LOCUS       NM_001114123            2876 bp    mRNA    linear   PRI 12-JUN-2024
DEFINITION  Homo sapiens ETS transcription factor ELK1 (ELK1), transcript
            variant 1, also known as 5'UTR long or 5'UTRL, mRNA.
ACCESSION   NM_001114123 XM_005272594
VERSION     NM_001114123.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2876)
  AUTHORS   Yan,G. and Lei,W.
  TITLE     Role of ELK1 in regulating colorectal cancer progression:
            miR-31-5p/CDIP1 axis in CRC pathogenesis
  JOURNAL   PeerJ 11, e15602 (2023)
   PUBMED   37547727
  REMARK    GeneRIF: Role of ELK1 in regulating colorectal cancer progression:
            miR-31-5p/CDIP1 axis in CRC pathogenesis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2876)
  AUTHORS   Kong,X., An,P., Xu,J., Liu,W., Lin,F. and Yang,Y.
  TITLE     A-Kinase Anchor Protein 95 Is Involved in ERK1/2-Elk-1 Signal
            Transduction in Colon Cancer
  JOURNAL   Anal Cell Pathol (Amst) 2023, 8242646 (2023)
   PUBMED   36691407
  REMARK    GeneRIF: A-Kinase Anchor Protein 95 Is Involved in ERK1/2-Elk-1
            Signal Transduction in Colon Cancer.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2876)
  AUTHORS   Rahim,G., Araud,T., Jaquier-Gubler,P. and Curran,J.
  TITLE     Alternative splicing within the elk-1 5' untranslated region serves
            to modulate initiation events downstream of the highly conserved
            upstream open reading frame 2
  JOURNAL   Mol Cell Biol 32 (9), 1745-1756 (2012)
   PUBMED   22354998
  REMARK    GeneRIF: demonstrate that ELK-1 expression arises by a combination
            of leaky scanning and reinitiation, with the latter mediated by the
            small upstream ORF2 conserved in both spliced isoforms
REFERENCE   4  (bases 1 to 2876)
  AUTHORS   Araud,T., Genolet,R., Jaquier-Gubler,P. and Curran,J.
  TITLE     Alternatively spliced isoforms of the human elk-1 mRNA within the
            5' UTR: implications for ELK-1 expression
  JOURNAL   Nucleic Acids Res 35 (14), 4649-4663 (2007)
   PUBMED   17591614
  REMARK    GeneRIF: The 5' UTR controls ribosomal access to the ELK-1 AUG
            initiation codon.
REFERENCE   5  (bases 1 to 2876)
  AUTHORS   Sharrocks,A.D.
  TITLE     Complexities in ETS-domain transcription factor function and
            regulation: lessons from the TCF (ternary complex factor)
            subfamily. The Colworth Medal Lecture
  JOURNAL   Biochem Soc Trans 30 (2), 1-9 (2002)
   PUBMED   12023815
  REMARK    GeneRIF: Complexities in Elk-1 transcription factor function and
            regulation
REFERENCE   6  (bases 1 to 2876)
  AUTHORS   Yamauchi,T., Toko,M., Suga,M., Hatakeyama,T. and Isobe,M.
  TITLE     Structural organization of the human Elk1 gene and its processed
            pseudogene Elk2
  JOURNAL   DNA Res 6 (1), 21-27 (1999)
   PUBMED   10231026
REFERENCE   7  (bases 1 to 2876)
  AUTHORS   Harindranath,N., Mills,F.C., Mitchell,M., Meindl,A. and Max,E.E.
  TITLE     The human elk-1 gene family: the functional gene and two processed
            pseudogenes embedded in the IgH locus
  JOURNAL   Gene 221 (2), 215-224 (1998)
   PUBMED   9795224
REFERENCE   8  (bases 1 to 2876)
  AUTHORS   Price,M.A., Rogers,A.E. and Treisman,R.
  TITLE     Comparative analysis of the ternary complex factors Elk-1, SAP-1a
            and SAP-2 (ERP/NET)
  JOURNAL   EMBO J 14 (11), 2589-2601 (1995)
   PUBMED   7540136
REFERENCE   9  (bases 1 to 2876)
  AUTHORS   Janknecht,R. and Nordheim,A.
  TITLE     Elk-1 protein domains required for direct and SRF-assisted
            DNA-binding
  JOURNAL   Nucleic Acids Res 20 (13), 3317-3324 (1992)
   PUBMED   1630903
REFERENCE   10 (bases 1 to 2876)
  AUTHORS   Rao,V.N., Huebner,K., Isobe,M., ar-Rushdi,A., Croce,C.M. and
            Reddy,E.S.
  TITLE     elk, tissue-specific ets-related genes on chromosomes X and 14 near
            translocation breakpoints
  JOURNAL   Science 244 (4900), 66-70 (1989)
   PUBMED   2539641
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL009172.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Oct 27, 2020 this sequence version replaced NM_001114123.2.
