LOCUS       NM_198449               4202 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens embigin (EMB), mRNA.
ACCESSION   NM_198449 XM_059649
VERSION     NM_198449.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4202)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 4202)
  AUTHORS   Zhou,J., Ma,C., Wang,K., Li,X., Zhang,H., Chen,J., Li,Z. and Shi,Y.
  TITLE     Rare and common variants analysis of the EMB gene in patients with
            schizophrenia
  JOURNAL   BMC Psychiatry 20 (1), 135 (2020)
   PUBMED   32213169
  REMARK    GeneRIF: Rare and common variants analysis of the EMB gene in
            patients with schizophrenia.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4202)
  AUTHORS   Forero-Quintero,L.S., Ames,S., Schneider,H.P., Thyssen,A.,
            Boone,C.D., Andring,J.T., McKenna,R., Casey,J.R., Deitmer,J.W. and
            Becker,H.M.
  TITLE     Membrane-anchored carbonic anhydrase IV interacts with
            monocarboxylate transporters via their chaperones CD147 and GP70
  JOURNAL   J Biol Chem 294 (2), 593-607 (2019)
   PUBMED   30446621
  REMARK    GeneRIF: This study analyzed the direct interaction between CAIV
            and the two Monocarboxylate transporters (MCTs) chaperones basigin
            (CD147) and embigin (GP70).
REFERENCE   4  (bases 1 to 4202)
  AUTHORS   Jung,D.E., Kim,J.M., Kim,C. and Song,S.Y.
  TITLE     Embigin is overexpressed in pancreatic ductal adenocarcinoma and
            regulates cell motility through epithelial to mesenchymal
            transition via the TGF-beta pathway
  JOURNAL   Mol Carcinog 55 (5), 633-645 (2016)
   PUBMED   25773908
  REMARK    GeneRIF: Study reports elevated expression of Embigin in pancreatic
            ductal adenocarcinoma and shows its novel functions in regulating
            cell proliferation, migration, and invasion.
REFERENCE   5  (bases 1 to 4202)
  AUTHORS   Chao,F., Zhang,J., Zhang,Y., Liu,H., Yang,C., Wang,J., Guo,Y.,
            Wen,X., Zhang,K., Huang,B., Liu,D. and Li,Y.
  TITLE     Embigin, regulated by HOXC8, plays a suppressive role in breast
            tumorigenesis
  JOURNAL   Oncotarget 6 (27), 23496-23509 (2015)
   PUBMED   26090721
  REMARK    GeneRIF: embigin is regulated by HOXC8 and its loss plays an
            important role in the progression of breast tumors
REFERENCE   6  (bases 1 to 4202)
  AUTHORS   Pertega-Gomes,N., Vizcaino,J.R., Miranda-Goncalves,V., Pinheiro,C.,
            Silva,J., Pereira,H., Monteiro,P., Henrique,R.M., Reis,R.M.,
            Lopes,C. and Baltazar,F.
  TITLE     Monocarboxylate transporter 4 (MCT4) and CD147 overexpression is
            associated with poor prognosis in prostate cancer
  JOURNAL   BMC Cancer 11, 312 (2011)
   PUBMED   21787388
  REMARK    GeneRIF: Data show that Gp70 (embigin) was negative in all normal,
            adjacent non-neoplastic and PIN lesions and only a very small
            percentage of cases.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 4202)
  AUTHORS   Guenette,R.S., Sridhar,S., Herley,M., Mooibroek,M., Wong,P. and
            Tenniswood,M.
  TITLE     Embigin, a developmentally expressed member of the immunoglobulin
            super family, is also expressed during regression of prostate and
            mammary gland
  JOURNAL   Dev Genet 21 (4), 268-278 (1997)
   PUBMED   9438341
REFERENCE   8  (bases 1 to 4202)
  AUTHORS   Ray,M.E., Su,Y.A., Meltzer,P.S. and Trent,J.M.
  TITLE     Isolation and characterization of genes associated with
            chromosome-6 mediated tumor suppression in human malignant melanoma
  JOURNAL   Oncogene 12 (12), 2527-2533 (1996)
   PUBMED   8700511
REFERENCE   9  (bases 1 to 4202)
  AUTHORS   Ozawa,M., Huang,R.P., Furukawa,T. and Muramatsu,T.
