LOCUS       NM_025165               1755 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens elongation factor for RNA polymerase II 3 (ELL3),
            mRNA.
ACCESSION   NM_025165
VERSION     NM_025165.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1755)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 1755)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1755)
  AUTHORS   Lee,J.Y., Lee,S.H., Kim,K.S., Park,K.H. and Park,K.S.
  TITLE     Ell3 functions as a critical decision maker at the crossroad
            between stem cell senescence and apoptosis
  JOURNAL   Stem Cell Res Ther 10 (1), 32 (2019)
   PUBMED   30654843
  REMARK    GeneRIF: Suppression of Ell3 expression induced senescence in stem
            cells by increasing Bcl-2 expression. Unlike the effect of Ell3
            suppression, the ectopic expression of Ell3 induces apoptosis of
            stem cells and induces apoptosis of adjacent cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1755)
  AUTHORS   Alexander,L.M.M., Watters,J., Reusch,J.A., Maurin,M.,
            Nepon-Sixt,B.S., Vrzalikova,K., Alexandrow,M.G., Murray,P.G. and
            Wright,K.L.
  TITLE     Selective expression of the transcription elongation factor ELL3 in
            B cells prior to ELL2 drives proliferation and survival
  JOURNAL   Mol Immunol 91, 8-16 (2017)
   PUBMED   28858629
  REMARK    GeneRIF: Selective expression of the transcription elongation
            factor ELL3 in B cells prior to ELL2 drives proliferation and
            survival
REFERENCE   5  (bases 1 to 1755)
  AUTHORS   Lee,J.Y., Park,Y.J., Oh,N., Kwack,K.B. and Park,K.S.
  TITLE     A transcriptional complex composed of ER(alpha), GATA3, FOXA1 and
            ELL3 regulates IL-20 expression in breast cancer cells
  JOURNAL   Oncotarget 8 (26), 42752-42760 (2017)
   PUBMED   28514748
  REMARK    GeneRIF: Authors demonstrated that ER(alpha), GATA3 and FOXA1 form
            a transcriptional complex with Ell3 to regulate IL-20 expression in
            ER(+) breast cancer cells.  FOXA1 represses IL-20 expression,
            whereas GATA3 and ER(alpha) activate it.
REFERENCE   6  (bases 1 to 1755)
  AUTHORS   Ahn,H.J., Kim,K.S., Shin,K.W., Lim,K.H., Kim,J.O., Lee,J.Y.,
            Kim,J., Park,J.H., Yang,K.M., Baek,K.H., Ko,J.J. and Park,K.S.
  TITLE     Ell3 stabilizes p53 following CDDP treatment via its effects on
            ubiquitin-dependent and -independent proteasomal degradation
            pathways in breast cancer cells
  JOURNAL   Oncotarget 6 (42), 44523-44537 (2015)
   PUBMED   26540344
  REMARK    GeneRIF: Ell3 stabilizes p53 following cisplatin treatment via its
            effects on ubiquitin-dependent and -independent proteasomal
            degradation pathways in breast cancer cells.
REFERENCE   7  (bases 1 to 1755)
  AUTHORS   Ahn,H.J., Kim,G. and Park,K.S.
  TITLE     Ell3 stimulates proliferation, drug resistance, and cancer stem
            cell properties of breast cancer cells via a MEK/ERK-dependent
            signaling pathway
  JOURNAL   Biochem Biophys Res Commun 437 (4), 557-564 (2013)
   PUBMED   23850691
  REMARK    GeneRIF: Ell3 may play a critical role in promoting oncogenesis in
            breast cancer by regulating cell proliferation and cancer stem cell
            properties via the ERK1/2 signaling pathway
REFERENCE   8  (bases 1 to 1755)
  AUTHORS   Smith,E.R., Lin,C., Garrett,A.S., Thornton,J., Mohaghegh,N., Hu,D.,
            Jackson,J., Saraf,A., Swanson,S.K., Seidel,C., Florens,L.,
            Washburn,M.P., Eissenberg,J.C. and Shilatifard,A.
