LOCUS       NM_153702               4399 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens ELMO domain containing 2 (ELMOD2), mRNA.
ACCESSION   NM_153702
VERSION     NM_153702.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4399)
  AUTHORS   Schiavon,C.R., Turn,R.E., Newman,L.E. and Kahn,R.A.
  TITLE     ELMOD2 regulates mitochondrial fusion in a mitofusin-dependent
            manner, downstream of ARL2
  JOURNAL   Mol Biol Cell 30 (10), 1198-1213 (2019)
   PUBMED   30865555
  REMARK    GeneRIF: Results suggest that ELMOD2 is functioning as an effector
            downstream of ARL2 and upstream of the mitofusins to promote
            mitochondrial fusion. Data provide insights into the pathway by
            which mitochondrial fusion is regulated in the cell.
REFERENCE   2  (bases 1 to 4399)
  AUTHORS   Ivanova,A.A., East,M.P., Yi,S.L. and Kahn,R.A.
  TITLE     Characterization of recombinant ELMOD (cell engulfment and motility
            domain) proteins as GTPase-activating proteins (GAPs) for ARF
            family GTPases
  JOURNAL   J Biol Chem 289 (16), 11111-11121 (2014)
   PUBMED   24616099
  REMARK    GeneRIF: The non-opioid sigma-1 receptor (S1R) was identified as a
            novel effector of GAP activity of ELMOD1-3 proteins as its direct
            binding to either ELMOD1 or ELMOD2 resulted in loss of GAP
            activity.
REFERENCE   3  (bases 1 to 4399)
  AUTHORS   Pulkkinen,V., Bruce,S., Rintahaka,J., Hodgson,U., Laitinen,T.,
            Alenius,H., Kinnula,V.L., Myllarniemi,M., Matikainen,S. and Kere,J.
  TITLE     ELMOD2, a candidate gene for idiopathic pulmonary fibrosis,
            regulates antiviral responses
  JOURNAL   FASEB J 24 (4), 1167-1177 (2010)
   PUBMED   19966137
  REMARK    GeneRIF: TLR3 pathway is dependent on ELMOD2
REFERENCE   4  (bases 1 to 4399)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   5  (bases 1 to 4399)
  AUTHORS   Bowzard,J.B., Cheng,D., Peng,J. and Kahn,R.A.
  TITLE     ELMOD2 is an Arl2 GTPase-activating protein that also acts on Arfs
  JOURNAL   J Biol Chem 282 (24), 17568-17580 (2007)
   PUBMED   17452337
  REMARK    GeneRIF: Results describe the purification from bovine testis of an
            Arl2 GAP and its identity as ELMOD2, a protein with no previously
            described function.
REFERENCE   6  (bases 1 to 4399)
  AUTHORS   Hodgson,U., Pulkkinen,V., Dixon,M., Peyrard-Janvid,M., Rehn,M.,
            Lahermo,P., Ollikainen,V., Salmenkivi,K., Kinnula,V., Kere,J.,
            Tukiainen,P. and Laitinen,T.
  TITLE     ELMOD2 is a candidate gene for familial idiopathic pulmonary
            fibrosis
  JOURNAL   Am J Hum Genet 79 (1), 149-154 (2006)
   PUBMED   16773575
  REMARK    GeneRIF: results suggest ELMOD2 as a novel candidate gene for
            susceptibility in familial idiopathic pulmonary fibrosis
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK312800.1, BX648843.1,
            AC093671.3 and BX648349.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_153702.3.
            
            Summary: This gene encodes one of six engulfment and motility
            (ELMO) domain-containing proteins. This gene is thought to play a
            role in antiviral responses. Mutations in this gene may be involved
            in the cause of familial idiopathic pulmonary fibrosis. [provided
            by RefSeq, Sep 2010].
