LOCUS       NM_019040               8093 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens elongator acetyltransferase complex subunit 4 (ELP4),
            transcript variant 1, mRNA.
ACCESSION   NM_019040
VERSION     NM_019040.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8093)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 8093)
  AUTHORS   Li,K., Kong,D.S., Zhang,J., Wang,X.S., Ye,X. and Zhao,Y.L.
  TITLE     Association between ELP4 rs986527 polymorphism and the occurrence
            and development of intracranial arachnoid cyst
  JOURNAL   Brain Behav 9 (12), e01480 (2019)
   PUBMED   31743616
  REMARK    GeneRIF: ELP4 rs986527 polymorphism affected the incidence of
            clinical symptoms and the levels of TNF-alpha and IL-1beta in
            patients with intracranial Arachnoid Cysts.
REFERENCE   3  (bases 1 to 8093)
  AUTHORS   Xu,Y., Zhou,W., Ji,Y., Shen,J., Zhu,X., Yu,H., Guo,J., Pang,Z. and
            Wei,W.
  TITLE     Elongator promotes the migration and invasion of hepatocellular
            carcinoma cell by the phosphorylation of AKT
  JOURNAL   Int J Biol Sci 14 (5), 518-530 (2018)
   PUBMED   29805303
  REMARK    GeneRIF: Elongator activated migration and invasion of
            hepatocellular carcinoma cells by promoting the expression of MMP-2
            and MMP-9 through the PI3K/AKT signaling pathway
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 8093)
  AUTHORS   Kojic,M. and Wainwright,B.
  TITLE     The Many Faces of Elongator in Neurodevelopment and Disease
  JOURNAL   Front Mol Neurosci 9, 115 (2016)
   PUBMED   27847465
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 8093)
  AUTHORS   Addis,L., Ahn,J.W., Dobson,R., Dixit,A., Ogilvie,C.M., Pinto,D.,
            Vaags,A.K., Coon,H., Chaste,P., Wilson,S., Parr,J.R., Andrieux,J.,
            Lenne,B., Tumer,Z., Leuzzi,V., Aubell,K., Koillinen,H., Curran,S.,
            Marshall,C.R., Scherer,S.W., Strug,L.J., Collier,D.A. and Pal,D.K.
  TITLE     Microdeletions of ELP4 Are Associated with Language Impairment,
            Autism Spectrum Disorder, and Mental Retardation
  JOURNAL   Hum Mutat 36 (9), 842-850 (2015)
   PUBMED   26010655
  REMARK    GeneRIF: Our results suggest that ELP4 deletions are highly likely
            to be pathogenic, predisposing to a range of neurodevelopmental
            phenotypes from ASD to language impairment and epilepsy.
REFERENCE   6  (bases 1 to 8093)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   7  (bases 1 to 8093)
  AUTHORS   Kim,J.H., Lane,W.S. and Reinberg,D.
  TITLE     Human Elongator facilitates RNA polymerase II transcription through
            chromatin
  JOURNAL   Proc Natl Acad Sci U S A 99 (3), 1241-1246 (2002)
   PUBMED   11818576
REFERENCE   8  (bases 1 to 8093)
  AUTHORS   Kleinjan,D.A., Seawright,A., Elgar,G. and van Heyningen,V.
  TITLE     Characterization of a novel gene adjacent to PAX6, revealing
            synteny conservation with functional significance
  JOURNAL   Mamm Genome 13 (2), 102-107 (2002)
   PUBMED   11889558
REFERENCE   9  (bases 1 to 8093)
  AUTHORS   Hawkes,N.A., Otero,G., Winkler,G.S., Marshall,N., Dahmus,M.E.,
            Krappmann,D., Scheidereit,C., Thomas,C.L., Schiavo,G.,
            Erdjument-Bromage,H., Tempst,P. and Svejstrup,J.Q.
