LOCUS       NM_001284225            2984 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens elongator acetyltransferase complex subunit 3 (ELP3),
            transcript variant 5, mRNA.
ACCESSION   NM_001284225 XM_005273553
VERSION     NM_001284225.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2984)
  AUTHORS   Pereira,M., Ribeiro,D.R., Berg,M., Tsai,A.P., Dong,C., Nho,K.,
            Kaiser,S., Moutinho,M. and Soares,A.R.
  TITLE     Amyloid pathology reduces ELP3 expression and tRNA modifications
            leading to impaired proteostasis
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (1), 166857 (2024)
   PUBMED   37640114
  REMARK    GeneRIF: Amyloid pathology reduces ELP3 expression and tRNA
            modifications leading to impaired proteostasis.
REFERENCE   2  (bases 1 to 2984)
  AUTHORS   Barznegar,M., Rahimi,K., Mahdavi,P., Menbari,M.N., Darvishi,N.,
            Vahabzadeh,Z., Hakhamaneshi,M.S., Andalibi,P. and Abdi,M.
  TITLE     Relation between the circular and linear form of the Elongator
            Acetyltransferase Complex Subunit 3 in the progression of
            triple-negative breast cancer
  JOURNAL   Cell Biochem Funct 40 (6), 550-558 (2022)
   PUBMED   35722999
  REMARK    GeneRIF: Relation between the circular and linear form of the
            Elongator Acetyltransferase Complex Subunit 3 in the progression of
            triple-negative breast cancer.
REFERENCE   3  (bases 1 to 2984)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 2984)
  AUTHORS   Li,M.T., Liang,J.Y., Sun,Y.P., Jin,J., Xiong,Y., Guan,K.L. and
            Yuan,H.X.
  TITLE     ELP3 Acetyltransferase is phosphorylated and regulated by the
            oncogenic anaplastic lymphoma kinase (ALK)
  JOURNAL   Biochem J 476 (15), 2239-2254 (2019)
   PUBMED   31341009
  REMARK    GeneRIF: study reveals a novel regulatory mechanism for ELP3,
            provides an example that acetyltransferase itself can be regulated
            by PTM, and suggests a potential target for ALK-positive cancer
            therapies.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2984)
  AUTHORS   Xu,Y., Zhou,W., Ji,Y., Shen,J., Zhu,X., Yu,H., Guo,J., Pang,Z. and
            Wei,W.
  TITLE     Elongator promotes the migration and invasion of hepatocellular
            carcinoma cell by the phosphorylation of AKT
  JOURNAL   Int J Biol Sci 14 (5), 518-530 (2018)
   PUBMED   29805303
  REMARK    GeneRIF: Elongator activated migration and invasion of
            hepatocellular carcinoma cells by promoting the expression of MMP-2
            and MMP-9 through the PI3K/AKT signaling pathway
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2984)
  AUTHORS   Barrios-Rodiles,M., Brown,K.R., Ozdamar,B., Bose,R., Liu,Z.,
            Donovan,R.S., Shinjo,F., Liu,Y., Dembowy,J., Taylor,I.W., Luga,V.,
            Przulj,N., Robinson,M., Suzuki,H., Hayashizaki,Y., Jurisica,I. and
            Wrana,J.L.
  TITLE     High-throughput mapping of a dynamic signaling network in mammalian
            cells
  JOURNAL   Science 307 (5715), 1621-1625 (2005)
   PUBMED   15761153
REFERENCE   7  (bases 1 to 2984)
  AUTHORS   Kim,J.H., Lane,W.S. and Reinberg,D.
  TITLE     Human Elongator facilitates RNA polymerase II transcription through
            chromatin
  JOURNAL   Proc Natl Acad Sci U S A 99 (3), 1241-1246 (2002)
   PUBMED   11818576
REFERENCE   8  (bases 1 to 2984)
  AUTHORS   Hawkes,N.A., Otero,G., Winkler,G.S., Marshall,N., Dahmus,M.E.,
            Krappmann,D., Scheidereit,C., Thomas,C.L., Schiavo,G.,
            Erdjument-Bromage,H., Tempst,P. and Svejstrup,J.Q.
