LOCUS       NM_152310               1400 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens ELOVL fatty acid elongase 3 (ELOVL3), mRNA.
ACCESSION   NM_152310
VERSION     NM_152310.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1400)
  AUTHORS   Zhou,Y., Lv,R., Ye,R.D., Ren,R. and Yu,L.
  TITLE     The 3-hydroxyacyl-CoA dehydratase 1/2 form complex with
            trans-2-enoyl-CoA reductase involved in substrates transfer in very
            long chain fatty acid elongation
  JOURNAL   Biochem Biophys Res Commun 704, 149588 (2024)
   PUBMED   38422897
REFERENCE   2  (bases 1 to 1400)
  AUTHORS   Creasy,K.T., Ren,H., Jiang,J., Peterson,M.L. and Spear,B.T.
  TITLE     Elongation of very long chain fatty acids-3 (Elovl3) is activated
            by ZHX2 and is a regulator of cell cycle progression
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 325 (6), G582-G592 (2023)
   PUBMED   37847682
  REMARK    GeneRIF: Elongation of very long chain fatty acids-3 (Elovl3) is
            activated by ZHX2 and is a regulator of cell cycle progression.
REFERENCE   3  (bases 1 to 1400)
  AUTHORS   Yang,Y., Liu,L., Li,M., Cheng,X., Fang,M., Zeng,Q. and Xu,Y.
  TITLE     The chromatin remodeling protein BRG1 links ELOVL3 trans-activation
            to prostate cancer metastasis
  JOURNAL   Biochim Biophys Acta Gene Regul Mech 1862 (8), 834-845 (2019)
   PUBMED   31154107
  REMARK    GeneRIF: Study found that BRG1 expression was up-regulated along
            with Elvol3 in prostate cancer cells. BRG1 over-expression
            dose-dependently augmented the induction of the Elovl3 promoter
            activity, suggesting that regulation of Elovl3 expression by BRG1
            occurred at the transcriptional level.
REFERENCE   4  (bases 1 to 1400)
  AUTHORS   Ohno,Y., Suto,S., Yamanaka,M., Mizutani,Y., Mitsutake,S.,
            Igarashi,Y., Sassa,T. and Kihara,A.
  TITLE     ELOVL1 production of C24 acyl-CoAs is linked to C24 sphingolipid
            synthesis
  JOURNAL   Proc Natl Acad Sci U S A 107 (43), 18439-18444 (2010)
   PUBMED   20937905
REFERENCE   5  (bases 1 to 1400)
  AUTHORS   Kobayashi,T., Zadravec,D. and Jacobsson,A.
  TITLE     ELOVL2 overexpression enhances triacylglycerol synthesis in 3T3-L1
            and F442A cells
  JOURNAL   FEBS Lett 581 (17), 3157-3163 (2007)
   PUBMED   17583696
REFERENCE   6  (bases 1 to 1400)
  AUTHORS   Westerberg,R., Mansson,J.E., Golozoubova,V., Shabalina,I.G.,
            Backlund,E.C., Tvrdik,P., Retterstol,K., Capecchi,M.R. and
            Jacobsson,A.
  TITLE     ELOVL3 is an important component for early onset of lipid
            recruitment in brown adipose tissue
  JOURNAL   J Biol Chem 281 (8), 4958-4968 (2006)
   PUBMED   16326704
REFERENCE   7  (bases 1 to 1400)
  AUTHORS   Westerberg,R., Tvrdik,P., Unden,A.B., Mansson,J.E., Norlen,L.,
            Jakobsson,A., Holleran,W.H., Elias,P.M., Asadi,A., Flodby,P.,
            Toftgard,R., Capecchi,M.R. and Jacobsson,A.
  TITLE     Role for ELOVL3 and fatty acid chain length in development of hair
            and skin function
  JOURNAL   J Biol Chem 279 (7), 5621-5629 (2004)
   PUBMED   14581464
REFERENCE   8  (bases 1 to 1400)
  AUTHORS   Leonard,A.E., Bobik,E.G., Dorado,J., Kroeger,P.E., Chuang,L.T.,
            Thurmond,J.M., Parker-Barnes,J.M., Das,T., Huang,Y.S. and
            Mukerji,P.
  TITLE     Cloning of a human cDNA encoding a novel enzyme involved in the
            elongation of long-chain polyunsaturated fatty acids
  JOURNAL   Biochem J 350 Pt 3 (Pt 3), 765-770 (2000)
   PUBMED   10970790
REFERENCE   9  (bases 1 to 1400)
  AUTHORS   Monne,M., Gafvelin,G., Nilsson,R. and von Heijne,G.
  TITLE     N-tail translocation in a eukaryotic polytopic membrane protein:
            synergy between neighboring transmembrane segments
  JOURNAL   Eur J Biochem 263 (1), 264-269 (1999)
   PUBMED   10429212
REFERENCE   10 (bases 1 to 1400)
  AUTHORS   Lehner,R. and Kuksis,A.
  TITLE     Biosynthesis of triacylglycerols
  JOURNAL   Prog Lipid Res 35 (2), 169-201 (1996)
   PUBMED   8944226
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from HY050356.1 and BC034344.1.
            
            On Nov 22, 2018 this sequence version replaced NM_152310.2.
            
            Summary: This gene encodes a protein that belongs to the GNS1/SUR4
            family. Members of this family play a role in elongation of long
            chain fatty acids to provide precursors for synthesis of
            sphingolipids and ceramides. [provided by RefSeq, Jul 2013].
