LOCUS       NM_133171               3666 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens engulfment and cell motility 2 (ELMO2), transcript
            variant 1, mRNA.
ACCESSION   NM_133171
VERSION     NM_133171.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3666)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 3666)
  AUTHORS   Liu,W., Gan,C.Y., Wang,W., Liao,L.D., Li,C.Q., Xu,L.Y. and Li,E.M.
  TITLE     Identification of lncRNA-associated differential subnetworks in
            oesophageal squamous cell carcinoma by differential co-expression
            analysis
  JOURNAL   J Cell Mol Med 24 (8), 4804-4818 (2020)
   PUBMED   32164040
  REMARK    GeneRIF: Identification of lncRNA-associated differential
            subnetworks in oesophageal squamous cell carcinoma by differential
            co-expression analysis.
REFERENCE   3  (bases 1 to 3666)
  AUTHORS   Vargel,I., Calis,M., Canter,H.I. and Cil,B.E.
  TITLE     Clinical and Molecular Study of ELMO-2-Related Massive Intraosseous
            Vascular Malformations: Lessons Learned From 25 Years of Follow-up
  JOURNAL   Ann Plast Surg 83 (3), 293-299 (2019)
   PUBMED   30882408
  REMARK    GeneRIF: Clinical and Molecular Study of ELMO-2-Related Massive
            Intraosseous Vascular Malformations: Lessons Learned From 25 Years
            of Follow-up.
REFERENCE   4  (bases 1 to 3666)
  AUTHORS   Weng,Z., Situ,C., Lin,L., Wu,Z., Zhu,J. and Zhang,R.
  TITLE     Structure of BAI1/ELMO2 complex reveals an action mechanism of
            adhesion GPCRs via ELMO family scaffolds
  JOURNAL   Nat Commun 10 (1), 51 (2019)
   PUBMED   30604775
  REMARK    GeneRIF: Study demonstrated that an evolutionarily conserved
            fragment in the C-terminal cytoplasmic tail of BAI-aGPCRs is
            specifically recognized by the RBD-ARR-ELMO (RAE) supramodule of
            the ELMO family scaffolds. The crystal structures of ELMO2-RAE and
            its complex with BAI1 uncover the molecular basis of BAI/ELMO
            interactions.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3666)
  AUTHORS   Peotter,J.L., Phillips,J., Tong,T., Dimeo,K., Gonzalez,J.M. Jr. and
            Peters,D.M.
  TITLE     Involvement of Tiam1, RhoG and ELMO2/ILK in Rac1-mediated
            phagocytosis in human trabecular meshwork cells
  JOURNAL   Exp Cell Res 347 (2), 301-311 (2016)
   PUBMED   27539661
  REMARK    GeneRIF: These data suggest a novel link between Tiam1 and RhoG/ILK
            /ELMO2 pathway as upstream effectors of the Rac1-mediated
            phagocytic process in trabecular meshwork cells.
REFERENCE   6  (bases 1 to 3666)
  AUTHORS   Rush,J., Moritz,A., Lee,K.A., Guo,A., Goss,V.L., Spek,E.J.,
            Zhang,H., Zha,X.M., Polakiewicz,R.D. and Comb,M.J.
  TITLE     Immunoaffinity profiling of tyrosine phosphorylation in cancer
            cells
  JOURNAL   Nat Biotechnol 23 (1), 94-101 (2005)
   PUBMED   15592455
REFERENCE   7  (bases 1 to 3666)
  AUTHORS   Katoh,H. and Negishi,M.
