LOCUS       NM_203414               1491 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens elongator acetyltransferase complex subunit 5 (ELP5),
            transcript variant 3, mRNA.
ACCESSION   NM_203414
VERSION     NM_203414.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1491)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 1491)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 1491)
  AUTHORS   Xu,S., Zhan,M., Jiang,C., He,M., Yang,L., Shen,H., Huang,S.,
            Huang,X., Lin,R., Shi,Y., Liu,Q., Chen,W., Mohan,M. and Wang,J.
  TITLE     Genome-wide CRISPR screen identifies ELP5 as a determinant of
            gemcitabine sensitivity in gallbladder cancer
  JOURNAL   Nat Commun 10 (1), 5492 (2019)
   PUBMED   31792210
  REMARK    GeneRIF: Loss of ELP5 impairs the integrity and stability of the
            Elongator complex to abrogate wobble U34 tRNA modification, and
            directly impedes the wobble U34 modification-dependent translation
            of hnRNPQ mRNA.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1491)
  AUTHORS   Kojic,M. and Wainwright,B.
  TITLE     The Many Faces of Elongator in Neurodevelopment and Disease
  JOURNAL   Front Mol Neurosci 9, 115 (2016)
   PUBMED   27847465
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1491)
  AUTHORS   Close,P., Gillard,M., Ladang,A., Jiang,Z., Papuga,J., Hawkes,N.,
            Nguyen,L., Chapelle,J.P., Bouillenne,F., Svejstrup,J., Fillet,M.
            and Chariot,A.
  TITLE     DERP6 (ELP5) and C3ORF75 (ELP6) regulate tumorigenicity and
            migration of melanoma cells as subunits of Elongator
  JOURNAL   J Biol Chem 287 (39), 32535-32545 (2012)
   PUBMED   22854966
  REMARK    GeneRIF: data identify DERP6/ELP5 and C3ORF75/ELP6 as key players
            for migration, invasion and tumorigenicity of melanoma cells, as
            integral subunits of Elongator.
REFERENCE   6  (bases 1 to 1491)
  AUTHORS   Yuan,J., Tang,W., Luo,K., Chen,X., Gu,X., Wan,B. and Yu,L.
  TITLE     Cloning and characterization of the human gene DERP6, which
            activates transcriptional activities of p53
  JOURNAL   Mol Biol Rep 33 (3), 151-158 (2006)
   PUBMED   16850183
  REMARK    GeneRIF: cloning and characterization of the DERP6 gene, isolated
            from testis cDNA library; results indicate that the DERP6 may be
            involved in p53-mediated gene transcription
REFERENCE   7  (bases 1 to 1491)
  AUTHORS   Lim,J., Hao,T., Shaw,C., Patel,A.J., Szabo,G., Rual,J.F.,
            Fisk,C.J., Li,N., Smolyar,A., Hill,D.E., Barabasi,A.L., Vidal,M.
            and Zoghbi,H.Y.
  TITLE     A protein-protein interaction network for human inherited ataxias
            and disorders of Purkinje cell degeneration
  JOURNAL   Cell 125 (4), 801-814 (2006)
   PUBMED   16713569
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC003688.1.
            
            On Mar 18, 2021 this sequence version replaced NM_203414.2.
            
            Transcript Variant: This variant (3) differs in the 5' UTR compared
            to variant 1. Variants 1, 3 and 4 encode the same isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK225983.1, AF087868.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            MANE Ensembl match               :: ENST00000396628.7/
                                                ENSP00000379869.3
            RefSeq Select criteria           :: based on manual assertion,
                                                conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-382               AC003688.1         54611-54992
            383-443             AC003688.1         55166-55226
            444-524             AC003688.1         55314-55394
            525-745             AC003688.1         56979-57199
            746-927             AC003688.1         59253-59434
            928-1023            AC003688.1         60984-61079
            1024-1124           AC003688.1         61222-61322
            1125-1491           AC003688.1         61967-62333
FEATURES             Location/Qualifiers
     source          1..1491
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.1"
     gene            1..1491
                     /gene="ELP5"
                     /gene_synonym="C17orf81; DERP6; HSPC002; MST071; MSTP071"
                     /note="elongator acetyltransferase complex subunit 5"
                     /db_xref="GeneID:23587"
                     /db_xref="HGNC:HGNC:30617"
                     /db_xref="MIM:615019"
     exon            1..382
                     /gene="ELP5"
                     /gene_synonym="C17orf81; DERP6; HSPC002; MST071; MSTP071"
                     /inference="alignment:Splign:2.1.0"
     CDS             337..1239
