LOCUS       NM_024930               3874 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens ELOVL fatty acid elongase 7 (ELOVL7), transcript
            variant 1, mRNA.
ACCESSION   NM_024930 XM_371740
VERSION     NM_024930.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3874)
  AUTHORS   Zhou,Y., Lv,R., Ye,R.D., Ren,R. and Yu,L.
  TITLE     The 3-hydroxyacyl-CoA dehydratase 1/2 form complex with
            trans-2-enoyl-CoA reductase involved in substrates transfer in very
            long chain fatty acid elongation
  JOURNAL   Biochem Biophys Res Commun 704, 149588 (2024)
   PUBMED   38422897
REFERENCE   2  (bases 1 to 3874)
  AUTHORS   Wang,W.M., Yang,Z.G., Liu,C. and Dong,Q.
  TITLE     ELOVL fatty acid elongase 7 (ELOVL7), upregulated by Mdr2-knockout,
            predicts advanced liver fibrosis in patients with chronic hepatitis
            B
  JOURNAL   Eur Rev Med Pharmacol Sci 27 (5), 1954-1970 (2023)
   PUBMED   36930494
  REMARK    GeneRIF: ELOVL fatty acid elongase 7 (ELOVL7), upregulated by
            Mdr2-knockout, predicts advanced liver fibrosis in patients with
            chronic hepatitis B.
REFERENCE   3  (bases 1 to 3874)
  AUTHORS   Nie,L., Pascoa,T.C., Pike,A.C.W., Bushell,S.R., Quigley,A.,
            Ruda,G.F., Chu,A., Cole,V., Speedman,D., Moreira,T., Shrestha,L.,
            Mukhopadhyay,S.M.M., Burgess-Brown,N.A., Love,J.D., Brennan,P.E.
            and Carpenter,E.P.
  TITLE     The structural basis of fatty acid elongation by the ELOVL
            elongases
  JOURNAL   Nat Struct Mol Biol 28 (6), 512-520 (2021)
   PUBMED   34117479
  REMARK    GeneRIF: The structural basis of fatty acid elongation by the ELOVL
            elongases.
REFERENCE   4  (bases 1 to 3874)
  AUTHORS   Wernick,A.I., Walton,R.L., Soto-Beasley,A.I., Koga,S., Ren,Y.,
            Heckman,M.G., Milanowski,L.M., Valentino,R.R., Kondru,N.,
            Uitti,R.J., Cheshire,W.P., Wszolek,Z.K., Dickson,D.W. and Ross,O.A.
  TITLE     Investigating ELOVL7 coding variants in multiple system atrophy
  JOURNAL   Neurosci Lett 749, 135723 (2021)
   PUBMED   33600908
  REMARK    GeneRIF: Investigating ELOVL7 coding variants in multiple system
            atrophy.
REFERENCE   5  (bases 1 to 3874)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 3874)
  AUTHORS   Purdy,J.G., Shenk,T. and Rabinowitz,J.D.
  TITLE     Fatty acid elongase 7 catalyzes lipidome remodeling essential for
            human cytomegalovirus replication
  JOURNAL   Cell Rep 10 (8), 1375-1385 (2015)
   PUBMED   25732827
  REMARK    GeneRIF: ELOVL7 knockdown or mTOR inhibition impairs HCMV-induced
            fatty acid elongation.
REFERENCE   7  (bases 1 to 3874)
  AUTHORS   Naganuma,T., Sato,Y., Sassa,T., Ohno,Y. and Kihara,A.
  TITLE     Biochemical characterization of the very long-chain fatty acid
            elongase ELOVL7
  JOURNAL   FEBS Lett 585 (20), 3337-3341 (2011)
   PUBMED   21959040
  REMARK    GeneRIF: progression of the VLCFA cycle enhances ELOVL7 activity.
REFERENCE   8  (bases 1 to 3874)
  AUTHORS   Ohno,Y., Suto,S., Yamanaka,M., Mizutani,Y., Mitsutake,S.,
            Igarashi,Y., Sassa,T. and Kihara,A.
