LOCUS       NM_005648               2015 bp    mRNA    linear   PRI 10-FEB-2025
DEFINITION  Homo sapiens elongin C (ELOC), transcript variant 1, mRNA.
ACCESSION   NM_005648
VERSION     NM_005648.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2015)
  AUTHORS   Xu,P., Liu,Y., Liu,C., Guey,B., Li,L., Melenec,P., Ricci,J. and
            Ablasser,A.
  TITLE     The CRL5-SPSB3 ubiquitin ligase targets nuclear cGAS for
            degradation
  JOURNAL   Nature 627 (8005), 873-879 (2024)
   PUBMED   38418882
REFERENCE   2  (bases 1 to 2015)
  AUTHORS   Wen,Z., Zhang,W.H., Liang,J.Y., Chai,J., Wang,Y.M., Xu,W.N.,
            Wang,Z. and Fan,L.N.
  TITLE     [Clinicopathological and molecular genetic characteristics of ELOC
            mutated renal cell carcinoma]
  JOURNAL   Zhonghua Bing Li Xue Za Zhi 52 (12), 1204-1209 (2023)
   PUBMED   38058035
  REMARK    GeneRIF: [Clinicopathological and molecular genetic characteristics
            of ELOC mutated renal cell carcinoma].
REFERENCE   3  (bases 1 to 2015)
  AUTHORS   Ramachandran,S., Makukhin,N., Haubrich,K., Nagala,M., Forrester,B.,
            Lynch,D.M., Casement,R., Testa,A., Bruno,E., Gitto,R. and Ciulli,A.
  TITLE     Structure-based design of a phosphotyrosine-masked covalent ligand
            targeting the E3 ligase SOCS2
  JOURNAL   Nat Commun 14 (1), 6345 (2023)
   PUBMED   37816714
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2015)
  AUTHORS   Zhou,Y., Liu,Y., Gupta,S., Paramo,M.I., Hou,Y., Mao,C., Luo,Y.,
            Judd,J., Wierbowski,S., Bertolotti,M., Nerkar,M., Jehi,L.,
            Drayman,N., Nicolaescu,V., Gula,H., Tay,S., Randall,G., Wang,P.,
            Lis,J.T., Feschotte,C., Erzurum,S.C., Cheng,F. and Yu,H.
  TITLE     A comprehensive SARS-CoV-2-human protein-protein interactome
            reveals COVID-19 pathobiology and potential host therapeutic
            targets
  JOURNAL   Nat Biotechnol 41 (1), 128-139 (2023)
   PUBMED   36217030
REFERENCE   5  (bases 1 to 2015)
  AUTHORS   Linossi,E.M., Li,K., Veggiani,G., Tan,C., Dehkhoda,F., Hockings,C.,
            Calleja,D.J., Keating,N., Feltham,R., Brooks,A.J., Li,S.S.,
            Sidhu,S.S., Babon,J.J., Kershaw,N.J. and Nicholson,S.E.
  TITLE     Discovery of an exosite on the SOCS2-SH2 domain that enhances SH2
            binding to phosphorylated ligands
  JOURNAL   Nat Commun 12 (1), 7032 (2021)
   PUBMED   34857742
  REMARK    Erratum:[Nat Commun. 2023 Dec 1;14(1):7951. doi:
            10.1038/s41467-023-42706-4.. PMID: 38040684]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2015)
  AUTHORS   Kibel,A., Iliopoulos,O., DeCaprio,J.A. and Kaelin,W.G. Jr.
  TITLE     Binding of the von Hippel-Lindau tumor suppressor protein to
            Elongin B and C
  JOURNAL   Science 269 (5229), 1444-1446 (1995)
   PUBMED   7660130
REFERENCE   7  (bases 1 to 2015)
  AUTHORS   Aso,T., Lane,W.S., Conaway,J.W. and Conaway,R.C.
  TITLE     Elongin (SIII): a multisubunit regulator of elongation by RNA
            polymerase II
  JOURNAL   Science 269 (5229), 1439-1443 (1995)
   PUBMED   7660129
REFERENCE   8  (bases 1 to 2015)
  AUTHORS   Duan,D.R., Pause,A., Burgess,W.H., Aso,T., Chen,D.Y., Garrett,K.P.,
            Conaway,R.C., Conaway,J.W., Linehan,W.M. and Klausner,R.D.
  TITLE     Inhibition of transcription elongation by the VHL tumor suppressor
            protein
  JOURNAL   Science 269 (5229), 1402-1406 (1995)
   PUBMED   7660122
REFERENCE   9  (bases 1 to 2015)
  AUTHORS   Garrett,K.P., Haque,D., Conaway,R.C. and Conaway,J.W.