                     /gene="ELP5"
                     /gene_synonym="C17orf81; DERP6; HSPC002; MST071; MSTP071"
                     /note="isoform 1 is encoded by transcript variant 3;
                     S-phase 2 protein; dermal papilla derived protein 6;
                     elongator complex protein 5"
                     /codon_start=1
                     /product="elongator complex protein 5 isoform 1"
                     /protein_id="NP_981959.2"
                     /db_xref="CCDS:CCDS11094.2"
                     /db_xref="GeneID:23587"
                     /db_xref="HGNC:HGNC:30617"
                     /db_xref="MIM:615019"
                     /translation="MLDSLLALGGLVLLRDSVEWEGRSLLKALVKKSALCGEQVHILG
                     CEVSEEEFREGFDSDINNRLVYHDFFRDPLNWSKTEEAFPGGPLGALRAMCKRTDPVP
                     VTIALDSLSWLLLRLPCTTLCQVLHAVSHQDSCPGDSSSVGKVSVLGLLHEELHGPGP
                     VGALSSLAQTEVTLGGTMGQASAHILCRRPRQRPTDQTQWFSILPDFSLDLQEGPSVE
                     SQPYSDPHIPPVDPTTHLTFNLHLSKKEREARDSLILPFQFSSEKQQALLRPRPGQAT
                     SHIFYEPDAYDDLDQEDPDDDLDI"
     exon            383..443
                     /gene="ELP5"
                     /gene_synonym="C17orf81; DERP6; HSPC002; MST071; MSTP071"
                     /inference="alignment:Splign:2.1.0"
     exon            444..524
                     /gene="ELP5"
                     /gene_synonym="C17orf81; DERP6; HSPC002; MST071; MSTP071"
                     /inference="alignment:Splign:2.1.0"
     exon            525..745
                     /gene="ELP5"
                     /gene_synonym="C17orf81; DERP6; HSPC002; MST071; MSTP071"
                     /inference="alignment:Splign:2.1.0"
     exon            746..927
                     /gene="ELP5"
                     /gene_synonym="C17orf81; DERP6; HSPC002; MST071; MSTP071"
                     /inference="alignment:Splign:2.1.0"
     exon            928..1023
                     /gene="ELP5"
                     /gene_synonym="C17orf81; DERP6; HSPC002; MST071; MSTP071"
                     /inference="alignment:Splign:2.1.0"
     exon            1024..1124
                     /gene="ELP5"
                     /gene_synonym="C17orf81; DERP6; HSPC002; MST071; MSTP071"
                     /inference="alignment:Splign:2.1.0"
     exon            1125..1491
                     /gene="ELP5"
                     /gene_synonym="C17orf81; DERP6; HSPC002; MST071; MSTP071"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1462..1467
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ELP5"
                     /gene_synonym="C17orf81; DERP6; HSPC002; MST071; MSTP071"
                     /note="hexamer: AATAAA"
     polyA_site      1491
                     /gene="ELP5"
                     /gene_synonym="C17orf81; DERP6; HSPC002; MST071; MSTP071"
                     /note="major polyA site"
ORIGIN      
        1 acttggcccg cgcttagggc cctcgcgggg ggcttgtggg tcctcctccc cctcccactg
       61 acaactgccc caactgctct tcccgccccg gtcacagtga aaatgtagac ggggtcgttg
      121 tccgtacgac tgtgcgccag ggctcgggga ggggcgccct ccgcgtgagc gcccccctgg
      181 gaatattgaa cataatcacc tctcattcca gactatgtta ggtcttaatg gtgggaggac
      241 gcccgagtgc tcggcccgtt tcaccccgag gaggaaggac actgggtcat gacgccatca
      301 gagggcgcca gagcagggac cggacgcgag ttggagatgt tggactcgct gttggccttg
      361 ggcggcctgg tgctgcttcg ggattccgtg gagtgggagg ggcgcagtct cttgaaggcg
      421 cttgtcaaga aatctgcact gtgtggggag caagtgcata tcctgggctg tgaagtgagc
      481 gaggaagagt ttcgtgaagg ttttgactct gatatcaaca atcggctggt ttaccatgac
      541 ttcttcagag accctctcaa ctggtcaaaa actgaggagg cctttcctgg ggggccgctg
      601 ggagccttga gagccatgtg caagaggaca gatcctgttc ctgtcaccat tgctctcgat
      661 tcactcagct ggctgctact tcgccttccc tgcaccacac tctgccaggt cctgcatgct
      721 gtgagccatc aggactcttg tcctggtgac agctcctcag tggggaaagt gagtgtgctg
      781 ggcttgctac atgaagagct tcatggacca ggccctgtgg gagctctcag cagccttgct
      841 cagactgagg tgaccctggg cggtaccatg ggccaggcct cggcccacat cctgtgtcgg
      901 aggccccgac agcgcccaac tgaccagact cagtggttct ccatccttcc ggacttcagc
      961 ctggatctcc aagaggggcc ctctgtagag tcccagccct actccgatcc tcatataccc
     1021 ccggtggatc ccacaactca tttgaccttt aaccttcacc tgtccaagaa agagagagaa
     1081 gccagagata gcctgatcct gcccttccag ttcagttctg aaaaacagca ggctctcctg
     1141 cggcctaggc cagggcaggc taccagccac atcttctatg agccagatgc ttatgatgac
     1201 ctggaccaag aagacccaga tgacgacctg gatatttgac tggccagatt tgattagatt
     1261 gtaattggag ggggcgcggg aagactttgg gcccagaacc atctttctat tgtttgtgtt
     1321 agccttaccc tgtccctgcc ccaccttggt tccccttgtc tatggagccc cgccttgtga
     1381 gccaggaagc agcgtctcat caggacagaa ggtaggatga agacatgggg taatgtgaga
     1441 gagtagaaca cccccgtacc taataaaaat ctttattttt ttattaaaaa a
//
