene="EML5"
                     /gene_synonym="EMAP-2; EMAP-5; FAP16"
                     /inference="alignment:Splign:2.1.0"
     exon            6247..6347
                     /gene="EML5"
                     /gene_synonym="EMAP-2; EMAP-5; FAP16"
                     /inference="alignment:Splign:2.1.0"
     exon            6348..9771
                     /gene="EML5"
                     /gene_synonym="EMAP-2; EMAP-5; FAP16"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7310..7315
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EML5"
                     /gene_synonym="EMAP-2; EMAP-5; FAP16"
                     /note="hexamer: AATAAA"
     polyA_site      7345
                     /gene="EML5"
                     /gene_synonym="EMAP-2; EMAP-5; FAP16"
                     /note="major polyA site"
     regulatory      9753..9758
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EML5"
                     /gene_synonym="EMAP-2; EMAP-5; FAP16"
                     /note="hexamer: AGTAAA"
     polyA_site      9771
                     /gene="EML5"
                     /gene_synonym="EMAP-2; EMAP-5; FAP16"
                     /note="major polyA site"
ORIGIN      
        1 cggctcgctc ggtttcgggg tgcgcggcgc gggtccgcca ggctgtggct acaaagccgc
       61 ggcggggcgc gagcgccgca ggtgaccggg gctgggagct gcgtgcgcgg gcggcggctg
      121 aggagctgga ggcgggccct cgctctcggc ccaggcgcta cgggctgagg agactaggcg
      181 agccgaggcg ggcgaagggc tctgggcatc cacttgacag ccggcggcgc tcgcggccct
      241 cagcatgttc cgcgaggcga gggttttcct cccgcctgtg ggctgaggcg gcggcggccc
      301 ccgaaacgag atgcacctga cgggcgcggc ttagaggacg cggctggcgg gaagtcccgg
      361 cagccagcgg gagggctttc gttgccgggc cgccgccgcc tcccgtcgcc gccgcgggcc
      421 cgagcgggag cggcgggtgg gcgccccgac atggcggccc ggagcgcccc gagctgccac
      481 ctgcggctcg agtgggtgta cggctaccgg ggccaccagt gccgcaacaa cctctactac
      541 actgcggcca aggagatcgt atacttcgtg gcgggggtcg gcgtggtgta cagcccgcgg
      601 gagcacaggc agaagttcta ccggggccac agcgacgaca tcatcagcct tgcattgcat
      661 cctgaacgag tgttggtagc aacaggacaa gttgggaaag agccttatat ttgtatttgg
      721 gattcataca ctgtgcagac catatcagtt ttaaaggatg ttcatacaca tggtatagct
      781 tgcttggcgt ttgacttaga tggacagcgc ttggtttcag ttggacttga ttcaaagaat
      841 gcagtttgtg tttgggactg gaaaagggga aaaatgttgt ctatggctcc tggtcataca
      901 gatagaatat ttgatatttc ttgggatttg taccagccaa ataaacttgt cagctgtggt
      961 gtaaaacata tcaagttctg gagtttatgt ggaaatgctc tgaccccaaa acgaggtgtc
     1021 tttggtaaga cgggtgacct tcagacaata ctgtgcctag cctgtgcaag ggatgaatta
     1081 acatattctg gtgcactcaa tggggatata tatgtttgga aaggaatcaa tcttatacga
     1141 acaatacaag gagcccatgc tgcaggaatt tttagcatga atgcttgtga agaaggcttt
