LOCUS       NM_021795               2167 bp    mRNA    linear   PRI 13-FEB-2025
DEFINITION  Homo sapiens ETS transcription factor ELK4 (ELK4), transcript
            variant b, mRNA.
ACCESSION   NM_021795 XR_108340 XR_111967 XR_114975
VERSION     NM_021795.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2167)
  AUTHORS   Li,H., Chen,Z., Huang,Y., Chen,C. and Cai,L.
  TITLE     ELK4 targets CHMP6 to inhibit ferroptosis and enhance malignant
            properties of skin cutaneous melanoma cells
  JOURNAL   Arch Dermatol Res 316 (9), 634 (2024)
   PUBMED   39305302
  REMARK    GeneRIF: ELK4 targets CHMP6 to inhibit ferroptosis and enhance
            malignant properties of skin cutaneous melanoma cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2167)
  AUTHORS   Gao,F., Wang,C., Bai,X., Ji,J. and Huang,X.
  TITLE     ELK4 Promotes Cell Cycle Progression and Stem Cell-like
            Characteristics in HPV-associated Cervical Cancer by Regulating the
            FBXO22/PTEN Axis
  JOURNAL   Balkan Med J 40 (6), 409-414 (2023)
   PUBMED   37519006
  REMARK    GeneRIF: ELK4 Promotes Cell Cycle Progression and Stem Cell-like
            Characteristics in HPV-associated Cervical Cancer by Regulating the
            FBXO22/PTEN Axis.
REFERENCE   3  (bases 1 to 2167)
  AUTHORS   Zheng,K., Sha,N., Hou,G., Leng,Z., Zhao,Q., Zhang,L., He,L., Xu,M.,
            Jiang,Y. and Chen,T.
  TITLE     IGF1R-phosphorylated PYCR1 facilitates ELK4 transcriptional
            activity and sustains tumor growth under hypoxia
  JOURNAL   Nat Commun 14 (1), 6117 (2023)
   PUBMED   37777542
  REMARK    GeneRIF: IGF1R-phosphorylated PYCR1 facilitates ELK4
            transcriptional activity and sustains tumor growth under hypoxia.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2167)
  AUTHORS   Mao,X., Ji,T., Liu,A. and Weng,Y.
  TITLE     ELK4-mediated lncRNA SNHG22 promotes gastric cancer progression
            through interacting with EZH2 and regulating miR-200c-3p/Notch1
            axis
  JOURNAL   Cell Death Dis 12 (11), 957 (2021)
   PUBMED   34663788
  REMARK    GeneRIF: ELK4-mediated lncRNA SNHG22 promotes gastric cancer
            progression through interacting with EZH2 and regulating
            miR-200c-3p/Notch1 axis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2167)
  AUTHORS   Zheng,L., Xu,H., Di,Y., Chen,L., Liu,J., Kang,L. and Gao,L.
  TITLE     ELK4 promotes the development of gastric cancer by inducing M2
            polarization of macrophages through regulation of the
            KDM5A-PJA2-KSR1 axis
  JOURNAL   J Transl Med 19 (1), 342 (2021)
   PUBMED   34372882
  REMARK    GeneRIF: ELK4 promotes the development of gastric cancer by
            inducing M2 polarization of macrophages through regulation of the
            KDM5A-PJA2-KSR1 axis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2167)
  AUTHORS   Adams,M.D., Kerlavage,A.R., Fleischmann,R.D., Fuldner,R.A.,
            Bult,C.J., Lee,N.H., Kirkness,E.F., Weinstock,K.G., Gocayne,J.D.,
            White,O. et al.
  TITLE     Initial assessment of human gene diversity and expression patterns
            based upon 83 million nucleotides of cDNA sequence
  JOURNAL   Nature 377 (6547 Suppl), 3-174 (1995)
   PUBMED   7566098
REFERENCE   7  (bases 1 to 2167)
  AUTHORS   Price,M.A., Rogers,A.E. and Treisman,R.
  TITLE     Comparative analysis of the ternary complex factors Elk-1, SAP-1a
            and SAP-2 (ERP/NET)
  JOURNAL   EMBO J 14 (11), 2589-2601 (1995)
   PUBMED   7540136
REFERENCE   8  (bases 1 to 2167)
  AUTHORS   Shipley,J., Sheer,D., Dalton,S., Treisman,R. and Patel,K.
