LOCUS       NM_014800               5092 bp    mRNA    linear   PRI 17-JUN-2024
DEFINITION  Homo sapiens engulfment and cell motility 1 (ELMO1), transcript
            variant 1, mRNA.
ACCESSION   NM_014800
VERSION     NM_014800.11
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5092)
  AUTHORS   Li,C., Yi,J., Jie,H., Liu,Z., Li,S., Zeng,Z. and Zhou,Y.
  TITLE     Acetylation of ELMO1 correlates with Rac1 activity and colorectal
            cancer progress
  JOURNAL   Exp Cell Res 439 (1), 114068 (2024)
   PUBMED   38750717
  REMARK    GeneRIF: Acetylation of ELMO1 correlates with Rac1 activity and
            colorectal cancer progress.
REFERENCE   2  (bases 1 to 5092)
  AUTHORS   Hassan,E.A., Elsaid,A.M., Abou-Elzahab,M.M., El-Refaey,A.M.,
            Elmougy,R. and Youssef,M.M.
  TITLE     The Potential Impact of MYH9 (rs3752462) and ELMO1 (rs741301)
            Genetic Variants on the Risk of Nephrotic Syndrome Incidence
  JOURNAL   Biochem Genet 62 (2), 1304-1324 (2024)
   PUBMED   37594641
  REMARK    GeneRIF: The Potential Impact of MYH9 (rs3752462) and ELMO1
            (rs741301) Genetic Variants on the Risk of Nephrotic Syndrome
            Incidence.
REFERENCE   3  (bases 1 to 5092)
  AUTHORS   Azarboo,A., Hosseinkhani,S., Ghaseminejad-Raeini,A., Aazami,H.,
            Mohammadi,S.M., Zeidi,S., Razi,F. and Bandarian,F.
  TITLE     Association between ELMO1 gene polymorphisms and diabetic kidney
            disease: A systematic review and meta-analysis
  JOURNAL   PLoS One 19 (1), e0295607 (2024)
   PUBMED   38277369
  REMARK    GeneRIF: Association between ELMO1 gene polymorphisms and diabetic
            kidney disease: A systematic review and meta-analysis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5092)
  AUTHORS   Wen,B., Li,S., Ruan,L., Yang,Y., Chen,Z., Zhang,B., Yang,X.,
            Jie,H., Li,S., Zeng,Z. and Liu,S.
  TITLE     Engulfment and cell motility protein 1 fosters reprogramming of
            tumor-associated macrophages in colorectal cancer
  JOURNAL   Cancer Sci 114 (2), 410-422 (2023)
   PUBMED   36310143
  REMARK    GeneRIF: Engulfment and cell motility protein 1 fosters
            reprogramming of tumor-associated macrophages in colorectal cancer.
REFERENCE   5  (bases 1 to 5092)
  AUTHORS   Shimazaki,A., Kawamura,Y., Kanazawa,A., Sekine,A., Saito,S.,
            Tsunoda,T., Koya,D., Babazono,T., Tanaka,Y., Matsuda,M., Kawai,K.,
            Iiizumi,T., Imanishi,M., Shinosaki,T., Yanagimoto,T., Ikeda,M.,
            Omachi,S., Kashiwagi,A., Kaku,K., Iwamoto,Y., Kawamori,R.,
            Kikkawa,R., Nakajima,M., Nakamura,Y. and Maeda,S.
  TITLE     Genetic variations in the gene encoding ELMO1 are associated with
            susceptibility to diabetic nephropathy
  JOURNAL   Diabetes 54 (4), 1171-1178 (2005)
   PUBMED   15793258
  REMARK    GeneRIF: These results indicate that ELMO1 is a novel candidate
            gene that both confers susceptibility to diabetic nephropathy and
            plays an important role in the development and progression of this
            disease.
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   6  (bases 1 to 5092)
  AUTHORS   Sanui,T., Inayoshi,A., Noda,M., Iwata,E., Stein,J.V., Sasazuki,T.
            and Fukui,Y.
  TITLE     DOCK2 regulates Rac activation and cytoskeletal reorganization
            through interaction with ELMO1
  JOURNAL   Blood 102 (8), 2948-2950 (2003)
   PUBMED   12829596
  REMARK    GeneRIF: the association of DOCK2 with ELMO1 is critical for
            DOCK2-mediated Rac activation, thereby suggesting that their
            association might be a therapeutic target for immunologic disorders
            caused by lymphocyte infiltration
REFERENCE   7  (bases 1 to 5092)
  AUTHORS   Katoh,H. and Negishi,M.
