LOCUS       NM_004433               3104 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens E74 like ETS transcription factor 3 (ELF3), transcript
            variant 1, mRNA.
ACCESSION   NM_004433
VERSION     NM_004433.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3104)
  AUTHORS   Gu,B., Le,G.H., Herrera,S., Blair,S.J., Meissner,T.B. and
            Strominger,J.L.
  TITLE     HLA-C expression in extravillous trophoblasts is determined by an
            ELF3-NLRP2/NLRP7 regulatory axis
  JOURNAL   Proc Natl Acad Sci U S A 121 (31), e2404229121 (2024)
   PUBMED   39052836
  REMARK    GeneRIF: HLA-C expression in extravillous trophoblasts is
            determined by an ELF3-NLRP2/NLRP7 regulatory axis.
REFERENCE   2  (bases 1 to 3104)
  AUTHORS   Lin,J., Hou,L., Zhao,X., Zhong,J., Lv,Y., Jiang,X., Ye,B. and
            Qiao,Y.
  TITLE     Switch of ELF3 and ATF4 transcriptional axis programs the amino
            acid insufficiency-linked epithelial-to-mesenchymal transition
  JOURNAL   Mol Ther 32 (6), 1956-1969 (2024)
   PUBMED   38627967
  REMARK    GeneRIF: Switch of ELF3 and ATF4 transcriptional axis programs the
            amino acid insufficiency-linked epithelial-to-mesenchymal
            transition.
REFERENCE   3  (bases 1 to 3104)
  AUTHORS   Ghosal,N., Tapadar,P., Biswas,D. and Pal,R.
  TITLE     ELF3 plays an important role in defining TRAIL sensitivity in
            breast cancer by modulating the expression of decoy receptor 2
            (DCR2)
  JOURNAL   Mol Biol Rep 51 (1), 671 (2024)
   PUBMED   38787503
  REMARK    GeneRIF: ELF3 plays an important role in defining TRAIL sensitivity
            in breast cancer by modulating the expression of decoy receptor 2
            (DCR2).
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3104)
  AUTHORS   Zhou,L., Zhong,Y., Wang,F., Guo,Y., Mao,R., Xie,H., Zhang,Y. and
            Li,J.
  TITLE     WTAP Mediated N6-methyladenosine RNA Modification of ELF3 Drives
            Cellular Senescence by Upregulating IRF8
  JOURNAL   Int J Biol Sci 20 (5), 1763-1777 (2024)
   PUBMED   38481803
  REMARK    GeneRIF: WTAP Mediated N6-methyladenosine RNA Modification of ELF3
            Drives Cellular Senescence by Upregulating IRF8.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3104)
  AUTHORS   Li,F., Qiu,F., Fan,X., Yu,Q., Liu,S., Guo,Y., Zhu,Y., Xi,X. and
            Du,B.
  TITLE     Expression of CD44 is regulated by ELF3 in 5-FU treated colorectal
            cancer cells
  JOURNAL   Gene 892, 147896 (2024)
   PUBMED   37832805
  REMARK    GeneRIF: Expression of CD44 is regulated by ELF3 in 5-FU treated
            colorectal cancer cells.
REFERENCE   6  (bases 1 to 3104)
  AUTHORS   Choi,S.G., Yi,Y., Kim,Y.S., Kato,M., Chang,J., Chung,H.W.,
            Hahm,K.B., Yang,H.K., Rhee,H.H., Bang,Y.J. and Kim,S.J.
  TITLE     A novel ets-related transcription factor, ERT/ESX/ESE-1, regulates
            expression of the transforming growth factor-beta type II receptor
  JOURNAL   J Biol Chem 273 (1), 110-117 (1998)
   PUBMED   9417054
REFERENCE   7  (bases 1 to 3104)
  AUTHORS   Tymms,M.J., Ng,A.Y., Thomas,R.S., Schutte,B.C., Zhou,J., Eyre,H.J.,
            Sutherland,G.R., Seth,A., Rosenberg,M., Papas,T., Debouck,C. and
            Kola,I.