  TITLE     Purification and characterization of the human elongator complex
  JOURNAL   J Biol Chem 277 (4), 3047-3052 (2002)
   PUBMED   11714725
REFERENCE   9  (bases 1 to 2984)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
REFERENCE   10 (bases 1 to 2984)
  AUTHORS   Ninomiya,Y., Okada,M., Kotomura,N., Suzuki,K., Tsukiyama,T. and
            Niwa,O.
  TITLE     Genomic organization and isoforms of the mouse ELP gene
  JOURNAL   J Biochem 118 (2), 380-389 (1995)
   PUBMED   8543574
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC019031.7, AK293424.1, AC021678.13 and BU683531.1.
            
            On Aug 14, 2020 this sequence version replaced NM_001284225.1.
            
            Transcript Variant: This variant (5) differs in the 5' UTR and
            lacks a portion of the 5' coding region, compared to variant 1.
            These differences cause translation initiation at a downstream AUG
            and result in an isoform (4) with a shorter N-terminus, compared to
            isoform 1. Variants 4 and 5 encode the same isoform (5).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074969.2025105.1,
                                           SRR1803617.175391.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                AC019031.7         80268-80282         c
            16-1925             AK293424.1         15-1924
            1926-2758           AC021678.13        24891-25723
            2759-2984           BU683531.1         16-241              c
FEATURES             Location/Qualifiers
     source          1..2984
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p21.1"
     gene            1..2984
                     /gene="ELP3"
                     /gene_synonym="KAT9"
                     /note="elongator acetyltransferase complex subunit 3"
                     /db_xref="GeneID:55140"
                     /db_xref="HGNC:HGNC:20696"
                     /db_xref="MIM:612722"
     exon            1..95
                     /gene="ELP3"
                     /gene_synonym="KAT9"
                     /inference="alignment:Splign:2.1.0"
     exon            96..234
                     /gene="ELP3"
                     /gene_synonym="KAT9"
                     /inference="alignment:Splign:2.1.0"
     exon            235..305
                     /gene="ELP3"
                     /gene_synonym="KAT9"
                     /inference="alignment:Splign:2.1.0"
     CDS             270..1556
                     /gene="ELP3"
                     /gene_synonym="KAT9"
                     /EC_number="2.3.1.311"
                     /note="isoform 4 is encoded by transcript variant 5;
                     elongator complex protein 3; elongation protein 3 homolog;
                     tRNA uridine(34) acetyltransferase; protein lysine
                     acetyltransferase ELP3"
                     /codon_start=1
                     /product="elongator complex protein 3 isoform 4"
                     /protein_id="NP_001271154.1"
                     /db_xref="CCDS:CCDS64861.1"
                     /db_xref="GeneID:55140"
                     /db_xref="HGNC:HGNC:20696"
                     /db_xref="MIM:612722"
                     /translation="MSTHQFYRKYMCPTSMRAIRARYDPFLQTRHRIEQLKQLGHSVD
