LOCUS       NM_001421               5140 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens E74 like ETS transcription factor 4 (ELF4), transcript
            variant 1, mRNA.
ACCESSION   NM_001421
VERSION     NM_001421.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5140)
  AUTHORS   Sun,L., Han,Y., Li,B., Yang,Y., Fang,Y., Ren,X., An,L., Hou,X.,
            Fan,H. and Wu,Y.
  TITLE     A Novel Frameshift Variant of the ELF4 Gene in a Patient with
            Autoinflammatory Disease: Clinical Features, Transcriptomic
            Profiling and Functional Studies
  JOURNAL   J Clin Immunol 44 (6), 127 (2024)
   PUBMED   38773005
  REMARK    GeneRIF: A Novel Frameshift Variant of the ELF4 Gene in a Patient
            with Autoinflammatory Disease: Clinical Features, Transcriptomic
            Profiling and Functional Studies.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5140)
  AUTHORS   Wu,S., Dai,X., Zhu,Z., Fan,D., Jiang,S., Dong,Y., Chen,B., Xie,Q.,
            Yao,Z., Li,Q., Thorne,R.F., Lu,Y., Gu,H. and Hu,W.
  TITLE     Reciprocal regulation of lncRNA MEF and c-Myc drives colorectal
            cancer tumorigenesis
  JOURNAL   Neoplasia 49, 100971 (2024)
   PUBMED   38301392
  REMARK    GeneRIF: Reciprocal regulation of lncRNA MEF and c-Myc drives
            colorectal cancer tumorigenesis.
REFERENCE   3  (bases 1 to 5140)
  AUTHORS   Xu,A., Sun,M., Li,Z., Chu,Y., Fang,K., Zhang,Y., Lian,J., Zhang,L.,
            Chen,T. and Xu,M.
  TITLE     ELF4 contributes to esophageal squamous cell carcinoma growth and
            metastasis by augmenting cancer stemness via FUT9
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 56 (1), 129-139 (2024)
   PUBMED   37674363
  REMARK    GeneRIF: ELF4 contributes to esophageal squamous cell carcinoma
            growth and metastasis by augmenting cancer stemness via FUT9.
REFERENCE   4  (bases 1 to 5140)
  AUTHORS   Sun,G., Wu,M., Lv,Q., Yang,X., Wu,J., Tang,W., Dai,R., Zhou,L.,
            Ding,Y., Zhang,Z., An,Y., Tang,X., Zheng,X., Wang,Z., Sun,L.,
            Xie,Y., Zhao,X. and Du,H.
  TITLE     A Multicenter Cohort Study of Immune Dysregulation Disorders Caused
            by ELF4 Variants in China
  JOURNAL   J Clin Immunol 43 (5), 933-939 (2023)
   PUBMED   36823308
  REMARK    GeneRIF: A Multicenter Cohort Study of Immune Dysregulation
            Disorders Caused by ELF4 Variants in China.
REFERENCE   5  (bases 1 to 5140)
  AUTHORS   Chen,X., Chen,J., Feng,W., Huang,W., Wang,G., Sun,M., Luo,X.,
            Wang,Y., Nie,Y., Fan,D., Wu,K. and Xia,L.
  TITLE     FGF19-mediated ELF4 overexpression promotes colorectal cancer
            metastasis through transactivating FGFR4 and SRC
  JOURNAL   Theranostics 13 (4), 1401-1418 (2023)
   PUBMED   36923538
  REMARK    GeneRIF: FGF19-mediated ELF4 overexpression promotes colorectal
            cancer metastasis through transactivating FGFR4 and SRC.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5140)
  AUTHORS   Hedvat,C.V., Yao,J., Sokolic,R.A. and Nimer,S.D.
  TITLE     Myeloid ELF1-like factor is a potent activator of interleukin-8
            expression in hematopoietic cells
  JOURNAL   J Biol Chem 279 (8), 6395-6400 (2004)
   PUBMED   14625302
  REMARK    GeneRIF: MEF is an important regulator of IL-8 expression
            Erratum:[J Biol Chem. 2006 Mar 31;281(13):8996]
REFERENCE   7  (bases 1 to 5140)
  AUTHORS   Suico,M.A., Koyanagi,T., Ise,S., Lu,Z., Hisatsune,A., Seki,Y.,
            Shuto,T., Isohama,Y., Miyata,T. and Kai,H.