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX648349.1, SRR1803611.232066.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000323570.8/ ENSP00000326342.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1004              AK312800.1         5-1008
            1005-1424           BX648843.1         985-1404
            1425-2709           BX648843.1         1409-2693
            2710-2710           AC093671.3         181193-181193
            2711-3756           BX648843.1         2695-3740
            3757-4399           BX648349.1         3763-4405
FEATURES             Location/Qualifiers
     source          1..4399
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q31.1"
     gene            1..4399
                     /gene="ELMOD2"
                     /gene_synonym="9830169G11Rik"
                     /note="ELMO domain containing 2"
                     /db_xref="GeneID:255520"
                     /db_xref="HGNC:HGNC:28111"
                     /db_xref="MIM:610196"
     exon            1..113
                     /gene="ELMOD2"
                     /gene_synonym="9830169G11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            114..264
                     /gene="ELMOD2"
                     /gene_synonym="9830169G11Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             123..1004
                     /gene="ELMOD2"
                     /gene_synonym="9830169G11Rik"
                     /note="ELMO/CED-12 domain containing 2"
                     /codon_start=1
                     /product="ELMO domain-containing protein 2"
                     /protein_id="NP_714913.1"
                     /db_xref="CCDS:CCDS3752.1"
                     /db_xref="GeneID:255520"
                     /db_xref="HGNC:HGNC:28111"
                     /db_xref="MIM:610196"
                     /translation="MFISLWEFFYGHFFRFWMKWLLRQMTGKCELQRIFDTYVGAQRT
                     HRIENSLTYSKNKVLQKATHVVQSEVDKYVDDIMKEKNINPEKDASFKICMKMCLLQI
                     TGYKQLYLDVESVRKRPYDSDNLQHEELLMKLWNLLMPTKKLNARISKQWAEIGFQGD
                     DPKTDFRGMGILGLINLVYFSENYTSEAHQILSRSNHPKLGYSYAIVGINLTEMAYSL
                     LKSEALKFHLYNLVPGIPTMEHFHQFYCYLVYEFDKFWFEEEPESIMYFNLYREKFHE
                     KIKGLLLDCNVALTLKV"
     exon            265..293
                     /gene="ELMOD2"
                     /gene_synonym="9830169G11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            294..391
                     /gene="ELMOD2"
                     /gene_synonym="9830169G11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            392..521
                     /gene="ELMOD2"
                     /gene_synonym="9830169G11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            522..655
                     /gene="ELMOD2"
                     /gene_synonym="9830169G11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            656..724
                     /gene="ELMOD2"
                     /gene_synonym="9830169G11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            725..858
                     /gene="ELMOD2"
                     /gene_synonym="9830169G11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            859..4399
                     /gene="ELMOD2"
                     /gene_synonym="9830169G11Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4377..4382
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ELMOD2"
                     /gene_synonym="9830169G11Rik"
                     /note="hexamer: AATAAA"
     polyA_site      4399
                     /gene="ELMOD2"
                     /gene_synonym="9830169G11Rik"
                     /note="major polyA site"
ORIGIN      
        1 gacttccggg tcgcggtgct tgaagggagt gttccgtcgt ttccgttgcc ggctgtttgc
       61 agtggggaaa ccgaggcagc tcctgctccc cctagttctt ccgctcctgt gaggaaaaaa
      121 aaatgtttat ttctttgtgg gagttcttct atgggcactt ttttcgattt tggatgaaat
      181 ggctattacg acagatgact gggaagtgtg aattgcagcg aatatttgat acctatgtag
      241 gtgcacaaag gacacacagg atagaaaatt ccttgacata ctccaagaat aaggttttac
      301 agaaggcgac acatgttgtt cagagtgaag tggacaaata tgtagatgat attatgaagg
      361 aaaagaatat taaccctgag aaggatgcca gttttaaaat atgcatgaag atgtgcttac
      421 tgcagataac tggttataaa cagctgtatt tggatgtaga aagtgtgagg aaaaggccat
      481 atgattctga taacctacag catgaagagc tactcatgaa gctttggaat cttctaatgc
      541 ccacgaagaa gttaaacgct agaatctcca agcagtgggc tgaaattggt tttcagggtg
      601 atgatcccaa gacagacttc agaggcatgg gcatacttgg gttaatcaat cttgtgtatt
      661 tcagtgaaaa ttacactagt gaagctcatc agattctttc ccgttcaaat catccaaaat