  TITLE     A teratocarcinoma glycoprotein carrying a developmentally regulated
            carbohydrate marker is a member of the immunoglobulin gene
            superfamily
  JOURNAL   J Biol Chem 263 (7), 3059-3062 (1988)
   PUBMED   2963822
  REMARK    GeneRIF: Reports the original cloning of the mouse embigin gene,
            referred to as gp70, from embryonal carcinoma cells.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC059398.1 and AC091833.2.
            
            On Nov 22, 2018 this sequence version replaced NM_198449.2.
            
            Summary: This gene encodes a transmembrane glycoprotein that is a
            member of the immunoglobulin superfamily. The encoded protein may
            be involved in cell growth and development by mediating
            interactions between the cell and extracellular matrix. A
            pseudogene of this gene is found on chromosome 1. [provided by
            RefSeq, Jan 2009].
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.60958.1,
                                           SRR1803611.273716.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000303221.10/ ENSP00000302289.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1514              BC059398.1         80-1593
            1515-4202           AC091833.2         22757-25444
FEATURES             Location/Qualifiers
     source          1..4202
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q11.1"
     gene            1..4202
                     /gene="EMB"
                     /gene_synonym="GP70"
                     /note="embigin"
                     /db_xref="GeneID:133418"
                     /db_xref="HGNC:HGNC:30465"
                     /db_xref="MIM:615669"
     exon            1..249
                     /gene="EMB"
                     /gene_synonym="GP70"
                     /inference="alignment:Splign:2.1.0"
     CDS             138..1121
                     /gene="EMB"
                     /gene_synonym="GP70"
                     /note="embigin homolog"
                     /codon_start=1
                     /product="embigin precursor"
                     /protein_id="NP_940851.1"
                     /db_xref="CCDS:CCDS3953.1"
                     /db_xref="GeneID:133418"
                     /db_xref="HGNC:HGNC:30465"
                     /db_xref="MIM:615669"
                     /translation="MRALPGLLEARARTPRLLLLQCLLAAARPSSADGSAPDSPFTSP
                     PLREEIMANNFSLESHNISLTEHSSMPVEKNITLERPSNVNLTCQFTTSGDLNAVNVT
                     WKKDGEQLENNYLVSATGSTLYTQYRFTIINSKQMGSYSCFFREEKEQRGTFNFKVPE
                     LHGKNKPLISYVGDSTVLTCKCQNCFPLNWTWYSSNGSVKVPVGVQMNKYVINGTYAN
                     ETKLKITQLLEEDGESYWCRALFQLGESEEHIELVVLSYLVPLKPFLVIVAEVILLVA
                     TILLCEKYTQKKKKHSDEGKEFEQIEQLKSDDSNGIENNVPRHRKNESLGQ"
     exon            250..333
                     /gene="EMB"
                     /gene_synonym="GP70"
                     /inference="alignment:Splign:2.1.0"
     exon            334..520
                     /gene="EMB"
                     /gene_synonym="GP70"
                     /inference="alignment:Splign:2.1.0"
     exon            521..609
                     /gene="EMB"
                     /gene_synonym="GP70"
                     /inference="alignment:Splign:2.1.0"
     exon            610..737
                     /gene="EMB"
