LOCUS       NM_016427               3095 bp    mRNA    linear   PRI 11-JUN-2024
DEFINITION  Homo sapiens elongin A2 (ELOA2), mRNA.
ACCESSION   NM_016427
VERSION     NM_016427.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3095)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 3095)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 3095)
  AUTHORS   Lim,J., Hao,T., Shaw,C., Patel,A.J., Szabo,G., Rual,J.F.,
            Fisk,C.J., Li,N., Smolyar,A., Hill,D.E., Barabasi,A.L., Vidal,M.
            and Zoghbi,H.Y.
  TITLE     A protein-protein interaction network for human inherited ataxias
            and disorders of Purkinje cell degeneration
  JOURNAL   Cell 125 (4), 801-814 (2006)
   PUBMED   16713569
REFERENCE   4  (bases 1 to 3095)
  AUTHORS   Aso,T., Yamazaki,K., Amimoto,K., Kuroiwa,A., Higashi,H.,
            Matsuda,Y., Kitajima,S. and Hatakeyama,M.
  TITLE     Identification and characterization of Elongin A2, a new member of
            the Elongin family of transcription elongation factors,
            specifically expressed in the testis
  JOURNAL   J Biol Chem 275 (9), 6546-6552 (2000)
   PUBMED   10692460
REFERENCE   5  (bases 1 to 3095)
  AUTHORS   Aso,T., Lane,W.S., Conaway,J.W. and Conaway,R.C.
  TITLE     Elongin (SIII): a multisubunit regulator of elongation by RNA
            polymerase II
  JOURNAL   Science 269 (5229), 1439-1443 (1995)
   PUBMED   7660129
REFERENCE   6  (bases 1 to 3095)
  AUTHORS   Bradsher,J.N., Jackson,K.W., Conaway,R.C. and Conaway,J.W.
  TITLE     RNA polymerase II transcription factor SIII. I. Identification,
            purification, and properties
  JOURNAL   J Biol Chem 268 (34), 25587-25593 (1993)
   PUBMED   8244996
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC012254.12, BC036022.1 and
            AB030834.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Aug 13, 2020 this sequence version replaced NM_016427.2.
            
            Summary: This gene encodes the transcriptionally active subunit of
            the SIII (or elongin) transcription elongation factor complex,
            which also includes two regulatory subunits, elongins B and C. This
            complex acts to increase the rate of RNA chain elongation by RNA
            polymerase II by suppressing transient pausing of the polymerase at
            many sites along the DNA template. Whereas a related protein with
            similar function, elongin A, is ubiquitously expressed, the encoded
            protein is specifically expressed in the testis, suggesting it may
            have a role in spermatogenesis. [provided by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC036022.1, AB030834.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000332567.6/ ENSP00000331302.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 AC012254.12        110576-110579
            5-404               BC036022.1         5-404
            405-476             AB030834.1         162-233
            477-1723            BC036022.1         477-1723
            1724-2907           AB030834.1         1481-2664
            2908-3050           BC036022.1         2908-3050
            3051-3095           AC012254.12        113626-113670
FEATURES             Location/Qualifiers
     source          1..3095
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18q21.1"