  TITLE     RhoG activates Rac1 by direct interaction with the Dock180-binding
            protein Elmo
  JOURNAL   Nature 424 (6947), 461-464 (2003)
   PUBMED   12879077
REFERENCE   8  (bases 1 to 5092)
  AUTHORS   Scott,M.P., Zappacosta,F., Kim,E.Y., Annan,R.S. and Miller,W.T.
  TITLE     Identification of novel SH3 domain ligands for the Src family
            kinase Hck. Wiskott-Aldrich syndrome protein (WASP),
            WASP-interacting protein (WIP), and ELMO1
  JOURNAL   J Biol Chem 277 (31), 28238-28246 (2002)
   PUBMED   12029088
REFERENCE   9  (bases 1 to 5092)
  AUTHORS   Brugnera,E., Haney,L., Grimsley,C., Lu,M., Walk,S.F.,
            Tosello-Trampont,A.C., Macara,I.G., Madhani,H., Fink,G.R. and
            Ravichandran,K.S.
  TITLE     Unconventional Rac-GEF activity is mediated through the
            Dock180-ELMO complex
  JOURNAL   Nat Cell Biol 4 (8), 574-582 (2002)
   PUBMED   12134158
  REMARK    GeneRIF: Dock180 ELMO complex functions as an unconventional
            two-part exchange factor for Rac.
REFERENCE   10 (bases 1 to 5092)
  AUTHORS   Gumienny,T.L., Brugnera,E., Tosello-Trampont,A.C., Kinchen,J.M.,
            Haney,L.B., Nishiwaki,K., Walk,S.F., Nemergut,M.E., Macara,I.G.,
            Francis,R., Schedl,T., Qin,Y., Van Aelst,L., Hengartner,M.O. and
            Ravichandran,K.S.
  TITLE     CED-12/ELMO, a novel member of the CrkII/Dock180/Rac pathway, is
            required for phagocytosis and cell migration
  JOURNAL   Cell 107 (1), 27-41 (2001)
   PUBMED   11595183
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC078843.2, AL136787.1 and
            AC007349.1.
            
            On Aug 13, 2020 this sequence version replaced NM_014800.10.
            
            Summary: This gene encodes a member of the engulfment and cell
            motility protein family. These proteins interact with dedicator of
            cytokinesis proteins to promote phagocytosis and cell migration.
            Increased expression of this gene and dedicator of cytokinesis 1
            may promote glioma cell invasion, and single nucleotide
            polymorphisms in this gene may be associated with diabetic
            nephropathy. Alternative splicing results in multiple transcript
            variants. [provided by RefSeq, Aug 2013].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1). Variants 1, 4 and 5 encode the same isoform.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL136787.1, SRR1803614.216024.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000310758.9/ ENSP00000312185.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                AC078843.2         27204-27214
            12-2260             AL136787.1         1-2249
            2261-5092           AC007349.1         122715-125546       c
FEATURES             Location/Qualifiers
     source          1..5092
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p14.2-p14.1"
     gene            1..5092
                     /gene="ELMO1"
                     /gene_synonym="CED-12; CED12; ELMO-1"
                     /note="engulfment and cell motility 1"
                     /db_xref="GeneID:9844"
                     /db_xref="HGNC:HGNC:16286"
                     /db_xref="MIM:606420"
     exon            1..190
                     /gene="ELMO1"
                     /gene_synonym="CED-12; CED12; ELMO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            191..341
                     /gene="ELMO1"
                     /gene_synonym="CED-12; CED12; ELMO-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             264..2447
                     /gene="ELMO1"
                     /gene_synonym="CED-12; CED12; ELMO-1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     engulfment and cell motility protein 1; ced-12 homolog 1"
                     /codon_start=1
