LOCUS       NM_003198               4838 bp    mRNA    linear   PRI 20-MAY-2024
DEFINITION  Homo sapiens elongin A (ELOA), mRNA.
ACCESSION   NM_003198
VERSION     NM_003198.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4838)
  AUTHORS   Cai,Y., Li,Y., Xu,Y., Yang,W. and Huang,M.
  TITLE     TCEB3 initiates ovarian cancer apoptosis by mediating
            ubiquitination and degradation of MCL-1
  JOURNAL   FASEB J 38 (8), e23625 (2024)
   PUBMED   38661028
  REMARK    GeneRIF: TCEB3 initiates ovarian cancer apoptosis by mediating
            ubiquitination and degradation of MCL-1.
REFERENCE   2  (bases 1 to 4838)
  AUTHORS   Kim,D.K., Weller,B., Lin,C.W., Sheykhkarimli,D., Knapp,J.J.,
            Dugied,G., Zanzoni,A., Pons,C., Tofaute,M.J., Maseko,S.B.,
            Spirohn,K., Laval,F., Lambourne,L., Kishore,N., Rayhan,A.,
            Sauer,M., Young,V., Halder,H., la Rosa,N.M., Pogoutse,O.,
            Strobel,A., Schwehn,P., Li,R., Rothballer,S.T., Altmann,M.,
            Cassonnet,P., Cote,A.G., Vergara,L.E., Hazelwood,I., Liu,B.B.,
            Nguyen,M., Pandiarajan,R., Dohai,B., Coloma,P.A.R., Poirson,J.,
            Giuliana,P., Willems,L., Taipale,M., Jacob,Y., Hao,T., Hill,D.E.,
            Brun,C., Twizere,J.C., Krappmann,D., Heinig,M., Falter,C., Aloy,P.,
            Demeret,C., Vidal,M., Calderwood,M.A., Roth,F.P. and
            Falter-Braun,P.
  TITLE     A proteome-scale map of the SARS-CoV-2-human contactome
  JOURNAL   Nat Biotechnol 41 (1), 140-149 (2023)
   PUBMED   36217029
REFERENCE   3  (bases 1 to 4838)
  AUTHORS   Wang,Y., Hou,L., Ardehali,M.B., Kingston,R.E. and Dynlacht,B.D.
  TITLE     Elongin A regulates transcription in vivo through enhanced RNA
            polymerase processivity
  JOURNAL   J Biol Chem 296, 100170 (2021)
   PUBMED   33298525
  REMARK    GeneRIF: Elongin A regulates transcription in vivo through enhanced
            RNA polymerase processivity.
REFERENCE   4  (bases 1 to 4838)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 4838)
  AUTHORS   Weems,J.C., Slaughter,B.D., Unruh,J.R., Boeing,S., Hall,S.M.,
            McLaird,M.B., Yasukawa,T., Aso,T., Svejstrup,J.Q., Conaway,J.W. and
            Conaway,R.C.
  TITLE     Cockayne syndrome B protein regulates recruitment of the Elongin A
            ubiquitin ligase to sites of DNA damage
  JOURNAL   J Biol Chem 292 (16), 6431-6437 (2017)
   PUBMED   28292928
  REMARK    GeneRIF: the Elongin A ubiquitin ligase and the CSB protein
            function together in a common pathway in response to Pol II
            stalling and DNA damage
REFERENCE   6  (bases 1 to 4838)
  AUTHORS   Pan,G., Aso,T. and Greenblatt,J.
  TITLE     Interaction of elongation factors TFIIS and elongin A with a human
            RNA polymerase II holoenzyme capable of promoter-specific
            initiation and responsive to transcriptional activators
  JOURNAL   J Biol Chem 272 (39), 24563-24571 (1997)
   PUBMED   9305922
REFERENCE   7  (bases 1 to 4838)
  AUTHORS   Aso,T., Haque,D., Fukudome,K., Brower,C.S., Conaway,J.W. and
            Conaway,R.C.
  TITLE     A human cDNA encoding the 110-kDa A subunit of RNA polymerase II
            transcription factor elongin
  JOURNAL   Gene 168 (2), 277-278 (1996)
   PUBMED   8654961
REFERENCE   8  (bases 1 to 4838)
  AUTHORS   Aso,T., Mokady,N., Haque,D., Conaway,R.C. and Conaway,J.W.