  TITLE     Mapping of the human SAP1 (SRF accessory protein 1) gene and SAP2,
            a gene encoding a related protein, to chromosomal bands 1q32 and
            12q23, respectively
  JOURNAL   Genomics 23 (3), 710-711 (1994)
   PUBMED   7851904
REFERENCE   9  (bases 1 to 2167)
  AUTHORS   Dalton,S. and Treisman,R.
  TITLE     Characterization of SAP-1, a protein recruited by serum response
            factor to the c-fos serum response element
  JOURNAL   Cell 76 (2), 411 (1994)
   PUBMED   8293474
  REMARK    Correction to:[Cell. 1992 Feb 7;68(3):597-612. doi:
            10.1016/0092-8674(92)90194-h.. PMID: 1339307]
REFERENCE   10 (bases 1 to 2167)
  AUTHORS   Dalton,S. and Treisman,R.
  TITLE     Characterization of SAP-1, a protein recruited by serum response
            factor to the c-fos serum response element
  JOURNAL   Cell 68 (3), 597-612 (1992)
   PUBMED   1339307
  REMARK    Erratum:[Cell. 1994 Jan 28;76(2):411.. PMID: 8293474]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC096533.3.
            
            On Jan 13, 2022 this sequence version replaced NM_021795.2.
            
            Summary: This gene is a member of the Ets family of transcription
            factors and of the ternary complex factor (TCF) subfamily. Proteins
            of the TCF subfamily form a ternary complex by binding to the the
            serum response factor and the serum reponse element in the promoter
            of the c-fos proto-oncogene. The protein encoded by this gene is
            phosphorylated by the kinases, MAPK1 and MAPK8. Several transcript
            variants have been described for this gene. [provided by RefSeq,
            Jul 2008].
            
            Transcript Variant: This variant (b) uses an alternate splice site
            in the 3' coding region which results in a frameshift compared to
            variant 1. This results in a shorter protein (isoform b) which has
            a shorter and distinct C-terminus compared to isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M85164.1, BC063676.1 [ECO:0000332]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-380               AC096533.3         93042-93421         c
            381-596             AC096533.3         85086-85301         c
            597-2167            AC096533.3         80678-82248         c
FEATURES             Location/Qualifiers
     source          1..2167
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q32.1"
     gene            1..2167
                     /gene="ELK4"
                     /gene_synonym="SAP1"
                     /note="ETS transcription factor ELK4"
                     /db_xref="GeneID:2005"
                     /db_xref="HGNC:HGNC:3326"
                     /db_xref="MIM:600246"
     exon            1..380
                     /gene="ELK4"
                     /gene_synonym="SAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            381..596
                     /gene="ELK4"
                     /gene_synonym="SAP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             390..1607
                     /gene="ELK4"
                     /gene_synonym="SAP1"
                     /note="isoform b is encoded by transcript variant b; ETS
                     domain-containing protein Elk-4; SAP-1; serum response
                     factor accessory protein 1; ELK4, ETS-domain protein (SRF
                     accessory protein 1); ELK4, ETS transcription factor"
                     /codon_start=1
                     /product="ETS domain-containing protein Elk-4 isoform b"
                     /protein_id="NP_068567.1"
                     /db_xref="CCDS:CCDS1457.1"
                     /db_xref="GeneID:2005"
                     /db_xref="HGNC:HGNC:3326"
                     /db_xref="MIM:600246"
                     /translation="MDSAITLWQFLLQLLQKPQNKHMICWTSNDGQFKLLQAEEVARL
                     WGIRKNKPNMNYDKLSRALRYYYVKNIIKKVNGQKFVYKFVSYPEILNMDPMTVGRIE
