LOCUS       NM_024712               2486 bp    mRNA    linear   PRI 27-JUL-2024
DEFINITION  Homo sapiens engulfment and cell motility 3 (ELMO3), mRNA.
ACCESSION   NM_024712
VERSION     NM_024712.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2486)
  AUTHORS   Kotowski,U., Kadletz,L., Schneider,S., Oberndorfer,F., Erovic,B.M.,
            Grasl,M.C., Lill,C. and Heiduschka,G.
  TITLE     ELMO3 - a Negative Prognostic Marker in Minor Salivary Gland
            Carcinoma
  JOURNAL   Pathol Oncol Res 25 (2), 585-591 (2019)
   PUBMED   30374620
  REMARK    GeneRIF: ELMO3 might serve as a clinical prognostic marker of
            patients with minor salivary gland carcinoma
REFERENCE   2  (bases 1 to 2486)
  AUTHORS   Hu,Y., Yu,Q., Zhong,Y., Shen,W., Zhou,X., Liu,X., Xu,M., Zhou,N.,
            Min,W. and Gao,D.
  TITLE     Silencing ELMO3 Inhibits the Growth, Invasion, and Metastasis of
            Gastric Cancer
  JOURNAL   Biomed Res Int 2018, 3764032 (2018)
   PUBMED   30345300
  REMARK    GeneRIF: the results indicate that ELMO3 participates in the
            processes of cell growth, invasion, and migration, and ELMO3 is
            expected to be a potential diagnostic and prognostic marker for
            gastric cancer.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2486)
  AUTHORS   Kadletz,L., Heiduschka,G., Wiebringhaus,R., Gurnhofer,E.,
            Kotowski,U., Haymerle,G., Brunner,M., Barry,C. and Kenner,L.
  TITLE     ELMO3 expression indicates a poor prognosis in head and neck
            squamous cell carcinoma - a short report
  JOURNAL   Cell Oncol (Dordr) 40 (2), 193-198 (2017)
   PUBMED   28039609
  REMARK    GeneRIF: The purpose of this study was to asses ELMO3 expression in
            postoperatively irradiated head and neck squamous cell carcinoma
            patients.
REFERENCE   4  (bases 1 to 2486)
  AUTHORS   Peng,H.Y., Yu,Q.F., Shen,W., Guo,C.M., Li,Z., Zhou,X.Y., Zhou,N.J.,
            Min,W.P. and Gao,D.
  TITLE     Knockdown of ELMO3 Suppresses Growth, Invasion and Metastasis of
            Colorectal Cancer
  JOURNAL   Int J Mol Sci 17 (12), 2119 (2016)
   PUBMED   27999268
  REMARK    GeneRIF: the silencing of ELMO3 inhibited cell proliferation,
            invasion, metastasis, and F-actin polymerization, and induced Gap 1
            (G1) phase cell cycle arrest, demonstrating that ELMO3 is involved
            in the processes of growth, invasion and metastasis of Colorectal
            Cancer
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2486)
  AUTHORS   Fan,W., Yang,H., Xue,H., Sun,Y. and Zhang,J.
  TITLE     ELMO3 is a novel biomarker for diagnosis and prognosis of non-small
            cell lung cancer
  JOURNAL   Int J Clin Exp Pathol 8 (5), 5503-5508 (2015)
   PUBMED   26191257
  REMARK    GeneRIF: The over-expression of ELMO3 was a potential diagnostic
            and prognostic marker for non-small cell lung cancer.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2486)
  AUTHORS   Hamoud,N., Tran,V., Croteau,L.P., Kania,A. and Cote,J.F.
  TITLE     G-protein coupled receptor BAI3 promotes myoblast fusion in
            vertebrates
  JOURNAL   Proc Natl Acad Sci U S A 111 (10), 3745-3750 (2014)
   PUBMED   24567399
REFERENCE   7  (bases 1 to 2486)
  AUTHORS   Coskun,M., Boyd,M., Olsen,J. and Troelsen,J.T.
