LOCUS       NM_024090               6570 bp    mRNA    linear   PRI 06-AUG-2024
DEFINITION  Homo sapiens ELOVL fatty acid elongase 6 (ELOVL6), transcript
            variant 1, mRNA.
ACCESSION   NM_024090
VERSION     NM_024090.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6570)
  AUTHORS   Wang,R., Liu,X., Li,X., Qian,M., Yang,X., Jiang,Q., Wang,Y.,
            Liu,H., Chen,J., Wang,X. and Gong,L.
  TITLE     ELOVL6 promotes the progression of head and neck squamous cell
            carcinoma via activating WNT/beta-catenin pathway
  JOURNAL   Mol Carcinog 63 (6), 1079-1091 (2024)
   PUBMED   38426809
  REMARK    GeneRIF: ELOVL6 promotes the progression of head and neck squamous
            cell carcinoma via activating WNT/beta-catenin pathway.
REFERENCE   2  (bases 1 to 6570)
  AUTHORS   Chen,B., Shen,K., Zhang,T. and Gao,W.C.
  TITLE     ELOVL6 is associated with immunosuppression in lung adenocarcinoma
            through bioinformatics analysis
  JOURNAL   Medicine (Baltimore) 102 (36), e35013 (2023)
   PUBMED   37682172
  REMARK    GeneRIF: ELOVL6 is associated with immunosuppression in lung
            adenocarcinoma through bioinformatics analysis.
REFERENCE   3  (bases 1 to 6570)
  AUTHORS   Fan,X., Zhu,W., Qiu,L., Zhang,G., Zhang,Y. and Miao,Y.
  TITLE     Elongase of very long chain fatty acids 6 (ELOVL6) promotes lipid
            synthesis in buffalo mammary epithelial cells
  JOURNAL   J Anim Physiol Anim Nutr (Berl) 106 (1), 1-11 (2022)
   PUBMED   33742447
REFERENCE   4  (bases 1 to 6570)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 6570)
  AUTHORS   Motoi,Y., Ito,Z., Suzuki,S., Takami,S., Matsuo,K., Sato,M., Ota,Y.,
            Tsuruta,M., Kojima,M., Noguchi,M., Uchiyama,K. and Kubota,T.
  TITLE     FADS2 and ELOVL6 mutation frequencies in Japanese Crohn's disease
            patients
  JOURNAL   Drug Discov Ther 13 (6), 354-359 (2019)
   PUBMED   31956234
  REMARK    GeneRIF: 33 ELOVL6 mutations were found with a new variant in the
            promoter region, though no mutation in the coding region was found.
            However no mutations were found that largely deviated in allele
            frequency as compared with healthy Japanese individuals.
REFERENCE   6  (bases 1 to 6570)
  AUTHORS   Kalsi,G., Kuo,P.H., Aliev,F., Alexander,J., McMichael,O.,
            Patterson,D.G., Walsh,D., Zhao,Z., Schuckit,M., Nurnberger,J. Jr.,
            Edenberg,H., Kramer,J., Hesselbrock,V., Tischfield,J.A.,
            Vladimirov,V., Prescott,C.A., Dick,D.M., Kendler,K.S. and
            Riley,B.P.
  TITLE     A systematic gene-based screen of chr4q22-q32 identifies
            association of a novel susceptibility gene, DKK2, with the
            quantitative trait of alcohol dependence symptom counts
  JOURNAL   Hum Mol Genet 19 (12), 2497-2506 (2010)
   PUBMED   20332099
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Erratum:[Hum Mol Genet. 2010 Oct 15;19(20):4121. Hesselbrock,
            Victor [added]; Tischfield, Jay A [added]]
REFERENCE   7  (bases 1 to 6570)
  AUTHORS   Matsuzaka,T. and Shimano,H.
  TITLE     Elovl6: a new player in fatty acid metabolism and insulin
            sensitivity
  JOURNAL   J Mol Med (Berl) 87 (4), 379-384 (2009)
   PUBMED   19259639
  REMARK    GeneRIF: Studies suggest that inhibition of ELOVL6 could be a new
            therapeutic approach for the treatment of insulin resistance,
            diabetes, cardiovascular disease, and other metabolic diseases.
            Review article
REFERENCE   8  (bases 1 to 6570)
  AUTHORS   Lu,Y., Dolle,M.E., Imholz,S., van 't Slot,R., Verschuren,W.M.,
            Wijmenga,C., Feskens,E.J. and Boer,J.M.
