LOCUS       NM_018255               8432 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens elongator acetyltransferase complex subunit 2 (ELP2),
            transcript variant 2, mRNA.
ACCESSION   NM_018255
VERSION     NM_018255.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8432)
  AUTHORS   Khalilov,D., Haryanyan,G., Salman,B., Yucesan,E., Ugur Iseri,S. and
            Bebek,N.
  TITLE     Epilepsy or neurodevelopmental disorders are associated with
            homozygous and pathogenic ELP2 variation in three siblings
  JOURNAL   Neurocase 28 (6), 488-492 (2022)
   PUBMED   36787709
  REMARK    GeneRIF: Epilepsy or neurodevelopmental disorders are associated
            with homozygous and pathogenic ELP2 variation in three siblings.
REFERENCE   2  (bases 1 to 8432)
  AUTHORS   Russo,A., Forest,C., Leone,G.J., Iascone,M., Tenconi,R., Maffei,M.,
            Cersosimo,A., Cordelli,D.M. and Suppiej,A.
  TITLE     ELP2 compound heterozygous variants associated with
            cortico-cerebellar atrophy, nodular heterotopia and epilepsy:
            Phenotype expansion and review of the literature
  JOURNAL   Eur J Med Genet 64 (12), 104361 (2021)
   PUBMED   34653680
  REMARK    GeneRIF: ELP2 compound heterozygous variants associated with
            cortico-cerebellar atrophy, nodular heterotopia and epilepsy:
            Phenotype expansion and review of the literature.
            Review article
REFERENCE   3  (bases 1 to 8432)
  AUTHORS   Kojic,M., Gawda,T., Gaik,M., Begg,A., Salerno-Kochan,A.,
            Kurniawan,N.D., Jones,A., Drozdzyk,K., Koscielniak,A.,
            Chramiec-Glabik,A., Hediyeh-Zadeh,S., Kasherman,M., Shim,W.J.,
            Sinniah,E., Genovesi,L.A., Abrahamsen,R.K., Fenger,C.D.,
            Madsen,C.G., Cohen,J.S., Fatemi,A., Stark,Z., Lunke,S., Lee,J.,
            Hansen,J.K., Boxill,M.F., Keren,B., Marey,I., Saenz,M.S., Brown,K.,
            Alexander,S.A., Mureev,S., Batzilla,A., Davis,M.J., Piper,M.,
            Boden,M., Burne,T.H.J., Palpant,N.J., Moller,R.S., Glatt,S. and
            Wainwright,B.J.
  TITLE     Elp2 mutations perturb the epitranscriptome and lead to a complex
            neurodevelopmental phenotype
  JOURNAL   Nat Commun 12 (1), 2678 (2021)
   PUBMED   33976153
  REMARK    GeneRIF: Elp2 mutations perturb the epitranscriptome and lead to a
            complex neurodevelopmental phenotype.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 8432)
  AUTHORS   Dogan,M., Terali,K., Eroz,R., Demirci,H. and Kocabay,K.
  TITLE     Clinical and molecular findings in a Turkish family with an
            ultra-rare condition, ELP2-related neurodevelopmental disorder
  JOURNAL   Mol Biol Rep 48 (1), 701-708 (2021)
   PUBMED   33393008
  REMARK    GeneRIF: Clinical and molecular findings in a Turkish family with
            an ultra-rare condition, ELP2-related neurodevelopmental disorder.
REFERENCE   5  (bases 1 to 8432)
  AUTHORS   Mencalha,A.L., Correa,S., Salles,D., Du Rocher,B., Santiago,M.F.
            and Abdelhay,E.