  TITLE     Control of intestinal promoter activity of the cellular migratory
            regulator gene ELMO3 by CDX2 and SP1
  JOURNAL   J Cell Biochem 109 (6), 1118-1128 (2010)
   PUBMED   20127720
  REMARK    GeneRIF: The present study reports the first characterization of
            the ELMO3 promoter and suggests a significant role of CDX2 in the
            basal transcriptional regulation of the intestine-specific
            expression of ELMO3, possibly through interaction with SP1.
REFERENCE   8  (bases 1 to 2486)
  AUTHORS   Gumienny,T.L., Brugnera,E., Tosello-Trampont,A.C., Kinchen,J.M.,
            Haney,L.B., Nishiwaki,K., Walk,S.F., Nemergut,M.E., Macara,I.G.,
            Francis,R., Schedl,T., Qin,Y., Van Aelst,L., Hengartner,M.O. and
            Ravichandran,K.S.
  TITLE     CED-12/ELMO, a novel member of the CrkII/Dock180/Rac pathway, is
            required for phagocytosis and cell migration
  JOURNAL   Cell 107 (1), 27-41 (2001)
   PUBMED   11595183
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA872517.1, AC040160.4 and
            BC034410.1.
            
            On May 17, 2019 this sequence version replaced NM_024712.4.
            
            Summary: The protein encoded by this gene is similar to a C.
            elegans protein that functions in phagocytosis of apoptotic cells
            and in cell migration. Other members of this small family of
            engulfment and cell motility (ELMO) proteins have been shown to
            interact with the dedicator of cyto-kinesis 1 protein to promote
            phagocytosis and effect cell shape changes. [provided by RefSeq,
            Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK300976.1, DRR138508.42197.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            MANE Ensembl match               :: ENST00000393997.8/
                                                ENSP00000377566.3
            RefSeq Select criteria           :: based on conservation,
                                                expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-362               DA872517.1         21-382
            363-388             AC040160.4         139068-139093       c
            389-394             AC040160.4         138868-138873       c
            395-2486            BC034410.1         13-2104
FEATURES             Location/Qualifiers
     source          1..2486
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q22.1"
     gene            1..2486
                     /gene="ELMO3"
                     /gene_synonym="CED-12; CED12; ELMO-3"
                     /note="engulfment and cell motility 3"
                     /db_xref="GeneID:79767"
                     /db_xref="HGNC:HGNC:17289"
                     /db_xref="MIM:606422"
     exon            1..274
                     /gene="ELMO3"
                     /gene_synonym="CED-12; CED12; ELMO-3"
                     /inference="alignment:Splign:2.1.0"
     CDS             197..2359
                     /gene="ELMO3"
                     /gene_synonym="CED-12; CED12; ELMO-3"
                     /note="ced-12 homolog 3"
                     /codon_start=1
                     /product="engulfment and cell motility protein 3"
                     /protein_id="NP_078988.3"
                     /db_xref="CCDS:CCDS10833.3"
                     /db_xref="GeneID:79767"
                     /db_xref="HGNC:HGNC:17289"
                     /db_xref="MIM:606422"
                     /translation="MAPPRNVVKIAIKMRDAIPQLIQLDQAKPLAAVLKEVCDAWSLT
                     HSERYALQFADGHRRYITENNRAEIKNGSILCLSTAPDLEAEQLLGGLQSNSPEGRRE
                     ALRRLVPLASDMIFAREVISRNGLQILGTIIEDGDDLGEVLALSLRAFSELMEHGVVS