  TITLE     The little elongation complex regulates small nuclear RNA
            transcription
  JOURNAL   Mol Cell 44 (6), 954-965 (2011)
   PUBMED   22195968
REFERENCE   9  (bases 1 to 1755)
  AUTHORS   Takahashi,H., Parmely,T.J., Sato,S., Tomomori-Sato,C., Banks,C.A.,
            Kong,S.E., Szutorisz,H., Swanson,S.K., Martin-Brown,S.,
            Washburn,M.P., Florens,L., Seidel,C.W., Lin,C., Smith,E.R.,
            Shilatifard,A., Conaway,R.C. and Conaway,J.W.
  TITLE     Human mediator subunit MED26 functions as a docking site for
            transcription elongation factors
  JOURNAL   Cell 146 (1), 92-104 (2011)
   PUBMED   21729782
REFERENCE   10 (bases 1 to 1755)
  AUTHORS   Miller,T., Williams,K., Johnstone,R.W. and Shilatifard,A.
  TITLE     Identification, cloning, expression, and biochemical
            characterization of the testis-specific RNA polymerase II
            elongation factor ELL3
  JOURNAL   J Biol Chem 275 (41), 32052-32056 (2000)
   PUBMED   10882741
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK126384.1 and AC018512.6.
            
            On Nov 23, 2018 this sequence version replaced NM_025165.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK026290.1, SRR5189667.282666.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000319359.8/ ENSP00000320346.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-896               AK126384.1         578-1473
            897-931             AC018512.6         89674-89708         c
            932-1103            AC018512.6         89380-89551         c
            1104-1148           AC018512.6         88502-88546         c
            1149-1710           AC018512.6         87863-88424         c
            1711-1755           AK126384.1         2288-2332
FEATURES             Location/Qualifiers
     source          1..1755
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q15.3"
     gene            1..1755
                     /gene="ELL3"
                     /note="elongation factor for RNA polymerase II 3"
                     /db_xref="GeneID:80237"
                     /db_xref="HGNC:HGNC:23113"
                     /db_xref="MIM:609885"
     exon            1..197
                     /gene="ELL3"
                     /inference="alignment:Splign:2.1.0"
     CDS             66..1259
                     /gene="ELL3"
                     /note="elongation factor RNA polymerase II-like 3"
                     /codon_start=1
                     /product="RNA polymerase II elongation factor ELL3"
                     /protein_id="NP_079441.1"
                     /db_xref="CCDS:CCDS10102.1"
                     /db_xref="GeneID:80237"
                     /db_xref="HGNC:HGNC:23113"
                     /db_xref="MIM:609885"
                     /translation="MEELQEPLRGQLRLCFTQAARTSLLLLRLNDAALRALQECQRQQ
                     VRPVIAFQGHRGYLRLPGPGWSCLFSFIVSQCCQEGAGGSLDLVCQRFLRSGPNSLHC
                     LGSLRERLIIWAAMDSIPAPSSVQGHNLTEDARHPESWQNTGGYSEGDAVSQPQMALE
                     EVSVSDPLASNQGQSLPGSSREHMAQWEVRSQTHVPNREPVQALPSSASRKRLDKKRS
                     VPVATVELEEKRFRTLPLVPSPLQGLTNQDLQEGEDWEQEDEDMDPRLEHSSSVQEDS
                     ESPSPEDIPDYLLQYRAIHSAEQQHAYEQDFETDYAEYRILHARVGTASQRFIELGAE
                     IKRVRRGTPEYKVLEDKIIQEYKKFRKQYPSYREEKRRCEYLHQKLSHIKGLILEFEE
                     KNRGS"
     exon            198..233
                     /gene="ELL3"
                     /inference="alignment:Splign:2.1.0"
     exon            234..346
