LOCUS       NM_012081               5826 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens elongation factor for RNA polymerase II 2 (ELL2),
            mRNA.
ACCESSION   NM_012081
VERSION     NM_012081.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5826)
  AUTHORS   Kohrt,S., Strobel,S., Mann,M.C., Sticht,H., Fleckenstein,B. and
            Thoma-Kress,A.K.
  TITLE     Characterizing the Interaction between the HTLV-1 Transactivator
            Tax-1 with Transcription Elongation Factor ELL2 and Its Impact on
            Viral Transactivation
  JOURNAL   Int J Mol Sci 22 (24), 13597 (2021)
   PUBMED   34948391
  REMARK    GeneRIF: Characterizing the Interaction between the HTLV-1
            Transactivator Tax-1 with Transcription Elongation Factor ELL2 and
            Its Impact on Viral Transactivation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5826)
  AUTHORS   Chen,Y., Vos,S.M., Dienemann,C., Ninov,M., Urlaub,H. and Cramer,P.
  TITLE     Allosteric transcription stimulation by RNA polymerase II super
            elongation complex
  JOURNAL   Mol Cell 81 (16), 3386-3399 (2021)
   PUBMED   34265249
  REMARK    GeneRIF: Allosteric transcription stimulation by RNA polymerase II
            super elongation complex.
REFERENCE   3  (bases 1 to 5826)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 5826)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 5826)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 5826)
  AUTHORS   Takahashi,H., Parmely,T.J., Sato,S., Tomomori-Sato,C., Banks,C.A.,
            Kong,S.E., Szutorisz,H., Swanson,S.K., Martin-Brown,S.,
            Washburn,M.P., Florens,L., Seidel,C.W., Lin,C., Smith,E.R.,
            Shilatifard,A., Conaway,R.C. and Conaway,J.W.
  TITLE     Human mediator subunit MED26 functions as a docking site for
            transcription elongation factors
  JOURNAL   Cell 146 (1), 92-104 (2011)
   PUBMED   21729782
REFERENCE   7  (bases 1 to 5826)
  AUTHORS   Martincic,K., Alkan,S.A., Cheatle,A., Borghesi,L. and Milcarek,C.
  TITLE     Transcription elongation factor ELL2 directs immunoglobulin
            secretion in plasma cells by stimulating altered RNA processing
  JOURNAL   Nat Immunol 10 (10), 1102-1109 (2009)
   PUBMED   19749764
  REMARK    GeneRIF: ELL2 addition regulates mRNA processing by enhancing
            poly(A) site choice and exon splice-site skipping
REFERENCE   8  (bases 1 to 5826)
  AUTHORS   Simone,F., Luo,R.T., Polak,P.E., Kaberlein,J.J. and Thirman,M.J.
  TITLE     ELL-associated factor 2 (EAF2), a functional homolog of EAF1 with
            alternative ELL binding properties
  JOURNAL   Blood 101 (6), 2355-2362 (2003)
   PUBMED   12446457
REFERENCE   9  (bases 1 to 5826)
  AUTHORS   Simone,F., Polak,P.E., Kaberlein,J.J., Luo,R.T., Levitan,D.A. and
            Thirman,M.J.
  TITLE     EAF1, a novel ELL-associated factor that is delocalized by
            expression of the MLL-ELL fusion protein
  JOURNAL   Blood 98 (1), 201-209 (2001)
   PUBMED   11418481
REFERENCE   10 (bases 1 to 5826)
  AUTHORS   Shilatifard,A., Duan,D.R., Haque,D., Florence,C., Schubach,W.H.,
            Conaway,J.W. and Conaway,R.C.
  TITLE     ELL2, a new member of an ELL family of RNA polymerase II elongation
            factors
  JOURNAL   Proc Natl Acad Sci U S A 94 (8), 3639-3643 (1997)
   PUBMED   9108030
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC028412.2, AB209343.1, BX538289.1, BC151238.1 and AV652801.1.