                     WETLSIPFVRKVVCYVNMNLMDASVPPLALGLLESVTLSSPALGQLVKSEVPLDRLLV
                     HLQVMNQQLQTKAMALLTALLQGASPVERKHMLDYLWQRNLRQFIYKNIIHSAAPMGD
                     EMAHHLYVLQALMLGLLEPRMRTPLDPYSQEQREQLQVLRQAAFEVEGESSGAGLSAD
                     RRRSLCAREFRKLGFSNSNPAQDLERVPPGLLALDNMLYFSRNAPSAYSRFVLENSSR
                     EDKHECPFARGSIQLTVLLCELLRVGEPCSETAQDFSPMFFGQDQSFHELFCVGIQLL
                     NKTWKEMRATQEDFDKVMQVVREQLARTLALKPTSLELFRTKVNALTYGEVLRLRQTE
                     RLHQEGTLAPPILELREKLKPELMGLIRQQRLLRLCEGTLFRKISSRRRQDKLWFCCL
                     SPNHKLLQYGDMEEGASPPTLESLPEQLPVADMRALLTGKDCPHVREKGSGKQNKDLY
                     ELAFSISYDRGEEEAYLNFIAPSKREFYLWTDGLSALLGSPMGSEQTRLDLEQLLTME
                     TKLRLLELENVPIPERPPPVPPPPTNFNFCYDCSIAEP"
     exon            275..315
                     /gene="ELMO3"
                     /gene_synonym="CED-12; CED12; ELMO-3"
                     /inference="alignment:Splign:2.1.0"
     exon            316..388
                     /gene="ELMO3"
                     /gene_synonym="CED-12; CED12; ELMO-3"
                     /inference="alignment:Splign:2.1.0"
     exon            389..439
                     /gene="ELMO3"
                     /gene_synonym="CED-12; CED12; ELMO-3"
                     /inference="alignment:Splign:2.1.0"
     exon            440..609
                     /gene="ELMO3"
                     /gene_synonym="CED-12; CED12; ELMO-3"
                     /inference="alignment:Splign:2.1.0"
     exon            610..709
                     /gene="ELMO3"
                     /gene_synonym="CED-12; CED12; ELMO-3"
                     /inference="alignment:Splign:2.1.0"
     exon            710..861
                     /gene="ELMO3"
                     /gene_synonym="CED-12; CED12; ELMO-3"
                     /inference="alignment:Splign:2.1.0"
     exon            862..940
                     /gene="ELMO3"
                     /gene_synonym="CED-12; CED12; ELMO-3"
                     /inference="alignment:Splign:2.1.0"
     exon            941..991
                     /gene="ELMO3"
                     /gene_synonym="CED-12; CED12; ELMO-3"
                     /inference="alignment:Splign:2.1.0"
     exon            992..1114
                     /gene="ELMO3"
                     /gene_synonym="CED-12; CED12; ELMO-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1115..1246
                     /gene="ELMO3"
                     /gene_synonym="CED-12; CED12; ELMO-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1247..1348
                     /gene="ELMO3"
                     /gene_synonym="CED-12; CED12; ELMO-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1349..1457
                     /gene="ELMO3"
                     /gene_synonym="CED-12; CED12; ELMO-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1458..1594
                     /gene="ELMO3"
                     /gene_synonym="CED-12; CED12; ELMO-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1595..1758
                     /gene="ELMO3"
                     /gene_synonym="CED-12; CED12; ELMO-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1759..1871
                     /gene="ELMO3"
                     /gene_synonym="CED-12; CED12; ELMO-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1872..1976
                     /gene="ELMO3"
                     /gene_synonym="CED-12; CED12; ELMO-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1977..2059
                     /gene="ELMO3"
                     /gene_synonym="CED-12; CED12; ELMO-3"
                     /inference="alignment:Splign:2.1.0"
     exon            2060..2146
                     /gene="ELMO3"
                     /gene_synonym="CED-12; CED12; ELMO-3"