  TITLE     Functional dissection of the ETS transcription factor MEF
  JOURNAL   Biochim Biophys Acta 1577 (1), 113-120 (2002)
   PUBMED   12151102
  REMARK    GeneRIF: Functional dissection of the transactivation mechanisms of
            the ETS transcription factor MEF
REFERENCE   8  (bases 1 to 5140)
  AUTHORS   Mao,S., Frank,R.C., Zhang,J., Miyazaki,Y. and Nimer,S.D.
  TITLE     Functional and physical interactions between AML1 proteins and an
            ETS protein, MEF: implications for the pathogenesis of
            t(8;21)-positive leukemias
  JOURNAL   Mol Cell Biol 19 (5), 3635-3644 (1999)
   PUBMED   10207087
REFERENCE   9  (bases 1 to 5140)
  AUTHORS   Aryee,D.N., Petermann,R., Kos,K., Henn,T., Haas,O.A. and Kovar,H.
  TITLE     Cloning of a novel human ELF-1-related ETS transcription factor,
            ELFR, its characterization and chromosomal assignment relative to
            ELF-1
  JOURNAL   Gene 210 (1), 71-78 (1998)
   PUBMED   9524226
REFERENCE   10 (bases 1 to 5140)
  AUTHORS   Miyazaki,Y., Sun,X., Uchida,H., Zhang,J. and Nimer,S.
  TITLE     MEF, a novel transcription factor with an Elf-1 like DNA binding
            domain but distinct transcriptional activating properties
  JOURNAL   Oncogene 13 (8), 1721-1729 (1996)
   PUBMED   8895518
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DN999740.1, CN314421.1,
            U32645.1, AL136450.8 and CD364651.1.
            
            On Dec 4, 2019 this sequence version replaced NM_001421.3.
            
            Summary: The protein encoded by this gene is a transcriptional
            activator that binds and activates the promoters of the CSF2, IL3,
            IL8, and PRF1 genes. The encoded protein is involved in natural
            killer cell development and function, innate immunity, and
            induction of cell cycle arrest in naive CD8+ cells. Two transcript
            variants encoding the same protein have been found for this
            gene.[provided by RefSeq, Jan 2010].
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Variants 1 and 2 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments and orthologous data.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U32645.1, SRR1803617.195689.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000308167.10/ ENSP00000311280.6
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-500               DN999740.1         12-511
            501-799             CN314421.1         419-717
            800-2767            U32645.1           800-2767
            2768-3540           AL136450.8         34330-35102         c
            3541-4175           CD364651.1         18-652              c
            4176-5140           AL136450.8         32730-33694         c
FEATURES             Location/Qualifiers
     source          1..5140
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq26.1"
     gene            1..5140
                     /gene="ELF4"
                     /gene_synonym="AIFBL2; ELFR; MEF"
                     /note="E74 like ETS transcription factor 4"
                     /db_xref="GeneID:2000"
                     /db_xref="HGNC:HGNC:3319"
                     /db_xref="MIM:300775"
     exon            1..173
                     /gene="ELF4"
                     /gene_synonym="AIFBL2; ELFR; MEF"
                     /inference="alignment:Splign:2.1.0"