  TITLE     RhoG activates Rac1 by direct interaction with the Dock180-binding
            protein Elmo
  JOURNAL   Nature 424 (6947), 461-464 (2003)
   PUBMED   12879077
REFERENCE   8  (bases 1 to 3666)
  AUTHORS   Deloukas,P., Matthews,L.H., Ashurst,J., Burton,J., Gilbert,J.G.,
            Jones,M., Stavrides,G., Almeida,J.P., Babbage,A.K., Bagguley,C.L.,
            Bailey,J., Barlow,K.F., Bates,K.N., Beard,L.M., Beare,D.M.,
            Beasley,O.P., Bird,C.P., Blakey,S.E., Bridgeman,A.M., Brown,A.J.,
            Buck,D., Burrill,W., Butler,A.P., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M., Clark,G., Clark,L.N., Clark,S.Y.,
            Clee,C.M., Clegg,S., Cobley,V.E., Collier,R.E., Connor,R.,
            Corby,N.R., Coulson,A., Coville,G.J., Deadman,R., Dhami,P.,
            Dunn,M., Ellington,A.G., Frankland,J.A., Fraser,A., French,L.,
            Garner,P., Grafham,D.V., Griffiths,C., Griffiths,M.N., Gwilliam,R.,
            Hall,R.E., Hammond,S., Harley,J.L., Heath,P.D., Ho,S., Holden,J.L.,
            Howden,P.J., Huckle,E., Hunt,A.R., Hunt,S.E., Jekosch,K.,
            Johnson,C.M., Johnson,D., Kay,M.P., Kimberley,A.M., King,A.,
            Knights,A., Laird,G.K., Lawlor,S., Lehvaslaiho,M.H., Leversha,M.,
            Lloyd,C., Lloyd,D.M., Lovell,J.D., Marsh,V.L., Martin,S.L.,
            McConnachie,L.J., McLay,K., McMurray,A.A., Milne,S., Mistry,D.,
            Moore,M.J., Mullikin,J.C., Nickerson,T., Oliver,K., Parker,A.,
            Patel,R., Pearce,T.A., Peck,A.I., Phillimore,B.J.,
            Prathalingam,S.R., Plumb,R.W., Ramsay,H., Rice,C.M., Ross,M.T.,
            Scott,C.E., Sehra,H.K., Shownkeen,R., Sims,S., Skuce,C.D.,
            Smith,M.L., Soderlund,C., Steward,C.A., Sulston,J.E., Swann,M.,
            Sycamore,N., Taylor,R., Tee,L., Thomas,D.W., Thorpe,A., Tracey,A.,
            Tromans,A.C., Vaudin,M., Wall,M., Wallis,J.M., Whitehead,S.L.,
            Whittaker,P., Willey,D.L., Williams,L., Williams,S.A., Wilming,L.,
            Wray,P.W., Hubbard,T., Durbin,R.M., Bentley,D.R., Beck,S. and
            Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 20
  JOURNAL   Nature 414 (6866), 865-871 (2001)
   PUBMED   11780052
REFERENCE   9  (bases 1 to 3666)
  AUTHORS   Gumienny,T.L., Brugnera,E., Tosello-Trampont,A.C., Kinchen,J.M.,
            Haney,L.B., Nishiwaki,K., Walk,S.F., Nemergut,M.E., Macara,I.G.,
            Francis,R., Schedl,T., Qin,Y., Van Aelst,L., Hengartner,M.O. and
            Ravichandran,K.S.
  TITLE     CED-12/ELMO, a novel member of the CrkII/Dock180/Rac pathway, is
            required for phagocytosis and cell migration
  JOURNAL   Cell 107 (1), 27-41 (2001)
   PUBMED   11595183
REFERENCE   10 (bases 1 to 3666)
  AUTHORS   Zhou,Z., Caron,E., Hartwieg,E., Hall,A. and Horvitz,H.R.
  TITLE     The C. elegans PH domain protein CED-12 regulates cytoskeletal
            reorganization via a Rho/Rac GTPase signaling pathway
  JOURNAL   Dev Cell 1 (4), 477-489 (2001)
   PUBMED   11703939
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA224400.1, AB058737.1,
            AL133227.15 and CA444293.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_133171.4.
            
            Summary: The protein encoded by this gene interacts with the
            dedicator of cyto-kinesis 1 protein. Similarity to a C. elegans
            protein suggests that this protein may function in phagocytosis of
            apoptotic cells and in cell migration. Alternative splicing results
            in multiple transcript variants. [provided by RefSeq, Dec 2015].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (a). Variants 1 and 2 encode the same isoform.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.33490.1,
                                           SRR1803614.60512.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000290246.11/ ENSP00000290246.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-115               DA224400.1         438-552