  TITLE     A novel epithelial-expressed ETS gene, ELF3: human and murine cDNA
            sequences, murine genomic organization, human mapping to 1q32.2 and
            expression in tissues and cancer
  JOURNAL   Oncogene 15 (20), 2449-2462 (1997)
   PUBMED   9395241
REFERENCE   8  (bases 1 to 3104)
  AUTHORS   Andreoli,J.M., Jang,S.I., Chung,E., Coticchia,C.M., Steinert,P.M.
            and Markova,N.G.
  TITLE     The expression of a novel, epithelium-specific ets transcription
            factor is restricted to the most differentiated layers in the
            epidermis
  JOURNAL   Nucleic Acids Res 25 (21), 4287-4295 (1997)
   PUBMED   9336459
REFERENCE   9  (bases 1 to 3104)
  AUTHORS   Oettgen,P., Alani,R.M., Barcinski,M.A., Brown,L., Akbarali,Y.,
            Boltax,J., Kunsch,C., Munger,K. and Libermann,T.A.
  TITLE     Isolation and characterization of a novel epithelium-specific
            transcription factor, ESE-1, a member of the ets family
  JOURNAL   Mol Cell Biol 17 (8), 4419-4433 (1997)
   PUBMED   9234700
REFERENCE   10 (bases 1 to 3104)
  AUTHORS   Chang,C.H., Scott,G.K., Kuo,W.L., Xiong,X., Suzdaltseva,Y.,
            Park,J.W., Sayre,P., Erny,K., Collins,C., Gray,J.W. and Benz,C.C.
  TITLE     ESX: a structurally unique Ets overexpressed early during human
            breast tumorigenesis
  JOURNAL   Oncogene 14 (13), 1617-1622 (1997)
   PUBMED   9129154
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CV570991.1, BC003569.1, BM976796.1, CV570925.1, BX093212.1 and
            BQ023145.1.
            
            On Nov 23, 2018 this sequence version replaced NM_004433.4.
            
            Transcript Variant: This variant represents the shorter transcript
            (1). Variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF017307.2, U97156.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000367284.10/ ENSP00000356253.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-7                 CV570991.1         26-32
            8-1926              BC003569.1         1-1919
            1927-2428           BM976796.1         31-532              c
            2429-2523           CV570925.1         271-365
            2524-3042           BX093212.1         110-628
            3043-3104           BQ023145.1         21-82               c
FEATURES             Location/Qualifiers
     source          1..3104
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q32.1"
     gene            1..3104
                     /gene="ELF3"
                     /gene_synonym="EPR-1; ERT; ESE-1; ESX"
                     /note="E74 like ETS transcription factor 3"
                     /db_xref="GeneID:1999"
                     /db_xref="HGNC:HGNC:3318"
                     /db_xref="MIM:602191"
     exon            1..120
                     /gene="ELF3"
                     /gene_synonym="EPR-1; ERT; ESE-1; ESX"
                     /inference="alignment:Splign:2.1.0"
     exon            121..291
                     /gene="ELF3"
                     /gene_synonym="EPR-1; ERT; ESE-1; ESX"
                     /inference="alignment:Splign:2.1.0"
     CDS             129..1244
                     /gene="ELF3"
                     /gene_synonym="EPR-1; ERT; ESE-1; ESX"
                     /note="E74-like factor 3 (ETS domain transcription factor,
                     serine box, epithelial-specific); E74-like factor 3 (ets
                     domain transcription factor, epithelial-specific);
                     E74-like factor 3 (ets domain transcription factor); ets
                     domain transcription factor, serine box