                     /gene="ELL3"
                     /inference="alignment:Splign:2.1.0"
     exon            347..548
                     /gene="ELL3"
                     /inference="alignment:Splign:2.1.0"
     exon            549..634
                     /gene="ELL3"
                     /inference="alignment:Splign:2.1.0"
     exon            635..710
                     /gene="ELL3"
                     /inference="alignment:Splign:2.1.0"
     exon            711..888
                     /gene="ELL3"
                     /inference="alignment:Splign:2.1.0"
     exon            889..931
                     /gene="ELL3"
                     /inference="alignment:Splign:2.1.0"
     exon            932..1103
                     /gene="ELL3"
                     /inference="alignment:Splign:2.1.0"
     exon            1104..1148
                     /gene="ELL3"
                     /inference="alignment:Splign:2.1.0"
     exon            1149..1755
                     /gene="ELL3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1749..1754
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ELL3"
                     /note="hexamer: ATTAAA"
     polyA_site      1755
                     /gene="ELL3"
                     /note="major polyA site"
ORIGIN      
        1 agaggaggtg gcggtggtgg ccctcgcctg tggcccccgt gctgcttgca ctcgaactcg
       61 tcgccatgga ggagctccag gagcctctga gaggacagct ccggctctgc ttcacgcaag
      121 ctgcccggac tagcctctta ctgctcaggc tcaacgacgc tgccctgcgg gcgctgcaag
      181 agtgtcagcg gcaacaggta cggccggtga ttgctttcca aggccaccga gggtatctga
      241 gactcccagg ccctggttgg tcctgcctct tctccttcat agtgtcccag tgttgtcagg
      301 agggcgctgg tggtagcttg gaccttgtgt gccaacgctt cctcaggtct gggcctaaca
      361 gcctccactg cctgggctca ctcagggagc gcctcattat ttgggcagcc atggattcta
      421 tcccagcccc atcatcagtt cagggacaca acctgactga agatgccaga catcctgaga
      481 gttggcagaa cacaggaggc tattctgaag gagatgcagt atcacagcca cagatggcac
      541 tagaggaggt gtcagtgtca gatccactgg caagcaacca aggacagtca ctcccaggat
      601 cctcaaggga gcacatggca cagtgggaag tgagaagcca gacccatgtt ccaaacagag
      661 aacctgttca ggcactgcct tcctctgcca gccggaaacg tctggacaag aaacgttcag
      721 tgcctgtagc cactgtagaa ctggaagaaa agaggttcag aactctgcct ttagtgccaa
      781 gccccctaca aggcctgacc aatcaggatt tacaagaggg agaagattgg gagcaagaag
      841 atgaggacat ggaccccaga ttagaacaca gttcctcagt tcaagaagat tctgaatccc
      901 caagtcctga agatatacca gactacctcc tgcaatacag ggccatccac agtgcagaac
      961 agcaacatgc ctatgagcag gactttgaga cagattatgc tgaataccgc atcctgcatg
     1021 cccgtgttgg gactgcaagc caaaggttca tagagctggg agcagagatt aaaagagttc
     1081 ggcgaggaac tccagaatac aaggtcctgg aagacaagat aatccaggaa tataaaaagt
     1141 tcaggaagca gtacccaagt tacagagaag aaaagcgtcg ctgtgagtac cttcaccaga
     1201 aattgtccca cattaaaggt ctcatcctgg agtttgagga aaagaacagg ggcagctgaa
     1261 gttatcaagg gaatttttga gcctctgctt agtgaaacac aaaggaacaa agcagctata
     1321 aactaaatag aatgcaacta tctgcttttc ttatgctgac cactggagtc catggtggca
     1381 agtagagagc tgctctaggt tcttgaggtt tggttttcat tattaatttt tagggtatgg
     1441 gcactgtgca aagactccat agctgtgcct aggagtctag gaaaagtgac agaggcttgg
     1501 cttttttacc tttagttcag ccaagtcatt ttcaagtcct gagaaatgac atcatcttca
     1561 ggataaaata atgaggacat tagacaaacc aaactaagtg aattttagcc tggtagcctc
     1621 tctaaggaaa cagtaataat aacttctgat aagagttaaa agaacttgta gcatacctgg
     1681 atataatggg aaagggcctg ggtgttaccc atgtactgaa aatgaacttt taccaacatg
     1741 gctaaaaaat taaaa
//