     1201 gctactggtg gcagagatgg ttgtattcgt ctttgggatt taacttttaa accaattact
     1261 gtgattgatc tcagggaaac agaccaggga tacaaaggtt tgtctgtaag gagtgtgtgt
     1321 tggcgaggtg accacattct agttggaaca caggacagtg aaatttttga aattgtggtg
     1381 caagaaagaa ataaaccttt tctaattatg caagggcatt gtgaaggtga actttgggca
     1441 cttgctgtcc atcctactaa acctttggct gtgactggaa gtgatgatcg ttcggtcagg
     1501 atatggagcc tagtagatca tgcattaata gcaaggtgta atatggaaga accaattcgt
     1561 tgtgcagctg tcaatgcaga tggaatccat cttgcccttg gaatgaagga tggctcattc
     1621 actgtactta gagtaagaga tatgacggaa gttgtacata ttaaagatag gaaggaggca
     1681 attcatgagt taaaatattc accagatgga acttaccttg ctgttggatg caatgacagc
     1741 tcggttgata tttatggagt tgctcagcgt tataaaaaag ttggcgagtg tttgggatcc
     1801 cttagtttca tcactcatct ggactggtct tcagacagta gatatttgca gacaaatgat
     1861 ggaaatggga aaagactttt ttatagaatg ccaggaggaa aggaagtgac aagtacagaa
     1921 gaaataaaag gtgttcattg ggcttcatgg acatgtgttt caggccttga agtaaatgga
     1981 atttggccca agtattcaga tatcaacgat ataaattcag tagatggaaa ttatattggc
     2041 caagttttag ttacagctga tgactatgga attataaaat tattccgata tccatgttta
     2101 agaaaagggg ccaagtttag aaaatatatt ggccattcag ctcacgtaac taatgtcaga
     2161 tggtcacatg attatcagtg ggttatttct attggtggag cagatcactc tgtctttcag
     2221 tggaaattta ttcctgaaag aaaactgaaa gatgctgttc acatagcacc ccaagaaagt
     2281 ctggctgact ctcatagtga tgaatcagat tcagatctgt ctgatgttcc agaactggat
     2341 tctgaaattg aacaagagac acagctcacc taccgtcgac aggtttacaa agaagatcta
     2401 cctcagctta aagaacagtg caaagagaaa caaaaaagtg ctacttctaa aagaagagag
     2461 cgggctccag gaaatagtat tcgattacac tttgttcacg gttacagagg ttatgactgt
     2521 cgaagtaatc tgttttatac tcaaattggt gaaattgtgt accatgtggc agcagtgggt
     2581 gtcatttata atcgacagca aaacacacag cgtttttatc tgggtcatga tgatgatatt
     2641 ctctgcctaa ctattcatcc tttgaaagac tacgtggcaa caggccaggt tggtagagat
     2701 ccctcaattc atatatggga tacagagacc attaaaccat tgtccatatt aaagggccac
     2761 caccagtatg gtgttagtgc cgttgatttc tcagcggatg ggaaacgttt ggcatcagtt
     2821 ggcatagatg atagccatac tgttgtgctc tgggactgga agaaaggaga gaaactttca
     2881 atagcaagag gaagtaaaga taagattttt gttgtaaaga tgaaccccta tgtgcctgat
     2941 aaactaatta cagctggaat taaacacatg aaattttggc gtaaagcagg gggaggattg
     3001 attggaagaa aaggctacat aggcacactg gggaaaaatg acacaatgat gtgtgcagtg
     3061 tatggatgga ctgaagagat ggctttttct ggaacatcca caggagatgt gtgtatctgg
     3121 agagacatct ttcttgtaaa aacagtgaaa gcgcatgatg ggccagtgtt cagtatgcat
     3181 gcattggaaa aagggtttgt aactggagga aaagatggta tagtagctct ttgggatgac
     3241 tcttttgaaa gatgtctcaa gacctatgct ataaaaagag ctgcattggc cccaggatct
     3301 aaaggtcttc tcttggaaga taatccatct atacgtgcca tatcattagg acatggtcat
