LOCUS       NM_032377               1010 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens elongation factor 1 (ELOF1), transcript variant 1,
            mRNA.
ACCESSION   NM_032377
VERSION     NM_032377.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1010)
  AUTHORS   van der Weegen,Y., de Lint,K., van den Heuvel,D., Nakazawa,Y.,
            Mevissen,T.E.T., van Schie,J.J.M., San Martin Alonso,M.,
            Boer,D.E.C., Gonzalez-Prieto,R., Narayanan,I.V., Klaassen,N.H.M.,
            Wondergem,A.P., Roohollahi,K., Dorsman,J.C., Hara,Y.,
            Vertegaal,A.C.O., de Lange,J., Walter,J.C., Noordermeer,S.M.,
            Ljungman,M., Ogi,T., Wolthuis,R.M.F. and Luijsterburg,M.S.
  TITLE     ELOF1 is a transcription-coupled DNA repair factor that directs RNA
            polymerase II ubiquitylation
  JOURNAL   Nat Cell Biol 23 (6), 595-607 (2021)
   PUBMED   34108663
  REMARK    GeneRIF: ELOF1 is a transcription-coupled DNA repair factor that
            directs RNA polymerase II ubiquitylation.
REFERENCE   2  (bases 1 to 1010)
  AUTHORS   Geijer,M.E., Zhou,D., Selvam,K., Steurer,B., Mukherjee,C.,
            Evers,B., Cugusi,S., van Toorn,M., van der Woude,M., Janssens,R.C.,
            Kok,Y.P., Gong,W., Raams,A., Lo,C.S.Y., Lebbink,J.H.G., Geverts,B.,
            Plummer,D.A., Bezstarosti,K., Theil,A.F., Mitter,R.,
            Houtsmuller,A.B., Vermeulen,W., Demmers,J.A.A., Li,S., van
            Vugt,M.A.T.M., Lans,H., Bernards,R., Svejstrup,J.Q., Ray
            Chaudhuri,A., Wyrick,J.J. and Marteijn,J.A.
  TITLE     Elongation factor ELOF1 drives transcription-coupled repair and
            prevents genome instability
  JOURNAL   Nat Cell Biol 23 (6), 608-619 (2021)
   PUBMED   34108662
  REMARK    GeneRIF: Elongation factor ELOF1 drives transcription-coupled
            repair and prevents genome instability.
            Erratum:[Nat Cell Biol. 2021 Jul;23(7):809. doi:
            10.1038/s41556-021-00720-y.. PMID: 34163038]
REFERENCE   3  (bases 1 to 1010)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1010)
  AUTHORS   Tsang,H.T., Connell,J.W., Brown,S.E., Thompson,A., Reid,E. and
            Sanderson,C.M.
  TITLE     A systematic analysis of human CHMP protein interactions:
            additional MIT domain-containing proteins bind to multiple
            components of the human ESCRT III complex
  JOURNAL   Genomics 88 (3), 333-346 (2006)
   PUBMED   16730941
REFERENCE   5  (bases 1 to 1010)
  AUTHORS   Prather,D., Krogan,N.J., Emili,A., Greenblatt,J.F. and Winston,F.
  TITLE     Identification and characterization of Elf1, a conserved
            transcription elongation factor in Saccharomyces cerevisiae
  JOURNAL   Mol Cell Biol 25 (22), 10122-10135 (2005)
   PUBMED   16260625
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BG718042.1 and AC008481.9.
            
            On Aug 13, 2020 this sequence version replaced NM_032377.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038196.479805.1, CB147853.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2142348
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000252445.8/ ENSP00000252445.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-398               BG718042.1         111-508
            399-1010            AC008481.9         137046-137657       c
FEATURES             Location/Qualifiers
     source          1..1010
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.2"
     gene            1..1010
                     /gene="ELOF1"
                     /gene_synonym="ELF1"
                     /note="elongation factor 1"
                     /db_xref="GeneID:84337"
                     /db_xref="HGNC:HGNC:28691"
                     /db_xref="MIM:619818"
     exon            1..40
                     /gene="ELOF1"
                     /gene_synonym="ELF1"
                     /inference="alignment:Splign:2.1.0"
     exon            41..174
                     /gene="ELOF1"
                     /gene_synonym="ELF1"
                     /inference="alignment:Splign:2.1.0"
     CDS             59..310
                     /gene="ELOF1"
                     /gene_synonym="ELF1"
                     /note="elongation factor 1 homolog (ELF1, S. cerevisiae);
                     ELF1 homolog, elongation factor 1"
                     /codon_start=1
                     /product="transcription elongation factor 1 homolog"
                     /protein_id="NP_115753.1"
                     /db_xref="CCDS:CCDS12264.1"
                     /db_xref="GeneID:84337"
                     /db_xref="HGNC:HGNC:28691"
                     /db_xref="MIM:619818"
                     /translation="MGRRKSKRKPPPKKKMTGTLETQFTCPFCNHEKSCDVKMDRARN
                     TGVISCTVCLEEFQTPITYLSEPVDVYSDWIDACEAANQ"
     exon            175..245
                     /gene="ELOF1"
                     /gene_synonym="ELF1"
                     /inference="alignment:Splign:2.1.0"
     exon            246..1010
                     /gene="ELOF1"
                     /gene_synonym="ELF1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      991..996
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ELOF1"
                     /gene_synonym="ELF1"
                     /note="hexamer: AATAAA"
     polyA_site      1010
                     /gene="ELOF1"
                     /gene_synonym="ELF1"
                     /note="major polyA site"
ORIGIN      
        1 actatctccc gggtgaacgg agctttcgca gctggagaag gctcatccac ctgcagacat
       61 ggggcgcaga aagtcaaaac gaaagccgcc tcccaagaag aagatgacag gcaccctcga
      121 gacccagttc acctgcccct tctgcaacca cgagaaatcc tgtgatgtga aaatggaccg
      181 tgcccgcaac accggagtca tctcttgtac cgtgtgccta gaggaattcc agacgcccat
      241 aacgtatctg tcagaacccg tggatgtgta cagtgattgg atagacgcct gcgaggcggc
      301 caatcagtag cgacacagag gacccgcccc ctgagcagcc ccgcgtactg tggatccagc
      361 tgttcggttc tggtccagag acattccagg ggtccagggt gtgggtcctg ggctgtcaca
      421 gccgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtagtgggt
      481 gtgcgtgtgg gtgtgggtgt gagtgagtgt gggtgtgtgt ggctgcacgt gtcactgggg
      541 tggccgtgag tgtgtgctca caggtacgcg gtggtgtcgg gttcctgggc ctgaggggcc
      601 tgaactgatc tcacttggct ccgaaagcct ttgctgtgtt ccctgcagcc cctggccccc
      661 cagccttggg gctctggctc cccccggcgg aattggggga ctgtttcctg acatcctgga
      721 caagggaagc ccactagagg ctggaacagg acctctccag cctcctcacc agcaccgtgc
      781 ccatctcaac tggacttccc gctctccttc tccaccttct agtgcccgtg gccggggatt
      841 caaagccgcc gttccccagg tccctgggct gggccctgac agggagccgc ccccctcccc
      901 atggtaacca ggaagcccgt ttcatgttca gttgcttttg tagaggaagc aagggctggg
      961 atggggacag ctgtcaatca caagccctta aataaagcag ccagcgcaca
//