            116-2172            AB058737.1         63-2119
            2173-2173           AL133227.15        49352-49352         c
            2174-3661           AB058737.1         2121-3608
            3662-3666           CA444293.1         24-28               c
FEATURES             Location/Qualifiers
     source          1..3666
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q13.12"
     gene            1..3666
                     /gene="ELMO2"
                     /gene_synonym="CED-12; Ced-12A; CED12; ELMO-2; VMPI"
                     /note="engulfment and cell motility 2"
                     /db_xref="GeneID:63916"
                     /db_xref="HGNC:HGNC:17233"
                     /db_xref="MIM:606421"
     exon            1..68
                     /gene="ELMO2"
                     /gene_synonym="CED-12; Ced-12A; CED12; ELMO-2; VMPI"
                     /inference="alignment:Splign:2.1.0"
     exon            69..143
                     /gene="ELMO2"
                     /gene_synonym="CED-12; Ced-12A; CED12; ELMO-2; VMPI"
                     /inference="alignment:Splign:2.1.0"
     exon            144..271
                     /gene="ELMO2"
                     /gene_synonym="CED-12; Ced-12A; CED12; ELMO-2; VMPI"
                     /inference="alignment:Splign:2.1.0"
     CDS             194..2356
                     /gene="ELMO2"
                     /gene_synonym="CED-12; Ced-12A; CED12; ELMO-2; VMPI"
                     /note="isoform a is encoded by transcript variant 1; PH
                     domain protein CED12A; engulfment and cell motility
                     protein 2; ced-12 homolog 2; protein ced-12 homolog A"
                     /codon_start=1
                     /product="engulfment and cell motility protein 2 isoform
                     a"
                     /protein_id="NP_573403.1"
                     /db_xref="CCDS:CCDS13398.1"
                     /db_xref="GeneID:63916"
                     /db_xref="HGNC:HGNC:17233"
                     /db_xref="MIM:606421"
                     /translation="MPPPSDIVKVAIEWPGANAQLLEIDQKRPLASIIKEVCDGWSLP
                     NPEYYTLRYADGPQLYITEQTRSDIKNGTILQLAISPSRAARQLMERTQSSNMETRLD
                     AMKELAKLSADVTFATEFINMDGIIVLTRLVESGTKLLSHYSEMLAFTLTAFLELMDH
                     GIVSWDMVSITFIKQIAGYVSQPMVDVSILQRSLAILESMVLNSQSLYQKIAEEITVG
                     QLISHLQVSNQEIQTYAIALINALFLKAPEDKRQDMANAFAQKHLRSIILNHVIRGNR
                     PIKTEMAHQLYVLQVLTFNLLEERMMTKMDPNDQAQRDIIFELRRIAFDAESDPSNAP
                     GSGTEKRKAMYTKDYKMLGFTNHINPAMDFTQTPPGMLALDNMLYLAKVHQDTYIRIV
                     LENSSREDKHECPFGRSAIELTKMLCEILQVGELPNEGRNDYHPMFFTHDRAFEELFG
                     ICIQLLNKTWKEMRATAEDFNKVMQVVREQITRALPSKPNSLDQFKSKLRSLSYSEIL
                     RLRQSERMSQDDFQSPPIVELREKIQPEILELIKQQRLNRLCEGSSFRKIGNRRRQER
                     FWYCRLALNHKVLHYGDLDDNPQGEVTFESLQEKIPVADIKAIVTGKDCPHMKEKSAL
                     KQNKEVLELAFSILYDPDETLNFIAPNKYEYCIWIDGLSALLGKDMSSELTKSDLDTL
                     LSMEMKLRLLDLENIQIPEAPPPIPKEPSSYDFVYHYG"
     exon            272..312
                     /gene="ELMO2"
                     /gene_synonym="CED-12; Ced-12A; CED12; ELMO-2; VMPI"
                     /inference="alignment:Splign:2.1.0"
     exon            313..385
                     /gene="ELMO2"
                     /gene_synonym="CED-12; Ced-12A; CED12; ELMO-2; VMPI"
                     /inference="alignment:Splign:2.1.0"
     exon            386..436
                     /gene="ELMO2"
                     /gene_synonym="CED-12; Ced-12A; CED12; ELMO-2; VMPI"
                     /inference="alignment:Splign:2.1.0"
     exon            437..618
                     /gene="ELMO2"
                     /gene_synonym="CED-12; Ced-12A; CED12; ELMO-2; VMPI"
                     /inference="alignment:Splign:2.1.0"
     exon            619..718
                     /gene="ELMO2"