                     KVEFIVMGGTFMALPEEYRDYFIRNLHDALSGHTSNNIYEAVKYSERSLTKCIGITIE
                     TRPDYCMKRHLSDMLTYGCTRLEIGVQSVYEDVARDTNRGHTVKAVCESFHLAKDSGF
                     KVVAHMMPDLPNVGLERDIEQFTEFFENPAFRPDGLKLYPTLVIRGTGLYELWKSGRY
                     KSYSPSDLVELVARILALVPPWTRVYRVQRDIPMPLVSSGVEHGNLRELALARMKDLG
                     IQCRDVRTREVGIQEIHHKVRPYQVELVRRDYVANGGWETFLSYEDPDQDILIGLLRL
                     RKCSEETFRFELGGGVSIVRELHVYGSVVPVSSRDPTKFQHQGFGMLLMEEAERIARE
                     EHGSGKIAVISGVGTRNYYRKIGYRLQGPYMVKMLK"
     exon            306..374
                     /gene="ELP3"
                     /gene_synonym="KAT9"
                     /inference="alignment:Splign:2.1.0"
     exon            375..529
                     /gene="ELP3"
                     /gene_synonym="KAT9"
                     /inference="alignment:Splign:2.1.0"
     exon            530..691
                     /gene="ELP3"
                     /gene_synonym="KAT9"
                     /inference="alignment:Splign:2.1.0"
     exon            692..818
                     /gene="ELP3"
                     /gene_synonym="KAT9"
                     /inference="alignment:Splign:2.1.0"
     exon            819..1012
                     /gene="ELP3"
                     /gene_synonym="KAT9"
                     /inference="alignment:Splign:2.1.0"
     exon            1013..1103
                     /gene="ELP3"
                     /gene_synonym="KAT9"
                     /inference="alignment:Splign:2.1.0"
     exon            1104..1169
                     /gene="ELP3"
                     /gene_synonym="KAT9"
                     /inference="alignment:Splign:2.1.0"
     exon            1170..1397
                     /gene="ELP3"
                     /gene_synonym="KAT9"
                     /inference="alignment:Splign:2.1.0"
     exon            1398..1479
                     /gene="ELP3"
                     /gene_synonym="KAT9"
                     /inference="alignment:Splign:2.1.0"
     exon            1480..2984
                     /gene="ELP3"
                     /gene_synonym="KAT9"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1899..1904
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ELP3"
                     /gene_synonym="KAT9"
                     /note="hexamer: AATAAA"
     polyA_site      1928
                     /gene="ELP3"
                     /gene_synonym="KAT9"
                     /note="major polyA site"
     regulatory      2961..2966
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ELP3"
                     /gene_synonym="KAT9"
                     /note="hexamer: AATAAA"
     polyA_site      2984
                     /gene="ELP3"
                     /gene_synonym="KAT9"
                     /note="major polyA site"
ORIGIN      
        1 ggctgtcagc tttccccgtg gtctgagttt gtggctgcat ttttatctct ggtggctctg
       61 ctacggcggc gcagaaatga ggcagaagcg gaaagggtga aaaccaagac agctgccaaa
      121 tatggccttt ctgcccagcc ccgcctggtg gatatcattg ctgccgtccc tcctcagtat
      181 cgcaaggtct tgatgcccaa gttaaaggcg aaacccatca gaactgctag tgggattgct
      241 gtcgtggctg tgatgtgcaa accccacaga tgtccacaca tcagttttac aggaaatata
      301 tgtgtccaac ctccatgaga gctatccgtg ccagatatga ccctttccta cagacaagac