                     /gene_synonym="GP70"
                     /inference="alignment:Splign:2.1.0"
     exon            738..1014
                     /gene="EMB"
                     /gene_synonym="GP70"
                     /inference="alignment:Splign:2.1.0"
     exon            1015..1048
                     /gene="EMB"
                     /gene_synonym="GP70"
                     /inference="alignment:Splign:2.1.0"
     exon            1049..1103
                     /gene="EMB"
                     /gene_synonym="GP70"
                     /inference="alignment:Splign:2.1.0"
     exon            1104..4202
                     /gene="EMB"
                     /gene_synonym="GP70"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4088..4093
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EMB"
                     /gene_synonym="GP70"
                     /note="hexamer: AATAAA"
     polyA_site      4109
                     /gene="EMB"
                     /gene_synonym="GP70"
     regulatory      4177..4182
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EMB"
                     /gene_synonym="GP70"
                     /note="hexamer: AAGAAA"
     polyA_site      4184
                     /gene="EMB"
                     /gene_synonym="GP70"
     polyA_site      4202
                     /gene="EMB"
                     /gene_synonym="GP70"
                     /note="major polyA site"
ORIGIN      
        1 cttttcttca gcgtcctacc cgcggcactg gctgcgagcg ccgggccacc tgcgagtgtg
       61 cgcagggact ctggacaccc gcggcggcga gctgagggag cagtctccac gaggacccag
      121 gcggaccctc tggcgccatg cgcgccctcc ccggcctgct ggaggccagg gcgcgtacgc
      181 cccggctgct cctcctccag tgccttctcg ctgccgcgcg cccaagctcg gcggacggca
      241 gtgccccaga ttcgcctttt acaagtccac ctctcagaga agaaataatg gcaaataact
      301 tttccttgga gagtcataac atatcactga ctgaacattc tagtatgcca gtagaaaaaa
      361 atatcacttt agaaaggcct tctaatgtaa atctcacatg ccagttcaca acatctgggg
      421 atttgaatgc agtaaatgtg acttggaaaa aagatggtga acaacttgag aataattatc
      481 ttgtcagtgc aacaggaagc accttgtata cccaatacag gttcaccatc attaatagca
      541 aacaaatggg aagttattct tgtttctttc gagaggaaaa ggaacaaagg ggaacattta
      601 atttcaaagt ccctgaactt catgggaaaa acaagccatt gatctcttac gtaggggatt
      661 ctactgtctt gacatgtaaa tgtcaaaatt gttttccttt aaattggacc tggtacagta
      721 gtaatgggag tgtaaaggtt cctgttggtg ttcaaatgaa taaatatgtg atcaatggaa
      781 catatgctaa cgaaacaaag ctgaagataa cacaactttt ggaggaagat ggggaatctt
      841 actggtgccg tgcactattc caattaggcg agagtgaaga acacattgag cttgtggtgc
      901 tgagctattt ggtgcccctc aaaccatttc ttgtaatagt ggctgaggtg attcttttag
      961 tggccaccat tctgctttgt gaaaagtaca cacaaaagaa aaagaagcac tcagatgagg
     1021 ggaaagaatt tgagcagatt gaacagctga aatcagatga tagcaatggt atagaaaata
     1081 atgtccccag gcatagaaaa aatgagtctc tgggccagtg aatacaaaac atcatgtcga
     1141 gaatcattgg aagatataca gagttcgtat ttcagctttg tttatccttc ctgttaagag
     1201 cctctgagtt tttagtttta aaaggatgaa aagcttatgc aacatgctca gcaggagctt
     1261 catcaacgat atatgtcaga tctaaaggta tattttcatt ctgtaattat gttacataaa
     1321 agcaatgtaa atcagaataa atatgttaga ccagaataaa attaattata ttctggtctt
     1381 caaaggacac acagaacaga tatcagcaga atcacttaat acttcataga acaaaaatca
     1441 ctcaaaacct gtttataacc aaagaattca tgaaaaagaa agcctttgcc atttgtctta
     1501 gaaagttatt ttttaaaaaa aaatcatact tactattagt atctatggaa gtatatgtaa