  TITLE     Assignment of a human gene encoding the 110-kDa subunit of general
            transcription factor elongin (SIII) to chromosome 1p36.1
  JOURNAL   Genomics 30 (2), 393-394 (1995)
   PUBMED   8586449
REFERENCE   9  (bases 1 to 4838)
  AUTHORS   Aso,T., Lane,W.S., Conaway,J.W. and Conaway,R.C.
  TITLE     Elongin (SIII): a multisubunit regulator of elongation by RNA
            polymerase II
  JOURNAL   Science 269 (5229), 1439-1443 (1995)
   PUBMED   7660129
REFERENCE   10 (bases 1 to 4838)
  AUTHORS   Duan,D.R., Pause,A., Burgess,W.H., Aso,T., Chen,D.Y., Garrett,K.P.,
            Conaway,R.C., Conaway,J.W., Linehan,W.M. and Klausner,R.D.
  TITLE     Inhibition of transcription elongation by the VHL tumor suppressor
            protein
  JOURNAL   Science 269 (5229), 1402-1406 (1995)
   PUBMED   7660122
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL031295.1.
            
            On Mar 18, 2021 this sequence version replaced NM_003198.2.
            
            Summary: This gene encodes the protein elongin A, which is a
            subunit of the transcription factor B (SIII) complex. The SIII
            complex is composed of elongins A/A2, B and C. It activates
            elongation by RNA polymerase II by suppressing transient pausing of
            the polymerase at many sites within transcription units. Elongin A
            functions as the transcriptionally active component of the SIII
            complex, whereas elongins B and C are regulatory subunits. Elongin
            A2 is specifically expressed in the testis, and capable of forming
            a stable complex with elongins B and C. The von Hippel-Lindau tumor
            suppressor protein binds to elongins B and C, and thereby inhibits
            transcription elongation. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853562.456.1, SRR11853559.555.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000613537.5/ ENSP00000484196.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-108               AL031295.1         42609-42716
            109-165             AL031295.1         48159-48215
            166-272             AL031295.1         48980-49086
            273-1458            AL031295.1         49983-51168
            1459-1570           AL031295.1         51545-51656
            1571-1726           AL031295.1         53238-53393
            1727-1824           AL031295.1         53501-53598
            1825-2005           AL031295.1         54981-55161
            2006-2117           AL031295.1         55412-55523
            2118-2290           AL031295.1         56091-56263
            2291-4838           AL031295.1         58650-61197
FEATURES             Location/Qualifiers
     source          1..4838
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.11"
     gene            1..4838
                     /gene="ELOA"
                     /gene_synonym="ELOA1; SIII; SIII p110; TCEB3; TCEB3A"
                     /note="elongin A"
                     /db_xref="GeneID:6924"
                     /db_xref="HGNC:HGNC:11620"
                     /db_xref="MIM:600786"
     exon            1..108
                     /gene="ELOA"
                     /gene_synonym="ELOA1; SIII; SIII p110; TCEB3; TCEB3A"
                     /inference="alignment:Splign:2.1.0"
     CDS             34..2352
                     /gene="ELOA"
                     /gene_synonym="ELOA1; SIII; SIII p110; TCEB3; TCEB3A"
                     /note="transcription elongation factor B alpha subunit;
