LOCUS       NM_018091               3148 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens elongator acetyltransferase complex subunit 3 (ELP3),
            transcript variant 1, mRNA.
ACCESSION   NM_018091
VERSION     NM_018091.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3148)
  AUTHORS   Pereira,M., Ribeiro,D.R., Berg,M., Tsai,A.P., Dong,C., Nho,K.,
            Kaiser,S., Moutinho,M. and Soares,A.R.
  TITLE     Amyloid pathology reduces ELP3 expression and tRNA modifications
            leading to impaired proteostasis
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (1), 166857 (2024)
   PUBMED   37640114
  REMARK    GeneRIF: Amyloid pathology reduces ELP3 expression and tRNA
            modifications leading to impaired proteostasis.
REFERENCE   2  (bases 1 to 3148)
  AUTHORS   Barznegar,M., Rahimi,K., Mahdavi,P., Menbari,M.N., Darvishi,N.,
            Vahabzadeh,Z., Hakhamaneshi,M.S., Andalibi,P. and Abdi,M.
  TITLE     Relation between the circular and linear form of the Elongator
            Acetyltransferase Complex Subunit 3 in the progression of
            triple-negative breast cancer
  JOURNAL   Cell Biochem Funct 40 (6), 550-558 (2022)
   PUBMED   35722999
  REMARK    GeneRIF: Relation between the circular and linear form of the
            Elongator Acetyltransferase Complex Subunit 3 in the progression of
            triple-negative breast cancer.
REFERENCE   3  (bases 1 to 3148)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 3148)
  AUTHORS   Li,M.T., Liang,J.Y., Sun,Y.P., Jin,J., Xiong,Y., Guan,K.L. and
            Yuan,H.X.
  TITLE     ELP3 Acetyltransferase is phosphorylated and regulated by the
            oncogenic anaplastic lymphoma kinase (ALK)
  JOURNAL   Biochem J 476 (15), 2239-2254 (2019)
   PUBMED   31341009
  REMARK    GeneRIF: study reveals a novel regulatory mechanism for ELP3,
            provides an example that acetyltransferase itself can be regulated
            by PTM, and suggests a potential target for ALK-positive cancer
            therapies.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3148)
  AUTHORS   Xu,Y., Zhou,W., Ji,Y., Shen,J., Zhu,X., Yu,H., Guo,J., Pang,Z. and
            Wei,W.
  TITLE     Elongator promotes the migration and invasion of hepatocellular
            carcinoma cell by the phosphorylation of AKT
  JOURNAL   Int J Biol Sci 14 (5), 518-530 (2018)
   PUBMED   29805303
  REMARK    GeneRIF: Elongator activated migration and invasion of
            hepatocellular carcinoma cells by promoting the expression of MMP-2
            and MMP-9 through the PI3K/AKT signaling pathway
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3148)
  AUTHORS   Barrios-Rodiles,M., Brown,K.R., Ozdamar,B., Bose,R., Liu,Z.,
            Donovan,R.S., Shinjo,F., Liu,Y., Dembowy,J., Taylor,I.W., Luga,V.,
            Przulj,N., Robinson,M., Suzuki,H., Hayashizaki,Y., Jurisica,I. and
            Wrana,J.L.
  TITLE     High-throughput mapping of a dynamic signaling network in mammalian
            cells
  JOURNAL   Science 307 (5715), 1621-1625 (2005)
   PUBMED   15761153
REFERENCE   7  (bases 1 to 3148)
  AUTHORS   Kim,J.H., Lane,W.S. and Reinberg,D.
  TITLE     Human Elongator facilitates RNA polymerase II transcription through
            chromatin
  JOURNAL   Proc Natl Acad Sci U S A 99 (3), 1241-1246 (2002)
   PUBMED   11818576
REFERENCE   8  (bases 1 to 3148)
  AUTHORS   Hawkes,N.A., Otero,G., Winkler,G.S., Marshall,N., Dahmus,M.E.,
            Krappmann,D., Scheidereit,C., Thomas,C.L., Schiavo,G.,
            Erdjument-Bromage,H., Tempst,P. and Svejstrup,J.Q.