      721 tagggtattc ttatgcaata gttggaatca atcttacaga gatggcttat agcttactga
      781 agagtgaagc tttgaagttt catctctata accttgttcc tggtatacca acaatggaac
      841 actttcatca gttttactgt tatcttgtct atgaatttga caagttttgg tttgaagaag
      901 aaccagaaag cattatgtat ttcaatttgt atagagagaa gtttcatgaa aagattaaag
      961 gacttttact ggattgtaat gtagcactta ctttaaaagt ataaatcatc cactgtatct
     1021 tctatttcta ccacattttg cacattcaac agaatttata tgttgtaata ggaattatct
     1081 gatcaattac actcttatat ataatttcct acaaaaatat ttcagaaatt ctatttaaga
     1141 aagctagtgg acaatcagtg tatgtttaca attgtttata cactgttctc caaaggtacc
     1201 ttatccttcc aaagatcccc tctgtagagt catgcgaact acagtttgga acttgggact
     1261 tagcccgttg gtgtaaaagt ataaatcagg tatttgtatt aaattgatta aaatgtgtaa
     1321 aatcaatttt cgtttttatg tgttataggg tcaagttggt atctttttca aagctcttta
     1381 agattttttt ggtttttagt ttggaaatgg ctgtttttaa ttttgtctga tttttatttc
     1441 taggttaatt aacagcaagt gtttctttat ggttttcttt gtttgcatct taattacatg
     1501 tcataacgtt gcttcattag tagcaaatag agcagagata cagcagagag aataaagaat
     1561 tagggcctcc ttttgggttt ctgtgattat tgagcataac tgatgagaga atgacagtat
     1621 tggtgactag cttttttgtt tttaaataac acactttaaa atgccacagt gttatttgaa
     1681 agcttaaagg cattttctca tcttcagtat ttgcttttta tcagttgtag aaaagaacct
     1741 tagtgttttc ttctctacct atgtatgctt atgaaaccgc tctacctaca tatgaaactt
     1801 ctctacctat gtatgtttac gaaaagagat gtatttgcca agaaaatctt gattatataa
     1861 aagacaaaaa gattataaaa gacagtttct gtttaagtaa aactgtcttt gaaacttaag
     1921 aaagcttaag ttttaaaaaa atctcagtta aacatcattg gtttatttga cttactgtta
     1981 actcttgctt ctctttgact ccatggtgtt tttagataac catgtatgaa ctttatgtta
     2041 atggtttgtg ggatactaaa atagcttgaa gatgacttga tgactgtgca ttttatatag
     2101 ttttattctc ctaaaatctc aggagggcag caagtgctgt caacgattat atagtgatga
     2161 gatttttatg ggaatgattt cttcttggtg cgttttacac atttgtactg atagcaaaac
     2221 taaagtttaa agcagcaaag tttaagttct ccttaaatcc tacagaaacc aaccttttaa
     2281 ggacataatt tcatctaaaa catgacgata tttagcacac cttttaatgt gggtatatat
     2341 caagtgttta aggactggct agtatgtgat agagcaagac ctgagacttt ataagtattt
     2401 gctcgtgtct gttgacagac ctctttcttt caaacttgtt agaagagtgg taagacatat
     2461 ccaattggaa aataagatgc agtgttgtat agcacataca tttaaagtgc ttgcgttaaa
     2521 attagtttct caataagata aaattatttt aaaaatttgg ttcactttat tacaatagtg
     2581 gcaatttagc ttttcagtat tacaggaatt taaaaattgg tttcttgtag gggacatctc
     2641 aactttggga atatcttcac ttaattttta aaaaatattt tcatgcttta ttgtccagct
     2701 atacaatatg tcgcaaaatc ctgacaagtt cattgtatta aggtattaac tattacatgg
     2761 aaagcaattc tgttcatctt ttgatgtttg tgttgaaaat gcttatcttt gtgttttgat
     2821 cttccaacag ctgagagctt gaactgattt aaacatttgt caatatactt aagaatgctt
     2881 taagtaaaga aggggaaaat tttaagtaag ttttttccct tctaggaaga aaaactatga
     2941 tgatgttaag aaaatgtcat tatagagctt gctcaataat atgttcttta aatccacctc
     3001 catttgtaca ttataggtat cattctgttt ttgcttaaaa taatctgcaa ccatttcaga
     3061 tagttttaca gcaaattgat ctaaaagcca ctaataaatt ctagggtttg agtctagaag
     3121 ccaagcaaac tgtcaccaat gtcagttgta aattagaatg caacatgagg cttcagactc
     3181 atgacaatga tatacatgaa aacaaaaata taattgtgtc taccttccta ctttcccttt
     3241 tgacatatgt agttggaatt ttacatagtc ttaaaatcca tatttagaat cttacctgtt
     3301 tctataataa ttagtaaaat gccaaagtag tgatagaata ttgtggcatt gaagtagccg
     3361 aaaaattgtt agttttagca tcaaaaaagt aaatagatgt tgaaatgaat ttttgtatgt
     3421 gccaggttga agagagtgtg ccagtgacag gaagtagtct aaaaaattaa cagttatggt
     3481 tttaatagga tctgaaagac aatctttaaa gaaatgggag aaattggggg tatcagtgaa
     3541 cctataccaa cctctctttg tacataaata tggtgatgta gctagatata aaaatcagtg
     3601 tcttactggc accatttaca gtttagaaaa caatcttttt cttaaaaatg cccatctgat
     3661 ttctattttt aggagctact tggatttgta tgtatttttt ctacgtgaaa atatatgtac
     3721 tcttcacttt tgttccagta ctataattgc tcatgcactc tttctcccct ttgagaacat
     3781 tcagtgaaat acaacttcat caaagatttg ctcaaaggag aagaatcgca tgagtgtgaa
     3841 aagtagatgc tcgtagccag aacagaaaag gttacacatg atcatggcac agaagatagg
     3901 aggtttgact tggtgggcca taatgtttat tatccttttt gaaataacag ggaccagcag
     3961 cagttttctc aggataaatg ctctacccca cttctctatg aacaggtgtg gggaggctta
     4021 ctttccattt tcatatttat acacctctct acaaaagcaa tttttaatga aggttagtgg
     4081 aattgttaaa aatctgagag gaatgatgac tggaggtgtt tggggttttt ttctgtattc
     4141 attttttaat gagaaaagtt ttaaatgtag tacaggttag acccaactac taccttacta
     4201 ttataggacg attctatgtt tctgttaaag tattcaagta gctttctctg ggggaaaaag
     4261 taccacttgg acacttaaag gaattgggat ttttgtctac tttggataag gcagttgact
     4321 tcttaagtaa aagcaatagt gtaaaatgtc attttgtttg gaatgttaag tgagcaaata
     4381 aaaaacatgt tgaaattgt
//