     1561 caatttttat gtaaaggtca tctttctgtg atagtgaaaa aatatgtctt tactaagttg
     1621 aaatgaatac tttctgcctt tgctaatgat agttattcta caatctccac aagaaaaata
     1681 taccttttat ccggaaatat tggtttaagg caaataaata aaactgtgct tgctctaaag
     1741 ctctgcacta caaaagcaaa ttttccagtc tttattccac tcataaccac tgctttcccc
     1801 accaggctaa agtgcttctt agtcttaaat agggttttta acttcataag gtacaccatt
     1861 gtttatgttt tagggtgcag gtccatatag tcgtaatact taaaacactg ctacactgat
     1921 gcttttgtgg ctcatggttt cctggttctt tgatttaaca cctggcttcc tggtatctat
     1981 ggctggttaa atatctaaac ctgcattatt agtgctttac aataataatt cccttgactg
     2041 aagtccagaa atactaaagc acttcttttt tattgctgtg aatgccttag acttatcttc
     2101 caaaatagga tacttcgttt ctattgcata tataactgaa atattttata aactcactgt
     2161 aatcaaatct tataaaatct gaatcaacat gaaaagttgt caatgcttga atgaatacta
     2221 aaatcatacc acaagatact agataacata aatgaccatg aagtgtccca ctgctcaaag
     2281 ggcaacaact ttaagaacag aagcaaagag tggtggtgtg gaacccaaga ttcttggcga
     2341 ctagggaatt taaaggttgg ggaggaggaa ttcaatgatt tgacaagaaa tactttataa
     2401 aaatttgctc catgtattgg ctaagaaaaa tataataaaa ttttggtagt gaaaattgta
     2461 tcactaatgt ttaccaatat tactagtatg aataatacac ataaggtagt gacttggaag
     2521 ctgctcaata ctttgttgct ataacaaaat gcaatatttt gttgtaaagc atcttaacta
     2581 cacatataag tttgctgaac ttgaatacat cccggtaatg gcaaacttca ttttattctt
     2641 ggttttcatt ttattctggt ctcagggcca tacatttatt ttagtttaat taattattat
     2701 tttgacaaca ttacttgggt aatatctata taatggtaga taaccaatca gttagcttaa
     2761 ttaatctaag ctatttgaat tcagggaaat attagtcaaa tctgctgttt gactaaatac
     2821 aattcaaagc agtgtatttg tgacttggaa tatagaacac aaacaaatgt gtaacccatc
     2881 tgcagtatgc attcttccat tttaccacca ctaaccattg aggctcatac aattttcaag
     2941 caacaagcat tgcttcccaa aggtaaaata atcaggaata tttctatagt aaatggagtt
     3001 tttaattggc aatactgttt atttttttct agcaaagaca atttatctca gtaaccttaa
     3061 ataggaaaag tactcaaaaa ttaaagttga cttttggctt tttgtagtct ctctggagga
     3121 cttccagaaa attaccactg ttggatttta atctgcttcc attaaccaat cttacagaga
     3181 tgataaatga attaactaat attgaccaaa tataaattga ctgcaaataa taagccgcat
     3241 aaaagttgaa gtaggaaaac tactccaagt ttatatatta ggcaccttgg ggaattctct
     3301 tagtctttcc agctaacaag gattttcagc ataataagta gatttaatga tggcataaaa
     3361 ttcccagata ctttcatata cattttttgc caaagtgtaa atcttctcct tttgcagtct
     3421 ttttgttatt atcccaacat ctagctgctc aggccctaat ttagaactca ttctgatatt
     3481 ttcttcttct gtattaatta atacttatgg gtcatgaatc cctgctcctt tgaccttttt
     3541 aatagctcat gaatccatcc cattgcctcc ccaactctgc ccacacctgc tgcaacacta
     3601 atgccttgat tttcctacct cagtctcctt ttctattaat ccctcttttg cgtggctgcc
     3661 tgagtccact ttctcaaaca caaacctcac tatgcaactt tggaatctct gtaggctcac
     3721 ctttgccatt tcttaatatt gcattctcca aattgctaat ctctatccag tctcttgaac
     3781 tagacttggc acatggagat tccgctcaga aagtgctctt cacacttcta cctgcttgac
     3841 taaccccaga ttatctttca agactttaat ctgatcttgt gtcttagaga agcccccata
     3901 cctggtagag catgtaccat cttacatgct taaataactc cacatttatt tgtgtttatt
     3961 actctgtgtt ataaatatac atttgttggt ctctctcttg gattattttg tttctttgtc
     4021 ctgtaactac cactgaaagg gtgcaataca gctttcttga aatgtgtatt gaacggatga
     4081 atgtataaat aaaaattaaa ttttgtaaat ttctgcttat tcttagaaaa agaatctaaa
     4141 ttgtgacaaa tcagaattga aaaaagtatt ctaataaaga aaaacaagct tttataactt
     4201 ca
//