                     /product="engulfment and cell motility protein 1 isoform
                     1"
                     /protein_id="NP_055615.8"
                     /db_xref="CCDS:CCDS5449.1"
                     /db_xref="GeneID:9844"
                     /db_xref="HGNC:HGNC:16286"
                     /db_xref="MIM:606420"
                     /translation="MPPPADIVKVAIEWPGAYPKLMEIDQKKPLSAIIKEVCDGWSLA
                     NHEYFALQHADSSNFYITEKNRNEIKNGTILRLTTSPAQNAQQLHERIQSSSMDAKLE
                     ALKDLASLSRDVTFAQEFINLDGISLLTQMVESGTERYQKLQKIMKPCFGDMLSFTLT
                     AFVELMDHGIVSWDTFSVAFIKKIASFVNKSAIDISILQRSLAILESMVLNSHDLYQK
                     VAQEITIGQLIPHLQGSDQEIQTYTIAVINALFLKAPDERRQEMANILAQKQLRSIIL
                     THVIRAQRAINNEMAHQLYVLQVLTFNLLEDRMMTKMDPQDQAQRDIIFELRRIAFDA
                     ESEPNNSSGSMEKRKSMYTRDYKKLGFINHVNPAMDFTQTPPGMLALDNMLYFAKHHQ
                     DAYIRIVLENSSREDKHECPFGRSSIELTKMLCEILKVGELPSETCNDFHPMFFTHDR
                     SFEEFFCICIQLLNKTWKEMRATSEDFNKVMQVVKEQVMRALTTKPSSLDQFKSKLQN
                     LSYTEILKIRQSERMNQEDFQSRPILELKEKIQPEILELIKQQRLNRLVEGTCFRKLN
                     ARRRQDKFWYCRLSPNHKVLHYGDLEESPQGEVPHDSLQDKLPVADIKAVVTGKDCPH
                     MKEKGALKQNKEVLELAFSILYDSNCQLNFIAPDKHEYCIWTDGLNALLGKDMMSDLT
                     RNDLDTLLSMEIKLRLLDLENIQIPDAPPPIPKEPSNYDFVYDCN"
     exon            342..382
                     /gene="ELMO1"
                     /gene_synonym="CED-12; CED12; ELMO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            383..455
                     /gene="ELMO1"
                     /gene_synonym="CED-12; CED12; ELMO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            456..506
                     /gene="ELMO1"
                     /gene_synonym="CED-12; CED12; ELMO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            507..676
                     /gene="ELMO1"
                     /gene_synonym="CED-12; CED12; ELMO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            677..712
                     /gene="ELMO1"
                     /gene_synonym="CED-12; CED12; ELMO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            713..812
                     /gene="ELMO1"
                     /gene_synonym="CED-12; CED12; ELMO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            813..964
                     /gene="ELMO1"
                     /gene_synonym="CED-12; CED12; ELMO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            965..1043
                     /gene="ELMO1"
                     /gene_synonym="CED-12; CED12; ELMO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1044..1094
                     /gene="ELMO1"
                     /gene_synonym="CED-12; CED12; ELMO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1095..1217
                     /gene="ELMO1"
                     /gene_synonym="CED-12; CED12; ELMO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1218..1349
                     /gene="ELMO1"
                     /gene_synonym="CED-12; CED12; ELMO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1350..1454
                     /gene="ELMO1"
                     /gene_synonym="CED-12; CED12; ELMO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1455..1563
                     /gene="ELMO1"
                     /gene_synonym="CED-12; CED12; ELMO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1564..1700
                     /gene="ELMO1"
                     /gene_synonym="CED-12; CED12; ELMO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1701..1864
                     /gene="ELMO1"
                     /gene_synonym="CED-12; CED12; ELMO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1865..1977
                     /gene="ELMO1"
                     /gene_synonym="CED-12; CED12; ELMO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1978..2085