     exon            174..457
                     /gene="ELF4"
                     /gene_synonym="AIFBL2; ELFR; MEF"
                     /inference="alignment:Splign:2.1.0"
     CDS             383..2374
                     /gene="ELF4"
                     /gene_synonym="AIFBL2; ELFR; MEF"
                     /note="myeloid Elf-1-like factor; E74-like factor 4 (ets
                     domain transcription factor)"
                     /codon_start=1
                     /product="ETS-related transcription factor Elf-4"
                     /protein_id="NP_001412.1"
                     /db_xref="CCDS:CCDS14617.1"
                     /db_xref="GeneID:2000"
                     /db_xref="HGNC:HGNC:3319"
                     /db_xref="MIM:300775"
                     /translation="MAITLQPSDLIFEFASNGMDDDIHQLEDPSVFPAVIVEQVPYPD
                     LLHLYSGLELDDVHNGIITDGTLCMTQDQILEGSFLLTDDNEATSHTMSTAEVLLNME
                     SPSDILDEKQIFSTSEMLPDSDPAPAVTLPNYLFPASEPDALNRAGDTSDQEGHSLEE
                     KASREESAKKTGKSKKRIRKTKGNRSTSPVTDPSIPIRKKSKDGKGSTIYLWEFLLAL
                     LQDRNTCPKYIKWTQREKGIFKLVDSKAVSKLWGKQKNKPDMNYETMGRALRYYYQRG
                     ILAKVEGQRLVYQFKEMPKDLVVIEDEDESSEATAAPPQASTASVASASTTRRTSSRV
                     SSRSAPQGKGSSSWEKPKIQHVGLQPSASLELGPSLDEEIPTTSTMLVSPAEGQVKLT
                     KAVSASSVPSNIHLGVAPVGSGSALTLQTIPLTTVLTNGPPASTTAPTQLVLQSVPAA
                     STFKDTFTLQASFPLNASFQDSQVAAPGAPLILSGLPQLLAGANRPTNPAPPTVTGAG
                     PAGPSSQPPGTVIAAFIRTSGTTAAPRVKEGPLRSSSYVQGMVTGAPMEGLLVPEETL
                     RELLRDQAHLQPLPTQVVSRGSHNPSLLGNQTLSPPSRPTVGLTPVAELELSSGSGSL
                     LMAEPSVTTSGSLLTRSPTPAPFSPFNPTSLIKMEPHDI"
     exon            458..629
                     /gene="ELF4"
                     /gene_synonym="AIFBL2; ELFR; MEF"
                     /inference="alignment:Splign:2.1.0"
     exon            630..722
                     /gene="ELF4"
                     /gene_synonym="AIFBL2; ELFR; MEF"
                     /inference="alignment:Splign:2.1.0"
     exon            723..914
                     /gene="ELF4"
                     /gene_synonym="AIFBL2; ELFR; MEF"
                     /inference="alignment:Splign:2.1.0"
     exon            915..998
                     /gene="ELF4"
                     /gene_synonym="AIFBL2; ELFR; MEF"
                     /inference="alignment:Splign:2.1.0"
     exon            999..1191
                     /gene="ELF4"
                     /gene_synonym="AIFBL2; ELFR; MEF"
                     /inference="alignment:Splign:2.1.0"
     exon            1192..1569
                     /gene="ELF4"
                     /gene_synonym="AIFBL2; ELFR; MEF"
                     /inference="alignment:Splign:2.1.0"
     exon            1570..5140
                     /gene="ELF4"
                     /gene_synonym="AIFBL2; ELFR; MEF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4144..4149
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ELF4"
                     /gene_synonym="AIFBL2; ELFR; MEF"
                     /note="hexamer: AATAAA"
     polyA_site      4166
                     /gene="ELF4"
                     /gene_synonym="AIFBL2; ELFR; MEF"
                     /note="major polyA site"
     regulatory      5118..5123
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ELF4"