                     /gene_synonym="CED-12; Ced-12A; CED12; ELMO-2; VMPI"
                     /inference="alignment:Splign:2.1.0"
     exon            719..870
                     /gene="ELMO2"
                     /gene_synonym="CED-12; Ced-12A; CED12; ELMO-2; VMPI"
                     /inference="alignment:Splign:2.1.0"
     exon            871..949
                     /gene="ELMO2"
                     /gene_synonym="CED-12; Ced-12A; CED12; ELMO-2; VMPI"
                     /inference="alignment:Splign:2.1.0"
     exon            950..1000
                     /gene="ELMO2"
                     /gene_synonym="CED-12; Ced-12A; CED12; ELMO-2; VMPI"
                     /inference="alignment:Splign:2.1.0"
     exon            1001..1123
                     /gene="ELMO2"
                     /gene_synonym="CED-12; Ced-12A; CED12; ELMO-2; VMPI"
                     /inference="alignment:Splign:2.1.0"
     exon            1124..1258
                     /gene="ELMO2"
                     /gene_synonym="CED-12; Ced-12A; CED12; ELMO-2; VMPI"
                     /inference="alignment:Splign:2.1.0"
     exon            1259..1363
                     /gene="ELMO2"
                     /gene_synonym="CED-12; Ced-12A; CED12; ELMO-2; VMPI"
                     /inference="alignment:Splign:2.1.0"
     exon            1364..1472
                     /gene="ELMO2"
                     /gene_synonym="CED-12; Ced-12A; CED12; ELMO-2; VMPI"
                     /inference="alignment:Splign:2.1.0"
     exon            1473..1609
                     /gene="ELMO2"
                     /gene_synonym="CED-12; Ced-12A; CED12; ELMO-2; VMPI"
                     /inference="alignment:Splign:2.1.0"
     exon            1610..1773
                     /gene="ELMO2"
                     /gene_synonym="CED-12; Ced-12A; CED12; ELMO-2; VMPI"
                     /inference="alignment:Splign:2.1.0"
     exon            1774..1886
                     /gene="ELMO2"
                     /gene_synonym="CED-12; Ced-12A; CED12; ELMO-2; VMPI"
                     /inference="alignment:Splign:2.1.0"
     exon            1887..1994
                     /gene="ELMO2"
                     /gene_synonym="CED-12; Ced-12A; CED12; ELMO-2; VMPI"
                     /inference="alignment:Splign:2.1.0"
     exon            1995..2077
                     /gene="ELMO2"
                     /gene_synonym="CED-12; Ced-12A; CED12; ELMO-2; VMPI"
                     /inference="alignment:Splign:2.1.0"
     exon            2078..2155
                     /gene="ELMO2"
                     /gene_synonym="CED-12; Ced-12A; CED12; ELMO-2; VMPI"
                     /inference="alignment:Splign:2.1.0"
     exon            2156..3666
                     /gene="ELMO2"
                     /gene_synonym="CED-12; Ced-12A; CED12; ELMO-2; VMPI"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3643..3648
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ELMO2"
                     /gene_synonym="CED-12; Ced-12A; CED12; ELMO-2; VMPI"
                     /note="hexamer: AATAAA"
     polyA_site      3666
                     /gene="ELMO2"
                     /gene_synonym="CED-12; Ced-12A; CED12; ELMO-2; VMPI"
                     /note="major polyA site"
ORIGIN      
        1 gggcggaggc tggaggagcc gccgagcgga gacccgggag caggagctgg gcctaggtct
       61 gcgccctgga gggaggtgta gaaagaggta catggagaac aagtttgtca atccgtctga
      121 acttcagttg ccttacctgt aaggcagccg tgtctgtgtt tttgtctcgc agaattagag
      181 cccattggga acgatgccac caccgtcaga cattgtcaaa gtggccattg agtggccagg
      241 tgctaacgcc cagctccttg aaatcgacca gaaacggccc ctggcatcca ttatcaagga
      301 agtttgtgat gggtggtcgt tgccaaaccc agagtattat accctccgtt atgcagatgg
      361 tcctcagctg tacatcaccg aacagactcg cagtgacatt aagaatggga caatcttaca
      421 actggctatc tccccgtccc gggctgcacg ccagctgatg gagaggaccc agtcatccaa
      481 catggagacc cggctggatg ccatgaagga gctggccaag ctctctgccg acgtgacttt