  TITLE     Purification and characterization of the human elongator complex
  JOURNAL   J Biol Chem 277 (4), 3047-3052 (2002)
   PUBMED   11714725
REFERENCE   10 (bases 1 to 8093)
  AUTHORS   Winkler,G.S., Petrakis,T.G., Ethelberg,S., Tokunaga,M.,
            Erdjument-Bromage,H., Tempst,P. and Svejstrup,J.Q.
  TITLE     RNA polymerase II elongator holoenzyme is composed of two discrete
            subcomplexes
  JOURNAL   J Biol Chem 276 (35), 32743-32749 (2001)
   PUBMED   11435442
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK000505.1, BM680240.1,
            D59285.1, BF969161.1, BQ083338.1 and Z83307.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_019040.4.
            
            Summary: This gene encodes a component of the six subunit elongator
            complex, a histone acetyltransferase complex that associates
            directly with RNA polymerase II during transcriptional elongation.
            The human gene can partially complement sensitivity phenotypes of
            yeast ELP4 deletion mutants. This gene has also been associated
            with Rolandic epilepsy. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, Dec 2013].
            
            Transcript Variant: This variant (1) represents the shortest
            transcript and encodes the shortest protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.26083.1,
                                           SRR1660803.84621.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000640961.2/ ENSP00000492152.1
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1550              AK000505.1         18-1567
            1551-1784           BM680240.1         428-661
            1785-1901           D59285.1           132-248
            1902-2276           BF969161.1         103-477
            2277-2294           BQ083338.1         298-315
            2295-8093           Z83307.1           13890-19688         c
FEATURES             Location/Qualifiers
     source          1..8093
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p13"
     gene            1..8093
                     /gene="ELP4"
                     /gene_synonym="AN; AN2; C11orf19; dJ68P15A.1; hELP4;
                     PAX6NEB; PAXNEB"
                     /note="elongator acetyltransferase complex subunit 4"
                     /db_xref="GeneID:26610"
                     /db_xref="HGNC:HGNC:1171"
                     /db_xref="MIM:606985"
     exon            1..241
                     /gene="ELP4"
                     /gene_synonym="AN; AN2; C11orf19; dJ68P15A.1; hELP4;
                     PAX6NEB; PAXNEB"
                     /inference="alignment:Splign:2.1.0"
     CDS             19..1293
                     /gene="ELP4"
                     /gene_synonym="AN; AN2; C11orf19; dJ68P15A.1; hELP4;
                     PAX6NEB; PAXNEB"
                     /note="isoform 1 is encoded by transcript variant 1;
                     elongator complex protein 4; PAX6 neighbor gene protein;
                     elongation protein 4 homolog"
                     /codon_start=1