                     /gene="ELMO1"
                     /gene_synonym="CED-12; CED12; ELMO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2086..2168
                     /gene="ELMO1"
                     /gene_synonym="CED-12; CED12; ELMO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2169..2246
                     /gene="ELMO1"
                     /gene_synonym="CED-12; CED12; ELMO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2247..5092
                     /gene="ELMO1"
                     /gene_synonym="CED-12; CED12; ELMO-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3618..3623
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ELMO1"
                     /gene_synonym="CED-12; CED12; ELMO-1"
                     /note="hexamer: AATAAA"
     polyA_site      3637
                     /gene="ELMO1"
                     /gene_synonym="CED-12; CED12; ELMO-1"
                     /note="major polyA site"
     regulatory      5068..5073
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ELMO1"
                     /gene_synonym="CED-12; CED12; ELMO-1"
                     /note="hexamer: AATAAA"
     polyA_site      5092
                     /gene="ELMO1"
                     /gene_synonym="CED-12; CED12; ELMO-1"
ORIGIN      
        1 agagtgtaag tgcgtgtgct ggggcgagcg ggagcgggcg aggatgggca caggatagag
       61 gcagagccac ccacgccgcc gcggccccac gctgggcgac agagcctcca gttccccttc
      121 aatggtggcg ggtcgccgga gctctgatcg ccgggaaccc ttgccgctgc tgtcctgcga
      181 ccccaagcag gtatagacac gtgtggccgt ttacgctgta ggatcctcat tcccactggc
      241 tttgaacatt ttggggactt acaatgccgc cacccgcgga catcgtcaag gtggccatag
      301 aatggccggg cgcctacccc aaactcatgg aaattgatca gaaaaaacca ctgtctgcaa
      361 taataaagga agtctgtgat gggtggtctc ttgccaacca tgaatatttt gcactccagc
      421 atgccgatag ttcaaacttc tatatcacag aaaagaaccg caatgagata aaaaatggca
      481 ctatccttcg attaaccaca tctccagctc agaacgccca gcagctccat gaacgaatcc
      541 agtcctcgag tatggatgcc aagctggaag ccctgaagga cttggccagc ctctcccggg
      601 atgtcacgtt tgcccaggag tttataaacc tggacggtat ctctctcctc acgcagatgg
      661 tggagagcgg cactgagcga taccagaaat tgcagaagat catgaagcct tgctttggag
      721 acatgctgtc cttcaccctg acggccttcg ttgagctgat ggaccatggc atagtgtcct
      781 gggatacatt ttcggtggcg ttcattaaga agatagcaag ttttgtgaac aagtcagcca
      841 tagacatctc gatcctgcag cggtccttgg ccattttgga gtcgatggtg ctcaatagcc
      901 atgacctcta ccagaaagtg gcgcaggaga tcaccatcgg ccagctcatt ccacacctgc
      961 aagggtcaga tcaagaaatc caaacctata ctattgcagt gattaatgcg cttttcctga
     1021 aggctcctga tgagaggagg caggagatgg cgaatatttt ggctcagaag caactgcgtt
     1081 ccatcatttt aacacatgtc atccgagccc agcgggccat caacaatgag atggcgcacc
     1141 agctgtatgt tctacaagtg ctcaccttta acctcctgga agacaggatg atgaccaaaa
     1201 tggaccccca ggaccaggct cagagggaca tcatatttga acttcgaaga attgcttttg
     1261 atgctgagtc tgaacctaac aacagcagtg gcagcatgga gaaacgcaag tccatgtaca
     1321 cgcgagatta taagaagctt gggttcatta atcatgtcaa ccctgccatg gacttcacgc
     1381 agactccacc tgggatgttg gctctggaca acatgctgta ctttgccaag caccaccaag
     1441 atgcctacat ccggattgtg cttgagaaca gtagtcgaga agacaagcat gaatgtccct
     1501 ttggccgcag tagtatagag ctgaccaaga tgctatgtga gatcttgaaa gtgggcgagt
     1561 tgcctagtga gacctgcaac gacttccacc cgatgttctt cacccacgac agatcctttg
     1621 aggagttttt ctgcatctgt atccagctcc tgaacaagac atggaaggaa atgagggcaa
     1681 cttctgaaga cttcaacaag gtaatgcagg tggtgaagga gcaggttatg agagcactta
     1741 caaccaagcc tagctccctg gaccagttca agagcaaact gcagaacctg agctacactg
     1801 agatcctgaa aatccgccag tccgagagga tgaaccagga agatttccag tcccgcccga
     1861 ttttggaact aaaggagaag attcagccag aaatcttaga gctgatcaaa cagcaacgcc
     1921 tgaaccgcct tgtggaaggg acctgcttta ggaaactcaa tgcccggcgg aggcaagaca
     1981 agttttggta ttgtcggctt tcgccaaatc acaaagtcct gcattacgga gacttagaag