  TITLE     A human cDNA encoding the small subunit of RNA polymerase II
            transcription factor SIII
  JOURNAL   Gene 150 (2), 413-414 (1994)
   PUBMED   7821821
REFERENCE   10 (bases 1 to 2015)
  AUTHORS   Bradsher,J.N., Jackson,K.W., Conaway,R.C. and Conaway,J.W.
  TITLE     RNA polymerase II transcription factor SIII. I. Identification,
            purification, and properties
  JOURNAL   J Biol Chem 268 (34), 25587-25593 (1993)
   PUBMED   8244996
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BM821650.1, AK057889.1 and
            AC022868.10.
            
            On Jun 2, 2019 this sequence version replaced NM_005648.3.
            
            Summary: This gene encodes the protein elongin C, which is a
            subunit of the transcription factor B (SIII) complex. The SIII
            complex is composed of elongins A/A2, B and C. It activates
            elongation by RNA polymerase II by suppressing transient pausing of
            the polymerase at many sites within transcription units. Elongin A
            functions as the transcriptionally active component of the SIII
            complex, whereas elongins B and C are regulatory subunits. Elongin
            A2 is specifically expressed in the testis, and capable of forming
            a stable complex with elongins B and C. The von Hippel-Lindau tumor
            suppressor protein binds to elongins B and C, and thereby inhibits
            transcription elongation. Multiple alternatively spliced transcript
            variants encoding two distinct isoforms have been identified.
            [provided by RefSeq, Mar 2011].
            
            Transcript Variant: This variant (1) represents the predominant
            transcript. Variants 1-7 encode the same protein (isoform a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.1135189.1,
                                           SRR3476690.803203.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000520242.6/ ENSP00000428171.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-24                BM821650.1         80-103
            25-1996             AK057889.1         1-1972
            1997-2015           AC022868.10        57307-57325
FEATURES             Location/Qualifiers
     source          1..2015
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q21.11"
     gene            1..2015
                     /gene="ELOC"
                     /gene_synonym="SIII; TCEB1"
                     /note="elongin C"
                     /db_xref="GeneID:6921"
                     /db_xref="HGNC:HGNC:11617"
                     /db_xref="MIM:600788"
     exon            1..115
                     /gene="ELOC"
                     /gene_synonym="SIII; TCEB1"
                     /inference="alignment:Splign:2.1.0"
     exon            116..169
                     /gene="ELOC"
                     /gene_synonym="SIII; TCEB1"
                     /inference="alignment:Splign:2.1.0"
     CDS             166..504
                     /gene="ELOC"
                     /gene_synonym="SIII; TCEB1"
                     /note="isoform a is encoded by transcript variant 1;
                     transcription elongation factor B polypeptide 1; SIII p15;
                     elongin 15 kDa subunit; RNA polymerase II transcription
                     factor SIII subunit C; transcription elongation factor B
                     (SIII), polypeptide 1 (15kDa, elongin C); transcription
                     elongation factor B subunit 1"
                     /codon_start=1
                     /product="elongin-C isoform a"
                     /protein_id="NP_005639.1"
                     /db_xref="CCDS:CCDS34910.1"
                     /db_xref="GeneID:6921"
                     /db_xref="HGNC:HGNC:11617"
                     /db_xref="MIM:600788"
                     /translation="MDGEEKTYGGCEGPDAMYVKLISSDGHEFIVKREHALTSGTIKA
                     MLSGPGQFAENETNEVNFREIPSHVLSKVCMYFTYKVRYTNSSTEIPEFPIAPEIALE
                     LLMAANFLDC"
     exon            170..313
                     /gene="ELOC"
                     /gene_synonym="SIII; TCEB1"
                     /inference="alignment:Splign:2.1.0"
     exon            314..2015
                     /gene="ELOC"
