LOCUS       NM_022142               1079 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens epididymal sperm binding protein 1 (ELSPBP1), mRNA.
ACCESSION   NM_022142 XM_946145 XM_946146 XM_946147
VERSION     NM_022142.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1079)
  AUTHORS   Tiwari,I., Yoon,M.H., Park,B.J. and Jang,K.L.
  TITLE     Hepatitis C virus core protein induces epithelial-mesenchymal
            transition in human hepatocytes by upregulating E12/E47 levels
  JOURNAL   Cancer Lett 362 (1), 131-138 (2015)
   PUBMED   25817725
  REMARK    GeneRIF: HCV core protein represses E-cadherin expression by
            upregulating E12/E47 levels to induce EMT in HCV-associated HCC.
REFERENCE   2  (bases 1 to 1079)
  AUTHORS   Loo,S.K., Shtir,C., Doyle,A.E., Mick,E., McGough,J.J.,
            McCracken,J., Biederman,J., Smalley,S.L., Cantor,R.M., Faraone,S.V.
            and Nelson,S.F.
  TITLE     Genome-wide association study of intelligence: additive effects of
            novel brain expressed genes
  JOURNAL   J Am Acad Child Adolesc Psychiatry 51 (4), 432-440 (2012)
   PUBMED   22449649
REFERENCE   3  (bases 1 to 1079)
  AUTHORS   Lee,J.H., Zhou,S. and Smas,C.M.
  TITLE     Identification of RANBP16 and RANBP17 as novel interaction partners
            for the bHLH transcription factor E12
  JOURNAL   J Cell Biochem 111 (1), 195-206 (2010)
   PUBMED   20503194
  REMARK    GeneRIF: These biochemical and functional data reveal RANBP16 and
            RANBP17 as novel regulators of E2A protein action, and demonstrate
            specific interaction of E12 with RANBP17.
REFERENCE   4  (bases 1 to 1079)
  AUTHORS   Ryan,D.P., Duncan,J.L., Lee,C., Kuchel,P.W. and Matthews,J.M.
  TITLE     Assembly of the oncogenic DNA-binding complex LMO2-Ldb1-TAL1-E12
  JOURNAL   Proteins 70 (4), 1461-1474 (2008)
   PUBMED   17910069
  REMARK    GeneRIF: characterize the assembly of a five-component complex
            containing TAL1, LMO2, Ldb1, E12, and DNA. The bHLH domains of TAL1
            and E12 alone primarily formed helical homodimers, but together
            formed heterodimers, to which LMO2 bound with high affinity
REFERENCE   5  (bases 1 to 1079)
  AUTHORS   Ekhlasi-Hundrieser,M., Schafer,B., Philipp,U., Kuiper,H., Leeb,T.,
            Mehta,M., Kirchhoff,C. and Topfer-Petersen,E.
  TITLE     Sperm-binding fibronectin type II-module proteins are genetically
            linked and functionally related
  JOURNAL   Gene 392 (1-2), 253-265 (2007)
   PUBMED   17307309
  REMARK    GeneRIF: Sperm-binding fibronectin type II-module proteins are
            genetically linked and functionally related.
REFERENCE   6  (bases 1 to 1079)
  AUTHORS   Saalmann,A., Munz,S., Ellerbrock,K., Ivell,R. and Kirchhoff,C.
  TITLE     Novel sperm-binding proteins of epididymal origin contain four
            fibronectin type II-modules
  JOURNAL   Mol Reprod Dev 58 (1), 88-100 (2001)
   PUBMED   11144225
REFERENCE   7  (bases 1 to 1079)
  AUTHORS   Law,S.F., Zhang,Y.Z., Fashena,S.J., Toby,G., Estojak,J. and
            Golemis,E.A.
  TITLE     Dimerization of the docking/adaptor protein HEF1 via a
            carboxy-terminal helix-loop-helix domain
  JOURNAL   Exp Cell Res 252 (1), 224-235 (1999)
   PUBMED   10502414
REFERENCE   8  (bases 1 to 1079)
  AUTHORS   Hsu,H.L., Wadman,I. and Baer,R.
  TITLE     Formation of in vivo complexes between the TAL1 and E2A
            polypeptides of leukemic T cells
  JOURNAL   Proc Natl Acad Sci U S A 91 (8), 3181-3185 (1994)
   PUBMED   8159721
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC010330.7, AF279147.1,
            BM663735.1 and BM661759.1.
            
            On Nov 22, 2018 this sequence version replaced NM_022142.4.