  TITLE     Purification and characterization of the human elongator complex
  JOURNAL   J Biol Chem 277 (4), 3047-3052 (2002)
   PUBMED   11714725
REFERENCE   9  (bases 1 to 3148)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
REFERENCE   10 (bases 1 to 3148)
  AUTHORS   Ninomiya,Y., Okada,M., Kotomura,N., Suzuki,K., Tsukiyama,T. and
            Niwa,O.
  TITLE     Genomic organization and isoforms of the mouse ELP gene
  JOURNAL   J Biochem 118 (2), 380-389 (1995)
   PUBMED   8543574
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA150994.1, AL834273.1 and BM663362.1.
            
            On Nov 22, 2018 this sequence version replaced NM_018091.5.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.936382.1,
                                           SRR1660809.110121.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000256398.13/ ENSP00000256398.8
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-70                DA150994.1         57-126
            71-2582             AL834273.1         1-2512
            2583-3144           AL834273.1         2514-3075
            3145-3148           BM663362.1         13-16               c
FEATURES             Location/Qualifiers
     source          1..3148
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p21.1"
     gene            1..3148
                     /gene="ELP3"
                     /gene_synonym="KAT9"
                     /note="elongator acetyltransferase complex subunit 3"
                     /db_xref="GeneID:55140"
                     /db_xref="HGNC:HGNC:20696"
                     /db_xref="MIM:612722"
     exon            1..95
                     /gene="ELP3"
                     /gene_synonym="KAT9"
                     /inference="alignment:Splign:2.1.0"
     CDS             77..1720
                     /gene="ELP3"
                     /gene_synonym="KAT9"
                     /EC_number="2.3.1.311"
                     /note="isoform 1 is encoded by transcript variant 1;
                     elongator complex protein 3; elongation protein 3 homolog;
                     tRNA uridine(34) acetyltransferase; protein lysine
                     acetyltransferase ELP3"
                     /codon_start=1
                     /product="elongator complex protein 3 isoform 1"
                     /protein_id="NP_060561.3"
                     /db_xref="CCDS:CCDS6065.1"
                     /db_xref="GeneID:55140"
                     /db_xref="HGNC:HGNC:20696"
                     /db_xref="MIM:612722"
                     /translation="MRQKRKGDLSPAELMMLTIGDVIKQLIEAHEQGKDIDLNKVKTK
                     TAAKYGLSAQPRLVDIIAAVPPQYRKVLMPKLKAKPIRTASGIAVVAVMCKPHRCPHI
                     SFTGNICVYCPGGPDSDFEYSTQSYTGYEPTSMRAIRARYDPFLQTRHRIEQLKQLGH
                     SVDKVEFIVMGGTFMALPEEYRDYFIRNLHDALSGHTSNNIYEAVKYSERSLTKCIGI
                     TIETRPDYCMKRHLSDMLTYGCTRLEIGVQSVYEDVARDTNRGHTVKAVCESFHLAKD
                     SGFKVVAHMMPDLPNVGLERDIEQFTEFFENPAFRPDGLKLYPTLVIRGTGLYELWKS
                     GRYKSYSPSDLVELVARILALVPPWTRVYRVQRDIPMPLVSSGVEHGNLRELALARMK
                     DLGIQCRDVRTREVGIQEIHHKVRPYQVELVRRDYVANGGWETFLSYEDPDQDILIGL
                     LRLRKCSEETFRFELGGGVSIVRELHVYGSVVPVSSRDPTKFQHQGFGMLLMEEAERI
                     AREEHGSGKIAVISGVGTRNYYRKIGYRLQGPYMVKMLK"
     exon            96..195
                     /gene="ELP3"
                     /gene_synonym="KAT9"