     gene            1..3095
                     /gene="ELOA2"
                     /gene_synonym="HsT832; TCEB3B; TCEB3L"
                     /note="elongin A2"
                     /db_xref="GeneID:51224"
                     /db_xref="HGNC:HGNC:30771"
                     /db_xref="MIM:609522"
     exon            1..3095
                     /gene="ELOA2"
                     /gene_synonym="HsT832; TCEB3B; TCEB3L"
                     /inference="alignment:Splign:2.1.0"
     CDS             358..2619
                     /gene="ELOA2"
                     /gene_synonym="HsT832; TCEB3B; TCEB3L"
                     /note="transcription elongation factor (SIII) elongin A2
                     elongin A2; RNA polymerase II transcription factor SIII
                     subunit A2; transcription elongation factor B subunit 3B;
                     transcription elongation factor B polypeptide 3B"
                     /codon_start=1
                     /product="elongin-A2"
                     /protein_id="NP_057511.2"
                     /db_xref="CCDS:CCDS11932.1"
                     /db_xref="GeneID:51224"
                     /db_xref="HGNC:HGNC:30771"
                     /db_xref="MIM:609522"
                     /translation="MAAGSTTLHAVEKLQVRLATKTEPKKLEKYLQKLSALPMTADIL
                     AETGIRKTVKRLRKHQHVGDFARDLAARWKKLVLVDRNTRPGPQDPEESASRQRFGEA
                     LQDQEKAWGFPENATAPRSPSHSPEHRRTARRTPPGQQRPHPRSHSREPRAERKCPRI
                     APADSGRYRASPTRTAPLRMPEGPEPAAPGKQPGRGHTHAAQGGPLLCPGCQGQPQGK
                     AVVSHSKGHKSSRQEKRPLCAQGDWHSPTLIREKSCGACLREETPRMPSWASARDRQP
                     SDFKTDKEGGQAGSGQRVPALEEAPDSHQKRPQHSHSNKKRPSLDGRDPGNGTHGLSP
                     EEKEQLSNDRETQEGKPPTAHLDRTSVSSLSEVEEVDMAEEFEQPTLSCEKYLTYDQL
                     RKQKKKTGKSATTALGDKQRKANESKGTRESWDSAKKLPPVQESQSERLQAAGADSAG
                     PKTVPSHVFSELWDLSEAWMQANYDPLSDSDSMTSQAKPEALSSPKFREEAAFPGRRV
                     NAKMPVYSGSRPACQLQVPTLRQQCAQVLRNNPDALSDVGEVPYWVLEPVLEGWRPDQ
                     LYRRKKDNHALVRETDELRRNHCFQDFKEEKPQENKTWREQYLRLPDAPEQRLRVMTT
                     NIRSARGNNPNGREAKMICFKSVAKTPYDTSRRQEKSAGDADPENGEIKPASKPAGSS
                     HTPSSQSSSGGGRDSSSSILRWLPEKRANPCLSSSNEHAAPAAKTRKQAAKKVAPLMA
                     KAIRDYKRRFSRR"
     regulatory      3069..3074
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ELOA2"
                     /gene_synonym="HsT832; TCEB3B; TCEB3L"
                     /note="hexamer: AATAAA"
     polyA_site      3095
                     /gene="ELOA2"
                     /gene_synonym="HsT832; TCEB3B; TCEB3L"
                     /note="major polyA site"
ORIGIN      
        1 aagagggtca gggctagagc cgtgagtgtc agcctgggat gggctacata aggcccagct
       61 ctggcaccag agcttcattc tttgttgcac agcaaactgc agaggtcact ccaggctgtg
      121 gctccacatc ccgaggaaca aaagcgggcc tgctcagctg tctgcaagga cggccgttcc
      181 agaccaagtg gcctgctgct ccgaggaccc agctcgctcc aggctgtgac tccacatccc
      241 gaggtcgctg cctggcgacc gggcagcgag gaccggccac cccagacttc ctgtcccgca
      301 gccccaaaga cagagctgcg accgccggga cagcgacgcc tgcacagctc tggtgagatg
      361 gcggcagggt ccactacgct gcacgcagtg gagaagctgc aggtgcgtct ggccactaag
      421 acggagccga aaaagctaga gaaatatttg cagaaactct ccgccttgcc catgacggca