  TITLE     Inhibition of STAT3-interacting protein 1 (STATIP1) promotes STAT3
            transcriptional up-regulation and imatinib mesylate resistance in
            the chronic myeloid leukemia
  JOURNAL   BMC Cancer 14, 866 (2014)
   PUBMED   25417721
  REMARK    GeneRIF: Studied the possible relationship between STATIP1, STAT3
            and CML resistance.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 8432)
  AUTHORS   Close,P., Gillard,M., Ladang,A., Jiang,Z., Papuga,J., Hawkes,N.,
            Nguyen,L., Chapelle,J.P., Bouillenne,F., Svejstrup,J., Fillet,M.
            and Chariot,A.
  TITLE     DERP6 (ELP5) and C3ORF75 (ELP6) regulate tumorigenicity and
            migration of melanoma cells as subunits of Elongator
  JOURNAL   J Biol Chem 287 (39), 32535-32545 (2012)
   PUBMED   22854966
REFERENCE   7  (bases 1 to 8432)
  AUTHORS   Suaud,L., Miller,K., Panichelli,A.E., Randell,R.L., Marando,C.M.
            and Rubenstein,R.C.
  TITLE     4-Phenylbutyrate stimulates Hsp70 expression through the Elp2
            component of elongator and STAT-3 in cystic fibrosis epithelial
            cells
  JOURNAL   J Biol Chem 286 (52), 45083-45092 (2011)
   PUBMED   22069317
  REMARK    GeneRIF: Elp2 and STAT-3 mediate, at least in part, the stimulation
            of Hsp70 expression by 4PBA.
REFERENCE   8  (bases 1 to 8432)
  AUTHORS   Kim,J.H., Lane,W.S. and Reinberg,D.
  TITLE     Human Elongator facilitates RNA polymerase II transcription through
            chromatin
  JOURNAL   Proc Natl Acad Sci U S A 99 (3), 1241-1246 (2002)
   PUBMED   11818576
REFERENCE   9  (bases 1 to 8432)
  AUTHORS   Hawkes,N.A., Otero,G., Winkler,G.S., Marshall,N., Dahmus,M.E.,
            Krappmann,D., Scheidereit,C., Thomas,C.L., Schiavo,G.,
            Erdjument-Bromage,H., Tempst,P. and Svejstrup,J.Q.
  TITLE     Purification and characterization of the human elongator complex
  JOURNAL   J Biol Chem 277 (4), 3047-3052 (2002)
   PUBMED   11714725
REFERENCE   10 (bases 1 to 8432)
  AUTHORS   Collum,R.G., Brutsaert,S., Lee,G. and Schindler,C.
  TITLE     A Stat3-interacting protein (StIP1) regulates cytokine signal
            transduction
  JOURNAL   Proc Natl Acad Sci U S A 97 (18), 10120-10125 (2000)
   PUBMED   10954736
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC091060.10, AK001741.1 and
            AC023043.8.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_018255.3.
            
            Summary: The protein encoded by this gene is a core subunit of the
            elongator complex, a histone acetyltransferase complex that
            associates with RNA polymerase II. In addition to histone
            acetylation, the encoded protein effects transcriptional elongation
            and may help remodel chromatin. [provided by RefSeq, May 2016].