                     /inference="alignment:Splign:2.1.0"
     exon            196..334
                     /gene="ELP3"
                     /gene_synonym="KAT9"
                     /inference="alignment:Splign:2.1.0"
     exon            335..405
                     /gene="ELP3"
                     /gene_synonym="KAT9"
                     /inference="alignment:Splign:2.1.0"
     exon            406..469
                     /gene="ELP3"
                     /gene_synonym="KAT9"
                     /inference="alignment:Splign:2.1.0"
     exon            470..538
                     /gene="ELP3"
                     /gene_synonym="KAT9"
                     /inference="alignment:Splign:2.1.0"
     exon            539..693
                     /gene="ELP3"
                     /gene_synonym="KAT9"
                     /inference="alignment:Splign:2.1.0"
     exon            694..855
                     /gene="ELP3"
                     /gene_synonym="KAT9"
                     /inference="alignment:Splign:2.1.0"
     exon            856..982
                     /gene="ELP3"
                     /gene_synonym="KAT9"
                     /inference="alignment:Splign:2.1.0"
     exon            983..1176
                     /gene="ELP3"
                     /gene_synonym="KAT9"
                     /inference="alignment:Splign:2.1.0"
     exon            1177..1267
                     /gene="ELP3"
                     /gene_synonym="KAT9"
                     /inference="alignment:Splign:2.1.0"
     exon            1268..1333
                     /gene="ELP3"
                     /gene_synonym="KAT9"
                     /inference="alignment:Splign:2.1.0"
     exon            1334..1561
                     /gene="ELP3"
                     /gene_synonym="KAT9"
                     /inference="alignment:Splign:2.1.0"
     exon            1562..1643
                     /gene="ELP3"
                     /gene_synonym="KAT9"
                     /inference="alignment:Splign:2.1.0"
     exon            1644..3148
                     /gene="ELP3"
                     /gene_synonym="KAT9"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2063..2068
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ELP3"
                     /gene_synonym="KAT9"
                     /note="hexamer: AATAAA"
     polyA_site      2092
                     /gene="ELP3"
                     /gene_synonym="KAT9"
                     /note="major polyA site"
     regulatory      3125..3130
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ELP3"
                     /gene_synonym="KAT9"
                     /note="hexamer: AATAAA"
     polyA_site      3148
                     /gene="ELP3"
                     /gene_synonym="KAT9"
                     /note="major polyA site"
ORIGIN      
        1 ggctgtcagc tttccccgtg gtctgagttt gtggctgcat ttttatctct ggtggctctg
       61 ctacggcggc gcagaaatga ggcagaagcg gaaaggagat ctcagccctg ctgagctgat
      121 gatgctgact ataggagatg ttattaaaca actgattgaa gcccacgagc aggggaaaga
      181 catcgatcta aataaggtga aaaccaagac agctgccaaa tatggccttt ctgcccagcc
      241 ccgcctggtg gatatcattg ctgccgtccc tcctcagtat cgcaaggtct tgatgcccaa
      301 gttaaaggcg aaacccatca gaactgctag tgggattgct gtcgtggctg tgatgtgcaa
      361 accccacaga tgtccacaca tcagttttac aggaaatata tgtgtatact gccctggtgg
      421 acctgattct gattttgagt attccaccca gtcttacact ggctatgagc caacctccat
