LOCUS       NM_001973              10288 bp    mRNA    linear   PRI 10-FEB-2025
DEFINITION  Homo sapiens ETS transcription factor ELK4 (ELK4), transcript
            variant a, mRNA.
ACCESSION   NM_001973
VERSION     NM_001973.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 10288)
  AUTHORS   Li,H., Chen,Z., Huang,Y., Chen,C. and Cai,L.
  TITLE     ELK4 targets CHMP6 to inhibit ferroptosis and enhance malignant
            properties of skin cutaneous melanoma cells
  JOURNAL   Arch Dermatol Res 316 (9), 634 (2024)
   PUBMED   39305302
  REMARK    GeneRIF: ELK4 targets CHMP6 to inhibit ferroptosis and enhance
            malignant properties of skin cutaneous melanoma cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 10288)
  AUTHORS   Gao,F., Wang,C., Bai,X., Ji,J. and Huang,X.
  TITLE     ELK4 Promotes Cell Cycle Progression and Stem Cell-like
            Characteristics in HPV-associated Cervical Cancer by Regulating the
            FBXO22/PTEN Axis
  JOURNAL   Balkan Med J 40 (6), 409-414 (2023)
   PUBMED   37519006
  REMARK    GeneRIF: ELK4 Promotes Cell Cycle Progression and Stem Cell-like
            Characteristics in HPV-associated Cervical Cancer by Regulating the
            FBXO22/PTEN Axis.
REFERENCE   3  (bases 1 to 10288)
  AUTHORS   Zheng,K., Sha,N., Hou,G., Leng,Z., Zhao,Q., Zhang,L., He,L., Xu,M.,
            Jiang,Y. and Chen,T.
  TITLE     IGF1R-phosphorylated PYCR1 facilitates ELK4 transcriptional
            activity and sustains tumor growth under hypoxia
  JOURNAL   Nat Commun 14 (1), 6117 (2023)
   PUBMED   37777542
  REMARK    GeneRIF: IGF1R-phosphorylated PYCR1 facilitates ELK4
            transcriptional activity and sustains tumor growth under hypoxia.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 10288)
  AUTHORS   Mao,X., Ji,T., Liu,A. and Weng,Y.
  TITLE     ELK4-mediated lncRNA SNHG22 promotes gastric cancer progression
            through interacting with EZH2 and regulating miR-200c-3p/Notch1
            axis
  JOURNAL   Cell Death Dis 12 (11), 957 (2021)
   PUBMED   34663788
  REMARK    GeneRIF: ELK4-mediated lncRNA SNHG22 promotes gastric cancer
            progression through interacting with EZH2 and regulating
            miR-200c-3p/Notch1 axis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 10288)
  AUTHORS   Zheng,L., Xu,H., Di,Y., Chen,L., Liu,J., Kang,L. and Gao,L.
  TITLE     ELK4 promotes the development of gastric cancer by inducing M2
            polarization of macrophages through regulation of the
            KDM5A-PJA2-KSR1 axis
  JOURNAL   J Transl Med 19 (1), 342 (2021)
   PUBMED   34372882
  REMARK    GeneRIF: ELK4 promotes the development of gastric cancer by
            inducing M2 polarization of macrophages through regulation of the
            KDM5A-PJA2-KSR1 axis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 10288)
  AUTHORS   Adams,M.D., Kerlavage,A.R., Fleischmann,R.D., Fuldner,R.A.,
            Bult,C.J., Lee,N.H., Kirkness,E.F., Weinstock,K.G., Gocayne,J.D.,
            White,O. et al.
  TITLE     Initial assessment of human gene diversity and expression patterns
            based upon 83 million nucleotides of cDNA sequence
  JOURNAL   Nature 377 (6547 Suppl), 3-174 (1995)
   PUBMED   7566098
REFERENCE   7  (bases 1 to 10288)
  AUTHORS   Price,M.A., Rogers,A.E. and Treisman,R.
  TITLE     Comparative analysis of the ternary complex factors Elk-1, SAP-1a
            and SAP-2 (ERP/NET)
  JOURNAL   EMBO J 14 (11), 2589-2601 (1995)
   PUBMED   7540136
REFERENCE   8  (bases 1 to 10288)
  AUTHORS   Shipley,J., Sheer,D., Dalton,S., Treisman,R. and Patel,K.