                     transcription elongation factor B polypeptide 3; elongin
                     110 kDa subunit; RNA polymerase II transcription factor
                     SIII subunit A1; transcription elongation factor B (SIII),
                     polypeptide 3 (110kDa, elongin A); transcription
                     elongation factor B subunit 3"
                     /codon_start=1
                     /product="elongin-A"
                     /protein_id="NP_003189.3"
                     /db_xref="CCDS:CCDS239.3"
                     /db_xref="GeneID:6924"
                     /db_xref="HGNC:HGNC:11620"
                     /db_xref="MIM:600786"
                     /translation="MAAESALQVVEKLQARLAANPDPKKLLKYLKKLSTLPITVDILA
                     ETGVGKTVNSLRKHEHVGSFARDLVAQWKKLVPVERNAEPDEQDFEKSNSRKRPRDAL
                     QKEEEMEGDYQETWKATGSRSYSPDHRQKKHRKLSELERPHKVSHGHERRDERKRCHR
                     MSPTYSSDPESSDYGHVQSPPSCTSPHQMYVDHYRSLEEDQEPIVSHQKPGKGHSNAF
                     QDRLGASQERHLGEPHGKGVVSQNKEHKSSHKDKRPVDAKSDEKASVVSREKSHKALS
                     KEENRRPPSGDNAREKPPSSGVKKEKDREGSSLKKKCLPPSEAASDNHLKKPKHRDPE
                     KAKLDKSKQGLDSFDTGKGAGDLLPKVKEKGSNNLKTPEGKVKTNLDRKSLGSLPKVE
                     ETDMEDEFEQPTMSFESYLSYDQPRKKKKKIVKTSATALGDKGLKKNDSKSTGKNLDS
                     VQKLPKVNKTKSEKPAGADLAKLRKVPDVLPVLPDLPLPAIQANYRPLPSLELISSFQ
                     PKRKAFSSPQEEEEAGFTGRRMNSKMQVYSGSKCAYLPKMMTLHQQCIRVLKNNIDSI
                     FEVGGVPYSVLEPVLERCTPDQLYRIEEYNHVLIEETDQLWKVHCHRDFKEERPEEYE
                     SWREMYLRLQDAREQRLRVLTKNIQFAHANKPKGRQAKMAFVNSVAKPPRDVRRRQEK
                     FGTGGAAVPEKIKIKPAPYPMGSSHASASSISFNPSPEEPAYDGPSTSSAHLAPVVSS
                     TVSYDPRKPTVKKIAPMMAKTIKAFKNRFSRR"
     exon            109..165
                     /gene="ELOA"
                     /gene_synonym="ELOA1; SIII; SIII p110; TCEB3; TCEB3A"
                     /inference="alignment:Splign:2.1.0"
     exon            166..272
                     /gene="ELOA"
                     /gene_synonym="ELOA1; SIII; SIII p110; TCEB3; TCEB3A"
                     /inference="alignment:Splign:2.1.0"
     exon            273..1458
                     /gene="ELOA"
                     /gene_synonym="ELOA1; SIII; SIII p110; TCEB3; TCEB3A"
                     /inference="alignment:Splign:2.1.0"
     exon            1459..1570
                     /gene="ELOA"
                     /gene_synonym="ELOA1; SIII; SIII p110; TCEB3; TCEB3A"
                     /inference="alignment:Splign:2.1.0"
     exon            1571..1726
                     /gene="ELOA"
                     /gene_synonym="ELOA1; SIII; SIII p110; TCEB3; TCEB3A"
                     /inference="alignment:Splign:2.1.0"
     exon            1727..1824
                     /gene="ELOA"
                     /gene_synonym="ELOA1; SIII; SIII p110; TCEB3; TCEB3A"
                     /inference="alignment:Splign:2.1.0"
     exon            1825..2005
                     /gene="ELOA"
                     /gene_synonym="ELOA1; SIII; SIII p110; TCEB3; TCEB3A"
                     /inference="alignment:Splign:2.1.0"
     exon            2006..2117
                     /gene="ELOA"
                     /gene_synonym="ELOA1; SIII; SIII p110; TCEB3; TCEB3A"
                     /inference="alignment:Splign:2.1.0"
     exon            2118..2290
                     /gene="ELOA"
                     /gene_synonym="ELOA1; SIII; SIII p110; TCEB3; TCEB3A"
                     /inference="alignment:Splign:2.1.0"