                     /product="elongator complex protein 4 isoform 1"
                     /protein_id="NP_061913.3"
                     /db_xref="CCDS:CCDS7875.2"
                     /db_xref="GeneID:26610"
                     /db_xref="HGNC:HGNC:1171"
                     /db_xref="MIM:606985"
                     /translation="MAAVATCGSVAASTGSAVATASKSNVTSFQRRGPRASVTNDSGP
                     RLVSIAGTRPSVRNGQLLVSTGLPALDQLLGGGLAVGTVLLIEEDKYNIYSPLLFKYF
                     LAEGIVNGHTLLVASAKEDPANILQELPAPLLDDKCKKEFDEDVYNHKTPESNIKMKI
                     AWRYQLLPKMEIGPVSSSRFGHYYDASKRMPQELIEASNWHGFFLPEKISSTLKVEPC
                     SLTPGYTKLLQFIQNIIYEEGFDGSNPQKKQRNILRIGIQNLGSPLWGDDICCAENGG
                     NSHSLTKFLYVLRGLLRTSLSACIITMPTHLIQNKAIIARVTTLSDVVVGLESFIGSE
                     RETNPLYKDYHGLIHIRQIPRLNNLICDESDVKDLAFKLKRKLFTIERLHLPPDLSDT
                     VSRSSKMDLAESAKRLGPGCGMMAGGKKHLDF"
     exon            242..277
                     /gene="ELP4"
                     /gene_synonym="AN; AN2; C11orf19; dJ68P15A.1; hELP4;
                     PAX6NEB; PAXNEB"
                     /inference="alignment:Splign:2.1.0"
     exon            278..399
                     /gene="ELP4"
                     /gene_synonym="AN; AN2; C11orf19; dJ68P15A.1; hELP4;
                     PAX6NEB; PAXNEB"
                     /inference="alignment:Splign:2.1.0"
     exon            400..531
                     /gene="ELP4"
                     /gene_synonym="AN; AN2; C11orf19; dJ68P15A.1; hELP4;
                     PAX6NEB; PAXNEB"
                     /inference="alignment:Splign:2.1.0"
     exon            532..671
                     /gene="ELP4"
                     /gene_synonym="AN; AN2; C11orf19; dJ68P15A.1; hELP4;
                     PAX6NEB; PAXNEB"
                     /inference="alignment:Splign:2.1.0"
     exon            672..756
                     /gene="ELP4"
                     /gene_synonym="AN; AN2; C11orf19; dJ68P15A.1; hELP4;
                     PAX6NEB; PAXNEB"
                     /inference="alignment:Splign:2.1.0"
     exon            757..945
                     /gene="ELP4"
                     /gene_synonym="AN; AN2; C11orf19; dJ68P15A.1; hELP4;
                     PAX6NEB; PAXNEB"
                     /inference="alignment:Splign:2.1.0"
     exon            946..1054
                     /gene="ELP4"
                     /gene_synonym="AN; AN2; C11orf19; dJ68P15A.1; hELP4;
                     PAX6NEB; PAXNEB"
                     /inference="alignment:Splign:2.1.0"
     exon            1055..1161
                     /gene="ELP4"
                     /gene_synonym="AN; AN2; C11orf19; dJ68P15A.1; hELP4;
                     PAX6NEB; PAXNEB"
                     /inference="alignment:Splign:2.1.0"
     exon            1162..8093
                     /gene="ELP4"
                     /gene_synonym="AN; AN2; C11orf19; dJ68P15A.1; hELP4;
                     PAX6NEB; PAXNEB"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1521..1526
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ELP4"