            
            Transcript Variant: This variant (2) lacks an in-frame alternate
            coding exon, compared to variant 1, resulting in a shorter protein
            (isoform 2).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.146340.1,
                                           SRR1660807.10350.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000358232.11/ ENSP00000350967.6
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-25                AC091060.10        190258-190282
            26-2519             AK001741.1         1-2494
            2520-8432           AC023043.8         14732-20644
FEATURES             Location/Qualifiers
     source          1..8432
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18q12.2"
     gene            1..8432
                     /gene="ELP2"
                     /gene_synonym="MRT58; SHINC-2; STATIP1; StIP"
                     /note="elongator acetyltransferase complex subunit 2"
                     /db_xref="GeneID:55250"
                     /db_xref="HGNC:HGNC:18248"
                     /db_xref="MIM:616054"
     exon            1..173
                     /gene="ELP2"
                     /gene_synonym="MRT58; SHINC-2; STATIP1; StIP"
                     /inference="alignment:Splign:2.1.0"
     CDS             36..2516
                     /gene="ELP2"
                     /gene_synonym="MRT58; SHINC-2; STATIP1; StIP"
                     /note="isoform 2 is encoded by transcript variant 2;
                     signal transducer and activator of transcription 3
                     interacting protein 1; elongator protein 2; elongator
                     complex protein 2; STAT3-interacting protein 1; elongation
                     protein 2 homolog"
                     /codon_start=1
                     /product="elongator complex protein 2 isoform 2"
                     /protein_id="NP_060725.1"
                     /db_xref="CCDS:CCDS11918.1"
                     /db_xref="GeneID:55250"
                     /db_xref="HGNC:HGNC:18248"
                     /db_xref="MIM:616054"
                     /translation="MVAPVLETSHVFCCPNRVRGVLNWSSGPRGLLAFGTSCSVVLYD
                     PLKRVVVTNLNGHTARVNCIQWICKQDGSPSTELVSGGSDNQVIHWEIEDNQLLKAVH
                     LQGHEGPVYAVHAVYQRRTSDPALCTLIVSAAADSAVRLWSKKGPEVMCLQTLNFGNG
                     FALALCLSFLPNTDVPILACGNDDCRIHIFAQQNDQFQKVLSLCGHEDWIRGVEWAAF
                     GRDLFLASCSQDCLIRIWKLYIKSTSLETQDDDNIRLKENTFTIENESVKIAFAVTLE
                     TVLAGHENWVNAVHWQPVFYKDGVLQQPVRLLSASMDKTMILWAPDEESGVWLEQVRV
                     GEVGGNTLGFYDCQFNEDGSMIIAHAFHGALHLWKQNTVNPREWTPEIVISGHFDGVQ
                     DLVWDPEGEFIITVGTDQTTRLFAPWKRKDQSQVTWHEIARPQIHGYDLKCLAMINRF
                     QFVSGADEKVLRVFSAPRNFVENFCAITGQSLNHVLCNQDSDLPEGATVPALGLSNKA
                     VFQGDIASQPSDEEELLTSTGFEYQQVAFQPSILTEPPTEDHLLQNTLWPEVQKLYGH
                     GYEIFCVTCNSSKTLLASACKAAKKEHAAIILWNTTSWKQVQNLVFHSLTVTQMAFSP
                     NEKFLLAVSRDRTWSLWKKQDTISPEFEPVFSLFAFTNKITSVHSRIIWSCDWSPDSK
                     YFFTGSRDKKVVVWGECDSTDDCIEHNIGPCSSVLDVGGAVTAVSVCPVLHPSQRYVV
                     AVGLECGKICLYTWKKTDQVPEINDWTHCVETSQSQSHTLAIRKLCWKNCSGKTEQKE