     exon            2291..4838
                     /gene="ELOA"
                     /gene_synonym="ELOA1; SIII; SIII p110; TCEB3; TCEB3A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2653..2658
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ELOA"
                     /gene_synonym="ELOA1; SIII; SIII p110; TCEB3; TCEB3A"
                     /note="hexamer: AATAAA"
     polyA_site      2685
                     /gene="ELOA"
                     /gene_synonym="ELOA1; SIII; SIII p110; TCEB3; TCEB3A"
                     /note="major polyA site"
     regulatory      4821..4826
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ELOA"
                     /gene_synonym="ELOA1; SIII; SIII p110; TCEB3; TCEB3A"
                     /note="hexamer: AATAAA"
     polyA_site      4838
                     /gene="ELOA"
                     /gene_synonym="ELOA1; SIII; SIII p110; TCEB3; TCEB3A"
                     /note="major polyA site"
ORIGIN      
        1 agttccggcg aggaggccgc gccagtgaca gcgatggcgg cggagtcggc gctccaagtt
       61 gtggagaagc tgcaggcgcg cctggccgcg aacccggacc ctaagaagct attgaaatat
      121 ttgaagaaac tctccaccct gcctattaca gtagacattc ttgcggagac tggggttggg
      181 aaaacagtaa atagcttgcg aaaacacgag catgttggaa gctttgccag ggacctagtg
      241 gcccagtgga agaagctggt tcctgtggaa cgaaatgctg agcctgatga acaggacttt
      301 gagaagagca attcccgaaa gcgccctcgg gatgccctgc agaaggagga ggagatggag
      361 ggggactacc aagaaacctg gaaagccacg gggagccgat cctatagccc tgaccacagg
      421 cagaagaaac ataggaaact ctcggagctc gagagacctc acaaagtgtc tcacggtcat
      481 gagaggagag atgagagaaa gaggtgtcac agaatgtcac caacttactc ttcagaccct
      541 gagtcttctg attatggcca tgttcaatcc cctccatctt gtaccagtcc tcatcagatg
      601 tacgtcgacc actacagatc cctggaggag gaccaggagc ccattgtttc acaccagaag
      661 cctgggaaag gccacagcaa tgcctttcag gacagactcg gggccagcca agaacgacac
      721 ctgggtgaac cccatgggaa aggggttgtg agtcaaaaca aggagcacaa atcttcccac
      781 aaggacaaac gccccgtgga tgccaagagt gatgagaagg cctctgtggt gagcagagag
      841 aaatcacaca aggccctctc caaagaggag aaccgaaggc caccctcagg ggacaatgca
      901 agggagaaac cgccctctag tggcgtaaag aaagagaagg acagagaggg cagcagcctg
      961 aagaagaagt gtttgcctcc ctcagaggcc gcttcagaca accacctgaa aaagccaaag
     1021 cacagagacc cagagaaagc caaattggac aaaagcaagc aaggtctgga cagctttgac
     1081 acaggaaaag gagcaggaga cctgttgccc aaggtaaaag agaagggttc taacaaccta
     1141 aagactccag aagggaaagt caaaactaat ttggatagaa agtcactggg ctccctccct
     1201 aaagttgagg agacagatat ggaggatgaa ttcgagcagc caaccatgtc ttttgaatcc
     1261 tacctcagct atgaccagcc ccggaagaaa aagaaaaaga ttgtgaaaac ttcagccacg
     1321 gcacttggag ataaaggact taaaaaaaat gactctaaaa gcactggtaa aaacttggac
     1381 tcagttcaga aattacccaa ggtgaacaaa accaagtcag agaagccggc tggagctgat
     1441 ttagccaagc tgagaaaggt gcctgatgtg ttgccagtgt tgccagacct cccgttaccc
     1501 gcgatacagg ccaattaccg tccactgcct tccctcgagc tgatatcctc cttccagcca
     1561 aagcgaaaag cgttctcttc accccaggaa gaagaagaag ctggatttac tgggcgcaga
     1621 atgaattcca agatgcaggt gtattctggt tccaagtgtg cctatctccc taaaatgatg
     1681 accttgcacc agcaatgcat ccgagtactt aaaaacaaca tcgattcaat ctttgaagtg
     1741 ggaggagtcc catactctgt tcttgaaccc gttttggaga ggtgtacacc tgatcagctg
     1801 tatcgcatag aggaatacaa tcatgtatta attgaagaaa cagatcaatt atggaaagtt
     1861 cattgtcacc gagactttaa ggaagaaaga cccgaagagt atgagtcgtg gcgagagatg
     1921 tacctgcggc ttcaggacgc ccgagagcag cggctacgag tactaacaaa gaatatccag
     1981 ttcgcacatg ccaataagcc caaaggccga caagcaaaga tggcctttgt caactctgtg