  TITLE     ELOVL1 production of C24 acyl-CoAs is linked to C24 sphingolipid
            synthesis
  JOURNAL   Proc Natl Acad Sci U S A 107 (43), 18439-18444 (2010)
   PUBMED   20937905
REFERENCE   9  (bases 1 to 3874)
  AUTHORS   Tamura,K., Makino,A., Hullin-Matsuda,F., Kobayashi,T., Furihata,M.,
            Chung,S., Ashida,S., Miki,T., Fujioka,T., Shuin,T., Nakamura,Y. and
            Nakagawa,H.
  TITLE     Novel lipogenic enzyme ELOVL7 is involved in prostate cancer growth
            through saturated long-chain fatty acid metabolism
  JOURNAL   Cancer Res 69 (20), 8133-8140 (2009)
   PUBMED   19826053
  REMARK    GeneRIF: Overexpression of ELOVL7 is associated with prostate
            cancer growth through saturated long-chain fatty acid metabolism.
REFERENCE   10 (bases 1 to 3874)
  AUTHORS   Lehner,R. and Kuksis,A.
  TITLE     Biosynthesis of triacylglycerols
  JOURNAL   Prog Lipid Res 35 (2), 169-201 (1996)
   PUBMED   8944226
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA247166.1, AC104113.3, AB181393.1, AL137506.1 and AI769834.1.
            
            On Nov 23, 2018 this sequence version replaced NM_024930.2.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1). Both variants 1 and 2 encode the same isoform.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.191961.1,
                                           SRR1803615.27658.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000508821.6/ ENSP00000424123.1
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                DA247166.1         6-24
            20-54               AC104113.3         55967-56001
            55-943              AB181393.1         1-889
            944-3870            AL137506.1         380-3306
            3871-3874           AI769834.1         24-27               c
FEATURES             Location/Qualifiers
     source          1..3874
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q12.1"
     gene            1..3874
                     /gene="ELOVL7"
                     /note="ELOVL fatty acid elongase 7"
                     /db_xref="GeneID:79993"
                     /db_xref="HGNC:HGNC:26292"
                     /db_xref="MIM:614451"
     exon            1..110
                     /gene="ELOVL7"
                     /inference="alignment:Splign:2.1.0"
     exon            111..161
                     /gene="ELOVL7"
                     /inference="alignment:Splign:2.1.0"
     exon            162..259
                     /gene="ELOVL7"
                     /inference="alignment:Splign:2.1.0"
     CDS             196..1041
                     /gene="ELOVL7"
                     /EC_number="2.3.1.199"
                     /note="isoform 1 is encoded by transcript variant 1;
                     elongation of very long chain fatty acids protein 7;
                     3-keto acyl-CoA synthase ELOVL7; ELOVL FA elongase 7; very
                     long chain 3-oxoacyl-CoA synthase 7; ELOVL family member
                     7, elongation of long chain fatty acids; very long chain
                     fatty acid elongase 7; very long chain 3-ketoacyl-CoA
                     synthase 7"
                     /codon_start=1
                     /product="very long chain fatty acid elongase 7 isoform 1"