                     /gene_synonym="AN; AN2; C11orf19; dJ68P15A.1; hELP4;
                     PAX6NEB; PAXNEB"
                     /note="hexamer: AATAAA"
     polyA_site      1550
                     /gene="ELP4"
                     /gene_synonym="AN; AN2; C11orf19; dJ68P15A.1; hELP4;
                     PAX6NEB; PAXNEB"
                     /note="major polyA site"
     regulatory      2999..3004
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ELP4"
                     /gene_synonym="AN; AN2; C11orf19; dJ68P15A.1; hELP4;
                     PAX6NEB; PAXNEB"
                     /note="hexamer: AATAAA"
     polyA_site      3021
                     /gene="ELP4"
                     /gene_synonym="AN; AN2; C11orf19; dJ68P15A.1; hELP4;
                     PAX6NEB; PAXNEB"
     regulatory      3461..3466
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ELP4"
                     /gene_synonym="AN; AN2; C11orf19; dJ68P15A.1; hELP4;
                     PAX6NEB; PAXNEB"
                     /note="hexamer: GATAAA"
     polyA_site      3481
                     /gene="ELP4"
                     /gene_synonym="AN; AN2; C11orf19; dJ68P15A.1; hELP4;
                     PAX6NEB; PAXNEB"
     regulatory      6702..6707
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ELP4"
                     /gene_synonym="AN; AN2; C11orf19; dJ68P15A.1; hELP4;
                     PAX6NEB; PAXNEB"
                     /note="hexamer: AATAAA"
     polyA_site      6721
                     /gene="ELP4"
                     /gene_synonym="AN; AN2; C11orf19; dJ68P15A.1; hELP4;
                     PAX6NEB; PAXNEB"
     regulatory      8073..8078
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ELP4"
                     /gene_synonym="AN; AN2; C11orf19; dJ68P15A.1; hELP4;
                     PAX6NEB; PAXNEB"
                     /note="hexamer: AATAAA"
     polyA_site      8093
                     /gene="ELP4"
                     /gene_synonym="AN; AN2; C11orf19; dJ68P15A.1; hELP4;
                     PAX6NEB; PAXNEB"
ORIGIN      
        1 aacactggag gctctaagat ggcggcagtg gcaacctgcg gtagtgttgc cgcgagtact
       61 gggtctgcag tggcgacagc cagcaagagc aacgtcacca gtttccagag gaggggtcct
      121 agagccagcg tgaccaacga cagcggccct cgactggtgt ccattgcggg cacgcgaccg
      181 tcggtgcgga atggacagct gctggtatca accgggctcc cagccctaga ccagctctta
      241 ggtggaggtt tagccgttgg aacagttctt ctaattgagg aggataaata taatatttac
      301 tcacctttgc tcttcaagta tttcctggca gaaggaattg tcaatgggca tactttgttg
      361 gttgcatctg ctaaagagga tcctgccaac attttacagg aacttccagc accattactt
      421 gatgataaat gtaaaaagga atttgatgaa gatgtataca atcataaaac accagaatct
      481 aatattaaga tgaaaatagc ttggcgttac cagttattac ccaagatgga gattggacca
      541 gtatcatctt caagatttgg tcactattat gatgcatcaa aaagaatgcc acaagaacta
      601 attgaggctt caaattggca tggatttttt cttccagaga aaatatcttc aactctcaaa
      661 gtagaaccct gttctttgac ccctggctac acaaagctgc ttcagtttat ccagaacatc
      721 atttatgagg aaggatttga tggatccaat cctcagaaaa aacagagaaa cattttaaga
