LOCUS       NM_031298                656 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens ER membrane protein complex subunit 6 (EMC6),
            transcript variant 2, mRNA.
ACCESSION   NM_031298
VERSION     NM_031298.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 656)
  AUTHORS   Tong,L., Zheng,X., Wang,T., Gu,W., Shen,T., Yuan,W., Wang,S.,
            Xing,S., Liu,X., Zhang,C. and Zhang,C.
  TITLE     Inhibition of UBA52 induces autophagy via EMC6 to suppress
            hepatocellular carcinoma tumorigenesis and progression
  JOURNAL   J Cell Mol Med 28 (6), e18164 (2024)
   PUBMED   38445807
  REMARK    GeneRIF: Inhibition of UBA52 induces autophagy via EMC6 to suppress
            hepatocellular carcinoma tumorigenesis and progression.
REFERENCE   2  (bases 1 to 656)
  AUTHORS   Gaspar,C.J., Vieira,L.C., Santos,C.C., Christianson,J.C.,
            Jakubec,D., Strisovsky,K., Adrain,C. and Domingos,P.M.
  TITLE     EMC is required for biogenesis of Xport-A, an essential chaperone
            of Rhodopsin-1 and the TRP channel
  JOURNAL   EMBO Rep 23 (1), e53210 (2022)
   PUBMED   34918864
REFERENCE   3  (bases 1 to 656)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 656)
  AUTHORS   Tan,J.H., Cao,R.C., Zhou,L., Zhou,Z.T., Chen,H.J., Xu,J.,
            Chen,X.M., Jin,Y.C., Lin,J.Y., Qi,Z.C., Zeng,J.L., Li,S.J., Luo,M.,
            Hu,G.D., Jin,J. and Zhang,G.W.
  TITLE     EMC6 regulates acinar apoptosis via APAF1 in acute and chronic
            pancreatitis
  JOURNAL   Cell Death Dis 11 (11), 966 (2020)
   PUBMED   33177505
  REMARK    GeneRIF: EMC6 regulates acinar apoptosis via APAF1 in acute and
            chronic pancreatitis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 656)
  AUTHORS   Pleiner,T., Tomaleri,G.P., Januszyk,K., Inglis,A.J., Hazu,M. and
            Voorhees,R.M.
  TITLE     Structural basis for membrane insertion by the human ER membrane
            protein complex
  JOURNAL   Science 369 (6502), 433-436 (2020)
   PUBMED   32439656
REFERENCE   6  (bases 1 to 656)
  AUTHORS   Wang,X., Xia,Y., Xu,C., Lin,X., Xue,P., Zhu,S., Bai,Y. and Chen,Y.
  TITLE     ER membrane protein complex subunit 6 (EMC6) is a novel tumor
            suppressor in gastric cancer
  JOURNAL   BMB Rep 50 (8), 411-416 (2017)
   PUBMED   28648145
  REMARK    GeneRIF: This is the first study to show that EMC6 induces cell
            death in gastric cancer cells. The molecular mechanism of how EMC6
            functions as a tumor suppressor needs to be further explored.
REFERENCE   7  (bases 1 to 656)
  AUTHORS   Shen,M.X. and Ding,J.B.
  TITLE     Expression levels and roles of EMC-6, Beclin1, and Rab5a in the
            cervical cancer
  JOURNAL   Eur Rev Med Pharmacol Sci 21 (13), 3038-3046 (2017)
   PUBMED   28742203
  REMARK    GeneRIF: The expression level of EMC-6 is significantly elevated in
            cervical cancer, without significant correlation with Beclin1 and
            Rab5a.
REFERENCE   8  (bases 1 to 656)
  AUTHORS   Li,Y., Zhao,Y., Hu,J., Xiao,J., Qu,L., Wang,Z., Ma,D. and Chen,Y.
  TITLE     A novel ER-localized transmembrane protein, EMC6, interacts with
            RAB5A and regulates cell autophagy
  JOURNAL   Autophagy 9 (2), 150-163 (2013)
   PUBMED   23182941
  REMARK    GeneRIF: Endoplasmic membrane protein complex subunit 6 (EMC6)
            interacted with both RAB5A and BECN1/Beclin 1 and colocalized with
            the omegasome marker ZFYVE1/DFCP1.