                     AEGAEWLHFASCGEDHTVKIHRVNKCAL"
     exon            174..252
                     /gene="ELP2"
                     /gene_synonym="MRT58; SHINC-2; STATIP1; StIP"
                     /inference="alignment:Splign:2.1.0"
     exon            253..323
                     /gene="ELP2"
                     /gene_synonym="MRT58; SHINC-2; STATIP1; StIP"
                     /inference="alignment:Splign:2.1.0"
     exon            324..480
                     /gene="ELP2"
                     /gene_synonym="MRT58; SHINC-2; STATIP1; StIP"
                     /inference="alignment:Splign:2.1.0"
     exon            481..558
                     /gene="ELP2"
                     /gene_synonym="MRT58; SHINC-2; STATIP1; StIP"
                     /inference="alignment:Splign:2.1.0"
     exon            559..623
                     /gene="ELP2"
                     /gene_synonym="MRT58; SHINC-2; STATIP1; StIP"
                     /inference="alignment:Splign:2.1.0"
     exon            624..690
                     /gene="ELP2"
                     /gene_synonym="MRT58; SHINC-2; STATIP1; StIP"
                     /inference="alignment:Splign:2.1.0"
     exon            691..831
                     /gene="ELP2"
                     /gene_synonym="MRT58; SHINC-2; STATIP1; StIP"
                     /inference="alignment:Splign:2.1.0"
     exon            832..927
                     /gene="ELP2"
                     /gene_synonym="MRT58; SHINC-2; STATIP1; StIP"
                     /inference="alignment:Splign:2.1.0"
     exon            928..1028
                     /gene="ELP2"
                     /gene_synonym="MRT58; SHINC-2; STATIP1; StIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1029..1160
                     /gene="ELP2"
                     /gene_synonym="MRT58; SHINC-2; STATIP1; StIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1161..1310
                     /gene="ELP2"
                     /gene_synonym="MRT58; SHINC-2; STATIP1; StIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1311..1499
                     /gene="ELP2"
                     /gene_synonym="MRT58; SHINC-2; STATIP1; StIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1500..1569
                     /gene="ELP2"
                     /gene_synonym="MRT58; SHINC-2; STATIP1; StIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1570..1665
                     /gene="ELP2"
                     /gene_synonym="MRT58; SHINC-2; STATIP1; StIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1666..1723
                     /gene="ELP2"
                     /gene_synonym="MRT58; SHINC-2; STATIP1; StIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1724..1796
                     /gene="ELP2"
                     /gene_synonym="MRT58; SHINC-2; STATIP1; StIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1797..1989
                     /gene="ELP2"
                     /gene_synonym="MRT58; SHINC-2; STATIP1; StIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1990..2111
                     /gene="ELP2"
                     /gene_synonym="MRT58; SHINC-2; STATIP1; StIP"
