LOCUS       NM_017770               3988 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens ELOVL fatty acid elongase 2 (ELOVL2), mRNA.
ACCESSION   NM_017770
VERSION     NM_017770.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3988)
  AUTHORS   Zhou,Y., Lv,R., Ye,R.D., Ren,R. and Yu,L.
  TITLE     The 3-hydroxyacyl-CoA dehydratase 1/2 form complex with
            trans-2-enoyl-CoA reductase involved in substrates transfer in very
            long chain fatty acid elongation
  JOURNAL   Biochem Biophys Res Commun 704, 149588 (2024)
   PUBMED   38422897
REFERENCE   2  (bases 1 to 3988)
  AUTHORS   Obeid,R., Rickens,P., Heine,G.H., Emrich,I.E., Fliser,D.,
            Zawada,A.M., Bodis,M. and Geisel,J.
  TITLE     ELOVL2-methylation and renal and cardiovascular event in patients
            with chronic kidney disease
  JOURNAL   Eur J Clin Invest 53 (12), e14068 (2023)
   PUBMED   37493252
  REMARK    GeneRIF: ELOVL2-methylation and renal and cardiovascular event in
            patients with chronic kidney disease.
REFERENCE   3  (bases 1 to 3988)
  AUTHORS   Paparazzo,E., Lagani,V., Geracitano,S., Citrigno,L., Aceto,M.A.,
            Malvaso,A., Bruno,F., Passarino,G. and Montesanto,A.
  TITLE     An ELOVL2-Based Epigenetic Clock for Forensic Age Prediction: A
            Systematic Review
  JOURNAL   Int J Mol Sci 24 (3), 2254 (2023)
   PUBMED   36768576
  REMARK    GeneRIF: An ELOVL2-Based Epigenetic Clock for Forensic Age
            Prediction: A Systematic Review.
            Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3988)
  AUTHORS   Hu,T., Zhang,H., Du,Y., Luo,S., Yang,X., Zhang,H., Feng,J.,
            Chen,X., Tu,X., Wang,C. and Zhang,Y.
  TITLE     ELOVL2 restrains cell proliferation, migration, and invasion of
            prostate cancer via regulation of the tumor suppressor INPP4B
  JOURNAL   Cell Signal 96, 110373 (2022)
   PUBMED   35640821
  REMARK    GeneRIF: ELOVL2 restrains cell proliferation, migration, and
            invasion of prostate cancer via regulation of the tumor suppressor
            INPP4B.
REFERENCE   5  (bases 1 to 3988)
  AUTHORS   Tanaka,K., Kandori,S., Sakka,S., Nitta,S., Tanuma,K., Shiga,M.,
            Nagumo,Y., Negoro,H., Kojima,T., Mathis,B.J., Shimazui,T.,
            Watanabe,M., Sato,T.A., Miyamoto,T., Matsuzaka,T., Shimano,H. and
            Nishiyama,H.
  TITLE     ELOVL2 promotes cancer progression by inhibiting cell apoptosis in
            renal cell carcinoma
  JOURNAL   Oncol Rep 47 (2) (2022)
   PUBMED   34841437
  REMARK    GeneRIF: ELOVL2 promotes cancer progression by inhibiting cell
            apoptosis in renal cell carcinoma.
REFERENCE   6  (bases 1 to 3988)
  AUTHORS   Jakobsson,A., Westerberg,R. and Jacobsson,A.
  TITLE     Fatty acid elongases in mammals: their regulation and roles in
            metabolism
  JOURNAL   Prog Lipid Res 45 (3), 237-249 (2006)
   PUBMED   16564093
  REMARK    Review article
REFERENCE   7  (bases 1 to 3988)
  AUTHORS   Leonard,A.E., Pereira,S.L., Sprecher,H. and Huang,Y.S.
  TITLE     Elongation of long-chain fatty acids
  JOURNAL   Prog Lipid Res 43 (1), 36-54 (2004)
   PUBMED   14636670
  REMARK    Review article
REFERENCE   8  (bases 1 to 3988)
  AUTHORS   Leonard,A.E., Kelder,B., Bobik,E.G., Chuang,L.T., Lewis,C.J.,
            Kopchick,J.J., Mukerji,P. and Huang,Y.S.