            
            Summary: This gene is a member of the Ets family of transcription
            factors and of the ternary complex factor (TCF) subfamily. Proteins
            of the TCF subfamily form a ternary complex by binding to the the
            serum response factor and the serum response element in the
            promoter of the c-fos proto-oncogene. The protein encoded by this
            gene is a nuclear target for the ras-raf-MAPK signaling cascade.
            This gene produces multiple isoforms by using alternative
            translational start codons and by alternative splicing. Related
            pseudogenes have been identified on chromosomes 7 and 14. [provided
            by RefSeq, Mar 2012].
            
            Transcript Variant: This variant (1, also known as 5'UTR long or
            5'UTRL) represents the longest transcript and encodes the longer
            isoform (a). Both variants 1 and 2 encode isoform a. Delayed
            translational reinitiation from an alternative downstream start
            codon, AUG sElk-1, can also result in a shorter isoform (sELK-1),
            as described in PMID:22354998.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7346977.942612.1,
                                           SRR18074967.1679677.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000376983.8/ ENSP00000366182.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            regulatory uORF        :: PMID: 22354998
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-141               AL009172.1         46549-46689         c
            142-247             AL009172.1         46047-46152         c
            248-491             AL009172.1         37358-37601         c
            492-935             AL009172.1         35021-35464         c
            936-1367            AL009172.1         33877-34308         c
            1368-1469           AL009172.1         33139-33240         c
            1470-2876           AL009172.1         31647-33053         c
FEATURES             Location/Qualifiers
     source          1..2876
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp11.23"
     gene            1..2876
                     /gene="ELK1"
                     /note="ETS transcription factor ELK1"
                     /db_xref="GeneID:2002"
                     /db_xref="HGNC:HGNC:3321"
                     /db_xref="MIM:311040"
     exon            1..141
                     /gene="ELK1"
                     /inference="alignment:Splign:2.1.0"
     exon            142..247
                     /gene="ELK1"
                     /inference="alignment:Splign:2.1.0"
     exon            248..491
                     /gene="ELK1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      259..267
                     /regulatory_class="uORF"
                     /gene="ELK1"
                     /experiment="DESCRIPTION:regulatory uORF[PMID:22354998]"
                     /note="this uORF is known as uORF2 and is predicted to
                     encode a 2 aa peptide (PMID:22354998)"
     CDS             282..1568
                     /gene="ELK1"
                     /note="isoform a is encoded by transcript variant 1, also
                     known as 5'UTR long or 5'UTRL; ETS domain-containing
                     protein Elk-1; ETS-like gene 1; tyrosine kinase (ELK1)
                     oncogene; ELK1, member of ETS oncogene family; ELK1, ETS
                     transcription factor"
                     /codon_start=1
                     /product="ETS domain-containing protein Elk-1 isoform a"
                     /protein_id="NP_001107595.1"
                     /db_xref="CCDS:CCDS14283.1"
                     /db_xref="GeneID:2002"
                     /db_xref="HGNC:HGNC:3321"
                     /db_xref="MIM:311040"
                     /translation="MDPSVTLWQFLLQLLREQGNGHIISWTSRDGGEFKLVDAEEVAR
                     LWGLRKNKTNMNYDKLSRALRYYYDKNIIRKVSGQKFVYKFVSYPEVAGCSTEDCPPQ
                     PEVSVTSTMPNVAPAAIHAAPGDTVSGKPGTPKGAGMAGPGGLARSSRNEYMRSGLYS
                     TFTIQSLQPQPPPHPRPAVVLPSAAPAGAAAPPSGSRSTSPSPLEACLEAEEAGLPLQ
                     VILTPPEAPNLKSEELNVEPGLGRALPPEVKVEGPKEELEVAGERGFVPETTKAEPEV
                     PPQEGVPARLPAVVMDTAGQAGGHAASSPEISQPQKGRKPRDLELPLSPSLLGGPGPE
                     RTPGSGSGSGLQAPGPALTPSLLPTHTLTPVLLTPSSLPPSIHFWSTLSPIAPRSPAK