            
            Summary: The protein encoded by this gene belongs to the
            sperm-coating protein family of epididymal origin. This protein and
            its canine homolog are the first known examples of proteins with
            four tandemly arranged fibronectin type 2 (Fn2) domains in the
            Fn2-module protein family. [provided by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189667.303856.1,
                                           SRR5189667.182627.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2148093 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000339841.7/ ENSP00000340660.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                AC010330.7         45010-45028         c
            20-791              AF279147.1         1-772
            792-1073            BM663735.1         16-297              c
            1074-1078           BM661759.1         19-23               c
            1079-1079           AC010330.7         14506-14506         c
FEATURES             Location/Qualifiers
     source          1..1079
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.33"
     gene            1..1079
                     /gene="ELSPBP1"
                     /gene_synonym="E12; EDDM12; EL149; HE12"
                     /note="epididymal sperm binding protein 1"
                     /db_xref="GeneID:64100"
                     /db_xref="HGNC:HGNC:14417"
                     /db_xref="MIM:607443"
     exon            1..180
                     /gene="ELSPBP1"
                     /gene_synonym="E12; EDDM12; EL149; HE12"
                     /inference="alignment:Splign:2.1.0"
     exon            181..267
                     /gene="ELSPBP1"
                     /gene_synonym="E12; EDDM12; EL149; HE12"
                     /inference="alignment:Splign:2.1.0"
     CDS             198..869
                     /gene="ELSPBP1"
                     /gene_synonym="E12; EDDM12; EL149; HE12"
                     /note="epididymal protein 12; epididymis luminal secretory
                     protein 149; epididymal secretory protein 12; epididymis
                     secretory sperm binding protein"
                     /codon_start=1
                     /product="epididymal sperm-binding protein 1 precursor"
                     /protein_id="NP_071425.3"
                     /db_xref="CCDS:CCDS12708.1"
                     /db_xref="GeneID:64100"
                     /db_xref="HGNC:HGNC:14417"
                     /db_xref="MIM:607443"
                     /translation="MTRWSSYLLGWTTFLLYSYESSGGMHEECVFPFTYKGSVYFTCT
                     HIHSLSPWCATRAVYNGQWKYCQSEDYPRCIFPFIYRGKAYNSCISQGSFLGSLWCSV
                     TSVFDEKQQWKFCETNEYGGNSLRKPCIFPSIYRNNVVSDCMEDESNKLWCPTTENMD
                     KDGKWSFCADTRISALVPGFPCHFPFNYKNKNYFNCTNEGSKENLVWCATSYNYDQDH
                     TWVYC"
     exon            268..405
                     /gene="ELSPBP1"
                     /gene_synonym="E12; EDDM12; EL149; HE12"
                     /inference="alignment:Splign:2.1.0"
     exon            406..552
                     /gene="ELSPBP1"
                     /gene_synonym="E12; EDDM12; EL149; HE12"
                     /inference="alignment:Splign:2.1.0"
     exon            553..711
                     /gene="ELSPBP1"
                     /gene_synonym="E12; EDDM12; EL149; HE12"
                     /inference="alignment:Splign:2.1.0"
     exon            712..876
                     /gene="ELSPBP1"
                     /gene_synonym="E12; EDDM12; EL149; HE12"
                     /inference="alignment:Splign:2.1.0"
     exon            877..1079
                     /gene="ELSPBP1"
                     /gene_synonym="E12; EDDM12; EL149; HE12"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1053..1058
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ELSPBP1"
                     /gene_synonym="E12; EDDM12; EL149; HE12"
                     /note="hexamer: AATAAA"
     polyA_site      1079
                     /gene="ELSPBP1"
                     /gene_synonym="E12; EDDM12; EL149; HE12"
                     /note="major polyA site"
ORIGIN      
        1 actgccttct gacagtaacc actgatgaag aaccctcctt tgagaagctg cctttgtgtc
       61 ctacagacag gctggggcca aagccattca accaatcccc agataatcca gagctcttgg
      121 gagcagaacc ttaaagagag atcgtggaga gagccagggc ccagaagaac tctctcaaag
      181 agaagagggc agccaagatg acccgatggt ccagttacct gttgggatgg acaaccttcc
      241 ttctctattc ctatgagtca agtggaggga tgcatgagga atgtgtcttt cctttcacct
      301 acaagggatc tgtttacttc acttgcaccc atattcatag cttatcccct tggtgtgcca
      361 ccagagccgt gtacaacggc cagtggaagt actgccagag tgaagattac ccacgctgta
      421 tcttcccttt catctatcga ggaaaggctt ataacagctg catctcccag ggcagcttct
      481 taggcagtct gtggtgctca gtcacctctg tcttcgatga gaaacagcag tggaaattct
      541 gtgaaacgaa tgagtatggg ggaaattctc tcaggaagcc ctgcatcttc ccctccatct
      601 acagaaataa tgtggtctct gattgcatgg aggatgaaag caacaagctc tggtgcccaa
      661 ccacagagaa catggataag gatggaaagt ggagtttctg tgccgacacc agaatttccg
      721 cgttggtccc tggctttcct tgtcactttc cgttcaacta taaaaacaag aattatttta
      781 actgcactaa cgaaggatca aaggagaacc ttgtgtggtg tgcaacttct tacaactacg
      841 accaagacca cacctgggtg tattgctgat gctgaggaaa ggagaaatat cttcagagga
      901 agactgccgc catactgagg ctgagcacag atttgtcttt ttcattgcat ctgtcaagct
      961 taaataacca cctttagaaa taccctctgc accacctgct tcaatcagct ggtcctttgt
     1021 gaagaacgta gagagaatgc ggcataacca ccaataaagg agtcttgatt taaccctgg
//