            
            On Nov 22, 2018 this sequence version replaced NM_012081.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.167336.1,
                                           SRR1660809.126265.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000237853.9/ ENSP00000237853.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-491               BC028412.2         223-713
            492-2140            AB209343.1         1-1649
            2141-3196           BC028412.2         2363-3418
            3197-3581           BX538289.1         2076-2460
            3582-4116           BC151238.1         3477-4011
            4117-4350           BX538289.1         2996-3229
            4351-4567           AV652801.1         485-701
            4568-5826           BX538289.1         3447-4705
FEATURES             Location/Qualifiers
     source          1..5826
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q15"
     gene            1..5826
                     /gene="ELL2"
                     /gene_synonym="MRCCAT1"
                     /note="elongation factor for RNA polymerase II 2"
                     /db_xref="GeneID:22936"
                     /db_xref="HGNC:HGNC:17064"
                     /db_xref="MIM:601874"
     exon            1..277
                     /gene="ELL2"
                     /gene_synonym="MRCCAT1"
                     /inference="alignment:Splign:2.1.0"
     CDS             131..2053
                     /gene="ELL2"
                     /gene_synonym="MRCCAT1"
                     /note="ELL-related RNA polymerase II, elongation factor;
                     elongation factor, RNA polymerase II, 2; elongation factor
                     RNA for polymerase II 2; metastatic renal cell
                     carcinoma-associated transcript 1"
                     /codon_start=1
                     /product="RNA polymerase II elongation factor ELL2"
                     /protein_id="NP_036213.2"
                     /db_xref="CCDS:CCDS4080.1"
                     /db_xref="GeneID:22936"
                     /db_xref="HGNC:HGNC:17064"
                     /db_xref="MIM:601874"
                     /translation="MAAGGTGGLREEQRYGLSCGRLGQDNITVLHVKLTETAIRALET
                     YQSHKNLIPFRPSIQFQGLHGLVKIPKNDPLNEVHNFNFYLSNVGKDNPQGSFDCIQQ
                     TFSSSGASQLNCLGFIQDKITVCATNDSYQMTRERMTQAEEESRNRSTKVIKPGGPYV
                     GKRVQIRKAPQAVSDTVPERKRSTPMNPANTIRKTHSSSTISQRPYRDRVIHLLALKA
                     YKKPELLARLQKDGVNQKDKNSLGAILQQVANLNSKDLSYTLKDYVFKELQRDWPGYS
                     EIDRRSLESVLSRKLNPSQNAAGTSRSESPVCSSRDAVSSPQKRLLDSEFIDPLMNKK
                     ARISHLTNRVPPTLNGHLNPTSEKSAAGLPLPPAAAAIPTPPPLPSTYLPISHPPQIV
                     NSNSNSPSTPEGRGTQDLPVDSFSQNDSIYEDQQDKYTSRTSLETLPPGSVLLKCPKP
                     MEENHSMSHKKSKKKSKKHKEKDQIKKHDIETIEEKEEDLKREEEIAKLNNSSPNSSG
                     GVKEDCTASMEPSAIELPDYLIKYIAIVSYEQRQNYKDDFNAEYDEYRALHARMETVA
                     RRFIKLDAQRKRLSPGSKEYQNVHEEVLQEYQKIKQSSPNYHEEKYRCEYLHNKLAHI
                     KRLIGEFDQQQAESWS"
     exon            278..325
                     /gene="ELL2"
                     /gene_synonym="MRCCAT1"