                     (epithelial-specific); epithelium-restricted Ets protein
                     ESX; epithelial-restricted with serine box;
                     epithelium-specific Ets transcription factor 1"
                     /codon_start=1
                     /product="ETS-related transcription factor Elf-3"
                     /protein_id="NP_004424.3"
                     /db_xref="CCDS:CCDS1419.1"
                     /db_xref="GeneID:1999"
                     /db_xref="HGNC:HGNC:3318"
                     /db_xref="MIM:602191"
                     /translation="MAATCEISNIFSNYFSAMYSSEDSTLASVPPAATFGADDLVLTL
                     SNPQMSLEGTEKASWLGEQPQFWSKTQVLDWISYQVEKNKYDASAIDFSRCDMDGATL
                     CNCALEELRLVFGPLGDQLHAQLRDLTSSSSDELSWIIELLEKDGMAFQEALDPGPFD
                     QGSPFAQELLDDGQQASPYHPGSCGAGAPSPGSSDVSTAGTGASRSSHSSDSGGSDVD
                     LDPTDGKLFPSDGFRDCKKGDPKHGKRKRGRPRKLSKEYWDCLEGKKSKHAPRGTHLW
                     EFIRDILIHPELNEGLMKWENRHEGVFKFLRSEAVAQLWGQKKKNSNMTYEKLSRAMR
                     YYYKREILERVDGRRLVYKFGKNSSGWKEEEVLQSRN"
     exon            292..513
                     /gene="ELF3"
                     /gene_synonym="EPR-1; ERT; ESE-1; ESX"
                     /inference="alignment:Splign:2.1.0"
     exon            514..606
                     /gene="ELF3"
                     /gene_synonym="EPR-1; ERT; ESE-1; ESX"
                     /inference="alignment:Splign:2.1.0"
     exon            607..726
                     /gene="ELF3"
                     /gene_synonym="EPR-1; ERT; ESE-1; ESX"
                     /inference="alignment:Splign:2.1.0"
     exon            727..816
                     /gene="ELF3"
                     /gene_synonym="EPR-1; ERT; ESE-1; ESX"
                     /inference="alignment:Splign:2.1.0"
     exon            817..933
                     /gene="ELF3"
                     /gene_synonym="EPR-1; ERT; ESE-1; ESX"
                     /inference="alignment:Splign:2.1.0"
     exon            934..1129
                     /gene="ELF3"
                     /gene_synonym="EPR-1; ERT; ESE-1; ESX"
                     /inference="alignment:Splign:2.1.0"
     exon            1130..3104
                     /gene="ELF3"
                     /gene_synonym="EPR-1; ERT; ESE-1; ESX"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1899..1904
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ELF3"
                     /gene_synonym="EPR-1; ERT; ESE-1; ESX"
                     /note="hexamer: AATAAA"
     polyA_site      1926
                     /gene="ELF3"
                     /gene_synonym="EPR-1; ERT; ESE-1; ESX"
                     /note="major polyA site"
     regulatory      3001..3006
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ELF3"
                     /gene_synonym="EPR-1; ERT; ESE-1; ESX"
                     /note="hexamer: ATTAAA"
     polyA_site      3027
                     /gene="ELF3"
                     /gene_synonym="EPR-1; ERT; ESE-1; ESX"
     regulatory      3081..3086
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ELF3"
                     /gene_synonym="EPR-1; ERT; ESE-1; ESX"
                     /note="hexamer: GATAAA"
     polyA_site      3104
                     /gene="ELF3"
                     /gene_synonym="EPR-1; ERT; ESE-1; ESX"
ORIGIN      
        1 aggctctatt tagagccggg taggggagcg cagcggccag atacctcagc gctacctggc
       61 ggaactggat ttctctcccg cctgccggcc tgcctgccac agccggactc cgccactccg
      121 gtagcctcat ggctgcaacc tgtgagatta gcaacatttt tagcaactac ttcagtgcga
      181 tgtacagctc ggaggactcc accctggcct ctgttccccc tgctgccacc tttggggccg