REFERENCE   9  (bases 1 to 656)
  AUTHORS   Christianson,J.C., Olzmann,J.A., Shaler,T.A., Sowa,M.E.,
            Bennett,E.J., Richter,C.M., Tyler,R.E., Greenblatt,E.J.,
            Harper,J.W. and Kopito,R.R.
  TITLE     Defining human ERAD networks through an integrative mapping
            strategy
  JOURNAL   Nat Cell Biol 14 (1), 93-105 (2011)
   PUBMED   22119785
  REMARK    Publication Status: Online-Only
REFERENCE   10 (bases 1 to 656)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            HY014822.1, BM825446.1, AA161105.1 and BU931404.1.
            
            On Nov 23, 2018 this sequence version replaced NM_031298.3.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BG474359.1, SRR1803611.148515.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000248378.6/ ENSP00000248378.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                HY014822.1         91-107
            18-613              BM825446.1         1-596
            614-652             AA161105.1         11-49               c
            653-656             BU931404.1         761-764
FEATURES             Location/Qualifiers
     source          1..656
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.2"
     gene            1..656
                     /gene="EMC6"
                     /gene_synonym="RAB5IFL; TMEM93"
                     /note="ER membrane protein complex subunit 6"
                     /db_xref="GeneID:83460"
                     /db_xref="HGNC:HGNC:28430"
                     /db_xref="MIM:620261"
     exon            1..88
                     /gene="EMC6"
                     /gene_synonym="RAB5IFL; TMEM93"
                     /inference="alignment:Splign:2.1.0"
     exon            89..656
                     /gene="EMC6"
                     /gene_synonym="RAB5IFL; TMEM93"
                     /inference="alignment:Splign:2.1.0"
     CDS             138..470
                     /gene="EMC6"
                     /gene_synonym="RAB5IFL; TMEM93"
                     /note="transmembrane protein 93"
                     /codon_start=1
                     /product="ER membrane protein complex subunit 6"
                     /protein_id="NP_112588.1"
                     /db_xref="CCDS:CCDS11033.1"
                     /db_xref="GeneID:83460"
                     /db_xref="HGNC:HGNC:28430"
                     /db_xref="MIM:620261"
                     /translation="MAAVVAKREGPPFISEAAVRGNAAVLDYCRTSVSALSGATAGIL
                     GLTGLYGFIFYLLASVLLSLLLILKAGRRWNKYFKSRRPLFTGGLIGGLFTYVLFWTF
                     LYGMVHVY"
     regulatory      637..642
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EMC6"
                     /gene_synonym="RAB5IFL; TMEM93"
                     /note="hexamer: ATTAAA"
     polyA_site      656
                     /gene="EMC6"
                     /gene_synonym="RAB5IFL; TMEM93"
                     /note="major polyA site"
ORIGIN      
        1 agtcttccga gcaagatggc gccgcgggca tttcttccac tgcccgtctg agggaacgct
       61 aagtagtgtg tccggcgccg tgttccagct ccgcgttgtt ccgcgagaaa gcgagaggcc
      121 gagcccgggc tggtgcgatg gccgcggtgg tggccaagcg ggaagggccg ccgttcatca
      181 gcgaggcggc cgtgcggggc aacgccgccg tcctggatta ttgccggacc tcggtgtcag
      241 cgctgtcggg ggccacggcc ggcatcctcg gcctcaccgg cctctacggc ttcatcttct
      301 acctgctcgc ctccgtcctg ctctccctgc tcctcattct caaggcggga aggaggtgga
      361 acaaatattt caaatcacgg agacctctct ttacaggagg cctcatcggg ggcctcttca
      421 cctacgtcct gttctggacg ttcctctacg gcatggtgca cgtctactga aatgggggcc
      481 cgggggactt ttttaaaaaa ccagatcggg aggactgtgg ccagcaatta acaccatgta
      541 gacttcctta gttcttaagt ggttgaattc gctgcttgtt ctgtaacgtt ataaataatt
      601 tatatctgaa gacggagagc ctgtaatatt cttcagatta aatgaagcgt gagaca
//