                     /inference="alignment:Splign:2.1.0"
     exon            326..447
                     /gene="ELL2"
                     /gene_synonym="MRCCAT1"
                     /inference="alignment:Splign:2.1.0"
     exon            448..611
                     /gene="ELL2"
                     /gene_synonym="MRCCAT1"
                     /inference="alignment:Splign:2.1.0"
     exon            612..871
                     /gene="ELL2"
                     /gene_synonym="MRCCAT1"
                     /inference="alignment:Splign:2.1.0"
     exon            872..996
                     /gene="ELL2"
                     /gene_synonym="MRCCAT1"
                     /inference="alignment:Splign:2.1.0"
     exon            997..1084
                     /gene="ELL2"
                     /gene_synonym="MRCCAT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1085..1655
                     /gene="ELL2"
                     /gene_synonym="MRCCAT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1656..1719
                     /gene="ELL2"
                     /gene_synonym="MRCCAT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1720..1891
                     /gene="ELL2"
                     /gene_synonym="MRCCAT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1892..1936
                     /gene="ELL2"
                     /gene_synonym="MRCCAT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1937..5826
                     /gene="ELL2"
                     /gene_synonym="MRCCAT1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3500..3505
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ELL2"
                     /gene_synonym="MRCCAT1"
                     /note="hexamer: AATAAA"
     polyA_site      3536
                     /gene="ELL2"
                     /gene_synonym="MRCCAT1"
                     /note="major polyA site"
     regulatory      5805..5810
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ELL2"
                     /gene_synonym="MRCCAT1"
                     /note="hexamer: AATAAA"
     polyA_site      5826
                     /gene="ELL2"
                     /gene_synonym="MRCCAT1"
                     /note="major polyA site"
ORIGIN      
        1 agtatatgac agtacgtcag cagcgggatg gccctagcag tggcggcggc tgcagaagcc
       61 caagcagccg cggccgcagt ggaggctaga gccggagcgg cggcggcggc ggcaccccgg
      121 ggagtttaag atggcggcgg gggggacagg gggcctgcgg gaggagcagc gctatgggct
      181 gtcgtgcgga cggctggggc aggacaacat caccgtactg catgtgaagc tcaccgagac
      241 ggcgatccgg gcgctcgaga cttaccagag ccacaagaat ttaattcctt ttcgaccttc
      301 aatccagttc caaggactcc acgggcttgt caaaattccc aaaaatgatc ccctcaatga
      361 agttcataac tttaactttt atttgtcaaa tgtgggcaaa gacaaccctc agggcagctt
      421 tgactgcatc cagcaaacat tctccagctc tggagcctcc cagctcaatt gcctgggatt
      481 tatacaagat aaaattacag tgtgtgcaac aaacgactcg tatcagatga cacgagaaag
      541 aatgacccag gcagaggagg aatcccgcaa ccgaagcaca aaagttatca aacccggtgg
      601 accatatgta gggaaaagag tgcaaattcg gaaagcacct caagctgttt cagatacagt
      661 tcctgagagg aaaaggtcaa cccccatgaa ccctgcaaat acaattcgaa agacacatag
      721 cagcagcacc atctctcaga ggccatacag ggacagggtg attcacttac tggccctgaa