  TITLE     Multiple genetic variants along candidate pathways influence plasma
            high-density lipoprotein cholesterol concentrations
  JOURNAL   J Lipid Res 49 (12), 2582-2589 (2008)
   PUBMED   18660489
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   9  (bases 1 to 6570)
  AUTHORS   Moon,Y.A., Shah,N.A., Mohapatra,S., Warrington,J.A. and Horton,J.D.
  TITLE     Identification of a mammalian long chain fatty acyl elongase
            regulated by sterol regulatory element-binding proteins
  JOURNAL   J Biol Chem 276 (48), 45358-45366 (2001)
   PUBMED   11567032
REFERENCE   10 (bases 1 to 6570)
  AUTHORS   Lehner,R. and Kuksis,A.
  TITLE     Biosynthesis of triacylglycerols
  JOURNAL   Prog Lipid Res 35 (2), 169-201 (1996)
   PUBMED   8944226
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK027031.1, BC001305.1, BE539688.1, DB368351.1, H65618.1 and
            AC004050.1.
            
            On Jun 2, 2019 this sequence version replaced NM_024090.2.
            
            Summary: Fatty acid elongases (EC 6.2.1.3), such as ELOVL6, use
            malonyl-CoA as a 2-carbon donor in the first and rate-limiting step
            of fatty acid elongation (Moon et al., 2001 [PubMed
            11567032]).[supplied by OMIM, Mar 2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK027031.1, SRR1660807.148193.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000302274.8/ ENSP00000304736.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1420              AK027031.1         1-1420
            1421-2889           BC001305.1         1254-2722
            2890-3023           BE539688.1         286-419
            3024-3322           DB368351.1         1-299               c
            3323-3343           H65618.1           1-21                c
            3344-6570           AC004050.1         66244-69470
FEATURES             Location/Qualifiers
     source          1..6570
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q25"
     gene            1..6570
                     /gene="ELOVL6"
                     /gene_synonym="FACE; FAE; hELO2; LCE"
                     /note="ELOVL fatty acid elongase 6"
                     /db_xref="GeneID:79071"
                     /db_xref="HGNC:HGNC:15829"
                     /db_xref="MIM:611546"
     exon            1..369
                     /gene="ELOVL6"
                     /gene_synonym="FACE; FAE; hELO2; LCE"
                     /inference="alignment:Splign:2.1.0"
     CDS             281..1078
                     /gene="ELOVL6"
                     /gene_synonym="FACE; FAE; hELO2; LCE"
                     /EC_number="2.3.1.199"
                     /note="long-chain fatty-acyl elongase; ELOVL family member
                     6, elongation of long chain fatty acids (FEN1/Elo2,
                     SUR4/Elo3-like, yeast); elongation of very long chain
                     fatty acids protein 6; fatty acid elongase 2; fatty
                     acyl-CoA elongase; 3-keto acyl-CoA synthase ELOVL6; ELOVL
                     FA elongase 6; very long chain 3-oxoacyl-CoA synthase 6;
                     very long chain 3-ketoacyl-CoA synthase 6"
                     /codon_start=1
                     /product="very long chain fatty acid elongase 6"
                     /protein_id="NP_076995.1"
                     /db_xref="CCDS:CCDS3690.1"
                     /db_xref="GeneID:79071"
                     /db_xref="HGNC:HGNC:15829"
                     /db_xref="MIM:611546"