  TITLE     Mapping of the human SAP1 (SRF accessory protein 1) gene and SAP2,
            a gene encoding a related protein, to chromosomal bands 1q32 and
            12q23, respectively
  JOURNAL   Genomics 23 (3), 710-711 (1994)
   PUBMED   7851904
REFERENCE   9  (bases 1 to 10288)
  AUTHORS   Dalton,S. and Treisman,R.
  TITLE     Characterization of SAP-1, a protein recruited by serum response
            factor to the c-fos serum response element
  JOURNAL   Cell 76 (2), 411 (1994)
   PUBMED   8293474
  REMARK    Correction to:[Cell. 1992 Feb 7;68(3):597-612. doi:
            10.1016/0092-8674(92)90194-h.. PMID: 1339307]
REFERENCE   10 (bases 1 to 10288)
  AUTHORS   Dalton,S. and Treisman,R.
  TITLE     Characterization of SAP-1, a protein recruited by serum response
            factor to the c-fos serum response element
  JOURNAL   Cell 68 (3), 597-612 (1992)
   PUBMED   1339307
  REMARK    Erratum:[Cell. 1994 Jan 28;76(2):411.. PMID: 8293474]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC096533.3.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jul 25, 2019 this sequence version replaced NM_001973.3.
            
            Summary: This gene is a member of the Ets family of transcription
            factors and of the ternary complex factor (TCF) subfamily. Proteins
            of the TCF subfamily form a ternary complex by binding to the the
            serum response factor and the serum reponse element in the promoter
            of the c-fos proto-oncogene. The protein encoded by this gene is
            phosphorylated by the kinases, MAPK1 and MAPK8. Several transcript
            variants have been described for this gene. [provided by RefSeq,
            Jul 2008].
            
            Transcript Variant: This variant (a) encodes the longer isoform
            (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DRR138518.63354.1,
                                           DRR138518.706095.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000357992.9/ ENSP00000350681.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-380               AC096533.3         93042-93421         c
            381-596             AC096533.3         85086-85301         c
            597-1469            AC096533.3         81376-82248         c
            1470-1586           AC096533.3         80367-80483         c
            1587-10288          AC096533.3         69353-78054         c
FEATURES             Location/Qualifiers
     source          1..10288
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q32.1"
     gene            1..10288
                     /gene="ELK4"
                     /gene_synonym="SAP1"
                     /note="ETS transcription factor ELK4"
                     /db_xref="GeneID:2005"
                     /db_xref="HGNC:HGNC:3326"
                     /db_xref="MIM:600246"
     exon            1..380
                     /gene="ELK4"
                     /gene_synonym="SAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            381..596
                     /gene="ELK4"