      241 atgacttggt actgaccctg agcaaccccc agatgtcatt ggagggtaca gagaaggcca
      301 gctggttggg ggaacagccc cagttctggt cgaagacgca ggttctggac tggatcagct
      361 accaagtgga gaagaacaag tacgacgcaa gcgccattga cttctcacga tgtgacatgg
      421 atggcgccac cctctgcaat tgtgcccttg aggagctgcg tctggtcttt gggcctctgg
      481 gggaccaact ccatgcccag ctgcgagacc tcacttccag ctcttctgat gagctcagtt
      541 ggatcattga gctgctggag aaggatggca tggccttcca ggaggcccta gacccagggc
      601 cctttgacca gggcagcccc tttgcccagg agctgctgga cgacggtcag caagccagcc
      661 cctaccaccc cggcagctgt ggcgcaggag ccccctcccc tggcagctct gacgtctcca
      721 ccgcagggac tggtgcttct cggagctccc actcctcaga ctccggtgga agtgacgtgg
      781 acctggatcc cactgatggc aagctcttcc ccagcgatgg ttttcgtgac tgcaagaagg
      841 gggatcccaa gcacgggaag cggaaacgag gccggccccg aaagctgagc aaagagtact
      901 gggactgtct cgagggcaag aagagcaagc acgcgcccag aggcacccac ctgtgggagt
      961 tcatccggga catcctcatc cacccggagc tcaacgaggg cctcatgaag tgggagaatc
     1021 ggcatgaagg cgtcttcaag ttcctgcgct ccgaggctgt ggcccaacta tggggccaaa
     1081 agaaaaagaa cagcaacatg acctacgaga agctgagccg ggccatgagg tactactaca
     1141 aacgggagat cctggaacgg gtggatggcc ggcgactcgt ctacaagttt ggcaaaaact
     1201 caagcggctg gaaggaggaa gaggttctcc agagtcggaa ctgagggttg gaactatacc
     1261 cgggaccaaa ctcacggacc actcgaggcc tgcaaacctt cctgggagga caggcaggcc
     1321 agatggcccc tccactgggg aatgctccca gctgtgctgt ggagagaagc tgatgttttg
     1381 gtgtattgtc agccatcgtc ctgggactcg gagactatgg cctcgcctcc ccaccctcct
     1441 cttggaatta caagccctgg ggtttgaagc tgactttata gctgcaagtg tatctccttt
     1501 tatctggtgc ctcctcaaac ccagtctcag acactaaatg cagacaacac cttcctcctg
     1561 cagacacctg gactgagcca aggaggcctg gggaggccct aggggagcac cgtgatggag
     1621 aggacagagc aggggctcca gcaccttctt tctggactgg cgttcacctc cctgctcagt
     1681 gcttgggctc cacgggcagg ggtcagagca ctccctaatt tatgtgctat ataaatatgt
     1741 cagatgtaca tagagatcta ttttttctaa aacattcccc tccccactcc tctcccacag
     1801 agtgctggac tgttccaggc cctccagtgg gctgatgctg ggacccttag gatggggctc
     1861 ccagctcctt tctcctgtga atggaggcag agacctccaa taaagtgcct tctgggcttt
     1921 ttctaacctt tgtcttagct acctgtgtac tgaaatttgg gcctttggat cgaatatggt
     1981 caagaggttg gaggggagga aaatgaaggt ctaccaggct gagggtgagg gcaaaggctg
     2041 acgaagaggg gagttacaga tttcctgtag caggtgtggg cttacagaca catggactgg
     2101 gctgggaggc gagcaaagga agcagctgag actgttggag aacgcttaca agacttcatg
     2161 caagcaagga catgaactca gaacactgag gtcagaagca tcctgctgtc atgacaccgc
     2221 tcgagtgacc ttgaccttga ccaagtctgt cctgtttagg actgattttt cctattaggc
     2281 tagggtttgg acctgatgtt ctcaagatgt ctagaattgc atggctggcc ttgtggaata
     2341 gatggttttg cattccagcc aagtgtgctg taaactgtat atctgtaata tgaatcccag
     2401 cttttgagtc tgacaaaatc agagttagga tcttgtaaag gaaaaaaaaa aaaaaacaaa
     2461 acaaaatgga gatgagtact tgctgagaaa gaatgaggga aggagttggc atttgttgaa
     2521 agtgtagtct ttttctcttt tttttttaat tgcaactttt actttagatt taggaggtcg
     2581 tgcgcaggtt tgttacatgg gtatattgtg tgatgctgag cttgggatgc gaatgatcct
     2641 gtcacccagg tagtgagtat agcacccagt gaaactgtag tctcatgcca ggcactgtgc
     2701 tagcccactc tggctcattt aatcctctcc taagaagaga ggagacacag cgtccccatt
     2761 tgacagatgc agaaagaggt tccacaggtg tgccttgatt ctgtcctaaa accgtttccc
     2821 ggaagctttt cctggtgtgg gcgcttctaa cctaatcctc aatcgattcc agaactatta
     2881 ctctgtttcc acagtgatac tgtgtctagg ttttagggag gacagttcat tgatgttact
     2941 taagaatgct ttccaggtgg aaagttcctt aagtttgagg cttcaaattc catacagcac
     3001 attaaaatcc cattcatgag tttgaaatac tgctctgttg tcttggaaat accaatcaga
     3061 ttgttggctg aagtgatgtg gataaagaag ggatcttaga aaaa
//