                     /inference="alignment:Splign:2.1.0"
     exon            2112..2245
                     /gene="ELP2"
                     /gene_synonym="MRT58; SHINC-2; STATIP1; StIP"
                     /inference="alignment:Splign:2.1.0"
     exon            2246..2359
                     /gene="ELP2"
                     /gene_synonym="MRT58; SHINC-2; STATIP1; StIP"
                     /inference="alignment:Splign:2.1.0"
     exon            2360..8432
                     /gene="ELP2"
                     /gene_synonym="MRT58; SHINC-2; STATIP1; StIP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2499..2504
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ELP2"
                     /gene_synonym="MRT58; SHINC-2; STATIP1; StIP"
                     /note="hexamer: AATAAA"
     polyA_site      2531
                     /gene="ELP2"
                     /gene_synonym="MRT58; SHINC-2; STATIP1; StIP"
                     /note="major polyA site"
     regulatory      3920..3925
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ELP2"
                     /gene_synonym="MRT58; SHINC-2; STATIP1; StIP"
                     /note="hexamer: AATAAA"
     polyA_site      3944
                     /gene="ELP2"
                     /gene_synonym="MRT58; SHINC-2; STATIP1; StIP"
                     /note="major polyA site"
     regulatory      5777..5782
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ELP2"
                     /gene_synonym="MRT58; SHINC-2; STATIP1; StIP"
                     /note="hexamer: AATAAA"
     polyA_site      5806
                     /gene="ELP2"
                     /gene_synonym="MRT58; SHINC-2; STATIP1; StIP"
     regulatory      8406..8411
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ELP2"
                     /gene_synonym="MRT58; SHINC-2; STATIP1; StIP"
                     /note="hexamer: AATAAA"
     polyA_site      8432
                     /gene="ELP2"
                     /gene_synonym="MRT58; SHINC-2; STATIP1; StIP"
ORIGIN      
        1 gcgtctcttg tttgtgcggc tgaccagttg gcgacatggt ggcacccgtg ctggagactt
       61 ctcacgtgtt ttgctgccca aaccgggtgc ggggagtcct gaactggagc tctgggccca
      121 gaggacttct ggcctttggc acgtcctgct ccgtggtgct ctatgacccc ctgaaaaggg
      181 ttgttgttac caacttgaat ggtcacaccg cccgagtcaa ttgcatacag tggatttgta
      241 aacaggatgg ctccccttct actgaattag tttctggagg atctgataat caagtgattc
      301 actgggaaat agaggataat cagcttttaa aagcagtgca tcttcaaggc catgaaggac
      361 ctgtttatgc ggtgcatgct gtttaccaga ggaggacatc agatcctgca ttatgtacac
      421 tgatcgtttc tgcagctgca gattctgctg ttcgactctg gtctaaaaag ggtccagaag
      481 taatgtgcct tcagacttta aactttggaa atggatttgc tttggctctc tgcttatctt
      541 ttttgccaaa tactgatgta ccaatattag catgtggcaa tgatgattgc agaattcaca
      601 tatttgctca acaaaatgat cagtttcaga aagtgctttc tctctgtgga catgaggatt
      661 ggattagagg agtggaatgg gcagcctttg gtagagatct tttcctagca agctgttcac
      721 aagattgcct gataagaata tggaagctgt atataaagtc aacatcttta gaaactcagg
      781 atgacgataa cataagactg aaagaaaata cttttaccat agaaaatgaa agtgttaaaa
      841 tagcatttgc tgttactctg gagacagtgc tagccggtca tgaaaactgg gtaaatgcag