                     /gene_synonym="SAP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             390..1685
                     /gene="ELK4"
                     /gene_synonym="SAP1"
                     /note="isoform a is encoded by transcript variant a; ETS
                     domain-containing protein Elk-4; SAP-1; serum response
                     factor accessory protein 1; ELK4, ETS-domain protein (SRF
                     accessory protein 1); ELK4, ETS transcription factor"
                     /codon_start=1
                     /product="ETS domain-containing protein Elk-4 isoform a"
                     /protein_id="NP_001964.2"
                     /db_xref="CCDS:CCDS1456.1"
                     /db_xref="GeneID:2005"
                     /db_xref="HGNC:HGNC:3326"
                     /db_xref="MIM:600246"
                     /translation="MDSAITLWQFLLQLLQKPQNKHMICWTSNDGQFKLLQAEEVARL
                     WGIRKNKPNMNYDKLSRALRYYYVKNIIKKVNGQKFVYKFVSYPEILNMDPMTVGRIE
                     GDCESLNFSEVSSSSKDVENGGKDKPPQPGAKTSSRNDYIHSGLYSSFTLNSLNSSNV
                     KLFKLIKTENPAEKLAEKKSPQEPTPSVIKFVTTPSKKPPVEPVAATISIGPSISPSS
                     EETIQALETLVSPKLPSLEAPTSASNVMTAFATTPPISSIPPLQEPPRTPSPPLSSHP
                     DIDTDIDSVASQPMELPENLSLEPKDQDSVLLEKDKVNNSSRSKKPKGLELAPTLVIT
                     SSDPSPLGILSPSLPTASLTPAFFSQTPIILTPSPLLSSIHFWSTLSPVAPLSPARLQ
                     GANTLFQFPSVLNSHGPFTLSGLDGPSTPGPFSPDLQKT"
     exon            597..1469
                     /gene="ELK4"
                     /gene_synonym="SAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1470..1586
                     /gene="ELK4"
                     /gene_synonym="SAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1587..10288
                     /gene="ELK4"
                     /gene_synonym="SAP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3327..3332
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ELK4"
                     /gene_synonym="SAP1"
                     /note="hexamer: ATTAAA"
     polyA_site      3348
                     /gene="ELK4"
                     /gene_synonym="SAP1"
     regulatory      10266..10271
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ELK4"
                     /gene_synonym="SAP1"
                     /note="hexamer: AATAAA"
     polyA_site      10288
                     /gene="ELK4"
                     /gene_synonym="SAP1"
                     /note="major polyA site"
ORIGIN      
        1 acggcgtctg ggagggaccc aggagcagtc ggggggtttg agagtggcgg cggccgcgga
       61 gggcctggca ggccccgccg ctgcaaggaa cgccccgaac gcgcgcgccc ggcgtgtagc
      121 ggccccaaga cccgcgccgc cgctgccgcg tgcgggggcg gggagggcgg ggcgccagga
      181 gccgcggcgg cgggagatgc gggcggctgc gggcacccgg cgggctcggc ttggccgccg
      241 ccgccttcta cggctccgcc gcgggggtcg cagcggctgc cgcgccgtcc tcgagtttcc
      301 agcgtgagga ggaggctgag ggcggagagg cgcatcgtgt tcgaggcgga gaccgagggg
      361 gagccccgcg cgcggcgtcg ctcattgcta tggacagtgc tatcaccctg tggcagttcc
      421 ttcttcagct cctgcagaag cctcagaaca agcacatgat ctgttggacc tctaatgatg