                     /protein_id="NP_079206.2"
                     /db_xref="CCDS:CCDS34164.1"
                     /db_xref="GeneID:79993"
                     /db_xref="HGNC:HGNC:26292"
                     /db_xref="MIM:614451"
                     /translation="MAFSDLTSRTVHLYDNWIKDADPRVEDWLLMSSPLPQTILLGFY
                     VYFVTSLGPKLMENRKPFELKKAMITYNFFIVLFSVYMCYEFVMSGWGIGYSFRCDIV
                     DYSRSPTALRMARTCWLYYFSKFIELLDTIFFVLRKKNSQVTFLHVFHHTIMPWTWWF
                     GVKFAAGGLGTFHALLNTAVHVVMYSYYGLSALGPAYQKYLWWKKYLTSLQLVQFVIV
                     AIHISQFFFMEDCKYQFPVFACIIMSYSFMFLLLFLHFWYRAYTKGQRLPKTVKNGTC
                     KNKDN"
     exon            260..450
                     /gene="ELOVL7"
                     /inference="alignment:Splign:2.1.0"
     exon            451..531
                     /gene="ELOVL7"
                     /inference="alignment:Splign:2.1.0"
     exon            532..588
                     /gene="ELOVL7"
                     /inference="alignment:Splign:2.1.0"
     exon            589..694
                     /gene="ELOVL7"
                     /inference="alignment:Splign:2.1.0"
     exon            695..831
                     /gene="ELOVL7"
                     /inference="alignment:Splign:2.1.0"
     exon            832..3874
                     /gene="ELOVL7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3851..3856
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ELOVL7"
                     /note="hexamer: AATAAA"
     polyA_site      3874
                     /gene="ELOVL7"
                     /note="major polyA site"
ORIGIN      
        1 agtcggcggc cgggacagcg ggggccgctg tgaggagctc cgcgctcgcg ctgccagtcg
       61 ccgccctctc tcccgcgcgc gcccggcgct tcggctccgc tccctgtgcg gcatttaaac
      121 ttccctctta gaactgcttt tgtggcatcc cataagtttt gaacccatta aaagagccag
      181 taaatcctgt ggaaaatggc cttcagtgat cttacatcga ggactgtgca tctttatgat
      241 aattggatca aagatgctga tccaagagtt gaagattggc tcctcatgtc ctcgcctctg
      301 ccacaaacca tcctcctagg attctatgtc tattttgtca cttccttggg accaaagctc
      361 atggaaaatc gcaagccctt tgaactcaag aaagcaatga taacgtacaa ttttttcata
      421 gtactctttt ctgtgtatat gtgttatgag tttgtgatgt ctggctgggg tataggttat
      481 tcatttcgat gtgacattgt tgactattca cggtcaccca cagctttgag gatggcacgt
      541 acctgctggc tttattactt ctccaaattt attgagctat tagatacgat cttttttgtt
      601 ctgcgcaaga aaaatagcca agtgactttc cttcatgtat tccatcatac catcatgccg
      661 tggacctggt ggtttggagt caaatttgct gcaggtggtt tgggaacatt ccatgccctt
      721 ctaaatacag ctgtacatgt agtcatgtat tcctactatg gactttctgc attggggcca
      781 gcctaccaga agtatttgtg gtggaaaaaa tatttgacat cattacagct tgtccagttt
      841 gttattgtcg ccatccacat aagccagttc tttttcatgg aggattgcaa gtatcagttt
      901 ccagtctttg cgtgcatcat tatgagttac agtttcatgt ttctgctgct ctttctccat
      961 ttttggtacc gtgcttacac caaaggtcag aggttgccca aaactgtgaa aaatggaact
     1021 tgcaaaaaca aagataattg aagcccaaca taagtctatg atcgaaactg atacattgtc
     1081 ttccttgaca atcaagagat atttacctat gcagtgcatt ttgtatattt ttcaaaacta
     1141 agagcttgta tttttatggt aagttattgg gatgtctgat atttgagagc ccgaagcttc
     1201 cagataacag tcttctgata attagagcct acagcagcca gaatttgttt ttgtttttgt
     1261 ttttgttttt ttagctgctt ttaaacctaa tccaaaggtt ttgtttaaaa cattttgttg