      361 accgaataga acagttaaaa caacttggtc atagtgtgga taaagtggag tttattgtga
      421 tgggtggaac gtttatggcc cttccagaag aatacagaga ttattttatt cgaaatttac
      481 atgatgcctt atcaggacat acttccaaca atatttacga ggcagtcaag tattctgaga
      541 gaagcctcac aaagtgtatt ggaattacta ttgaaaccag accagattac tgcatgaagc
      601 gacatttaag tgacatgttg acctatggct gcacaaggct ggagattggg gtgcagagtg
      661 tttatgaaga tgtggctaga gacaccaaca ggggccacac tgtgaaggca gtgtgtgagt
      721 catttcacct ggccaaagat tccggtttta aagtggtggc ccatatgatg cctgacctgc
      781 caaacgtggg actagaaaga gacattgaac agttcacaga gttttttgag aaccctgctt
      841 ttcgtcccga tgggctgaaa ctctatccta ccctggtgat tcgtgggacc gggctttatg
      901 agctttggaa atcaggaaga tataagagtt actctcctag tgacctggtt gaattggtgg
      961 ctcggatcct agccctcgtg cctccatgga ctcgagtgta ccgagtacag agggatattc
     1021 caatgccttt agttagctca ggagtagagc atggtaacct gagagagctg gcacttgcaa
     1081 gaatgaaaga cctcggaata cagtgtcgag atgtgagaac cagagaagtt ggaatccaag
     1141 aaattcatca caaagtacgg ccataccagg ttgaattggt aaggagagat tatgttgcaa
     1201 atggtggctg ggaaacattc ttgtcatacg aagacccaga tcaagacatt ttgattggcc
     1261 tcctacgatt acgcaagtgt tcagaagaaa ctttccgttt cgaattgggt ggaggtgtct
     1321 ccatagtacg agagctgcat gtgtatggga gtgtggtccc tgtgagcagc cgggatccta
     1381 ctaaatttca gcatcaggga tttggcatgc tgctgatgga ggaagcagaa agaatagcta
     1441 gagaagaaca tgggtctggg aaaatcgctg tgatatcagg ggtcggcacc aggaattatt
     1501 atagaaagat cggctacaga ttacaaggcc cgtacatggt gaagatgctg aaataatggc
     1561 cacaccagtc cactcttctg cagtatcctc cctggcagaa cacggagaat caggatttct
     1621 taaatactca acagagaggc tgagcagagc aaatgggggg cttcaccctc atcccgcagc
     1681 tgcagagact ggaaactgcc ttcaaggcca cggctggtca tctgctgacc acaccccaga
     1741 tccgccctct cctgcgtgca ccccaaaaaa tcacttgcgt ttttgaggct taaatcatct
     1801 atccagtttc tacattttgc atgaggcctg caggtggcct attttgactc agacggtgaa
     1861 aaaagcaaat taactcattt ggacaccata actcatgcaa taaaactgat tgtcattcga
     1921 ggagcaaact taagagtagt ttatttatat accctgggga cagaaagtca ggttgaaaca
     1981 ggaaaaccac cagactctaa tctcagccct ttaacgacat acgcattgga gcgcaagtta
     2041 ggaaaatgag cttttgtttt catggaaatc attctgatta cagtgctgat gtttagaaat
     2101 aaatagcagt gtgactggga aagaggaatt gcagttgtgg gggtgtgagc ctggcagcag
     2161 ccagccagca gcctctccca ggcgggagtc taccatccga gacggcgatg acaaagagct
     2221 tcattccaca ttctttgtta tctctacttc ccaccctctt ggcaactaca gagcagtgtg
     2281 ggcagcccca agtgtggtcc ccagagagcg tttggctttc ctgtctgtct atcctgagcg
     2341 ggtggagtct caggttgtgt gcccctaaat caagatttgc ttccacagaa gccattactt
     2401 gcaatttttt ttttttttct gagaaagtct cgctgtgtca cccaggctgg agtgcagtgg
     2461 cgcaatctca ctgcatcctc cgcctcccgg gttcaagcga ttctcccgcc tcagcctcct
     2521 gagtagctgg gattacaggc acccgccgct gctaattttt gtatttttag tagagatggg
     2581 ggtttcacca tattggtcag gctggtctcg aactcctgac ctcaggtgat caacccacct
     2641 tggcctccct aaatgccggg attacaggca tgagccaccg ctcccagcct ttgatttttt
     2701 aaggtggatt ttggttgtta taaatggaga aaggtaagag ttcaagttca acccgtgtgt
     2761 gaaagcaaaa caatggaaaa caggattggc ttcttcaaag gctcctcttg tagaactgcc
     2821 tctttgaaat ttcgaggtaa tctactttgg agactctgcc tggagagggt cagttcctaa
     2881 gttaaaagca tcgcttaacc ttggctcctg tggcatttta caaaggttta aaggaattga
     2941 ttcctctgaa agggcctgaa aataaaaagt ctttaacata caaa
//