                     /gene_synonym="AIFBL2; ELFR; MEF"
                     /note="hexamer: AATAAA"
     polyA_site      5140
                     /gene="ELF4"
                     /gene_synonym="AIFBL2; ELFR; MEF"
ORIGIN      
        1 acttctcctt tcgccggcgc cgagttcctg gcgccgctcg cccggcccgg cttccgaggg
       61 gagaggacgg gctggcgggg ctggggaccc gcgtctcggc ccccggagcg gggaccacgg
      121 agacagaccc cggcccggcg accgagctgg gcccgtgagc cactcggcct caggtcgctc
      181 ctgtggttgg tccagcccag aatgcagcct tgagcctggc ttaggccacc acctactcca
      241 gctctctcca ccccctattt tactgcagct cagggggtag gctctaggct ccaaagtacc
      301 tgggtattgt cccttcatca agaaagcccc acagctctgg agggctctga taatcccgtt
      361 gtcagctctc tgaaaagaca gcatggctat taccctacag cccagtgacc tgatctttga
      421 gttcgcaagc aacgggatgg atgatgatat ccaccagctg gaagacccct ctgtgttccc
      481 agctgtgatc gtggagcagg taccctaccc tgatttactg catctgtact cgggactgga
      541 gttggacgac gttcacaatg gcatcataac agacgggacc ttgtgcatga cgcaggatca
      601 gatcctggaa ggcagttttt tgctgacaga tgacaatgag gccacctcgc acaccatgtc
      661 aaccgcggaa gtcttactca atatggagtc tcccagcgat atcctggatg agaagcagat
      721 cttcagtacc tccgaaatgc ttccagactc ggaccctgca ccagctgtca ctctgcccaa
      781 ctacctgttt cctgcctctg agcccgatgc cctgaacagg gcgggtgaca ctagtgacca
      841 ggaggggcat tctctggagg agaaggcctc cagagaggaa agtgccaaga agactgggaa
      901 atcaaagaag agaatccgga agaccaaggg caaccgaagt acctcacctg tcactgaccc
      961 cagcatcccc attaggaaga aatcaaagga tggcaaaggc agcaccatct atctgtggga
     1021 gttcctcctg gctcttctgc aagacagaaa cacctgtccc aagtacatca agtggaccca
     1081 gcgagagaaa ggcatcttca aactggtgga ctccaaagct gtgtccaagc tgtgggggaa
     1141 gcagaaaaac aagcctgaca tgaactatga gacaatgggg cgggcactaa gatactacta
     1201 ccaaagaggc atactggcca aagtggaagg gcagaggctg gtgtaccagt ttaaggagat
     1261 gcccaaggac ctggtggtca ttgaagatga ggatgagagc agcgaagcca cagcagcccc
     1321 acctcaggcc tccacggcct ctgtggcctc tgccagtacc acccggcgaa ccagctccag
     1381 ggtctcatcc agatctgccc cccagggcaa gggcagctct tcttgggaga agccaaaaat
     1441 tcagcatgtc ggtctccagc catctgcgag tctggaattg ggaccgtcgc tagacgagga
     1501 gatccccact acctccacca tgctcgtctc tccagcagag ggccaggtca agctcaccaa
     1561 agctgtgagt gcatcttcag tgcccagcaa catccaccta ggagtggccc ccgtggggtc
     1621 gggctcggcc ctgaccctgc agacgatccc actgaccacg gtgctgacca atgggcctcc
     1681 tgccagtact actgctccca ctcagctcgt tctccagagt gttccagcgg cctctacttt
     1741 caaggacacc ttcactttgc aggcctcttt ccccctgaac gccagtttcc aagacagcca
     1801 ggtggcagcc ccaggggctc cactgattct cagtggcctc ccccaacttc tggctggggc
     1861 caaccgtccg accaacccgg cgccacccac ggtcacaggg gctggaccag cagggcccag
     1921 ctctcagccc cctgggactg tcattgctgc cttcatcagg acttctggca ctacagcagc
     1981 ccctagggtc aaggaggggc cactgaggtc ctcctcctat gttcagggta tggtgacggg
     2041 ggcccccatg gaggggctgc tggttcctga agagaccctg agggagctcc tgagagatca
     2101 ggctcatctt cagccacttc caacccaggt ggtttccagg ggttcccaca atccgagcct
     2161 tctgggcaac cagactttgt ctcctcccag ccgccccact gttgggctga ccccagtggc
     2221 tgaacttgag ctctcctcag gctcagggtc cctgctgatg gctgagccta gtgtgaccac
     2281 atctgggagc cttctgacaa gatcccccac cccagcccct ttctccccat tcaaccctac
     2341 ttccctcatt aagatggagc cccatgacat ataagcaaag gggtcagggc aagtgtgacc
     2401 caccaggcaa aattgagcag cattttcata gggaccgact tcagtagcac acctgcccct