  TITLE     Identification and expression of mammalian long-chain PUFA
            elongation enzymes
  JOURNAL   Lipids 37 (8), 733-740 (2002)
   PUBMED   12371743
REFERENCE   9  (bases 1 to 3988)
  AUTHORS   Leonard,A.E., Bobik,E.G., Dorado,J., Kroeger,P.E., Chuang,L.T.,
            Thurmond,J.M., Parker-Barnes,J.M., Das,T., Huang,Y.S. and
            Mukerji,P.
  TITLE     Cloning of a human cDNA encoding a novel enzyme involved in the
            elongation of long-chain polyunsaturated fatty acids
  JOURNAL   Biochem J 350 Pt 3 (Pt 3), 765-770 (2000)
   PUBMED   10970790
REFERENCE   10 (bases 1 to 3988)
  AUTHORS   Lehner,R. and Kuksis,A.
  TITLE     Biosynthesis of triacylglycerols
  JOURNAL   Prog Lipid Res 35 (2), 169-201 (1996)
   PUBMED   8944226
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC050278.1, AK000341.1, AL121955.20 and AL080199.1.
            
            On Nov 23, 2018 this sequence version replaced NM_017770.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC060809.1, BC050278.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000354666.4/ ENSP00000346693.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1008              BC050278.1         87-1094
            1009-1990           AK000341.1         1018-1999
            1991-2959           AL121955.20        23035-24003         c
            2960-3988           AL080199.1         1-1029
FEATURES             Location/Qualifiers
     source          1..3988
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p24.2"
     gene            1..3988
                     /gene="ELOVL2"
                     /gene_synonym="SSC2"
                     /note="ELOVL fatty acid elongase 2"
                     /db_xref="GeneID:54898"
                     /db_xref="HGNC:HGNC:14416"
                     /db_xref="MIM:611814"
     exon            1..78
                     /gene="ELOVL2"
                     /gene_synonym="SSC2"
                     /inference="alignment:Splign:2.1.0"
     CDS             76..966
                     /gene="ELOVL2"
                     /gene_synonym="SSC2"
                     /EC_number="2.3.1.199"
                     /note="elongation of very long chain fatty acids
                     (FEN1/Elo2, SUR4/Elo3, yeast)-like 2; elongation of very
                     long chain fatty acids protein 2; 3-keto acyl-CoA synthase
                     ELOVL2; ELOVL FA elongase 2; very long chain 3-oxoacyl-CoA
                     synthase 2; very long chain 3-ketoacyl-CoA synthase 2"
                     /codon_start=1
                     /product="very long chain fatty acid elongase 2"
                     /protein_id="NP_060240.3"
                     /db_xref="CCDS:CCDS4518.1"
                     /db_xref="GeneID:54898"
                     /db_xref="HGNC:HGNC:14416"
                     /db_xref="MIM:611814"
                     /translation="MEHLKAFDDEINAFLDNMFGPRDSRVRGWFMLDSYLPTFFLTVM
                     YLLSIWLGNKYMKNRPALSLRGILTLYNLGITLLSAYMLAELILSTWEGGYNLQCQDL
                     TSAGEADIRVAKVLWWYYFSKSVEFLDTIFFVLRKKTSQITFLHVYHHASMFNIWWCV
                     LNWIPCGQSFFGPTLNSFIHILMYSYYGLSVFPSMHKYLWWKKYLTQAQLVQFVLTIT
                     HTMSAVVKPCGFPFGCLIFQSSYMLTLVILFLNFYVQTYRKKPMKKDMQEPPAGKEVK