      901 ttcactggca acctgtgttt tacaaagatg gtgtcctaca gcagccagtg agattattat
      961 ctgcttccat ggataaaacc atgattctct gggctccaga tgaagagtca ggagtttggc
     1021 tagaacaggt tcgagtaggt gaagtaggtg ggaatacttt gggattttat gattgccagt
     1081 tcaatgaaga tggctccatg atcattgctc atgctttcca cggagcgttg cacctttgga
     1141 aacagaatac agttaaccca agagagtgga ctccagagat tgtcatttca ggacactttg
     1201 atggtgtcca agacctagtc tgggatccag aaggagaatt tattatcact gttggtactg
     1261 atcagacaac tagacttttt gctccatgga agagaaaaga ccaatcacag gtgacttggc
     1321 atgaaattgc aaggcctcag atacatgggt atgacctgaa atgtttggca atgattaatc
     1381 ggtttcagtt tgtatctgga gcagatgaaa aagttcttcg ggttttttct gcacctcgga
     1441 attttgtgga aaatttttgt gccattacag gacaatcact gaatcatgtg ctctgtaatc
     1501 aagatagtga tcttccagaa ggagccactg tccctgcatt gggattatca aataaagctg
     1561 tctttcaggg agatatagct tctcagcctt ctgatgaaga ggagctgtta actagtactg
     1621 gttttgagta tcagcaggtg gcctttcagc cctccatact tactgagcct cccactgagg
     1681 atcatcttct gcagaatact ttgtggcctg aagttcaaaa actatatggg cacggttatg
     1741 aaatattttg tgttacttgt aacagttcaa agactctgct tgcctcagct tgtaaggcag
     1801 ctaagaaaga gcatgcagct atcattcttt ggaacactac atcttggaaa caggtgcaga
     1861 atttagtttt ccacagtttg acagtcacgc agatggcctt ctcacctaat gagaagttct
     1921 tactagctgt ttccagagat cgaacctggt cattgtggaa aaagcaggat acaatctcac
     1981 ctgagttcga gccagttttt agtctttttg ccttcaccaa caaaattact tctgtgcaca
     2041 gtagaattat ttggtcttgt gattggagtc ctgacagcaa gtatttcttc actgggagtc
     2101 gagacaaaaa ggtggttgtc tggggtgagt gcgactccac tgatgactgt attgagcaca
     2161 acattggccc ctgctcctca gtcctggacg tgggtggggc tgtgacagct gtcagcgtct
     2221 gcccagtgct ccacccttct caacgatacg tggttgcagt aggattggag tgtggaaaga
     2281 tttgcttata tacctggaaa aagactgatc aagttccaga aataaatgac tggacccact
     2341 gtgtagaaac aagtcaaagc caaagtcata cactggctat cagaaaatta tgctggaaga
     2401 attgcagtgg aaaaactgaa cagaaggaag cagaaggtgc tgagtggtta cactttgcaa
     2461 gctgtggtga agatcacact gtgaagatac acagagtcaa taaatgtgca ctgtaatgga
     2521 cttaataact acatgcttgc agtcactggt atcttaaaat attatcatgt aaacaggtca
     2581 tctttacctt cataactgaa ttgagtttct gggttttttt tttttttgag atggagtctt
     2641 gctttgtcac aacctccacc tcccaggttc aagcgattct ctttcttcag cctcctgagt
     2701 agctgggact agaggcacac caccaattcc ggctaatttt tgtattttta gtagagactg
     2761 ggtttcaccg ttggccaggc gggtctcaaa ctcctcgtct caggtgatct gcttgcctcg
     2821 gcctcccaaa gtgctgggat tacaggcgtg agccactgcg cccagcctga gtttcatttt
     2881 ttaagtcaca tagcagtagt ccttatttca gtgctagacc ctttgaaatg cgatgaaagc
     2941 tatatggacc cttcgctttg ttatataaca tatgcacaca tacccagaat tttgcacata
     3001 tgttcagaga ttcctagacc tgcagacctg cctctgtgtg tcccaattta agaacctctg
     3061 ttctttcttc atgactggat ttgcccaatt ttgtgttatt ttgggactta atttgtccct
     3121 ctttgggaca tttccttatt tattgccctc ttcagagagt agatgtagaa aataaagaga
     3181 ggaaacctag attacttaat tttattttaa cattttctat agatagcata ccacgccaag
     3241 tgtgctctgt cttgatcccc ttctttctag catctgccag acattgtaga gtttcgcaag
     3301 cagttgtagg tttgagctgc agccagtcat ttcttttatt ctttaaaagt acatagattt
     3361 gtctttttag ggctttactg aaagtaaaat atcctgacat ttaaactgac agatgtagga