      781 ataggaattc agaatcttgg ctcaccttta tggggagacg atatttgctg tgcagaaaat
      841 ggtggcaaca gtcacagcct taccaagttc ctctatgttc tccgtggtct tctgagaacc
      901 tctctttcag cctgcatcat cacaatgcca acacatctga tccagaataa agccattatt
      961 gcccgtgtca caaccttgtc agatgtagta gttggtctgg aatcatttat tggttctgag
     1021 agagaaacta acccattgta taaggattat catggattga ttcatatacg gcagattcct
     1081 cggcttaata acttgatctg tgatgaatca gatgtcaaag acttagcttt taaattaaaa
     1141 aggaagctat tcaccattga gcgactgcat ttgcctccag acttgtcaga cacagtgagc
     1201 cgctcaagca aaatggatct ggcagaatcc gccaagcggc tgggcccagg ctgtggcatg
     1261 atggccggag gcaagaagca cctggacttc tagggattcc tccttagtcg ctgcatgcag
     1321 aattctatga cactctaatt atgattgcta atagcttatg taaatatttt tcttaacaat
     1381 ttgaccctcc actccttgaa aaacacagga ttataaaatg gtgccgccat ttctcatttt
     1441 ttaacttttt acagaactag cacagcagaa atacttttaa atttttcctt catgctctag
     1501 agaaaataat tttattttta aataaacgcc aaaaaatgtc aaaatctcaa gattcctgac
     1561 agtggtcatt cgtgtgtgta ctaaggcatt tagtgtcatg gtaaagtgca tgtcacagca
     1621 ggtagcatac aaaacatgat gaaattcaag attgtatgtg aaaacatact ttctctttat
     1681 tacagaaaca gtcacttgcc accaaaaatg ctgtttttta aatgaaaatg tgtttactaa
     1741 tatataaaat aaatttgcat ttatgtatcc agttattaaa ttgataaaga caaagtaata
     1801 ttttgggatt tagattccac tagagataat tagtctacca tagtagttat taaatataaa
     1861 gaacttcagt gataggaaac atagaaaaaa gaagtggatg gtctttagtt tagtaatcct
     1921 aaacaattga agtcagtact atgaaattat gtcaacaggc atcattcagg attgaaattc
     1981 aaactgacag ctacattaat gctaggatac caggagaaaa acatatactg aagcttgttg
     2041 agagatttta cagaacatag gtctgagaca aagtgaaaaa atgaaactaa ctcagatttc
     2101 cattgcatca cataaatatt ttgttaataa tgaacattgg ttgagtgtgt aaatttctaa
     2161 ccatgtaaac atgtctttgg ggggtatagc atatcgaacc agttttcata tgaaacatta
     2221 ggtgttttaa ttacaattct atattctcaa agcttttgac agataatgga taaaaaatga
     2281 aagttgaaaa gtaacttgca tatttaagag tcttgatttt ttaaaaggtg tttaacatcc
     2341 attgggagaa actgaatttc caaaatacat tttcaaatgt atttaatatt ttgaagcagt
     2401 tataactagc atttttaagc agcttgcttt taatatacca caaattatac tttatttgtt
     2461 cttgacaaca ttgtagaaaa caaagactag gtttttaaaa ctgtctaacc aatatgatga
     2521 atgtcagtca cttaaaaaaa cccactgtag cataaacaca tactgtatac agcttttatt
     2581 cagaattaga ataattgaat caatgacagt gatttgccag gatgtcaaat ctctccatca
     2641 tatcctgtca ctaccagttt attttttgtg atcaaaatca aaaagacaac tattttgtca
     2701 cccgctattt cattagtact aaaaatcagg tttcttattc tattttttta gaatgtcggg
     2761 tttatttttt tcatttcttt taattctaaa gacacagatt cttccccatt ttcttttcaa
     2821 aataaagttt cagaattgat ctgtcagtta aaattaaagg gctttatatt aagcaaaggt
     2881 gcttttaaat tttaaagcaa cttcaaaaaa ttgatttagt ccatagataa taaataatgt
     2941 tgtgcggata ctccacaaaa gctctgctat gtcctttgaa agcattatga acattctgaa
     3001 taaattcaaa tgagtatttt agtcagttta ttattttaat aactctaacc tttttcttac
     3061 cgtgttgatt cattttatac aacacacaat ggaacaatta catagcattt gacttgctga
     3121 aaaagagata cgaggtcatc agatatgtaa attgcttgtc aaaatactta ataggtcatt
     3181 gatatacttc cctggctacc atgtctataa aattaacagc caattactag ttaatatatg