                     /translation="MNMSVLTLQEYEFEKQFNENEAIQWMQENWKKSFLFSALYAAFI
                     FGGRHLMNKRAKFELRKPLVLWSLTLAVFSIFGALRTGAYMVYILMTKGLKQSVCDQG
                     FYNGPVSKFWAYAFVLSKAPELGDTIFIILRKQKLIFLHWYHHITVLLYSWYSYKDMV
                     AGGGWFMTMNYGVHAVMYSYYALRAAGFRVSRKFAMFITLSQITQMLMGCVVNYLVFC
                     WMQHDQCHSHFQNIFWSSLMYLSYLVLFCHFFFEAYIGKMRKTTKAE"
     exon            370..501
                     /gene="ELOVL6"
                     /gene_synonym="FACE; FAE; hELO2; LCE"
                     /inference="alignment:Splign:2.1.0"
     exon            502..653
                     /gene="ELOVL6"
                     /gene_synonym="FACE; FAE; hELO2; LCE"
                     /inference="alignment:Splign:2.1.0"
     exon            654..6570
                     /gene="ELOVL6"
                     /gene_synonym="FACE; FAE; hELO2; LCE"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3008..3013
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ELOVL6"
                     /gene_synonym="FACE; FAE; hELO2; LCE"
                     /note="hexamer: AATAAA"
     polyA_site      3035
                     /gene="ELOVL6"
                     /gene_synonym="FACE; FAE; hELO2; LCE"
                     /note="major polyA site"
     regulatory      3360..3365
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ELOVL6"
                     /gene_synonym="FACE; FAE; hELO2; LCE"
                     /note="hexamer: ATTAAA"
     polyA_site      3380
                     /gene="ELOVL6"
                     /gene_synonym="FACE; FAE; hELO2; LCE"
     regulatory      5343..5348
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ELOVL6"
                     /gene_synonym="FACE; FAE; hELO2; LCE"
                     /note="hexamer: AATAAA"
     polyA_site      5366
                     /gene="ELOVL6"
                     /gene_synonym="FACE; FAE; hELO2; LCE"
     regulatory      6539..6544
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ELOVL6"
                     /gene_synonym="FACE; FAE; hELO2; LCE"
                     /note="hexamer: AATAAA"
     polyA_site      6570
                     /gene="ELOVL6"
                     /gene_synonym="FACE; FAE; hELO2; LCE"
ORIGIN      
        1 actaagaccg caaggcattc atttcctcct acggtggatg cggacgccgg gaggaggaga
       61 gccccagaga gaggagctgg gagcggaggc gcaggcaatg ctcagccctg gatgtagctg
      121 agaggctggg agaagagacg accgctggag accgagcggc gtggggaaga cctagggggg
      181 tgggtggggg aagcagacag gagaacactc gaaatcaagc gctttacaga ttattttatt
      241 ttgtatagag aacacgtagc gactccgaag atcagcccca atgaacatgt cagtgttgac
      301 tttacaagaa tatgaattcg aaaagcagtt caacgagaat gaagccatcc aatggatgca
      361 ggaaaactgg aagaaatctt tcctgttttc tgctctgtat gctgccttta tattcggtgg
      421 tcggcaccta atgaataaac gagcaaagtt tgaactgagg aagccattag tgctctggtc
      481 tctgaccctt gcagtcttca gtatattcgg tgctcttcga actggtgctt atatggtgta
      541 cattttgatg accaaaggcc tgaagcagtc agtttgtgac cagggttttt acaatggacc
      601 tgtcagcaaa ttctgggctt atgcatttgt gctaagcaaa gcacccgaac taggagatac
      661 aatattcatt attctgagga agcagaagct gatcttcctg cactggtatc accacatcac
      721 tgtgctcctg tactcttggt actcctacaa agacatggtt gccgggggag gttggttcat
      781 gactatgaac tatggcgtgc acgccgtgat gtactcttac tatgccttgc gggcggcagg
      841 tttccgagtc tcccggaagt ttgccatgtt catcaccttg tcccagatca ctcagatgct
      901 gatgggctgt gtggttaact acctggtctt ctgctggatg cagcatgacc agtgtcactc
      961 tcactttcag aacatcttct ggtcctcact catgtacctc agctaccttg tgctcttctg