                     NGFSKAYFTAANGVMNKKAQ"
     exon            79..142
                     /gene="ELOVL2"
                     /gene_synonym="SSC2"
                     /inference="alignment:Splign:2.1.0"
     exon            143..330
                     /gene="ELOVL2"
                     /gene_synonym="SSC2"
                     /inference="alignment:Splign:2.1.0"
     exon            331..408
                     /gene="ELOVL2"
                     /gene_synonym="SSC2"
                     /inference="alignment:Splign:2.1.0"
     exon            409..580
                     /gene="ELOVL2"
                     /gene_synonym="SSC2"
                     /inference="alignment:Splign:2.1.0"
     exon            581..705
                     /gene="ELOVL2"
                     /gene_synonym="SSC2"
                     /inference="alignment:Splign:2.1.0"
     exon            706..840
                     /gene="ELOVL2"
                     /gene_synonym="SSC2"
                     /inference="alignment:Splign:2.1.0"
     exon            841..3988
                     /gene="ELOVL2"
                     /gene_synonym="SSC2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3966..3971
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ELOVL2"
                     /gene_synonym="SSC2"
                     /note="hexamer: AATAAA"
     polyA_site      3988
                     /gene="ELOVL2"
                     /gene_synonym="SSC2"
                     /note="major polyA site"
ORIGIN      
        1 gggcagaggg acccggctac cctggacagc gcatcgccgc ccgcccgggt cgccgcgcca
       61 cagccgctgc ggatcatgga acatctaaag gcctttgatg atgaaatcaa tgcttttttg
      121 gacaatatgt ttggaccgcg agattctcga gtcagagggt ggttcatgtt ggactcttac
      181 cttcctacct tttttcttac tgtcatgtat ctgctctcaa tatggctggg taacaagtat
      241 atgaagaaca gacctgctct ttctctcagg ggtatcctca ccttgtataa tcttggaatc
      301 acacttctct ccgcgtacat gctggcagag ctcattctct ccacttggga aggaggctac
      361 aacttacagt gtcaagatct taccagcgca ggggaagctg acatccgggt agccaaggtg
      421 ctttggtggt actatttctc caaatcagta gagttcctgg acacaatttt cttcgttttg
      481 cggaaaaaaa cgagtcagat tacttttctt catgtatatc atcatgcttc tatgtttaac
      541 atctggtggt gtgtcttgaa ctggatacct tgtggacaaa gtttctttgg accaacactg
      601 aacagtttta tccacattct tatgtactcc tactatggac tttctgtgtt tccatctatg
      661 cacaagtatc tttggtggaa gaaatatctc acacaggctc agctggtgca gttcgtgctc
      721 accatcacgc acaccatgag cgccgtcgtg aaaccgtgtg gcttcccctt cggttgtctc
      781 atcttccagt catcttatat gctaacgtta gtcatcctct tcttaaattt ttacgttcag
      841 acataccgaa aaaagccaat gaagaaagat atgcaagagc cacctgcagg gaaagaagtg
      901 aagaatggtt tttccaaagc ctacttcact gcagcaaatg gagtgatgaa caagaaagca
      961 caataaaaat gagtaacaga aaaagcacat atactagcct aacagattgg cttgttttaa
     1021 agcaaagact gaattgaagg ttacatgttt taggataaac taatttcttt tgagttcata
     1081 aatcatttgt acccagaatg tattaatata ttgctattag gttaatctgt taactgaatg
     1141 ctttgatcag cattgaggtg atgctcacct ccgaggacct cagaactggt gcagcttctc
     1201 tctccctccc tcccacagac tgaacctttc gccagaagct gtccttataa cgccttatac
     1261 gcatacacag ccaggaaacg tggagcattg tttctcacag agagtctcca aataaaaagg
     1321 gttttgttca gattaaaatg tttacaacaa aatgttaatt atattctaaa tacagggtat