      541 cgctactgag ttcatcaaca tggatggcat cattgtgctg acaaggctcg tggaaagtgg
      601 aaccaagctc ttgtcccact acagtgagat gctggcattc accctgactg ccttcctaga
      661 gctcatggac catggcattg tctcctggga catggtttca atcaccttta ttaagcagat
      721 tgcagggtat gtgagccagc ccatggtgga cgtgtcaatc cttcagaggt ccctggccat
      781 cctggagagc atggtcttga acagccagag tctgtaccag aagatagccg aggaaatcac
      841 cgtgggacag ctcatctcac acctccaggt ctccaaccag gagattcaga cctacgccat
      901 tgcactgatt aatgcacttt ttctgaaggc tcctgaggac aaacgacagg atatggcaaa
      961 tgcatttgca cagaagcatc tccggtctat aatcctgaat catgtgatcc gagggaaccg
     1021 ccccatcaaa actgagatgg cccatcagct atatgtcctt caagtcctaa cctttaacct
     1081 tctggaagaa aggatgatga ccaagatgga ccccaatgac caggctcaaa gggacatcat
     1141 atttgaactg aggaggattg catttgacgc agagtctgat cctagcaatg cccctgggag
     1201 tgggaccgaa aaacgcaaag ccatgtacac aaaggactac aaaatgctgg gatttaccaa
     1261 ccacatcaat ccagccatgg actttaccca gactcctcct ggaatgctgg ccttggacaa
     1321 catgctgtac ttggctaaag tccaccagga cacctacatc cggattgtct tggagaacag
     1381 tagccgggaa gacaaacatg aatgcccctt tggccgcagt gccattgagc tcaccaaaat
     1441 gctctgtgaa atcctgcagg ttggggaact accaaatgaa ggacgcaatg actaccaccc
     1501 gatgttcttt acccatgacc gagcctttga agagctcttt ggaatctgca tccagctgtt
     1561 gaacaagacc tggaaggaga tgagggcaac agcagaggac ttcaacaagg ttatgcaagt
     1621 cgtccgagag caaatcactc gagctttgcc ctccaaaccc aactctttgg atcagttcaa
     1681 gagcaaattg cgtagcctga gttactctga gattctacga ctgcgccagt ctgagaggat
     1741 gagtcaggat gacttccagt ccccgccaat tgtggagctg agggagaaga tccagcccga
     1801 gatccttgag ctgatcaagc agcagcgcct gaaccggctc tgtgagggca gcagcttccg
     1861 aaagattggg aaccgccgaa ggcaagaacg gttctggtac tgccggttgg cactgaacca
     1921 caaggtcctt cactatggtg acttggatga caacccacaa ggggaggtga catttgaatc
     1981 cctgcaggag aaaattcctg ttgcagacat taaggccatt gtcactggga aagattgtcc
     2041 ccacatgaaa gagaaaagtg ctctgaaaca gaacaaggag gtgttggaat tggccttctc
     2101 catcctgtat gaccctgatg agaccttaaa cttcatcgca cctaataaat atgagtactg
     2161 catctggatt gatggcctca gtgcccttct ggggaaggac atgtccagtg agctgaccaa
     2221 gagtgacctg gacaccctgc tgagcatgga gatgaagctg cggctcctgg acctggagaa
     2281 catccagatt cccgaagccc caccccccat ccccaaggag cccagcagct atgactttgt
     2341 ctatcactat ggctgagcct ggagccagaa acgacggtac ccaggagaag ggattttggg
     2401 cccaggagaa acacttacat tctggtgcct tgtcttttgc ttgtacagaa tctgtagtga
     2461 ttttggtggc cagtaaatgc cagccatttc tcaaacccac ctcggaccac ccagagtttc
     2521 ctcttggtcc ctgtctacta agagtcatga aggcagggtg ctctgcccac tccatcacca
     2581 tgaagcctgg gattgggcca cgaggaacaa acagcagatg cccttgcctt ccagtccaag
     2641 aaactgcttc ttgaaatgga tttaacaaca gccactcacc ttttcctcct gagcctgctc
     2701 tctgatcagc tggatcccca cgtgagcaac agctggccca ggaaaggctg cctgcagagg
     2761 acaggtgtgt tgggcgtgtt gagagccttg aagtgactac ctgtatctta gatctgagta
     2821 caagcctgag gcttttgctt ttgtcttttt tgatgagggc tcactccagc ttcatatggt
     2881 gccaagacgt tgctgcttct gaggttggct ctaacatctc tggtctttag agccaccaga
     2941 tctctctggc ccatacagat atcagagcag acggaaattt ctccctgcaa gcgctcagtc
     3001 tcatcccagc aagtcaaaga cctcctggcc aagtcctgcc ctcttaagtc tccaggaacg
     3061 ctgcagggaa aacccagctg aggcctgggc ctagactgtg gtgaggtcac tagattctac
     3121 tgctcttccc ccacattaat accttttcct tcctcagaga gaaatctccc ctaacctgaa
     3181 ttgcagcccc ctccagtttg ctttcctttg gccttccaga ccccaggaag ttggccttcc
     3241 cttcctagtg ctatggtttc tgccattggc catgatttca gggagctggc tgaggccggc
     3301 tgaggccaca cctgtgccag tggggcttcc ctggtgctgc agcacttgta aaccacacac
     3361 acagcctctc tccctggaca tacgttagca cattggcatt cagtattggt ggcctggcat
     3421 ggtaggtact acccaatgaa gagtgtacta tatattttca ttactatagg ccatacttat
     3481 acagacgtgt atatatattt atataagatc tacctatctt aggatggaac cttggggaaa
     3541 aataaaattg aggggaagta aaaagtatgt aacacttcca gttgtgagcc aagattgtaa
     3601 ccagagagca gccaggagct tcctgtcagt aaccatgttt tcaataaata ctctttcatg
     3661 tacaaa
//