     3361 attttagttg gcacaaagaa tggtgaaata ctagaagtgg ataaaagtgg cccaataaca
     3421 cttctggttc agggacacat ggaaggagag gtgtggggtt tagctacaca cccttatctg
     3481 cccatctgtg ctactgtaag cgatgataaa accttaagaa tatgggatct ctcacctagt
     3541 cattgtatgt tggctgtccg gaagctgaaa aagggtggga ggtgttgctg tttttctcct
     3601 gatggtaaag ctttagccgt aggtctcaac gatggaagct tcttaatggc aaatgcggat
     3661 actctagagg atcttgtgtc ttttcatcac agaaaagata tgatttcaga tattcgattt
     3721 tcacctggtt ctgggaaata tcttgctgta gcatcccatg acagctttat agatatatac
     3781 aatgtaatga gtagtaaacg agtaggaata tgcaaaggag ctaccagtta cataacccat
     3841 attgattggg atattagagg aaagctttta caggtcaaca ctggtgctaa ggaacaatta
     3901 ttctttgaag ctcccagagg gaaaaaacaa accatcccca gcgtggaggt agaaaaaatt
     3961 gcttgggcat catggacaag tgtacttggt ttatgctgtg aaggaatttg gccagtaatt
     4021 ggagaagtta cagatgtaac tgcttcttgc ctcaccagtg acaaaatggt tctagctacc
     4081 ggggacgatt tgggatttgt gaagttattt agatatccta ctaaagggaa atttggaaag
     4141 tttaagaggt atgtggccca tagtacacat gtcacaaatg ttcgctggac ttatgatgac
     4201 agcatgttgg ttaccctagg cggtacagat atgtctttaa tggtgtggac aaatgagatg
     4261 gaaggctatc gagaaaaaag gccttgtgat agtgaagaat ccgacattga ttctgaagaa
     4321 gatgggggct atgacagtga tgttacaagg gagaatgaaa tcagttacac catcagagcc
     4381 ttatcaacaa atattcgccc aatgttagga atcaagcctc atttacaaca aaaagaaccc
     4441 tcaattgatg aaaggcaggg agtagtaaga ggttccaggc ctccagtgag cagggcccca
     4501 ccacagccag agaaactcca gacaaacaat gtaggcaaga aaaagagacc tatagaggac
     4561 cttgtgttgg agctcatttt tggttatcga ggcagagact gtaggaataa tgttcactat
     4621 ttaaatgatg gtgatgatat aatttatcac actgcatctg ttggaattct gcacaatgtt
     4681 gctacaggtt ctcagagttt ttatcaggaa cataatgatg atattctgtg cctcacagta
     4741 aaccagcacc ccaaatttat caacatagtg gcaactggcc aagtaggtga ttcagcagac
     4801 atgtcagcta cagctccttc tattcacatc tgggatgcaa tgaacaagca gactttatct
     4861 atcctaagat gctaccattc aaagggagta tgttcagtca gcttcagtgc tactggcaaa
     4921 ctattgctgt ctgtgggact agacccagaa catactatta ccatttggag atggcaggaa
     4981 ggtgccaaaa ttgccagcag agctggtcac aatcaacgta tttttgtggc agaattccga
     5041 ccagattcag atacccagtt tgtctcagtg ggagtaaaac atgtgaagtt ctggaccctg
     5101 gcaggaagag ctcttcttag caaaaaaggg ctactgagca cactggaaga tgcccggatg
     5161 cagaccatgc tcgctattgc atttggtgca aataacttga cgtttacagg taccatcagt
     5221 ggtgatgtct gtgtgtggaa agatcacata ttgtgtagaa tcgtggcgag agctcacaac
     5281 gggcctgtgt ttgccatgta caccaccctg cgagatggac ttatcgtgac tgggggaaag
     5341 gaaaggccgt caaaagaagg aggagcggtt aaactgtggg atcaggaact gaggcggtgc
     5401 cgtgccttca ggcttgagac aggacaagcc acagattgtg ttcgttctgt gtgcagaggc