                     GDCESLNFSEVSSSSKDVENGGKDKPPQPGAKTSSRNDYIHSGLYSSFTLNSLNSSNV
                     KLFKLIKTENPAEKLAEKKSPQEPTPSVIKFVTTPSKKPPVEPVAATISIGPSISPSS
                     EETIQALETLVSPKLPSLEAPTSASNVMTAFATTPPISSIPPLQEPPRTPSPPLSSHP
                     DIDTDIDSVASQPMELPENLSLEPKDQDSVLLEKDKVNNSSRSKKPKGLELAPTLVIT
                     SSDPSPLGILSPSLPTASLTPAFFSQVACSLFMVSPLLSFICPFKQIQNLYTQVCFLL
                     LRFVLERLCVTVM"
     exon            597..2167
                     /gene="ELK4"
                     /gene_synonym="SAP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1694..1699
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ELK4"
                     /gene_synonym="SAP1"
                     /note="hexamer: AATAAA"
     polyA_site      1727
                     /gene="ELK4"
                     /gene_synonym="SAP1"
                     /note="major polyA site"
     regulatory      2145..2150
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ELK4"
                     /gene_synonym="SAP1"
                     /note="hexamer: AATAAA"
     polyA_site      2167
                     /gene="ELK4"
                     /gene_synonym="SAP1"
                     /note="major polyA site"
ORIGIN      
        1 acggcgtctg ggagggaccc aggagcagtc ggggggtttg agagtggcgg cggccgcgga
       61 gggcctggca ggccccgccg ctgcaaggaa cgccccgaac gcgcgcgccc ggcgtgtagc
      121 ggccccaaga cccgcgccgc cgctgccgcg tgcgggggcg gggagggcgg ggcgccagga
      181 gccgcggcgg cgggagatgc gggcggctgc gggcacccgg cgggctcggc ttggccgccg
      241 ccgccttcta cggctccgcc gcgggggtcg cagcggctgc cgcgccgtcc tcgagtttcc
      301 agcgtgagga ggaggctgag ggcggagagg cgcatcgtgt tcgaggcgga gaccgagggg
      361 gagccccgcg cgcggcgtcg ctcattgcta tggacagtgc tatcaccctg tggcagttcc
      421 ttcttcagct cctgcagaag cctcagaaca agcacatgat ctgttggacc tctaatgatg
      481 ggcagtttaa gcttttgcag gcagaagagg tggctcgtct ctgggggatt cgcaagaaca
      541 agcctaacat gaattatgac aaactcagcc gagccctcag atactattat gtaaagaata
      601 tcatcaaaaa agtgaatggt cagaagtttg tgtacaagtt tgtctcttat ccagagattt
      661 tgaacatgga tccaatgaca gtgggcagga ttgagggtga ctgtgaaagt ttaaacttca
      721 gtgaagtcag cagcagttcc aaagatgtgg agaatggagg gaaagataaa ccacctcagc
      781 ctggtgccaa gacctctagc cgcaatgact acatacactc tggcttatat tcttcattta
      841 ctctcaactc tttgaactcc tccaatgtaa agcttttcaa attgataaag actgagaatc
      901 cagccgagaa actggcagag aaaaaatctc ctcaggagcc cacaccatct gtcatcaaat
      961 ttgtcacgac accttccaaa aagccaccgg ttgaacctgt tgctgccacc atttcaattg
     1021 gcccaagtat ttctccatct tcagaagaaa ctatccaagc tttggagaca ttggtttccc
     1081 caaaactgcc ttccctggaa gccccaacct ctgcctctaa cgtaatgact gcttttgcca
     1141 ccacaccacc catttcgtcc ataccccctt tgcaggaacc tcccagaaca ccttcaccac
     1201 cactgagttc tcacccagac atcgacacag acattgattc agtggcttct cagccaatgg
     1261 aacttccaga gaatttgtca ctggagccta aagaccagga ttcagtcttg ctagaaaagg
     1321 acaaagtaaa taattcatca agatccaaga aacccaaagg gttagaactg gcacccaccc
     1381 ttgtgatcac gagcagtgat ccaagcccac tgggaatact gagcccatct ctccctacag
     1441 cttctcttac accagcattt ttttcacagg tagcttgctc gctctttatg gtgtcaccat
     1501 tgctttcatt tatttgccct tttaagcaaa tccagaattt atacactcaa gtttgctttc
     1561 tgttacttag gtttgtctta gaaaggttat gtgtgactgt catgtgaaag ttaccccatt
     1621 tctcatctta attaggattg ctaaaataga aagtttggag tattttctta aaaaattcat
     1681 tgttctacaa gtaaataaat attttgattt ttctatttcc tcctaaagaa agtacacaca
     1741 ctctctcgct ctctctcggt cttataaaac tcgttggtgt cttataaaac aaacagtgat
     1801 aatctcaagt tagaaaacag taggtcctga gaaccataag aaaaatgact ggtgtgatgt
     1861 tgagtaacaa gttggtacag ttactttagc tatttattaa cttgctcatc tcatagaaca
     1921 ttttagtaga tttttcacac acctcattat taaaaaaaaa caaacatgct ggtgtcttgg
     1981 ttacccatta ttcctctgta cctgaattca ggttggtttt tctatttgga aaagacttta
     2041 taaatgttgg cttaaaaaga ggttgagcac cagaatctca gaatttacca ccaaagaact
     2101 catccatgta accaaaaacc acttgtaccc ccaaaaacta ttgaaataaa aatttaaaaa
     2161 attttaa
//