      481 gacatcctgg cggagactgg aatcagaaag acggtgaagc gcctgcggaa gcaccagcac
      541 gtgggcgact ttgccagaga cttagcggcc cggtggaaga agctggtgct cgtggaccga
      601 aacacccggc ctggcccaca ggaccctgag gagagcgctt cccgacagcg cttcggggag
      661 gctcttcagg accaggaaaa ggcctggggc ttcccagaaa acgcgacggc ccccaggagc
      721 ccatctcaca gccctgagca cagacggaca gcacgcagaa cacctccggg gcaacagaga
      781 cctcacccga ggtctcacag tcgcgagccc agagctgaga gaaagtgccc cagaatagcc
      841 ccagctgatt ccggccgcta tcgggcctct ccaacgcgca cagctcccct ccggatgccc
      901 gagggccctg agcccgctgc gcccgggaag caacccggaa gaggccacac tcacgcggct
      961 cagggcgggc ctctgctgtg tccaggctgc cagggccaac cccaggggaa agccgttgtg
     1021 agccacagca aggggcacaa atcgtctcgc caggaaaaac gccccttgtg tgcccaggga
     1081 gattggcact cccctacttt gatcagggag aaatcatgcg gggcctgctt aagagaggaa
     1141 accccaagga tgccctcctg ggcaagtgcc agggacaggc agccttcgga cttcaagaca
     1201 gacaaggaag gggggcaagc tggcagcggc cagcgtgtcc ctgccttgga ggaggctcca
     1261 gacagtcacc agaagaggcc tcagcacagt cactcgaaca agaagaggcc cagtctagac
     1321 ggccgggacc caggaaatgg gacacacggc ctgtcgcccg aggagaaaga gcagctttcc
     1381 aacgaccgag agactcaaga ggggaagcca ccgactgctc atttggacag aacgtccgtg
     1441 agctccctct ctgaggtgga ggaggtagat atggctgagg aattcgagca gcccactctg
     1501 tcatgtgaaa aatacctcac ctacgatcag ttgcggaagc aaaagaaaaa gactggaaaa
     1561 tctgccacca ctgcacttgg agataaacaa aggaaagcaa acgaatccaa gggcactcgt
     1621 gagtcctggg attcggctaa gaaattgcct cctgtccagg aaagccagtc agagaggctg
     1681 caggcggccg gcgctgattc cgccgggccg aaaacggtgc ccagccatgt cttctcagag
     1741 ctctgggacc tctcagaggc ctggatgcag gccaactacg atccgctttc ggattctgac
     1801 tccatgacct cccaggcaaa gccagaagca ctctcttcac caaagttccg ggaggaagct
     1861 gctttccctg gacgcagagt gaatgctaag atgccggtgt actcgggctc caggcctgcc
     1921 tgccagctcc aggtgccgac gctgcgccag cagtgtgccc aggtgcttag aaacaatccg
     1981 gacgccctca gcgacgtggg agaggtcccc tactgggttc ttgaacctgt tctggaaggg
     2041 tggaggcccg atcagctgta tcgcagaaag aaagacaatc acgcactcgt tagagagaca
     2101 gacgaattac ggaggaatca ttgtttccag gacttcaagg aagaaaagcc acaggaaaac
     2161 aaaacttgga gggagcagta cctgcggctt ccggacgccc cagagcagcg gctgagagta
     2221 atgacaacga atatccgatc tgcacgtgga aacaacccca acggcagaga ggcaaagatg
     2281 atctgtttca aatctgtggc caagacgcct tatgatactt caaggaggca agagaagtct
     2341 gcaggagacg ctgaccccga aaatggggag atcaagccag cctccaagcc cgcgggaagc
     2401 agccacactc cctccagcca gagcagcagc ggcggtggca gagacagcag cagcagcatc
     2461 cttcgctggc tccctgagaa gcgggccaac ccctgcctga gcagcagcaa tgagcacgcg
     2521 gcgcccgcgg ccaaaacccg gaaacaggct gccaagaaag tggccccgct gatggccaag
     2581 gcaattcgag actacaagag aagattctcc cgacgataaa ctcaggactt gccttgcaga
     2641 taaaatctgg ggggattttt gcattggcaa agtcaatgcg ggttggggaa cgaaacttcc
     2701 aatggacacc agaaccttta acttggtgca aagttgagcc tttgaattct gcaggtgtca
     2761 tgtgctggcc ctgtgatttt gcctcccaca cccagccact acctcccagc ttggagaaca
     2821 cctcagaatt cagaagatat gaacgcattg ggaacaattc tattttggat gttcactgat
     2881 aatttttaaa aacaccctag ttgtaatcat aaataaggaa aaagatgtga gatttccttt
     2941 ttcctttctt ttttttttcg aaatcaagta gataagaact tcttagacaa aaacacacaa
     3001 gccattagtt gacactgata actccgaata cataaaatgt ttgctgttgc tgccgttgtt
     3061 gttgttttaa taaaaggctg agcatgatct tgtaa
//