     3421 ggtaaaaaat agagttctga aacatttgaa tttatgtgac agctgaagtc acgagatgag
     3481 ggatatatgt cccccaggga ggatgcagaa agaagaaaag ggtactggaa acagcatgtc
     3541 agtggtgcca gctgagggct ggaggcagcc aggagagttg ggagcctggg tgctgggtgg
     3601 agagaggtta acagggaaga catgggaagt attgtgaagg ctggtgtgag caggggacta
     3661 ctccagccct gttggaacat agagccattt ggcagattga caatgcagtg acagctgtat
     3721 ataataaatg tgttgaaagg aggaaggtga ggattttctt ggtgggagtt tatgctgtta
     3781 tttaacatat tttgcttcca aaggggttaa gatgttttac ctaaatggag gtttctaggt
     3841 cagtgctata caatatttct aatctgtgtt ttatagtgtg agctacatat gtaattttaa
     3901 aattttcaag tagccacata ataaaggaaa caggtgaaat ttaatgacat atttccttta
     3961 atacggtata tccaaaatat tattatgtca acctataatc agtataaaaa cctgttactg
     4021 aaatatttta tagggcccat ctcagttcag actagccaca tttaagtgct tcatagccac
     4081 atgtggctca tggccatcca tatttggaca atgtacttta gactattgca tctgtatact
     4141 cttgtgccgt cagctggggg gtggggtgtg tgtgcgtgta taccaaggca gtgagcatct
     4201 gagctttgaa cctcaaagac caaaatgccc tgcccatttt cctgcttatc agctgaggaa
     4261 tctttaccca cattgacaca tgggcttgtt ctgacccaag tgcatgcagg cttccagagc
     4321 agattcagag gcctaactta gtcctttagc tttcctccca gcacagaact cccaaggtta
     4381 tctgcaagta ggccttgcct agagagactg agttttcaag ttgtcagttt tcccaaattg
     4441 tcctcaagca tcttcctctg gaatcacctt actgtttagt aaacattcag aggacttgct
     4501 acacatctgg gcagtctgca ttgtaattca tatgtgttta cacatttgtg tcttcatctg
     4561 ctaaagcacc tttgaaccat attgtaattc ataatatctg aagcaattat tatgaattgt
     4621 agtaattcat aatattgaag cgattcataa tatctgaagc aatccccaga tacgggttag
     4681 gcatggccct gctctgagca ggatggcaaa agtggcagtc cgtgacgcag cccttgttac
     4741 cccaggctat tactaaatgg tggtggtggt tttatcttaa ttaaaatgac atcaccaaca
     4801 atgggccctt tcctgtctgc caggaaaagt tttctgtagt gacgcacgtg ttgtgtgtgt
     4861 atgtgtgcgt ttgaggctat attactcatt gctacggcag ttcaaaatga cttggaaaaa
     4921 aacaatgaac gctggtcatt gatatgtata ctgacatgtt tgagggaagt tactgtggtc
     4981 tgtaacttat gaaatacata aaaaatatga tgggtggagt gacggacaca tggacagata
     5041 tgaagcaagc actgtaaaat attagtggta gtttttgtat gcccatactc acggcaccat
     5101 tattcacagt agctaagaga tggaagcaat atgtgcccat cagtgggtga atgatcaaca
     5161 aaatgtggta tattcataca gtggaatatt attcagcctc taaaaggaag atacgctgac
     5221 atgtgctgca acatggatga atcttgagga catgatgcta agtgaagtaa gccagtcact
     5281 ggaagacaaa tactctatgc ttccatttat gtgaagtatc tagagcagtc aaatgcatag
     5341 aaacaagtag aatggtagtt gccaaggact gggggaggag gaaatgagga gttgtttaat
     5401 gggtatagtg tttcagtttt gcaagataaa aagtcctgtg gattggttgc acagttaagt
     5461 tatgtgaatg ctgtatgcca actcaactgt acactctaaa atggttaaga tggtaaatct
     5521 tatctttatt ttaccacagt tttttttaaa gcatggtaaa caccatttcc caggatgtaa
     5581 atcggtacta aaaaaaaagt gctccaaagt aagatatatt tgggaaacac agggataact
     5641 aaggttagat aggtgttctt tattgcagga attctaagag catttaacaa attaatttac
     5701 actgggaatt ttcagtgtgg agggtctggc tcatagcatt tcacaaacat tatacttcag
     5761 agtcccaaag cctttaaata aaatgttaat ggtagaaact ccttaagggg tgttcactgt
     5821 acaattcttt caacttttct gcatgctggg agtttttttg gtaacaacgt gttggggaaa
     5881 atggccttgg aatatttcat tcaaattgga gccaagctaa cacaaagctg ttgctgctag