     2041 gccaagccac ctcgtgacgt ccggaggagg caggaaaagt ttggaacggg aggagcagct
     2101 gtccctgaga aaatcaagat caagccagcc ccgtacccca tgggaagcag ccatgcttcc
     2161 gccagtagca tcagctttaa ccccagccct gaggagccgg cctatgatgg cccaagcacc
     2221 agcagtgccc acttggcacc agtggtcagc agcactgttt cctatgatcc taggaaaccc
     2281 actgtgaaga aaattgcccc aatgatggcc aagacaatta aagctttcaa gaacagattc
     2341 tcccgacgat aaactgagga cttgccttgg aaatggaatc tggggaggca ggaatacaag
     2401 gacagtgggg gttggggaat ggaattctac aggagactgg agtcttgctt tgtggatcct
     2461 tttggtctcc gagtcctgca gtctgcaggt gctgcccctg ggaacctgcg tgccacagcc
     2521 ccgcctccct gcctggagca cactttagaa ttctgaagat gtgaagcctc tgtctcactg
     2581 aggattttaa aggtcaatta tacttttgtt gttcattagc atctttgtaa actataagac
     2641 gtagttttaa ttaataaata ttgcccccag attgtattta tattatcccc caggtttgtt
     2701 tttgtttttt gtcctctacc acacatttag ccttttatct tccaggtcct tattaaaatc
     2761 agatgaaagc ctagtgaaag ccagtctcct gccccagctc agctctgtgt ggactctggt
     2821 ccagacagag gactgggcat ctccagagcc tgcacagtac ctgctgcacg tagggcaagg
     2881 aatgagcact agaccgcctg tccccaaggg agcctcagtg gggcgacagg gtgctcggcg
     2941 gactccacct caggccctcc ccactgttgc tgtgcattcc tgtgcaggtg catctctttc
     3001 ttactaactg gtatttatta agggaggtgc tctgtaggtc tggagccttt ccctcatcct
     3061 ttttgcgagt ccccaccttt ttgttttttt ttttttcttt gaggctcact agaggacgca
     3121 gaaccttggg agattgattt gcacagaact ccccacctcc cacttttaca atttccagtt
     3181 tctgattgaa aattttaggg tttctcccca ctgcccttcc ctatctttcc ttcccctcaa
     3241 caccatgaag gaaaaacaca cacggcaggg ctttttgtag ccctgaaggc aactttagac
     3301 atttaaaatc cagcacttta atctcttgtt ctctgtgaat cactatgaga agtgaatggt
     3361 tttaaaggct gtaatgctat gttggaaatt ggtttgtttt gccttttatt gaaaaggtaa
     3421 gatcatgtga ttggaagaac acaactgttg gcttgggaag aggactttgc tgctgaagtg
     3481 ttttctacct tctgagtgtg tttaaggcag gatttggagg gaaggaccag cttagggaga
     3541 gtgtctgagc cacagcgtca ggatggggga aaccacatgg gatccatcaa gttccagttg
     3601 aacaggagca agatcagaac ttaggagggc agtgtcagct cccttgttgg ctgtcaagga
     3661 acaccgatct agtagaaacc cacttggttg tgacccaggt agaggtagat gccatacatt
     3721 tgagatatgc gtccttaagg aacctgacaa gcagactgaa gggatggtaa gtgtgacagc
     3781 ctgataagtt ttctcaaagc ccaggataca gagccagtgt tttctgtaac tggagacctc
     3841 agttaggcca acttcgaatt ccagagcaac gtaggaagtc tattcagcag aaactcgaca
     3901 ttgttcagtg tgtattgctg tgcagggtgc ctattgtgac aggacacaaa tgttactatg
     3961 ttttaatttg ctatattttt gaatgggtaa agcattactt tacttctctt ggttacttgt
     4021 accaccattc cacccctatc cctagcctgc cccacaaatc taatattagg aagcctctta
     4081 actgaaacca aatgaacatt tgggtcaggt gccagatgtc tgctgcctag aatagctttt
     4141 tctaggtgtc taccaccttg aatttatctc ttaactgtgt gttcaagtct ttgtcattga
     4201 aactagtttt tcatatctta gattcagttg tgtatgattt aatgtccctt attaggagtc
     4261 tttaggcagg gagggaagaa aaaacagatt tgttcatagc aatgtcagta tccattttgg
     4321 cacataaaga tttttgatga gccctgtttg catagagcca gatgttttcc cctcccccaa
     4381 gagtatctac atcagggatg tgacttggtg cgaagagtca ggggaaagag gaaaaaccca
     4441 atttctaaat gacctccttg cccagcttac taaaatggct gcagagcaga cacaggatga
     4501 atttgaacct gacacaggat gaatttgaac ctttggtctc atttatggaa aaacttgtgc
     4561 aatttttttt ctgtgctaca ctacatacaa atcaccaaat tacaaattac ccttttgtga
     4621 tccttggtgt actgagcagt ttctttgggg ctttttcttt ctgggaagcg ggagggaaag
     4681 gagcaaggtg tcatcctgct cttcatttgt attttggtcc caaaatgtaa atacaatttt
     4741 ctatgttact tttttgtggt aactaccgag atgaatattt taattagata agttatatga
     4801 aaaggaaaat tccatgtcta aataaaaaac aaactcca
//