      481 ggcagtttaa gcttttgcag gcagaagagg tggctcgtct ctgggggatt cgcaagaaca
      541 agcctaacat gaattatgac aaactcagcc gagccctcag atactattat gtaaagaata
      601 tcatcaaaaa agtgaatggt cagaagtttg tgtacaagtt tgtctcttat ccagagattt
      661 tgaacatgga tccaatgaca gtgggcagga ttgagggtga ctgtgaaagt ttaaacttca
      721 gtgaagtcag cagcagttcc aaagatgtgg agaatggagg gaaagataaa ccacctcagc
      781 ctggtgccaa gacctctagc cgcaatgact acatacactc tggcttatat tcttcattta
      841 ctctcaactc tttgaactcc tccaatgtaa agcttttcaa attgataaag actgagaatc
      901 cagccgagaa actggcagag aaaaaatctc ctcaggagcc cacaccatct gtcatcaaat
      961 ttgtcacgac accttccaaa aagccaccgg ttgaacctgt tgctgccacc atttcaattg
     1021 gcccaagtat ttctccatct tcagaagaaa ctatccaagc tttggagaca ttggtttccc
     1081 caaaactgcc ttccctggaa gccccaacct ctgcctctaa cgtaatgact gcttttgcca
     1141 ccacaccacc catttcgtcc ataccccctt tgcaggaacc tcccagaaca ccttcaccac
     1201 cactgagttc tcacccagac atcgacacag acattgattc agtggcttct cagccaatgg
     1261 aacttccaga gaatttgtca ctggagccta aagaccagga ttcagtcttg ctagaaaagg
     1321 acaaagtaaa taattcatca agatccaaga aacccaaagg gttagaactg gcacccaccc
     1381 ttgtgatcac gagcagtgat ccaagcccac tgggaatact gagcccatct ctccctacag
     1441 cttctcttac accagcattt ttttcacaga cacccatcat actgactcca agccccttgc
     1501 tctccagtat ccacttctgg agtactctca gtcctgttgc tcccctaagt ccagccagac
     1561 tgcaaggtgc taacacactt ttccagtttc cttctgtact gaacagtcat gggccattca
     1621 ctctgtctgg gctggatgga ccttccaccc ctggcccatt ttccccagac ctacagaaga
     1681 cataacctat gcacttgtgg aatgagagaa ccgaggaacg aagaaacaga cattcaacat
     1741 gattgcattt gaagtgagca attgatagtt ctacaatgct gataatagac tattgtgatt
     1801 tttgccattc cccattgaaa acatcttttt aggattctct ttgaatagga ctcaagttgg
     1861 actatatgta taaaaatgcc ttaattggag tctaaactcc acctccctct gtcttttcct
     1921 tttctttttc tttccttcct tccttttctt ttctccttta aaaatatttt gagctttgtg
     1981 ctgaagaagt ttttggtggg ctttagtgac tgtgctttgc aaaagcaatt aagaacaaag
     2041 ttactccttc tggctattgg gaccctttgg ccaggaaaaa ttatgcttag aatctattat
     2101 ttaaagaaat atttgtgaaa tgaattggca tctttaggac taagtgtgct ctgttgaatg
     2161 acttaaagtg agctgttcct aagcagtgga agaagaagaa tcattcctat tcatacaaag
     2221 taagattgga gcagtcatac tggggagatt gttttgtgtg aactataacg tgtaagcaac
     2281 tccatgaaaa ggcatcttgt ttacctttat tcagggtgga tctcttagcc atatgtatga
     2341 tcctgtctga acctgtcaac agagcatgga gctagtctat ttcactatag aaagattttt
     2401 agacctgggg tttaagacag tttttggaac acctagtaag aatatgggac ctcacatcta
     2461 gcacagaaat gctctttgcc ctctgggtgg tatgattata tgcccatgga atacagcatg
     2521 ggaaatgatc acttttagga ggatgaactt ggattttgaa tatttgaaac atctctgagt
     2581 aaaagattcg atcagataac ttgaaacaac atgtagtggt tttctcaatt agaagataac
     2641 caagtgaagg acctgtcttt ttcctgttca ttttacctca ttttctacta tacatttatc
     2701 acctttcctt tatgtttaag gttgttagag gttatgatag ttttaaagat gcagttagga
     2761 aggtagaatt caaagtgaag cctccccagt caggagcgaa gatgtgctta tttccttttt
     2821 tttttttttt tttttttttt gagacagagt cttgctctat cacccaggct ggagtgcagt
     2881 ggcgcgatct cagctcactg taagctccgc ctcccgggtt caagcaattc tcctgcctca