     5461 aaaggcaaga tccttgttgg gacaaggaat gctgaaataa tcgaagttgg agagaaaaat
     5521 gcagcttgta atattttagt taacggtcat gtggatgggc caatctgggg actagcaaca
     5581 catccttcca gggatttttt cctttctgct gcagaagatg ggacagtgag actttgggat
     5641 attgctgata aaaagatgtt aaacaaagtg aatttgggac atgctgctcg tactgtgtgt
     5701 tacagccctg aaggggacat ggtggctatt ggaatgaaaa atggagaatt tatcatttta
     5761 ctagtgagtt ctctaaaaat atggggaaag aagagagaca ggagatgtgc aatccatgat
     5821 atcagattta gtccggattc ccggtatctg gcagtaggtt ctagtgagaa ctcagtggat
     5881 ttttatgacc taacgctggg ccccactctt aacagaatca gctactgcaa agacattcca
     5941 agctttgtca ttcaaatgga cttctctgca gatagcagtt atctccaggt ctctagtggc
     6001 tgctataaac ggcatgtcta tgaagtgcct tcaggaaaac atcttatgga tcatgccgct
     6061 attgacagaa ttacttgggc tacatggact agtattctag gagatgaggt tttgggaatc
     6121 tggtccagac atgctgagaa agctgatgtc aactgtgcct gtgtatctca ttcaggaatc
     6181 agtcttgtta caggagatga ctttggcatg gttaagttat ttgacttccc atgtccagaa
     6241 aaatttgcaa aacacaaaag gttcttgggt cattcgcccc atgtgacaaa tattcgattt
     6301 accagtggtg atcgacatgt tgttagtgct ggaggtgatg actgcagctt atttgtctgg
     6361 aaatgtgtac atacacctca ctgagagatg ctgagatgac tacagaaatt aactttgaga
     6421 ccagaattac agagaagaaa aaccaaaacc caaccctgca tggtcaagtg gtgctaaccc
     6481 aagactgtaa cagggagaaa tgcccagaat catcaaaata gtgaaagact gatctgttca
     6541 aaatatttgc tatatgcact gggtataatc cgtaatccat acactgccag ataatgccat
     6601 ttcaaggaag gatcgaatac ttgatggtaa aggccaagtc cccctgtatt gggaagtgtg
     6661 tgatttcggc agacctgctg ggaaaattta gggtagagca ctctttacag aagaactcaa
     6721 aaacccaatt tggataattt tcattatctt tttagcaaaa tggtttctta atgtttatat
     6781 tttattttca aggttcattg tttaatgaaa tattttattc ttgcatttcc ataaggaaag
     6841 ggaaagtcat gatcatccta aaggatcaca gtttttaaaa ggcaaacatt ttccctaagg
     6901 aaacagacac aagctttcct agagaatatg atgtttttta ggcattaata aggtcctttt
     6961 ttataaagga cacttttctc ctagtagttt tgaattcagg aacagatcca aagttagcag
     7021 tatatggctg ctacatttcc attttcattt tcgagccatc agtttatgtt cagatgccat
     7081 ctctgtaatc gcacatttaa aacataactg tagcctcact aatggaaaag tagtatgatg
     7141 aacaatcatt cccaatggtg tacaatgtaa gggttttagg gagcaacagt atttaactgg
     7201 aagaaagaat tgcatattta atgtagtcta atatatacac atttgtttaa catgtaaaca
     7261 aaagtgttaa attcacatat acaacattat acaatttaat cactcttgga ataaaatttt
     7321 tatagccttt tttctattgg gaaaatttgt ttagatgtgt gccactccat aggtttattt
     7381 ccaaaatgaa tgagcccaac tccatttgta aaaacttgtc agttagaatt ccttttttta
     7441 gtggattagg gctgaattct tagatcctta tttcttttca ctttaaatgc tgccaaagat
     7501 cactactcat cattcaggaa ttcgctgtct agcctatctg tagtttcctg aagattgaaa
     7561 attatgtaga ctgctattta aaaatatatt tttctaagtg tgaggtttaa gatgctgtat