     2041 agagtcctca gggagaagtg ccccacgatt ccttgcagga caaactgccg gtggcagata
     2101 tcaaagccgt ggtgacggga aaggactgcc ctcatatgaa agagaaaggt gcccttaaac
     2161 aaaacaagga ggtgcttgaa ctcgctttct ccatcttgta tgactcaaac tgccaactga
     2221 acttcatcgc tcctgacaag catgagtact gtatctggac ggatggactg aatgcgctac
     2281 tcgggaagga catgatgagc gacctgacgc ggaatgacct ggacaccctg ctcagcatgg
     2341 aaatcaagct ccgcctcctg gacctggaaa acatccagat ccctgacgca cctccgccga
     2401 ttcccaagga gcccagcaac tatgacttcg tctatgactg taactgaagt ggccgggccc
     2461 agacatgccc cttccaaaac tggaacacct agctaacagg agagaggaat gaaaacacac
     2521 ccacgccttg gaaccgtcct ttggtaaagg gaagctgtgg gtccacattc ccttcagcat
     2581 cacctctagc cctggcaact ttcagcccct agctggcatc ttgctcaccg ccctgattct
     2641 gttcctcggc tccactgctt caggtcactt cccatggctg cagtccactg gtgggacaag
     2701 agcaaagccc actgccagta agaaggccaa agggcccttc catcctagcc ctctgcaggc
     2761 atgcccttcc ttcccttggg caggaaagcc agcagcccca gactgcccaa aaacttgccc
     2821 accagaccaa gggcagtgcc ccaaggcccc tgtctggagg aaatggccta gctatttgat
     2881 gagaagacca aaccccacat cctcctttcc cctctctcta gaatcatctc gcaccaccag
     2941 ttacacttga attaagatct gcgctcaaat ctcctcccac ctctctccct gcttttgcct
     3001 tgctctgttc ctctttggtc ccaagagcag cagccgcagc ctcctcgtga tcctccctag
     3061 cataaatttc ccaaacagtc cacaggtccc atgcccactt tgcgtctgca ctgtgatcgt
     3121 gacaaatctt ccctcctcac cagctagtct ggggtttcct ctccctgccc caggccagaa
     3181 ctgccttctt catttccacc cacgctccca gcctcttagc tgaaagcaca aatggtgaaa
     3241 tcagtagtct cgctccatct ctaatagact aaacctaaat gcctctagga cggactgttg
     3301 ctatccaagc gtttggtgtt accttctcct gggaggtcct gctgcaactc aagttccaca
     3361 ggatggtcaa gctgtcagac atccaagttt acatcattgt aattattact ggtatttaca
     3421 atttgcaaga gttttgggtt agtttttttt tttttttttg ctttgttttt gtacaaaaga
     3481 gtctaacatt ttttgccaaa cagatatata tttaatgaaa agaagagata cataaatgtg
     3541 tgaatttcca gttttttttt aattatttta atcccaaaca tcttcctgaa aataacattc
     3601 ccttaaacat gctgtggaat aaaatggatt gtgatgattt ggggagctgg tgttttgatt
     3661 tagtaactta ggttcttgct actcagtcat cagcatcacc tgggagcttg ttggagatgc
     3721 cagctcttca gctccaccct agacctgctg aattgggtga tgtttatgta cattggtttg
     3781 aaaaacactg ctgtgggaaa ccctccacca ttgctaggtc accataggct ctgagcatca
     3841 gtggagaatg ttacttctaa gaagaccatc tcgactcact gagaaaatca gacccactgt
     3901 atgaaaatat ctattccttt tacattgctg tctcttgacc atgactttct cttttttctt
     3961 tcttaccatg atataattta tagaatgggt ctaattaaag acatcacaac tttgagggag
     4021 cacatttagc aatgaaaaga atgcataccc acagacctga aataagccag aactaaataa
     4081 atctaaccgt gggttaataa attataggtc agagcccagc gaaggatgtt tcttaagtca
     4141 tttgcactgg aggcattatc aggattgtaa actcccagca ctgggaggga tgtcagaagg
     4201 gtccaagcat gcagtattaa gcgtggcaca gcaccagcca ctctggcctc acagcacaag
     4261 ctgtggaagc atccaggtca tttctcttta ccgtcatcag gatgtgcaat tacagattga
     4321 cctgggttga gatgatatgg tccagagcac tgcatgcatt gcaggaaaaa agtcctttgc
     4381 attcacaggg gttccttctt cccatcagag cactcacacc tgtgtcaagc tgttaattcc
     4441 ttgatcatta agcttcgatg ttattaacat gtacttgcta tcaggagcag ttattaatct
     4501 acccatcatc atgataaaac agtaagtgtt aggtcaaagg cagcaaacaa agtcatatta
     4561 tttttttctt atgggttaca agatccaatc catgaaaaag ggaactttct ggaccaggat
     4621 ctctgaggtc ctgagacact gggtttaaga aatgtatctg tcctgtgacc ttggttgggg
     4681 agatccagcc cctctctctt ctggcactcc agctttggtg catttaatag aaagaaacct
     4741 tttcaggact atgaaaggca gcattctcca gctcctccct agaccctcct ttggacctgt
     4801 gagatctgaa gagtatgcca tctgtttcca ttcattttgt gaccatgtgg ggaaggattg
     4861 ttgcccatat ttggccacct caccttctct ctccaggctg cccaaggctt tttttcccat
     4921 gcaatgagcc taccacctcc aactcatctc ctgttgcctg cagtttccta agcctgggca
     4981 actcagccaa atccaaggca gaagtaaagt aggaagactg atgttgtcgt gaagtccaag
     5041 ttgcattctg ctattcatat tactcaaaat aaaactgatt acttaatttg aa
//