     2941 gcctcctgag tagctgggac tacaggcatg cgccactacg cctggctaat ttttgtattt
     3001 ttagtagaga cggggtttca ccatgttggc caggatggtc ttgatctctt gaccttgtga
     3061 tccgcccacc tcagcctccc aaaggcgcag gctcagatgt gcttatttct ttcaactttt
     3121 tttttttaaa tggggaagag cagagttcat ttgggaatgc ttatacatag ggattggatt
     3181 gttcatatta gtagtaaaaa atgtaggcct tattctctac attaccaaat ttttaaaata
     3241 ttactatatg gtaatcaatg ccaggtacag atttgttggt tccccaaact gaattgatat
     3301 cagtatcaca gtggagtctt ttgaaaatta aagtccagga ttaaattata tgttgtcacc
     3361 attcaccacc actaccaccc tcccccacca atctctccca ccggttaaac tcgtcttcta
     3421 atcctgtaga atcacatgaa ctaaatgaag aagtaagaac ttgaaggctc agactgacac
     3481 tgttacaaac tagcatcttc agatgcatgg tatttacttt aaatgtgctt atatacagtg
     3541 tagagaagct cttgtataag aagacatcta tgctagctaa cttagtagta gtagagggaa
     3601 catattcagt gagctgcctt tatatctgta gtgtcggaga cttgttactg gttcatttgt
     3661 ggttatcagt tgaaggttct gttcctgaga tgtgcaatag tagtgttgaa aggtattgtt
     3721 taatagtgat ggggaacaga catattggac ttttttttcc atattaaatt atttagtttg
     3781 catgcctgtt tgaaattgga cctctcagca gcactttgaa atagttttaa ttaggttaac
     3841 attttgtaca ttaaataagt agatatagat ggttgattta actagatgtg ttaaattttg
     3901 aaagcacaaa ggtattttat ctttttgaat taaaggagaa aagccattga tttgttttca
     3961 cagacagtat ttttaataat taactgtctc agcacagagg taccttggaa ccaagggcac
     4021 cattgaaact cagttgaagc aacttcctag taaaccattt tagtgagtcc tttttgcata
     4081 aatctatagc ctctcagagg tgtgaggctg tcacagattg gtgatctgct atctctttga
     4141 gatcaactaa tttggagaag tgtgtgtgtg cgtatccttt tttaagtcaa agtttacaac
     4201 cttactgcag gtgtatgagg cagacagttc tgtttataga ctacctcctt cctggaaaag
     4261 tctcagcttc atattctgtt gaatatatgc agaattctta gtgtgaaagg tgatgtacca
     4321 cttcagatca gttttcactg gagagacttg taattggtag ctgtagctcg tatccatccc
     4381 tagtcacttt gccaggatga atgctgttgg gcagcagtag cctaagttac ggaaggggag
     4441 cagattgaat ggggttttga gacatcttct ctgatacctt agctttcctt ctgctctggt
     4501 cgctatccac tcagtcgtgt gctagaaatg tttaacaacc aggatctctg gggtgggggt
     4561 gggggggagc gctgaatttg tagcatttgc tgcaaatata aattataaat aaaattctaa
     4621 tataaattag aattttatat caaattcttt gatataaatt agttactcct cctgtggctg
     4681 atttcaagct accaccttag agttcagaaa ggatgtgcac agttggctca gagccagtgc
     4741 tggcaaacca ttgcatttac tccacccaag agtggatttt cacataattt ctaaaataat
     4801 tttttcttat ttatatactg acttttcaaa atacaaaatt aaaatatcat gtctgacttc
     4861 agtgatcttt ttctttttct ttttttagaa atgagatctt tcagtaatcc tttaatttaa
     4921 ttttttagag atggagtctt ggtgtgttac ccagggtgga ctcaaactcc cgggctcaag
     4981 tgatcctcct gcctcagcct cctgcatagc tgggctacag gcatgcacca ccacacctgg
     5041 cttagtaatc cttctttatt aatggtttgt cacagtacgt ttgtgatgtt atattgctca
     5101 tggcatactt tatgtgttcg aacaaaggtg gaaatttcca ttgatttttt tttttttaaa
     5161 tgtatgcaca aacaatctgg attttgagga gtacggtcag gaaaaaaaaa aaagaattag
     5221 aggcccttga aaggtcaacc gtaagcttct tagagttaaa atatgagttt aattttttcc
     5281 cacattttga cagttgaaat tttgataggg acagtaaacc tatgagcctc tattaggcta
     5341 ctggattttt tttaactgga aaattccttg aagatttaca tactatatta cagattttaa