     7621 tgaccctatg agtttttaat gtgttaatta tctttatagc ataatagatc gctttaggtt
     7681 cctggaatcc catttggtct gacaggatat atgaagattc ttaataccta ttttctgtgt
     7741 ctaatacttg gttaatacta aaaatagaaa tgactaaatt acatcacaga aagcataacc
     7801 agtgattgaa cctggtagtt ttaaagctct aaatagctgt ggctgaagga ctgattatgg
     7861 ggctaagaag cttgaaacgt aagttggtac ttgttcatca gtggattctc ctaaattaag
     7921 ccaaattttg aaatacatga ctattaagtt tctactcatg tatttacagt cagtcaataa
     7981 attaaaggag gaaaaaaatc cctgaacaac ctgcccataa aaagaaaaat actctacatt
     8041 tgagcctgct gcagttttaa attttccctc tgggtcaagt ttgccagctt ttggctacag
     8101 agaaattata tttccattac agtgcaggta gaaactctgt aaccttaagc atgtaaacta
     8161 catagaataa aactgtttcc actgcatttc tgtccttcaa agtggccaac ctgattaagt
     8221 cagccttaat cactgctgct gtcagtttca cgactaaagg tcatattgac taagtagtca
     8281 tcagctgacc acctcgctgt atcagccagc aacgagggga aggtgaagaa acatgatagg
     8341 ccatatagaa tctgccctat gtttactttt ttaacccaga taattatttt tgtgtgcagt
     8401 atctaagctc ctgattgtgt aacctgggac ttctggcacc ttttgttcca ttcattttat
     8461 gtataaaatg catgccaaag cacactgtgc cctctggtac ccttgcttcc aatcgccaac
     8521 catgctcatt tccttccttt ttttgtggtc cctttttgtg gtgatcattt taaaccacgt
     8581 catccaacaa atgttttatg gtcaacctta gcttgttcat aagccatagc aactgaaaga
     8641 ttaaactctt aaatatgtgt ctgggcagtg gctattaaat agcaaaaaac aatcagattt
     8701 tagtatttta ttatttcctt gtaaaatggc tgaactaaat taaacccttg tttcccattt
     8761 gttctataat ttatagtgaa actgagaaca aaactatctt tataaatgat agctaaaagt
     8821 atttccagat atttaaacaa tttaaaataa atttcttctg cagagatgca aagcatctca
     8881 acactggaat gaacaaatgc cttaaattca atggagtaaa cctttagaat gaagaggaac
     8941 tgtcatttca cccaagccga agacaacagc cttatgcact tgtgtgctct gtctttgctg
     9001 cttctcgtgt ttcaagcctt tcctgtggga tcagcacagc aaagtgcaac ttaccaaatg
     9061 gtttaatgac tggttaattc tttcttctcc caatggaaaa gcaatggcaa cacaacagta
     9121 gactgctggc ttgacaatct taaacgtgag cctttgcaca tgtaggttta tcatcatttg
     9181 agtatacgac taagcaagtc aatgaacttt tttttttttt ttagcagttt aatttggtcc
     9241 tgagaatgtt gcagtcttta ttaccccttt tgcattaatc cacttttcta accacctttt
     9301 aagctttaat ttttaacact atacaccaag tctttgaaat cagtgatctg ttatttaact
     9361 ctaaagcatt tgacacttct tgccttaaca gttttaaaaa ccacacacaa aaaaactctg
     9421 taagtaatac agtaggccaa aagtttcatc ctatctatct tgcagtttac ctatctgatc
     9481 tgatctctgt aattatagtt ctgtcattta aaatatacta tttaaatcta atttttacat
     9541 ttcaaaaatt atcttcagta gtaactaagt atattttctg tggattctga gaatgttatt
     9601 tttcagaatg tgagaatata tatgtacatt tataatcttg tgactttaaa gtctgttttc
     9661 agatacagta tgtaaatact tgtaaaaaaa tttgtataat tttgtgataa tgtagtttcc
     9721 caaaaaaatt atttagaagg cattatgtta ttagtaaatg agagcactgt a
//