                     /gene_synonym="SIII; TCEB1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      504..509
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ELOC"
                     /gene_synonym="SIII; TCEB1"
                     /note="hexamer: AATAAA"
     regulatory      519..524
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ELOC"
                     /gene_synonym="SIII; TCEB1"
                     /note="hexamer: AATAAA"
     polyA_site      524
                     /gene="ELOC"
                     /gene_synonym="SIII; TCEB1"
                     /note="major polyA site"
     polyA_site      531
                     /gene="ELOC"
                     /gene_synonym="SIII; TCEB1"
                     /note="major polyA site"
     regulatory      716..721
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ELOC"
                     /gene_synonym="SIII; TCEB1"
                     /note="hexamer: AATAAA"
     polyA_site      739
                     /gene="ELOC"
                     /gene_synonym="SIII; TCEB1"
                     /note="major polyA site"
     regulatory      1014..1019
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ELOC"
                     /gene_synonym="SIII; TCEB1"
                     /note="hexamer: GATAAA"
     polyA_site      1035
                     /gene="ELOC"
                     /gene_synonym="SIII; TCEB1"
     regulatory      1489..1494
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ELOC"
                     /gene_synonym="SIII; TCEB1"
                     /note="hexamer: AATATA"
     polyA_site      1522
                     /gene="ELOC"
                     /gene_synonym="SIII; TCEB1"
                     /note="major polyA site"
ORIGIN      
        1 ctttcgactg ccccggaacc caccggagca ggcagctggg ggtggggggg cggccctggg
       61 ataggggctg tggcagtacg cggggacccg gctgcggtgg ctgcgggact gacgagaaac
      121 tactaaagtt cctggggaag caaagtagaa tttcataaga acaaaatgga tggagaggag
      181 aaaacctatg gtggctgtga aggacctgat gccatgtatg tcaaattgat atcatctgat
      241 ggccatgaat ttattgtaaa aagagaacat gcattaacat caggcacgat aaaagccatg
      301 ttgagtggcc caggtcagtt tgctgagaac gaaaccaatg aggtcaattt tagagagata
      361 ccttcacatg tgctatcgaa agtatgcatg tattttacgt acaaggttcg ctacactaac
      421 agctccaccg agattcctga attcccaatt gcacctgaaa ttgcactgga actgctgatg
      481 gctgcgaact tcttagattg ttaaataaaa taaattataa taaactgtta actcttttca
      541 gtatttaata cctgtagttc agttagtaac tttttcatat atagcatgtt gcctgtatgc
      601 agttgaacta tataaagttc attgcaaagc agattatctt gtttttttgc atagcaatca
      661 aagttgaaat ttgtttgcta catcaacaaa ttaaggacat tttcacaaac tgagaaataa
      721 acaaatatgc caattcgtag gtggttttgc cttatccttt gaatgtgact taaaatcagc
      781 aatgatgata tagtaaatac tgaaatttag gtgtaaatca atacgttcta cagggaaata
      841 atgaggctaa gtatttttat gtttttagtg gttttttaga aacctaatct tatagccgcc
      901 attagcatta ctagagttat gcaaataatt gcattataaa catgtttata acttagccaa
      961 aacattgatt tttataactc tccaagtatg agttgaaatt tcttatgtct tttgataaac
     1021 tgcagtattc tttaagtgta ctttgtcctt ttgtttattg ctacaattta agaactttat
     1081 ttaaaaacaa ttttggaagg ttactaggta cagcttttgc agaagaaact gaactgtagc
     1141 cagatggtca gcaagtaaac tacatgactt agagttcttg tgcattatac attttgggta
     1201 attcaaagta ctgtatttgc attgactata aagcgtcgtt tgcaatattt attcttcctt
     1261 catagtccct tgttgtgatt atacttccag ttgtttaaat gtattttaaa agactcacta
     1321 ttaactttat tcagatctta aaagctacac ctttttgaac tattccagtc tttctccatc
     1381 caattagaat gttatggaat aacatgtgaa gagatacagt gaaaatcata ttataatgca
     1441 ttgaagatat cctacatgaa ttatcttcta ttaaaatatg tcccaataaa tatacccata
     1501 atcagtgggt cttctactga aatcaagctc attcagcttt tctattaagc agccaaaaaa
     1561 ttttttgaaa aaatatgaca gcatcattcc ttatgcatgg ggaaagaagc actggagatg
     1621 ggtttagtat tgtctttatc tcagaggtgg aacaaagttg tcattatagg gtctataaac
     1681 ttaagtctcc agcttatttg agactggctt aatatggctg agcccggtgg ctcatgcctg
     1741 taatcccagc actttcagag gacgaggcgg gtagatcact tgaggccagg agtttgagac
     1801 cagcctggcc accatggcaa aaccccatct ctaccaaaaa tgcaaaaatt agctaggcca
     1861 tggtggcaca cgcctgtaat cccagctact tgtgaggctg aggcatgaga atcgcttgaa
     1921 cctgggaggt ggaggtggca gtgagccgag atcgcaccac tgcactccag cctgggtgac
     1981 agagcgagac tgtctcaaaa aaaaaaaaaa aaaaa
//