                     LSFQFPSSGSAQVHIPSISVDGLSTPVVLSPGPQKP"
     exon            492..935
                     /gene="ELK1"
                     /inference="alignment:Splign:2.1.0"
     exon            936..1367
                     /gene="ELK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1368..1469
                     /gene="ELK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1470..2876
                     /gene="ELK1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2856..2861
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ELK1"
                     /note="hexamer: AATATA"
     polyA_site      2876
                     /gene="ELK1"
                     /note="major polyA site"
ORIGIN      
        1 ctaggtgctg ccgccgccac cgccaccacc acctccaccg ccgcctcgga acccaggcct
       61 ggggggcggt ggggccgcgt atggagcccc cgccccccgg agctgccaac attgccaacg
      121 ccaccgccac gctacacaca gcctcaactt tcaggagacc cgtccgtggc cttatttatt
      181 ccacccttcc tgtacatcgt agcgaatcaa tccgtggcgc cgcactcctc cgcatccctc
      241 tttaacagta cccctgggat ggcgtgagca ctcccccagc gatggaccca tctgtgacgc
      301 tgtggcagtt tctgctgcag ctgctgagag agcaaggcaa tggccacatc atctcctgga
      361 cttcacggga tggtggtgaa ttcaagctgg tggatgcaga ggaggtggcc cggctgtggg
      421 ggctacgcaa gaacaagacc aacatgaatt acgacaagct cagccgggcc ttgcggtact
      481 actatgacaa gaacatcatc cgcaaggtga gcggccagaa gttcgtctac aagtttgtgt
      541 cctaccctga ggtcgcaggg tgctccactg aggactgccc gccccagcca gaggtgtctg
      601 ttacctccac catgccaaat gtggcccctg ctgctataca tgccgcccca ggggacactg
      661 tctctggaaa gccaggcaca cccaagggtg caggaatggc aggcccaggc ggtttggcac
      721 gcagcagccg gaacgagtac atgcgctcgg gcctctattc caccttcacc atccagtctc
      781 tgcagccgca gccaccccct catcctcggc ctgctgtggt gctccccagt gcagctcctg
      841 caggggcagc agcgcccccc tcggggagca ggagcaccag tccaagcccc ttggaggcct
      901 gtctggaggc tgaagaggcc ggcttgcctc tgcaggtcat cctgaccccg cccgaggccc
      961 caaacctgaa atcggaagag cttaatgtgg agccgggttt gggccgggct ttgcccccag
     1021 aagtgaaagt agaagggccc aaggaagagt tggaagttgc gggggagaga gggtttgtgc
     1081 cagaaaccac caaggccgag ccagaagtcc ctccacagga gggcgtgcca gcccggctgc
     1141 ccgcggttgt tatggacacc gcagggcagg cgggcggcca tgcggcttcc agccctgaga
     1201 tctcccagcc gcagaagggc cggaagcccc gggacctaga gcttccactc agcccgagcc
     1261 tgctaggtgg gccgggaccc gaacggaccc caggatcggg aagtggctcc ggcctccagg
     1321 ctccggggcc ggcgctgacc ccatccctgc ttcctacgca tacattgacc ccggtgctgc
     1381 tgacacccag ctcgctgcct cctagcattc acttctggag caccctgagt cccattgcgc
     1441 cccgtagccc ggccaagctc tccttccagt ttccatccag tggcagcgcc caggtgcaca
     1501 tcccttctat cagcgtggat ggcctctcga cccccgtggt gctctcccca gggccccaga
     1561 agccatgact actaccacca ccaccaccac cccttctggg gtcactccat ccatgctctc
     1621 tccagccagc catctcaagg agaaacatag ttcaactgaa agactcatgc tctgattgtg
     1681 gtggggtggg gatccttggg aagaattact cccaagagta actctcatta tctcctccac
     1741 agaaaacaca cagcttccac aacttctctg ttttctgtca gtcccccagt ggccgccctt
     1801 acacgtctcc tacttcaatg gtaggggcgg tttatttatt tattttttga aggccactgg
     1861 gaggagcctg acctaacctt ttagggtggt taggacatct cccccacctc cccacttttt
     1921 tccccaagac aagacaatcg aggtctggct tgagaacgac ctttctttct ttatttctca
     1981 gcctgccctt ggggagatga gggagccctg tctgcgtttt tggatgtgag tagaagagtt
     2041 agtttgtttt gttttattat tcctggccat actcaggggt ccaggaagaa tttgtaccat
     2101 ttaatgggtt gggagtcttg gccaaggaag aatcacaccc ttggaataga aatttccacc
     2161 tccccaacct ttctctcaga cagcttatcc ttttcaacca actttttggc cagggaggaa
     2221 tgtccctttt gttcttcccc ctgagaagcc attcctttgt ctgccaacct ccctggggtc
     2281 ctgcctgttt cctcccaatg gagggttttt ttggggggtg gtccccgtct ggggggcccc
     2341 tccagccagt actccaggtc tccctgtctc tcccccgctg ccattttgat agtataatct
     2401 atttttaaat ggggcttttc aataggggag agggagtcat ctcttcctat atttggtggg
     2461 gtgggtggga aggaagggat ttggggggga atcttcctgc cgcctccccc actccaagtg
     2521 tttatttttg ataccaaaca tgaattttca gttccctccc tcccagcccc ccaatttcct
     2581 gcgggcgggt acaaaggacc ctttcaatgt ccctggagtt gggagggagg aatgggggac
     2641 ataaagcctg tcctgtctct attctaggca agagagagtg ggttcaaaag actcctgggc
     2701 tcacctgtta gcgctggccc agcccaggcc ttgggacctg ggggttggtg atttggggga
     2761 cagtgctaca ctcgtctcca ctgtttgttt tacttcccca aaatggacct tttttttttc
     2821 taaagagtcc cagagaatgg ggaattgttc ctgtaaatat atatttttca aagtga
//