     1381 gttctaatct atattaagca ataatgccag tgcataatca ttccatttgt tcctttagca
     1441 atcaacccca gaaaatatta aaatgggatc atacacagaa gatagaaaaa tctagcaaaa
     1501 cttctctttc tgtaagccag agtcttgtct atcagattcc cacaaccact cctgattcta
     1561 aatttagtga tatggtaatg aaattggtat ttattttaaa tattagttat tctaaggaga
     1621 aaaaaatgct tctgcaagat tttcataatt caggggctgt ggataggatt gttcctctgt
     1681 ttccctaatc attcatctgt tcatgtctcc ctcttgtgcc agtcagccta ggttatacag
     1741 atgccatgct ccacaccacg agcagtgtac aaatctggct gcccgtttac tttctgagca
     1801 agcactggag tccactccga cctttttctt tgaacatgca tgctgctgga atatgtataa
     1861 atcagaacta gcagaagtag cagagtgatg ggagcaaaat aggcactgaa ttcgtcaact
     1921 cttttttgtg agcctacttg tgaatattac ctcagatacc tgttgtcact cttcacaggt
     1981 tatttaagtt tttgaagctg ggaggaaaaa gatggagtag cttggaaaga ttccagcact
     2041 gagccgtggg ccggtcatga gccacgataa aaaatgccag tttggcaaac tcagcactcc
     2101 tgttccctgc tcaggtatat gcgatctcta ccgagaagca agcacaaaag tagacaaaag
     2161 tattaatgag tatttccttt ctccataagt gcaggactgt tactcactac taaactctac
     2221 caagaatgga aacaaagaat attttctgaa gatttttttg aagattaatt tataccctat
     2281 aaaataaaac ttgttagctt cgatgaagtc acttcatctt ctctcctgcc ttattttttt
     2341 aaataagttt ttaggtcctg acactgacat caaatacatg cacaccagaa aggcatttcc
     2401 accaccgtcc ccactcatta gcgtccagag tgcctttctc tctcggcttt ttttcccccc
     2461 tgagctctag ttttaaactt tctcctgtta aaaaaattgt acttttattt catgtaaact
     2521 gcccctctga ggatttgggc atattttttg gaaggtgcct aatgcttagg atagtctcta
     2581 gggtgatgca ctgcacctgc ttccttccct tcagtgcggc cgacccattt ctgttgaaca
     2641 gatgtctcct gtgtgatgcc cctgactctt acatttatct ttctaaatca ttttctgaag
     2701 ctgacttgct ctagggtgct tcatcaccac ttccatcttg catcacctta taactgttct
     2761 gtcttgttct ctcccagcaa tttattttaa aacaagggct agcttcaagc atgactgtta
     2821 atggctcctc tgtgacaaaa cacaagttgg accaaggaga aagccctttg gagaaactgg
     2881 accctagttc agtttagatc tcaaatatag gctgaaatct cttaccaaag tgcgttccag
     2941 ataaaaatga gacttagaag acagactggt ctaatatgct cactggtcat cacattcagc
     3001 ttattcttac gtgccagtga ggccctaagg tctcagtgca tagcatacct gccactctgg
     3061 atgttttcct gggcttcata tctgtatggc aaggagggag ctgtccttca gcagacaaag
     3121 tcaagcagct ttaagtacaa ggcagcttga aacctctctg atgaaagtga aaaatgtggg
     3181 tagcttatac tttcaaacta atgccagtga ctagagagag gtttcattca tgatgtgtat
     3241 ttccaatttg gtcttcaatt caagagatgc ttcataaaac acttatagcc ttaaaccatt
     3301 caagggctaa ttaaaaaaat agttatgaaa tcttagccac aaaaaataaa tcaggtaaac
     3361 attttaacct gtcgttaagt gttgtaactt caaaaaacca aaatgcttat tttaatgtga
     3421 tttttctaaa actattgaaa aattaatatt tctataatct attaaaaaaa atggagaatg
     3481 ttttctctca aatttcctct gacccatggg aatgaaaata cttaaatact gtaaagcata
     3541 tctattaata attcccccaa ttttttaaac taacaaaatg gaatgttaac tgaatggaat
     3601 taaacatagc aattgtcaag ccatcaaaat tatatatcga accacttagg catgttacgg
     3661 ggtaaagtcc tcacccctgc atttgagaaa tattttatta tttttatttt aaggcaaaac
     3721 agtgtttact gtgatgggca gaacagcctt ttgtatctag gagtccattt gagttctttc
     3781 caatatttcc atatcgttca taaatgtgtc tgggggcttc cttgtttgga aaatatggat
     3841 atcgctttgt tttcctttga aagtaattat atcttaagaa catagtatca tgaatggagt
     3901 agacagggag gctgcagaag ccatttctct ttgtagataa aaagcattat ctatgattgt
     3961 tgtataataa attgattttt acattaaa
//