     1321 cagtgaaaaa aagatatgaa gcaatacagt actcttcaaa gaagtccaat aaagatgaaa
     1381 aatatcatta ggtattttga gcacagacgg agatccatgt gataaaatag attccttctg
     1441 ctgggtctgg aaagtctgga aaccacctgt aggccctggc tttgtcattt attgactgta
     1501 ttcagaagat actatatttg ctctagagtt aactcccatt ttagcaagct agcacaggtg
     1561 aaaattgagt gagtttttga taacttgtca tttaaaatca ttaatgataa ttttcaatgg
     1621 atcttttcag tagccatcac cagttttgct gataagactt cctcacaacc catttgttgt
     1681 acaaactgtt tcaaagtagc aatcctttgg gttagtacac ttgataccaa gtttcattca
     1741 gttgattatt ttcaaaacaa ggtgatttgt tttaatgggt taatgaatac tttgctatta
     1801 ctgttttaca attaactttg tatatctctg gaaagaggtg aatttgtcaa tgaaaaaagt
     1861 attgtgtagt tcagtgggaa aaacctgttg tctgttatag tatcacatca ctttcttaca
     1921 ttgtcatggt ttaaattatt atcttggtga aatatatagg ttagatactt aaatgttcat
     1981 attattagca cactacaggt actaccctta aatcataaat aatattaccc attgtacaca
     2041 gtttccagat atgagttaga gtggctgtga agcaactaga ggcaaattgt ggcacagaga
     2101 atatccaggg gaaaattgat tatgtaagca agggctgttc tactttgaga gagagacaga
     2161 cagactacat aatagtaata tattatataa ttaatgttat agatacactg aacaataaaa
     2221 cattttctgg aattatgaat taattaacaa cctggatttc tgtttccaga cctataaacc
     2281 atgtaatgaa ggactgaaat tcgtttggca tacactttgt ttctttaaaa ttgctagttt
     2341 ctttctgtta tttttacatt ttcttgtcag agaatcaaaa ctattagtca gtagagtttt
     2401 gtccatgaaa taatatttgg acatttgtga atttttccct attttttttc ttcttttatt
     2461 tatactcaat tttgaagcac tgtttatgtt tgtaggactt taaacaatta gtacttaaag
     2521 ccccagttaa ttttgaacac acagagatac ttattgtact ctgtgtacag taagtatttt
     2581 tatgtttaca cttaccagat tcataaggtt atttgccttt aagtgatctt ttgtgatttt
     2641 acttgattac agcatgagaa ggtaaaggtt gataaatggg agtaattaca tatatatata
     2701 taatttatta tttttttttc tgaagcagag ttttactctt gttgcccagg ctagagtgca
     2761 atggcacaat ctcggttcac tgcaacctct gcctcccagg ttcaagtgat tctcctgtct
     2821 cagcctccca agtagctggg attacaggtg cccgccacca tgctcagcta atttttgtat
     2881 ttttagtaga gacagggttg gccaggctgg tctcgagctc ctgacctcag gtgatcctcc
     2941 cacctcggcc tcccaaagtt ctgggattac aggggtgagc cactgtgccc ggccataatt
     3001 ttatattttt agaaaataaa gaatgaagga caaaagagca cagctaaatg aaactgctgc
     3061 tctaatttat tccactggaa aggtctcagg actccttaac tgttttccag gtttggctct
     3121 tcatatctaa cctgtgctaa aatgagaagg tatgctaggt gctgttagaa atcacaccat
     3181 ttccaaagaa cccaagtagt atagagacca aaatgaggca aaaataaaag agatgaaaca
     3241 ggagagttta tttcttgcat actttccgac cttcatcata caacctctcc taacctccct
     3301 gtagtcttta aaatgtttaa cttgcctata agctaacatg taataaaaca catactcaat
     3361 tatatgaata gaagtggaga gccagaatgc tacaaaagaa atcacagctg ctagaagtat
     3421 cctccataga aacatcaaca tgattgtgga tcaaaatgat tttcactgga tatggaattt
     3481 gtatgggcca tatttattaa aagagttctg tgtggtcaca tagagttcct ttgggatttc
     3541 atcccacttt tcaggactta atttgtttgg gtttgcttac ctaacaagca acaacaacaa
     3601 caaaataaat agttccaaaa tctagtttat tacataaatc tctatgaatc cttgagggcc
     3661 tatatctata ttataaataa atacaaatat agatttttaa atatctatgg gactttgcca
     3721 tttacagcct taagtataaa attacgagat tatattcttt ccattaccct ttatttctgc
     3781 taacttttta aagactggaa cattctgtgg atgttgtcaa agtttgagtt tgtttttccc
     3841 tgtgtattat aataaatttg tggtattgca tgta
//