      781 ggcctacaag aaaccggagc tacttgctag actccagaaa gatggtgtca atcaaaaaga
      841 caagaactcc ctgggagcaa ttctgcaaca ggtagccaat ctgaattcta aggacctctc
      901 atatacctta aaggattatg tttttaaaga gcttcaaaga gactggcctg gatacagtga
      961 aatagacaga cggtcattgg agtcagtgct ctctagaaaa ctaaatccgt ctcagaatgc
     1021 tgcaggcacc agccgttcag aatctcctgt atgttctagt agagacgctg tatcttctcc
     1081 tcagaaacgg cttttggatt cagagtttat tgatccttta atgaataaaa aagcccgaat
     1141 atctcacctg acgaacagag taccaccaac actaaatggt catttgaatc ccaccagtga
     1201 aaaatctgct gcaggcctcc cgctgccccc tgcggctgct gccatcccta cccctccacc
     1261 gctgccttca acctatctgc ccatctcaca tcctcctcag attgtaaatt ctaactccaa
     1321 ctcccctagc actccagaag gccgggggac tcaagaccta cctgttgaca gttttagtca
     1381 aaacgatagt atctatgagg accagcaaga caaatatacc tctaggactt ctctggaaac
     1441 cttaccccct ggttccgttc tactaaagtg tccaaagcct atggaagaaa accattcaat
     1501 gtctcacaaa aagtccaaaa agaagtctaa aaaacataag gaaaaggacc aaataaaaaa
     1561 gcacgacatt gagactattg aggaaaagga ggaagatctt aagagagaag aggaaattgc
     1621 caagctaaat aactccagtc caaattccag tggaggagtt aaagaggatt gcactgcctc
     1681 catggaacct tcagcaattg aactcccaga ttatttgata aaatatatcg ctatcgtctc
     1741 ctatgagcaa cgccagaatt ataaggatga cttcaatgca gagtatgatg agtacagagc
     1801 tttgcatgcc aggatggaga ctgtagctag aagatttatc aaactagatg cacaaagaaa
     1861 gcgcctttct ccaggctcaa aagagtatca gaatgttcat gaagaagtct tacaagaata
     1921 tcagaagata aagcagtcta gtcccaatta ccatgaagaa aaatacagat gtgaatatct
     1981 tcataacaag ctggctcaca tcaaaaggct aataggtgaa tttgaccaac agcaagcaga
     2041 gtcatggtcc tagaactctg cttggaccag aagatgtgaa taaacttaag cttatttatt
     2101 taaaattcca aatgagttgc tctagattct aaaaaggtga aactttggct gttgaaagtt
     2161 tcagtattag taaacttgag ttactttttc ttttccattt tactttgctt ccctgcattt
     2221 cgaagctgct ctttctggtc ctccccacca ccccaccccc aagacttgtg tttgttaata
     2281 gaaataattt ttttaggtat tggggatcca ttgtctatat ttcaaatcag ttttttttcc
     2341 tcaaaaactt gtgtttgtta ttagaaatga ttttttagat attggggatc cagtgtccac
     2401 acttaaaagt tgtatgtgtt taaaaaacaa caacagtaat gtgcaaggtg aaatgctttt
     2461 ggataaacgt aagcctattt tctgacgttt cttaatgcaa actctttgcc ttaaatggta
     2521 gaatatttag aaatttgcac aaaattaaaa aaataaacat tgtcttggag ggttaaaaaa
     2581 tagaaaggtg tatgtgtata gattcacata cacatatgta tatacaggct gacttgatct
     2641 agaacattaa atccgccctg caagttaacc ccccattgca atggttgcct taaggtgttt
     2701 gctagttgtg tacatagtgt ggttaatcat tagctacact gcttcccact tgattagagc
     2761 aatgggaagc atactgtggc ctaccagcat ctggaagtgt gtgctcgatc tgtatgtgtg
     2821 cagaggtggt gtggatgtga gcgtgcatga aggaaaaaaa gctgctactc ctagtaggcc
     2881 aaacgctcag gttaaacaac tgacgagtgt tactgtaggg tgtttttttg tttttttgtt
     2941 ttttttcttc tatcaaattg ctacttttgt tgtggaagac aaaagcattt ccatttcaac
     3001 gagtttgtca gctttattaa tgttgggcaa aaattgatat gtcatgaaaa tgaaacagat
     3061 ctatagtttt gggacaaaat tataaaatga aatgtgtagg taacctattt atatactgct
     3121 ataaagtatt ttttgaagag agatatgcaa agaagctatt acctacataa gaggtatatt
     3181 taaagatttt ttttttcatc ctggtgccag gaatataaaa aagagtggat atatttaacc
     3241 ataacatact gtgattcatc aaacagcaca aactttcatt tcatggagtt tatctgttga