     2461 gcatttcagt gggatgtcaa tacacttgac cccaagtccc ccggccctgc ctggtgtcac
     2521 tgtggccaaa cagtgcccag cttaagcatc cctggcatca gactatggcc ttcaagagca
     2581 ctagggcata tgcttttggc agcataacgg gctgacttgg tgatggaggg aaaaagcctt
     2641 gagccaggca gaagtttgtg gccagggttt gtgcagcagc tttgtgagaa gagcccttct
     2701 acctggctct atctcactgg ctgcattccc tacacaggga atttactacc ctatatgtga
     2761 atatccctgt atgtacttgt gtgtacttgt tggtctgtat cttagtttct ttggggagga
     2821 cagggctgta gctgtgaggt cttgtctcca agggtgtgtg tatgtctccg tggatcagcc
     2881 acagggatag ggattttgtt tttaagggaa agcattctct aattcccttt gttcatgccg
     2941 agattcagtt gctctgagac tatggggtac aagtttgatc ctccgaatct ggagatgttg
     3001 tagagctgga acgagtgcag agtaggaacg ctttgatgcg catgcacatt ggggaagatg
     3061 cgctcctcag ggacacaaag gccgagtggg gtaaaaccac gaagggaggg aagggaagtc
     3121 agctctggga gcagccctca ctggctggac caaggtactc ttcctggagt ttgccgtgtt
     3181 agcaaccaca gtcaccttgc agtcaggctg gaatcttggg ccaccccaaa gtgctttgct
     3241 gaaggattta gacggggatg aagtgccctc cagcctcaga gctagccaca aagcccccag
     3301 agctgaattc attgagtatt tgtgcctagg gcttgggctg tttgtgtgat accggccccc
     3361 cgccagacaa tagcctttgc tgacacccca gcctacttcc ccgatcctgg gctccctctt
     3421 gattactttt tgacattttc cagctgtcag gcatcactgc ggctagtccg gcagcgacct
     3481 agatggggtc cacccccatt cctgctcaag catgggcacc taccacatgg tttctgctgc
     3541 tcagcctgcc tgcaactcac ctcgaaggcg gaccagcctg cctctgtgat gactgcagca
     3601 gacctccttg ggtgtaccaa tgcccctcat ctcccacttt cacacctaac cctgactcct
     3661 tcaccaagaa gacgggagtc ggcagccagg agttcccgtg gcacctctct ctcttcgtgg
     3721 ctccctgctt cccccttccc tctttccgag gaagggtcaa cctattctct ctcaaagcca
     3781 acccctaggc caattgcctg gatctcctcc cctctccctt ctttaaacga gcttgcctcc
     3841 ctcctgccaa gtttgagggc aaggctaaga aatgtcagcc acggaaacaa ctctattatc
     3901 tggtgacttt gggtaatgtg aatcagtgcc tgaggacctt tgctgtgtcc ttggtacaga
     3961 accatccact tgacctaact acctcccctg gccgcgctct cgctcttctc ttctttgtta
     4021 agccaacaac tatcaccctc tcctactctt cttctccctg ccccctggag ggcactgtgt
     4081 ttggttgtgc aaatgtattt actatgcgtg tttccagcag ttggcattaa agtgcctttt
     4141 tctaataaaa tcagtttatt atgacagttt cctgatggtt gaaagtaagc atcttgataa
     4201 agggtcacca ttaaaaaaaa attttgcata aaggtgctgc atgggttggg gtagccccgc
     4261 ccccacctga aaactggttt ctgccacccc tactccaact ccatggaaac tcattgctgg
     4321 aaggtcatca atgacctcat ggtgaaatca aatgtcttct tcacagttct cgggcccccg
     4381 tgagcccaca ctagctgggc tctcctgcat cccccatcac cctttccggg gctggttctt
     4441 cacctaccac ttccaacgtg gctgttcaag aatctcatcc attttgggct cattttggct
     4501 cctcggagat gggtcctaaa tctagagctc cagtcccaac ctttctctta agctcctggc
     4561 tcacatttcc agcaatctgc tgaacatttc catgtgggtg cttgtcagct ccttaaagat
     4621 agcccctcta tcaacaatgt ttttgtttgt tcgtttgttt ttgagtcaga gtcttgctct
     4681 gtcggctgga gtgcagtggt gcaatctcgg ttcactgcaa cctctgcctc ccaggctcaa
     4741 gtgattctcc tgcctcagcc tcctgagtag ctgggagtac aggcacatgc caccatgccc
     4801 agctaatttt tgtattttca gtagagccag ggtttcacca tttcggccag gctggtctcg
     4861 aactcctggc ctcaggtgat ccacccacct tggcctccca aagtgctggg attacaggcg
     4921 tgagcaacca cggctggcca acaatggatt tttaaattat ttccacgctc acaaaaaacc
     4981 tttccaagat gacgggttga tgggtgcagc aaaccaccat ggcacatgta tacctatgta
     5041 acaaacctgc acgttctgca catgtatccc agaacttaaa gtataataat aataataata
     5101 ataataataa taataataat aaaaatcaag caaacaaaaa
//