     3241 ctttgcaaat agataactac tataaaaatt gaatatgcat atttgaaccc ttattttaaa
     3301 tataaaagaa acttttcaaa ctcagtaaaa gtgcattttg aataataagt gtacctgggc
     3361 tttccaaaaa tcatatccaa gtgctttgtt tttctaattc actgggccgg ctttgtaaaa
     3421 ataagctact ggagaggggt gtgtattttt gtcttcctct gataaaaacg cactctgaaa
     3481 atgtgttttc ctttcttctg gaaacattat ttgttactca ttatgttaat aacttactac
     3541 ataaacatat ctctcttcaa taatgctacc ttaggtatag acaccatttt gatacattat
     3601 gaaatataca ctccattaac agattttttt taattatcag cttgactcaa agatataaat
     3661 acttaagaac aatgccaaac gtaatatctg aaatgatatc ttttaagtgt ttctagtata
     3721 tgaacttcaa aaccctatat ggtactcatt tcttacacta gatttgcctt tctttaacat
     3781 gagataaata ttttgactac tgcagtttgc tcaggtgctc gggttctaag actttttgaa
     3841 tttcctttta gtagccacca tacaatatct acttttctct tccatttatt ccttatgtcc
     3901 acctccagga tctttaaata ctaacagtag acaaaataaa actactttag aaggaagcga
     3961 cactctgcaa tcaattccct gtccatcttt taacaaatca gacacacata ggcatacaaa
     4021 aggagagtgg ggggaccccc ctattcattt gtttaagccc attattaatg tcatttctaa
     4081 gacagcatgt tactgctttc caaagatagt caccgtcaac attattgaaa taagcagtac
     4141 taaccctaag tacttacact ttgaacttta aaaccgagca gttgagtcat tcagtaccaa
     4201 gccaaaacac agaaaaacaa aaaagcagat gaggtttatt cttgagaaat gaaaaagaga
     4261 agaatatata tttcgccttg gtgagccaaa catacagaga agaaaaggct ttttaaaatc
     4321 ttactagtat gagaggccca gagtaaaaag aaataagcaa aagaatatag acacaatcct
     4381 aagatgacat tcacagaaca aagctgaatc ttcaaataat actgtatgag tgaatcttag
     4441 gaaacctagt gatgatagta agaagaaatg gcagtgagct gtagcaagaa accagttgtt
     4501 caccatttaa gggttaggag gcatagcttt gggggaaaaa tattctagaa attcattgca
     4561 gtaaaatgca tttttttact tagagcagtt tgaacgttta ttacttaaaa cattcagctc
     4621 ttattctatt cacctggttt tcccaagtca gtcaagtttg gagaaaaaat ttagacgttt
     4681 agtcctggga ttctactgaa gtcttcacaa ataatctcca tcctggaaga tggtgtcaaa
     4741 acatccctgc agatacccca ttgataaata tataaatata tgtatcgtta aataaataat
     4801 aaacaaaaat tatttcaaca atgagtaaaa ggccaactcc caggcactgc taccacacag
     4861 agcctgccat gctgtcccca agagagtgcc tggagctctg tttggaagga cagctcatgt
     4921 ccctagggtg tgggcagaag gcaaggcagc cgttcccatc ctgccggacc agagggcttc
     4981 tgcagctgag cagccgcttc ttcagactat accagactgt gctactttgc cctggcaatc
     5041 ctgaccttca gagcacacat atacgtgccc aagtgcacac atacagaccc tccgctccca
     5101 cgtcactcct tttctcccat tcccacctct tgcacctggc gtgcgacatc cgggtctcca
     5161 aagtctctgc tgtctacaca acagaaccgt gggccggaac tggctgcctg accgtggtgg
     5221 aaattacagc cagcgagaag gaagaagtaa gccagccagc agctgtggca tgcactccca
     5281 catagccctt ctctgacagt tccctcagca cacagccctc agggaatgta ggctgcaaaa
     5341 tgtcaggagg tagaaatgtc tgcaccggca attgtaccaa cagtgcgtat gtgtgctcac
     5401 tcccctgcag aaatgtgctg ctgtgcagtg caggctgaca ctgaacaaaa ctacatgcac
     5461 acatacaaaa actgcaactt aggaaggtgt ctccaaatgt gcagcaactc tggtggaata
     5521 aaattattag tatatttcat gccggagcaa tgaatctcaa ttatctgttc acaagtaatt
     5581 ccttaactaa aaaacagtag atattgaacg agaaggtcat gtttaaatcc ttccattaat