     3301 cattgattta aactgtcact tgttttatca tgtgggaaca taagttatgt ggtcaaaaat
     3361 ataaggattt tgaattaatg ttgattcaag ttgtattgtc ttattgtatt gtcttttcaa
     3421 agtgctgcca gttgaaaagg gaagcattat gtttacaaat ctgttttgaa atgtttgcca
     3481 aaattttggt agtgtcttta ataaagatgt ttgtctccag catccagaaa aataaatgaa
     3541 taactttgtt gtgtatcact gtaaaccaga aaaatgttgg ttatctagaa aacttgagag
     3601 agcatgtaga ttaacttttc tctttggagt tctaaaacat taactggaaa gattagataa
     3661 tatactaaat gtatacagaa gtatacagac tatacaaaga ctgaaacaag tcccttttgc
     3721 actacaactc tataacatta ccgcagaaat tttggttcta tgtagcatgg acctcctaag
     3781 gaattctgtt tcttttagca ttgagatccc tggtgctctt tttttacctc agaattggta
     3841 caatcattat taaacgttaa tttatttcaa actttttaat tgaaaaaagg aaagggaaac
     3901 ttaattgggg ataaattcag gcatcatatt attatgatag agtctcctga gtggttcgtc
     3961 tataggtaat gaactcattg gtgttatttc ttggacatct tggcctttta atcaaagact
     4021 gtgtgctgct atttgctatg agcaaggttt ctcaaaagca aaaggtgctt ggaccatttg
     4081 gatcacctga gttagaatct ctaggtatag ggcccaagta tctgcatttt cacaggtttc
     4141 ttgtaggtga ctttctgcaa gctaaagtat gagaaccatt ggcttggatg tagttctaaa
     4201 cttttaggtc tgtaaatctt gaaatcttga actgaaggtc aactattggc tttttttttt
     4261 ttttaatgtc catcatgtca gcaggtgcaa atcacttttc ccctttgcat gatctgaggc
     4321 acctcctcag ttgtttcact gccaactctt gtttcagaac ctgtttacaa acaagccttc
     4381 cagttggtga atggttagcc attggagctc ctaccctgta catcagcaca tcttctggtt
     4441 tacaagttgg gtaacaatga aagctggaga tgctaaatgg aaatccagca ttgcataccc
     4501 ttagacctga tcacatacca gtaaaagcct taatttagat gttagttgta tgtgttggac
     4561 agatccttgc aaaagtgtgt ctgtctatta gttgtaaatt tgaaaattat aaatctctga
     4621 atctgctact atccaagttt catccctttt gaagatgagg catgagccta ttaaaatatt
     4681 tataatcatt tttcgtcccc tactgcaaga cttttagatt cttacaaatg attactacag
     4741 gaatagtggc cacttaatgt cagttactcc ggtggaagaa tttatctagt tttttttctt
     4801 ttcttttttg gaaggatggt gtgaaaaata gcaagattag agaatgagtt gtatagtttt
     4861 ttctatcaca tttcatctaa aatgatttga aggacttttg aagattttta ccaacatcct
     4921 taaatcaact ccaggttgga tgaacaactg atttaaaaca aactaagaga acattaacta
     4981 gatgtgggct ttttaaaata tataggtatt gcatttccta ccttgttatt tattccactt
     5041 tgaatacttt agagggctta actttcaact ctttaaggta gtaatggata gttttatact
     5101 tgttctcaca aaattgttat ggtcagttta tatcattgct ccatgcattg attataaaaa
     5161 ttcagtatta attttttctg atcttataag ctttatagga gttttctttt ctcttataaa
     5221 gtgtttcacc ttatgtaaaa caaatgcctg cttgcatatt ggaagatgtt gaaattagtt
     5281 ttagacaaaa gtggtccatc aattcagaca ctctgcttgg atgccttacc cttttcatta
     5341 gtgcattctt tgcttctgaa acttggcaga aactcgttag ccagtccact gcctttctga
     5401 caatgtgtgg agtcacgtat gcttggtata tgcctttact acttttaaag ttctacagtt
     5461 tattacttgc ccaagtgtta ctaaatcctt ttcttatgtg tactggatgg agaaaaaatt
     5521 atagccagca ctttgagagg aaagttttca gaaacaatat taactggcac tactaactga
     5581 aggccacagg agatgctatc aatgttattt gtaatctgaa gattgaacaa ggctgtgagg
     5641 ctcatttcaa actattttga ggtgttaaaa tatatatatg ctgtttctca gctgttccac
     5701 tcaaaccgtg ttaggactct caaaggtaaa atgtcacagg ggcttttcag ttgttacaga
     5761 gctcagcagc tgtggttgcc cctgttctac accaatttca gttcaataaa aatgttaact
     5821 ttgcaa
//