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC034344.1, SRR5189667.154606.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2142680
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000370005.4/ ENSP00000359022.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-87                HY050356.1         23-109
            88-1400             BC034344.1         1-1313
FEATURES             Location/Qualifiers
     source          1..1400
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q24.32"
     gene            1..1400
                     /gene="ELOVL3"
                     /gene_synonym="CIG-30; CIG30"
                     /note="ELOVL fatty acid elongase 3"
                     /db_xref="GeneID:83401"
                     /db_xref="HGNC:HGNC:18047"
                     /db_xref="MIM:611815"
     exon            1..351
                     /gene="ELOVL3"
                     /gene_synonym="CIG-30; CIG30"
                     /inference="alignment:Splign:2.1.0"
     CDS             251..1063
                     /gene="ELOVL3"
                     /gene_synonym="CIG-30; CIG30"
                     /EC_number="2.3.1.199"
                     /note="elongation of very long chain fatty acids
                     (FEN1/Elo2, SUR4/Elo3, yeast)-like 3; elongation of very
                     long chain fatty acids protein 3; cold-inducible
                     glycoprotein of 30 kDa; 3-keto acyl-CoA synthase ELOVL3;
                     ELOVL FA elongase 3; very long chain 3-oxoacyl-CoA
                     synthase 3; very long chain 3-ketoacyl-CoA synthase 3"
                     /codon_start=1
                     /product="very long chain fatty acid elongase 3"
                     /protein_id="NP_689523.1"
                     /db_xref="CCDS:CCDS7531.1"
                     /db_xref="GeneID:83401"
                     /db_xref="HGNC:HGNC:18047"
                     /db_xref="MIM:611815"
                     /translation="MVTAMNVSHEVNQLFQPYNFELSKDMRPFFEEYWATSFPIALIY
                     LVLIAVGQNYMKERKGFNLQGPLILWSFCLAIFSILGAVRMWGIMGTVLLTGGLKQTV
                     CFINFIDNSTVKFWSWVFLLSKVIELGDTAFIILRKRPLIFIHWYHHSTVLVYTSFGY
                     KNKVPAGGWFVTMNFGVHAIMYTYYTLKAANVKPPKMLPMLITSLQILQMFVGAIVSI
                     LTYIWRQDQGCHTTMEHLFWSFILYMTYFILFAHFFCQTYIRPKVKAKTKSQ"
     exon            352..483
                     /gene="ELOVL3"
                     /gene_synonym="CIG-30; CIG30"
                     /inference="alignment:Splign:2.1.0"
     exon            484..635
                     /gene="ELOVL3"
                     /gene_synonym="CIG-30; CIG30"
                     /inference="alignment:Splign:2.1.0"
     exon            636..1400
                     /gene="ELOVL3"
                     /gene_synonym="CIG-30; CIG30"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1382..1387
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ELOVL3"
                     /gene_synonym="CIG-30; CIG30"
                     /note="hexamer: ATTAAA"
     polyA_site      1400
                     /gene="ELOVL3"
                     /gene_synonym="CIG-30; CIG30"
                     /note="major polyA site"
ORIGIN      
        1 gcaggaaaga ggtcgcgcca gcccgggcag gcagctttgc aagtccgcgt tatatatcgc
       61 agtggctgcg cccgggatag ctggctgcgc cgccgcgcac atgcctaggt tcgacgccct
      121 cctccctttg cccaggagtt ccttctgtcc cggctctgtt ccgtctcgcc ccgaggttca
      181 cgccatcctc ggagccccag cctttcaccc agcgcctcca agctttggac cttgacttct
      241 gcaaaactag atggtcacag ccatgaatgt ctcacatgaa gtaaatcagc tgttccagcc
      301 ctataacttc gagctgtcca aggacatgag gccctttttc gaggagtatt gggcaacctc
      361 attccccata gccctgatct acctggttct catcgctgtg gggcagaact acatgaagga
      421 acgcaagggc ttcaacctgc aagggcctct catcctctgg tccttctgcc ttgcaatctt
      481 cagtatcctg ggggcagtga ggatgtgggg cattatgggg actgtgctac ttaccggggg
      541 cctaaagcaa accgtgtgct tcatcaactt catcgataat tccacagtca aattctggtc
      601 ctgggtcttt cttctcagca aggtcataga actcggagac acagccttca tcatcctgcg
      661 taagcggcca ctcatcttta ttcactggta ccaccacagc acagtgctcg tgtacacaag
      721 ctttggatac aagaacaaag tgcctgcagg aggctggttc gtcaccatga actttggtgt
      781 tcatgccatc atgtacacct actacactct gaaggctgcc aacgtgaagc cccccaagat
      841 gctgcccatg ctcatcacca gcctgcagat cttgcagatg tttgtaggag ccatcgtcag
      901 catcctcacg tacatctgga ggcaggatca gggatgccac accacgatgg aacacttatt
      961 ctggtccttc atcttgtata tgacctattt catcctcttt gcccacttct tctgccagac
     1021 ctacatcagg cccaaggtca aagccaagac caagagccag tgaaggtttg gagagaacaa
     1081 tgaagctcca ggctctctct tctccagggc accaagaggc tgggcttagt tttgggagaa
     1141 tgattaggtt gccttacctg catggtttcc ccagaggatg tgtgccccaa ggtggctgga
     1201 atttttgaca gacaagaagg gtgaccttgg gatgggggtg tggtctgtta ctttaatgtt
     1261 tctgttttta atgtgaaggc caagcaggcc ctgggatggg agtggggcgg aggagggtcc
     1321 taagagctga ttatttaatt tctatccaga aatctttctt cttcttgctc tgttttttta
     1381 aattaaagat ttcaacaaaa
//