     5641 ttctacattt ctgatcattt gcttttgggg atttttttaa agcagagtat aattcagtgg
     5701 aagtgtgtct ttgtccccag aggtttctgc atgtgcaagc attttaatct agactgccag
     5761 aacccccagg ctttttagtg aagtttgcag aggaagactt atctgtattg acttatatgt
     5821 tgcacagaac aaatgaaagt ctcagacagt ccttttttac ccaacaaagg cttatttttt
     5881 tccatccttt gcttgggctc aagcactcct gccctgcgtg cctccacttt aaacatgatc
     5941 agaactgtgc ttcattgcaa ataacaactg accaacaatg ggccctgctt catagatttg
     6001 ggaatgtttg gcttaagctg ccaatgactg aaggccttta attcccaccg gccagtcaca
     6061 gtctgctttg ttgttgtctg ttgatgtgtc tgtgctcatt attccttgac atgcaacatc
     6121 ccccctccac cctccaacca tccacaaccg cacagaaagc aagattcaaa tgggaacagc
     6181 tgtagtggtt caatgggaaa tgatgcctct tgtgcaaagg ggagggagac agaaaaggga
     6241 gagggcctat ttgaaaaagg caacagcttt cagaaagtct cctttaagaa atctactttt
     6301 gaatatactt cagtgaaatc attgttgaaa taggctgaca atggaaatct gcccagattg
     6361 aaaatgccag tcctaattca aaaaacaatt cctagctaat cgcttgttgc atttttaaat
     6421 tatttctaga ctttgagctt tagaattaaa tggctaactg ggaaatgtta ccattttgta
     6481 tatatgttgt gggtataaat gggcacagat ctacaccctg ctgtaagtgg aatttttttc
     6541 taacacgttt ttgatttatg gtatctataa ggattatttt ttaaggatca tcaggatgta
     6601 aaacagagtg tgtgtgaaag taaccattgg tttagaatgt tgatctaaca tggaaataaa
     6661 atttgtaaca ccacactata aggttaaaaa gaaaactgta taataaagga aatacaaagg
     6721 ctttggcatg gttttttaca atcaacaatg gttaattttg atatgtagtt gtgaacaact
     6781 tcaaaacact taagtttaaa actcttgcaa gcacttttaa ttgattagga atgaactcta
     6841 gatgcacaaa atgattggac cgtgaacagt aatacaacta tatctaagaa caattaactt
     6901 ttgctggcca aaaaagaaac gtatgattgc atgaaaatgt gtataaaaca tctatattct
     6961 tgtcaaatat aaatgaaatt aactttatta tagaaatcat tctgaggatt tctagggaag
     7021 acaaatactt acattttgac ataaaacaaa ttggattata tcgaagacac actctacctt
     7081 ttagctatca actttttttc ttccttgaat ttatatctta cccttttttg cacataaact
     7141 tcatctgtta acaacctttg gaaaaccaac agatatttct gacataaatc tagtgcatgt
     7201 tgttccaggt ttaattatat gcaaaggaat gatacaaact tggaacatca gtccataaac
     7261 tatgaacaga tgggtagaag tattcgatat atcttgataa aactcttaaa ttcgtggcaa
     7321 agcttgttga tcatggtttt ctttttaaaa aaaaaaaaaa caacttcatg accaacacag
     7381 atcaaacatc catccagtct acattgttct ttttttcatt ataacataca aatgcccatt
     7441 tacaaataat acaccaaaat gaataaaagt ttggatacca aaatgaagat ttgttccaac
     7501 tgatatcgtg ccttctgtat acaaaggtcc ttgtttcaag tccattcctt ccccagtggt
     7561 acaatacagg acacaattgt agaactgaag cggctctaac agccattttt ctttctttcc
     7621 tgaaagctca actgttgtgt ccccatagtc actgactgaa ttaacacaat atttcctttc
     7681 cttttttttt tttttttttt ttttactgta atcttggcca gtattgagac atatcaggtt
     7741 cacttccggg aacttgaact ggaactgaca caccagggga aatgagtcct agaagtggat
     7801 gaaagaaata gccatgtaga tattcccttt gagaaacaga catggaatac aaatttatag
     7861 gtttacaaaa aaaaaaaaaa aaaaaaaaac taatactttc taacattttt tactgtatta
     7921 aaatcacttc aattgttaca aataaaagta gcaccttcag aaactagaca atatatgtat
     7981 atatacctat tggatcccaa gtacccccca ccccaatcca aaggaaaaga aaaaaaaaat
     8041 cctctgtttg tttgcatgtt tggaactttt acaataaagc tgtctctgga aaa
//