      481 gagagctatc cgtgccagat atgacccttt cctacagaca agacaccgaa tagaacagtt
      541 aaaacaactt ggtcatagtg tggataaagt ggagtttatt gtgatgggtg gaacgtttat
      601 ggcccttcca gaagaataca gagattattt tattcgaaat ttacatgatg ccttatcagg
      661 acatacttcc aacaatattt acgaggcagt caagtattct gagagaagcc tcacaaagtg
      721 tattggaatt actattgaaa ccagaccaga ttactgcatg aagcgacatt taagtgacat
      781 gttgacctat ggctgcacaa ggctggagat tggggtgcag agtgtttatg aagatgtggc
      841 tagagacacc aacaggggcc acactgtgaa ggcagtgtgt gagtcatttc acctggccaa
      901 agattccggt tttaaagtgg tggcccatat gatgcctgac ctgccaaacg tgggactaga
      961 aagagacatt gaacagttca cagagttttt tgagaaccct gcttttcgtc ccgatgggct
     1021 gaaactctat cctaccctgg tgattcgtgg gaccgggctt tatgagcttt ggaaatcagg
     1081 aagatataag agttactctc ctagtgacct ggttgaattg gtggctcgga tcctagccct
     1141 cgtgcctcca tggactcgag tgtaccgagt acagagggat attccaatgc ctttagttag
     1201 ctcaggagta gagcatggta acctgagaga gctggcactt gcaagaatga aagacctcgg
     1261 aatacagtgt cgagatgtga gaaccagaga agttggaatc caagaaattc atcacaaagt
     1321 acggccatac caggttgaat tggtaaggag agattatgtt gcaaatggtg gctgggaaac
     1381 attcttgtca tacgaagacc cagatcaaga cattttgatt ggcctcctac gattacgcaa
     1441 gtgttcagaa gaaactttcc gtttcgaatt gggtggaggt gtctccatag tacgagagct
     1501 gcatgtgtat gggagtgtgg tccctgtgag cagccgggat cctactaaat ttcagcatca
     1561 gggatttggc atgctgctga tggaggaagc agaaagaata gctagagaag aacatgggtc
     1621 tgggaaaatc gctgtgatat caggggtcgg caccaggaat tattatagaa agatcggcta
     1681 cagattacaa ggcccgtaca tggtgaagat gctgaaataa tggccacacc agtccactct
     1741 tctgcagtat cctccctggc agaacacgga gaatcaggat ttcttaaata ctcaacagag
     1801 aggctgagca gagcaaatgg ggggcttcac cctcatcccg cagctgcaga gactggaaac
     1861 tgccttcaag gccacggctg gtcatctgct gaccacaccc cagatccgcc ctctcctgcg
     1921 tgcaccccaa aaaatcactt gcgtttttga ggcttaaatc atctatccag tttctacatt
     1981 ttgcatgagg cctgcaggtg gcctattttg actcagacgg tgaaaaaagc aaattaactc
     2041 atttggacac cataactcat gcaataaaac tgattgtcat tcgaggagca aacttaagag
     2101 tagtttattt atataccctg gggacagaaa gtcaggttga aacaggaaaa ccaccagact
     2161 ctaatctcag ccctttaacg acatacgcat tggagcgcaa gttaggaaaa tgagcttttg
     2221 ttttcatgga aatcattctg attacagtgc tgatgtttag aaataaatag cagtgtgact
     2281 gggaaagagg aattgcagtt gtgggggtgt gagcctggca gcagccagcc agcagcctct
     2341 cccaggcggg agtctaccat ccgagacggc gatgacaaag agcttcattc cacattcttt
     2401 gttatctcta cttcccaccc tcttggcaac tacagagcag tgtgggcagc cccaagtgtg
     2461 gtccccagag agcgtttggc tttcctgtct gtctatcctg agcgggtgga gtctcaggtt
     2521 gtgtgcccct aaatcaagat ttgcttccac agaagccatt acttgcaatt tttttttttt
     2581 ttctgagaaa gtctcgctgt gtcacccagg ctggagtgca gtggcgcaat ctcactgcat
     2641 cctccgcctc ccgggttcaa gcgattctcc cgcctcagcc tcctgagtag ctgggattac
     2701 aggcacccgc cgctgctaat ttttgtattt ttagtagaga tgggggtttc accatattgg
     2761 tcaggctggt ctcgaactcc tgacctcagg tgatcaaccc accttggcct ccctaaatgc
     2821 cgggattaca ggcatgagcc accgctccca gcctttgatt ttttaaggtg gattttggtt
     2881 gttataaatg gagaaaggta agagttcaag ttcaacccgt gtgtgaaagc aaaacaatgg
     2941 aaaacaggat tggcttcttc aaaggctcct cttgtagaac tgcctctttg aaatttcgag
     3001 gtaatctact ttggagactc tgcctggaga gggtcagttc ctaagttaaa agcatcgctt
     3061 aaccttggct cctgtggcat tttacaaagg tttaaaggaa ttgattcctc tgaaagggcc
     3121 tgaaaataaa aagtctttaa catacaaa
//