                     /inference="alignment:Splign:2.1.0"
     exon            2147..2486
                     /gene="ELMO3"
                     /gene_synonym="CED-12; CED12; ELMO-3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2462..2467
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ELMO3"
                     /gene_synonym="CED-12; CED12; ELMO-3"
                     /note="hexamer: AATAAA"
     polyA_site      2486
                     /gene="ELMO3"
                     /gene_synonym="CED-12; CED12; ELMO-3"
                     /note="major polyA site"
ORIGIN      
        1 ggaactaacc tcggctccct tgggaaggcc gcgttgcatg gccaggagca gcagtctggg
       61 ccgcgagtgc gggacaccga ggtcaggtct cggaaaggga ggacctcctc gtccccaggg
      121 gccccaggcc aggtgcaccc ttggccgcag gtgcacggtc tccggaaagt gcaggcgccc
      181 acgtcccagc tggaccatgg cgcctccgcg gaacgtggtg aagattgcca tcaagatgcg
      241 tgacgccatc ccgcagctca tccagctgga ccaggcgaag cccctggccg ctgtgctgaa
      301 ggaggtgtgc gacgcgtgga gcctgacgca ctctgagcgt tacgccctgc agtttgcgga
      361 tgggcaccgg agatacatca ccgagaataa ccgcgcggag atcaagaatg gcagcatcct
      421 gtgcctcagc acggccccag accttgaggc tgagcagctc ttgggtgggc tgcagagtaa
      481 cagtcctgaa gggcgccggg aagccctgag gcgccttgtt ccgctggcct cggacatgat
      541 ctttgccagg gaggtcatca gccgtaatgg gctccagata ctaggcacca tcattgaaga
      601 tggggacgac ctaggagagg tgctggccct cagcctgagg gccttctcag agctcatgga
      661 gcacggcgtg gtgtcctggg agactctgag catccccttt gtgaggaagg tggtgtgcta
      721 cgtgaacatg aacctcatgg atgcctccgt gcctcccctg gcccttgggc tgctggagag
      781 tgtgaccttg agcagcccag ccctgggcca gctggtcaag agcgaggtgc ccctggatag
      841 gctgctggtg cacctacagg tgatgaacca gcagctgcaa accaaggcca tggccctgct
      901 gacagccttg ctgcaggggg ccagccctgt ggaacgcaag cacatgcttg actatctttg
      961 gcagaggaac cttcgccagt tcatctataa gaacatcatc cacagtgcag caccaatggg
     1021 cgacgagatg gctcatcacc tgtacgtact gcaggctctc atgctggggc tgctggagcc
     1081 gcgcatgcgg acgcccctgg acccctacag ccaggagcag cgggagcagc tgcaggtcct
     1141 acgccaggct gccttcgagg tggaggggga gtcctcgggt gccgggctaa gtgctgaccg
     1201 tcgccgttcc ctctgtgccc gagagttccg caaactgggc ttttctaaca gcaacccagc
     1261 acaggacctg gagcgcgtgc cccccggtct gctggccctg gacaacatgt tgtacttctc
     1321 cagaaacgcg cccagcgcgt acagccggtt tgtgttggag aacagcagcc gcgaggacaa
     1381 gcacgagtgc ccctttgccc ggggcagcat ccagctgacg gtgctgctgt gtgagctgct
     1441 ccgtgttggg gagccctgct ctgagacagc ccaggacttc tcacccatgt tcttcggcca
     1501 agaccagagc ttccacgagc tcttctgtgt gggcatccag ctgttgaata agacctggaa
     1561 ggagatgcgg gctacacagg aggacttcga caaggtcatg caggtggtgc gggagcagct
     1621 ggcccgcact ctggccctga agcccacttc cctggagctc ttccgaacca aggtgaatgc
     1681 gctcacttat ggggaggtgc tgcggctgcg gcagactgaa cggctgcacc aggagggcac
     1741 actggctccc cctatactgg agctgcggga gaagctgaag ccagagctca tgggcctgat
     1801 ccgccagcag cgcttgctcc gcctctgtga ggggacgctc ttccgcaaga tcagcagccg
     1861 gcggcgccag gataagctgt ggttctgctg cctgtccccc aaccacaagc tgctgcagta
     1921 cggagacatg gaggagggcg ccagcccgcc taccctggag agtctgcccg agcaactccc
     1981 tgtggccgac atgagggcac tcctgacagg caaggactgc ccccatgtcc gggagaaggg
     2041 ctccgggaag cagaacaagg acctctatga gttggccttc tcaatcagct atgaccgtgg
     2101 ggaggaggaa gcgtacctca acttcattgc cccctccaag cgggagttct acctgtggac
     2161 agatgggctc agtgccttgc tgggcagtcc catgggcagc gagcagacac ggctggacct
     2221 ggagcagctg ctgaccatgg agaccaagct gcgtctgctg gagctggaga acgtgcccat
     2281 ccccgagcgg ccaccccctg tgcccccacc ccccaccaac ttcaacttct gctatgactg
     2341 cagcatcgct gaaccttgac agtgtggctg gccatgggcc acagctgcgg ccactgcagc
     2401 agccatgaag ggcagtgggt agaggagtgc aggcaccctg accagcagag attgctgcag
     2461 aaataaagtc tgcttggctc ttggga
//