     5401 aagtcaagac tgacttaagt aaatcagagg tttggaattc tggagctgta actccaggct
     5461 gttgatagta tcacttcagt tccattcacc cctgcattgt gtgacgtcca gtctgacaac
     5521 attgtttcat cctgatctga ctttctacta tgattcttaa gttcttaaag gtgtcctttt
     5581 atgtttttgg tgaatgtaag cacatttaga gccactcagt accacttctc aatacctctg
     5641 aagcagtggt tcagaaaagg agtgtccagc ctttttgaac acacaaattg atcagtaaga
     5701 gttattgaac ataaaaactt tccctattaa aaattcatat gggtatatgt taaattatat
     5761 accgctatac caaagtaata tgtgtgttat aaaaaaatac acaaaaattg aagtgaagga
     5821 tggcataaaa agtaattctt gagtagcagt tatagtattt tcttcccaca ccccagttgg
     5881 ttgtcttgtg caccctccag aagcacacgc ttttcctaaa gactgctgac tcaggatatt
     5941 ctcattctaa tctccaaaca tatatgatgc tctcttatga tatatggaga aatcctagag
     6001 atttggagtt tttcaggaga gcttattgtc aacttttgaa atttcacatt aattcttttt
     6061 gataaattcc caaataataa tccattacca catgttttcc acagctttat tcctattact
     6121 ttcgtcagcc tgttgtctct tatcttcatg ttaggtatga ctctattttt attttactag
     6181 tctgctcaca gacttctttg ggacttatgt tatattttac caacaaattt agaattattt
     6241 caagttgctt tatgttaaaa tatataacaa gttacatttt cttgctgcat taataagttt
     6301 ttgattttta aaatctgata tttcagcaac taaaggaata cttttcttta taggtctgtt
     6361 ctgtttttaa cctcattgac tgtatatgtt ttatttaccc gtgccaggag tctagaatcg
     6421 tgcttaggtg ccattcttag gtatgaaaac aagtttggag accaatgcag gtctctgtgc
     6481 agaaatctgg ggctctaaat gaattaccaa accaatagga aagttaaaat actactcatg
     6541 atgtagtgtg tcatctgaag ctatgataga atatattatt tctaaaatag tattgagaag
     6601 ttaattgttc agtccatagt agtgtaagtg aagtgtggag gtcagccata gttgtctttc
     6661 ttcagcaggt actctaacca gagactgggt tctgtggaaa atagaattat attcttggtt
     6721 tgggatcaac aaatgttttg ttattgtttt aatgttgctg gcattgcctg aaacaaagtg
     6781 ccctgttatt cctcttatgt catcagaact ctgcttactg aagttgaagt ttaatcttag
     6841 gatctagaat tcttgtggtt ggtcgtgtat taagaaaaga aggtggtttg attttatttc
     6901 ttgtacttgg tggaacctgt tactatacaa gtcatgtttt gacctgtaag ccgagcaaat
     6961 ctgaaaggtg aatcgttaat ggtagtataa ttgtttcatt tgaaactgtc agtttcttca
     7021 agtcacttct ctgaaaaaaa ttatgataga ttgatagcct gccagaaaat agcaatttct
     7081 aaggtgctgc catccacact tacttattgt gaaatatgaa aatccagagt ggtttgtatg
     7141 agaggggaaa tactggctct aagctttcta cagaaaacag gaaattcatg ctgttgttga
     7201 cataatttta aaggaaactt ttaacaagaa aattcatgag ggatacaatc aaacatagtt
     7261 aatctcttga gtgctaatca tttgagtata gtccacatca ggaagtttta tgaggttgaa
     7321 aactttactt tgaaatattt aattgggaga ctagaccatt tctttttcca agtcattctg
     7381 atttattgtc ctagtaaatg tatgtgtatg catatatact gatgtattga ctgaatgtgt
     7441 gtgtgtgtgt gtgtgcgcgt gtaaatctgt tttcataggg aacatacatt gatggctcct
     7501 agtctatttt atactaaaac ttaaaaaaat ttgctgcact ttgcagttgc cactttttaa
     7561 aagattaatg ctttgcacat ttcagtaggc cttaaagatg aattgctcac caacatttta
     7621 gaaatacact gcttacatgt gacatactct aaacaaagtc atagtaaact gttctcttag
     7681 gttcatgtat tattgagcaa ataaggatgt cctttcttaa aatttctaca tttatgtttg
     7741 cttttgtgta aaatctttat tagtttgtaa gtttctcaaa gaggaggttt atactggaag
     7801 cagtatttct aaagtacaga gattcgacca tggattgaat acagtagtgg aggaatgctg