     1021 ccatttcttc tttgaggcct acatcggcaa aatgaggaaa acaacgaaag ctgaatagtg
     1081 ttggaactga ggaggaagcc atagctcagg gtcatcaaga aaaataatag acaaaagaaa
     1141 atggcacaag gaatcacacg tggtgcagct aaaacaaaac aaaacatgag caaacacaaa
     1201 acccaaggca gcttagggat aattaggttg atttaaccca gtaagtttat gatcctttta
     1261 gggtgaggac tcactgagtg cacctccatc tccaagcact gctgctggaa gaccccattc
     1321 cctctttatc tatcaactct aggacaaggg agaacaaaag caagccagaa gcagaggaga
     1381 ctaatcaaag gcaaacaaag gctattaaca cataggaaaa aatgtattta ctaagtgtca
     1441 catttctcta agatgaaaga tttttactct agaaactgtg cgagcacaac acacacaatc
     1501 ctttctaact ttatggacac taaactggag ccaatagaaa agacaaaaat gaaagagaca
     1561 cagggtgtat atctagaacg ataatgcttt tgcagaaact aaagcctttt taagaaatgc
     1621 cagctgctgt agaccccatg agaaaagatg tcttaatcat ccttatgaaa acagatgtaa
     1681 acaactatat ttcaactaac ttcatcttca ctgcatagcc tcaggctagt gagtttgcca
     1741 aaaccaaagg gggtgaatac ttccccaaga ttcttcctgg gaggatggaa acagtgcagc
     1801 ccaggtccca tgggggcagc tccatcccag agcatttctg atagttgaac tgtaatttct
     1861 actcttaagt gagatatgaa gcattatcct tttgttcagt tgccccgggc ttttgaacag
     1921 aagagtaaat acagaattga aaaagataaa cactcaacca aacaatgtga aaacgggttc
     1981 tgtagtattt gtaaaaaggc ccggcccagg accactgtga gctggaaaag ggagaaaggc
     2041 agtgggaaaa gaggtgagcc gaagatcaat tcgacagaca gatggtgtgt atgcccctcc
     2101 ctgtttgact tcacacacac tcataacttt ccaaatgaaa ccccacagta tagcgcatat
     2161 tttcgatatt tttgtgaatt ccaaaaggaa atcacagggc tgttcgaaat attgggggaa
     2221 cactgtgttt ctgcatcatc tgcatttgct ccccaagcaa tgtagaggtg tttaaagggc
     2281 cctctgctgg ctgagtggca atactacaac aaacttcaag gcaagtttgg ctgaaaacag
     2341 ttgacaacaa agggccccca tacacttatc cctcaaattt taagtgatat gaaatacttg
     2401 tcatgtcttt ggccaaatca gaagatattc atcctgcttc aagtcagctt cagaaatgtt
     2461 ttaaaaggga ctttagctct ggaactcaaa atcaatttat taagagccat attctttaaa
     2521 aaaaaaaagc tggataatat tctctgtaat atttcagtcc tttacaagcc aaatacatgt
     2581 gtcaatgttt ctagtatttc aaagaagcaa ttatgtaaag ttgttcaatg tgacataata
     2641 gtattataat tggttaagta gcttaatgat taggcaaact agatgaaaag attaggggct
     2701 tccacactgc atagattaca cgcacatagc cacgcataca cacacagaca cacagatgtg
     2761 gggtacactg aacttcaaag cccaaatgaa tagaaacaca ttttctggct agcagaaaaa
     2821 aacaaaacaa aactgttgtt tctctttctt gctttgagag tgtacagtaa aagggatttt
     2881 ttcgaattat ttttatatta ttttagcttt aattgtgctg tcgttcatga aacagagctg
     2941 ctctgctttt ctgtcagaga tggcaagggc tttttcagca tctcgtttat gtgtggaatt
     3001 taaaaagaat aaagttttat tccattctgt gtgaatggtt tgagcagtga acaaagaatc
     3061 catgcaaacc aagtcatgac tggaagaaat ggggagtggg ggacagtgca ggggaggaaa
     3121 gctgttacat ctatgttaaa tgattgtgag cagtctataa tgtcttgatg ttggttcata
     3181 ggtgagacac aactgatgga ggaatgtatt ataaattatg caaaatctga catgagctga
     3241 aaagacaggt ccttttataa gagctaatag atgcttagga tgcaaatgtt attttgagct
     3301 tcgcaaatac atgataccgt gcaataagcc ttttttcctt ataacagaaa atgagaataa
     3361 ttaaaatgag gagaaggcca cataacagtt gacttgaatt taattgaagg acccattgga
     3421 ggctcatctg gttgatttaa ttatttaatt gagtgattta ttgcagatct cttaatgcag
     3481 gttagaaacg gaagtgagca taaaccttaa aaagactcta aatgatgctt ccaaagcact
     3541 ttcattttgg tattaggttc atgtttgttt gtctttactt gtaaaataat ttggaatttt
     3601 tgtttacagg gtgaatgtct taatagtttt aaaattagct aaatatatct aaaggcattt
     3661 ccaatgttta tcatgggagg aaaaaagcca catttttttt aaaacaaaac aaaacaaaac
     3721 aaaattttgg taatataggt tcaatacact gtttttaaca tctcagctta gccgctttaa