     5941 tgggaacagc cctgatgtcc atgtaacaag ctgccctccc caactccctc cttcctgttt
     6001 ctccctcctc ggcacccact tctaggatta acaggcaggg agacgggaga gcccagctct
     6061 gggtacagtt gggccacagc agaaggaggg ccagggtaga ggtttgggcc ttggctctga
     6121 tgcttgaaca taaacacacc tagtcagaag tacatcagta caaagtgggc cctacaaaat
     6181 tatagggtca gaaaacaggt aagtggttac caggggctgg gaatggggag aggagtgact
     6241 acagagggac ctagattctt caacaaatac attacaagag gaaaagggaa gggaagggaa
     6301 gcctggagat tgaaagatac ttgagacgtg tgaatccagt gcaatgtatg aaccttgttt
     6361 gcctcttgat ctgaactagc caatcaatct tgtaaaaatg tgcttaaggg acaaagcaaa
     6421 tttgaactct ggctggatat ttgatgatat taaggaaaca acatttaaac atatgacagt
     6481 ggggctatgg ttatgattgg ttttgttttt tttttctcta gagactgggt tttgcagtgt
     6541 tacctaagct ggtcttgaac tcctgggctc aagcagttct cccacctcag ccttggttta
     6601 agaaaaaaaa aaaaaaagtt ctcttgaatc ataatttcag tatttatgga tgaaatcaat
     6661 ttatgtcttg ggttgtttca taatgattgt gtgtgtgtca aggactagat gggttttaga
     6721 tgtgtggatt attaatgaag ctgggcagtg ttggggtggt catactattc taatttttta
     6781 atatacttaa aatttcctta taagaattgt ttagaaagaa tgagcatatc cataagttaa
     6841 atacaaaaat tgttacattg tgaggagttc ttccccttct agcatgtagt ggatggtcca
     6901 gtattaaggc tctgccatgc ttaaacaaga gactggcact ccaaggacaa tgaggctgag
     6961 gccagaagag agacagcgtg ttggatggct gcatgtggtt ggtggataga ggactctgag
     7021 ccccactctg gtggactcag agatctggga cccgggccgg gcgtggtggc tcatgcctgt
     7081 aatcccagca atttgggagg ctgaggcggg tggatcactt gaggtcagga gttcgagacc
     7141 agcctggcca acatggtgaa accccatctc tactaaaaat acaaaaaaaa aaaaaaaatt
     7201 agtcgggcat ggtggtgggc gcctgtaatc ccagatgttc cagaggctga ggcaggagaa
     7261 ccgcttgaac ccaggaggag gaggaggttg cagtgggccg agatcgagcc actgcactcc
     7321 agcctgggca acagagtgag actccatctc aaaaaaaaaa aaaaaaaaaa aaaaaatctg
     7381 ggacccagta ctgagtgaag acaccagagt gaaggagaga ggccatgctg tgtccgagaa
     7441 gctcctactg gggtggaagg gacagctcca caaaggctgc tcttgcaggg gctctcctgc
     7501 agcaaggtgc ctgctgactg tccccagact gtctcccgac acagagggat gcaaaggcag
     7561 cctcttcctg ctcagtggaa tagggaaatt atatcacctt tcacttccca ctctcacttc
     7621 tgcccctgct acccttagtc tttggctttt gctgacattt tcccctctta tcttttctcc
     7681 tgaccaagtt ctaggtattt catagggcag tctaggtgag ggttggaacc ccaatgagtt
     7741 gggcaacaga aacccagctc acactggctg tcactgtggg caagctgttc ccctcatctc
     7801 taaaagtgga gatgagatta gtgtatgagt ctggcttcca ttcaactgtg tgtgaaaaaa
     7861 aattgtaaaa ttttctttct ggtttacgca agttaaaagt ttatttctct catatgaaag
     7921 gagtcaaggc agacagacca ggatggggag ggagatgtct acagggtcaa ggacccaggc
     7981 tcttatttcg ctgtctgacg tccttagtat gaggctttca ccttccagga tggctgcttg
     8041 gcctcctgcc atggtctttg cgttccagcc agcaaagagg aagaaggcat gaagaaaggc
     8101 ctgcccctga ctttaaaaac atttcttgga agtcccatac tattttgctt aatctcctcg
     8161 ggcagaattt agtgttgtgg ccataccgag cttcaggaga agctgggaaa ttaaatcttt
     8221 attgcagatg cccatgtgct cagcagagaa ctggggtgct tcattctgga agaaagggag
     8281 aacaacagta accagtgtgt aggattgttc tgagaattaa atgagccaat atatgaaaaa
     8341 cactagtttg gtccctggga tataaataag acagcagtaa tttgtatctg gtactattat
     8401 gattaaataa agctctgctc gtgtcaactc ca
//