     7861 gtattgtggc ctaatttatc cttttaaact gtatgtcatt agtattagcc aaaacctcag
     7921 agtggagtgt cttgggctga atgatcttct caactttgcc ttgtttccca tctcataaag
     7981 gctccttctg gttcttttcc cttccaagga ttgtgagtca tgctcacata ggcctgggat
     8041 cttctggatg gggtcgggga ggaggtgggg gtttcctgtg gctggcccag agttctagcc
     8101 aatggaatca ttcaagaatg cctaaagttc aggggtggga atgccatata ttggtgttaa
     8161 tcacttggca ctttcttggg caccaatatt agcactgttt catttttaat aactggaagc
     8221 acttaatgat tattttgttt gtttaatttc aacttaagga tattgagggt cagagaagta
     8281 aggtttattt cttgtttatg ttttctggaa tttatagggt gtttgtagaa gggataaatg
     8341 ggttacctaa tgagccattc ttctaggctc tgtaaggtat gcccttttgg ctaggatatt
     8401 ttaaaataat ttgcaagctt ttaatattgt gctttgtaga aatttacgat ttttaaaaat
     8461 aatttgcaat tgatagatta cacttaaatt tataaagtat ccaattttaa gtttcttttc
     8521 tgtttggtca ttgttgctta ttgtctattg tgtaggggac acaatcctga catttcattg
     8581 ttttgttact tggggcagta ttaaccagtg gcctttgtat gtacattcat tgcttacatt
     8641 tattgtttaa gtggtagagt agcattttta tgaacttccc tgttcagtat tagtgaaatt
     8701 gacagatgcg tatatgtaaa gatagaaaag aaacgaatac aattaatttt ttattccttg
     8761 aggcctattt atttgttttg gccctggatc ttttctaatc acaattatat ttctttattt
     8821 ttgcctttga gcagtttcat ttatctttgt gggcagggaa gattaaatat gaaattcagt
     8881 ccagtcattt tgctactggt tagctttagt ttgaggcaag taaaaatttt tgattaaaat
     8941 tagtttctta aaattatgcc cttgctttac caaataatca aattggctaa aaaataaggg
     9001 tatgtaactt tgcattttga agaacaaacc aataattttt catgagccct actcgatctt
     9061 ctttaaagaa gaccttccta agagacaatt agggatgagt ttgattaatg ggaaatagct
     9121 ctaggttaga ttattttaaa ttccatacac caagtgattt aaccacagtg gcagtggcag
     9181 tttctgaacc gtcaagtatg aacatcactt aaaaattaaa agatgcttaa taataaactc
     9241 ttaattttca ttaagccaat ctgtaattca gaagaaaagc atatgtctgc catgggacta
     9301 ttgcagtgcg tctccatcag tgttaacaca ggagagatat gttattttat gtgtatgtct
     9361 tagtttggga tatgtggtag taagaacatg tcaagagtgc tttcttcaaa cctgtcagct
     9421 caactgagaa gacagttact tcattgctta ttttttccct tgttttattg aaatctgtat
     9481 ctcatatcca gtatctaaca ctttgtagag atacttacat ataatgtaag tgcacaccta
     9541 cccagaggaa tggataactg ttaaagtgtt aataatagct cgtcttagtt gatttcagca
     9601 taatttacat tagggagacc taaaaagcac cttcaaagta ttaaaagcac cttttttttt
     9661 tctttttcct aaaaaagcaa ttaaaatggt cactgctaac atttattaaa cttcatgtta
     9721 gttgatgaaa cagctggagg gaagctgcca catctcctag ctaagcagtc tgacttacct
     9781 gttgggaaac aaagggatat tgctctaaga ttgattagga tgattgtagc tagagtcttg
     9841 aattctatct gtatacggca gagaaacttt atagagtgta gagaggtgag cgaaaggatg
     9901 caaaagcact ttgagggctt tataataata tgctgcttga aaaaaaaaat gtgtagttga
     9961 tactcagtgc atctccagac atagtaaggg gttgctctga ccaatcaggt gatcattttt
    10021 tctatcactt cccaggtttt atgcaaaaat tttgttaaat tctataatgg tgatatgcat
    10081 cttttaggaa agatatacat ttttaaaaat ctattttatg taagaactga cagaggaatt
    10141 tgctttgtat aatgcaggct ggctttacaa aagcactgta gcaaatttac tacaagtcta
    10201 aaagtataca tatatgttaa tagatatatg tgcaactaga tatggacagc agttgtattt
    10261 ttttaaataa atatttttaa caaaatga
//