     3781 tcatatcaag atatgaggct ggatcactgg cccatgacaa atctgaaacc taccagagaa
     3841 ttgactgctg catagataat cctgctgcca gttaacattc cagaaaaact tgggcaggca
     3901 agtttttata gctgccccac tatgctgcaa tagagtatct ttctattgaa gattttccac
     3961 tgcatcccga tcctactatg gtgaaagcat tgttcttggg ctaaaaaaaa atcctttatt
     4021 tcatacacac atgatttcat acactaggtc tgagcatcaa gccaagtcca tgagtttgca
     4081 atgaagttct agtgagaaat gctctattca taaagcaggg ggtttacgtg gaccttctag
     4141 tgttgcttat gggaaaagag taactaccat attacatcta acgcaaggcc aaagtaccaa
     4201 attaaaacca tggattgagg tggttattcg aagtcactta ctcccatcct tctaattatg
     4261 ctccactaca aaagtaaggg gagaagaggg aatactttac atgtacattg ctagagggaa
     4321 aagaaaggct tgattatatc ccctcgcttc tccacctctc tgctcatgta aagaaactga
     4381 tgagaaaaga gactaatatg tctagactga gttagaaact tcatatgagt gggttttgta
     4441 gaattgatgg gaaagacagt gggaacctag aagaacagaa agagacccac agaatgtctt
     4501 tctttttttt tttttttttt tttttgaggt ggattcttgc tgttgttgcc caggctggag
     4561 tgcagtggcg cgatctagac tcactgcaac ctccgcctcc caggttccag caattctcct
     4621 gcctcagcct cccaaatagc tgaggttaca ggcgcccgcc accacaccca gctaattttt
     4681 gtatttttag tagagacagg gtttcaccat gttggccagg ctggtctcga gctcctgacc
     4741 tcaggggatc cacccgcctt ggtctcccaa agtgctggga ttataggcgt gagccaccgt
     4801 gcctggccca gaatgttttt ttaaatcaga tgtagcatct tcataaggta aagcctgtca
     4861 catcagagta acaaagctcc tggagtacag tgatgctaga gtagaatgtt ccagaagtct
     4921 ggccatagcc ccagcttctg aattacctgg gagagacaag atgctcaggt tactattttt
     4981 tctttattct gatagtacag cctctactca gagaccacgg tgtgtgtcac acaaccgagg
     5041 cagctagggc atattctgag ggcttttttt tttttttggt ttccttaatg attctttaac
     5101 agagtaactg gattggccaa ggtctgattc aagaggctgt gaggagagta gagaacaaat
     5161 agactttgcc tctcagagtt cagagcttta agttgtataa gcatggtcca tgtccacctc
     5221 ttgtagacac ttattcctta aaagtttcca tcatgaaaaa taatatcatg tcaaaatttt
     5281 ataagcaccc agaatgtccc agtagtcaaa tgtagtgtct ttctccagtc tctgttttcg
     5341 ataataaata ccttgctctc aatttaggat gatcgtaaag cctatgttca tgctgtgagt
     5401 cattgtctcc cacagctttt gaaacatcgt tctttgtctt ttctatacaa cacctgattc
     5461 tttgtgcctc agactcattg ctatcaggaa gagactttgc caagatccac caccacattt
     5521 ggccagtagt gtatacacat taaagtgaga gctgatgaaa tcacaatgct ctattttgtt
     5581 ccgacaatca gtatgaaggg gtaggtccca gtttgccaat gagcaacagc ctctgtatgc
     5641 tggtgtccaa gacttacaca aaacaagtgt cagtgcagtc acagcatttt cttgaatgct
     5701 gttgtgacag actccagtta taaacatctg cgagccatat ggcacaactc atagctaaag
     5761 aggccggtac agggcacatg cacagagctt tgaagaacat acacaaacct gttgaatcaa
     5821 gttactttcc tcatcctcag agactttgac aattcagagc tcacagatgg cagggggaat
     5881 tctcaggctt cccttcctcc tgattgacac tttttaaagg aagtgatgtg gaagttgttc
     5941 tagaagttag atggacagtg ggagcacatt cgtgagtggg gcttgggaga gctcaaaagt
     6001 ggcactttga ttttaggctg ggcaggcaga agtctcacag taaaatatat ttcactagac
     6061 gtccaaacca acactgcatt gtagtaacct cttctgaagt aactggttaa attaataact
     6121 ggtcccataa gtcagggtca agccacattt ataacccatt cgggccggcc atgaagggtt
     6181 ctgactcgac attggtattt aaatgctgtt actttcccaa tgcttagtag cacttgagac
     6241 tttatttcca tcgacaaaaa ctaagaaggc cacagaagta gcctaacagt cctccctggt
     6301 catactcgtt tcaaacaggt ctgcctgtct agacatattc aggcaggagg ttgcttgctg
     6361 ctatcttgaa aaccactgga agattcagct tcttggggac ctcagagccc atattcatat
     6421 ggaagcccac ccatataagc ctcacagagc aaatcacagc aatgttgaag ttgttatttt
     6481 caagtgctta tttcacgaca ttaaaaaaaa tattttttcc tggtgtatta aaattaaaaa
     6541 taaaatcata acttttgatt taaaatcaaa
//
