LOCUS       NM_001331036            4003 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens E74 like ETS transcription factor 2 (ELF2), transcript
            variant 6, mRNA.
ACCESSION   NM_001331036 XM_005262803
VERSION     NM_001331036.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4003)
  AUTHORS   Li,B., Yao,B., Guo,X., Wang,Z., Xie,W., Wu,X., Wang,F. and Mei,Y.
  TITLE     c-Myc-induced long noncoding RNA MIRE cooperates with hnRNPK to
            stabilize ELF2 mRNA and promotes clear cell renal cell
            carcinogenesis
  JOURNAL   Cancer Gene Ther 30 (9), 1215-1226 (2023)
   PUBMED   37248433
  REMARK    GeneRIF: c-Myc-induced long noncoding RNA MIRE cooperates with
            hnRNPK to stabilize ELF2 mRNA and promotes clear cell renal cell
            carcinogenesis.
REFERENCE   2  (bases 1 to 4003)
  AUTHORS   Ma,X. and Li,Y.
  TITLE     Circ_0028007 Aggravates the Malignancy of Nasopharyngeal Carcinoma
            by Regulating miR-656-3p/ELF2 Axis
  JOURNAL   Biochem Genet 60 (6), 2069-2086 (2022)
   PUBMED   35239093
  REMARK    GeneRIF: Circ_0028007 Aggravates the Malignancy of Nasopharyngeal
            Carcinoma by Regulating miR-656-3p/ELF2 Axis.
REFERENCE   3  (bases 1 to 4003)
  AUTHORS   Moon,S.L. and Parker,R.
  TITLE     EIF2B2 mutations in vanishing white matter disease hypersuppress
            translation and delay recovery during the integrated stress
            response
  JOURNAL   RNA 24 (6), 841-852 (2018)
   PUBMED   29632131
  REMARK    GeneRIF: Mutations in eIF2B genes cause vanishing white matter
            disease due to translation defects.
REFERENCE   4  (bases 1 to 4003)
  AUTHORS   Liu,Y., Tao,Z., Qu,J., Zhou,X. and Zhang,C.
  TITLE     Long non-coding RNA PCAT7 regulates ELF2 signaling through
            inhibition of miR-134-5p in nasopharyngeal carcinoma
  JOURNAL   Biochem Biophys Res Commun 491 (2), 374-381 (2017)
   PUBMED   28728844
  REMARK    GeneRIF: PCAT7 contributed to the progression of nasopharyngeal
            carcinoma through regulating miR-134-5p/ELF2 signaling pathway.
REFERENCE   5  (bases 1 to 4003)
  AUTHORS   Yin,Y., Morgunova,E., Jolma,A., Kaasinen,E., Sahu,B.,
            Khund-Sayeed,S., Das,P.K., Kivioja,T., Dave,K., Zhong,F.,
            Nitta,K.R., Taipale,M., Popov,A., Ginno,P.A., Domcke,S., Yan,J.,
            Schubeler,D., Vinson,C. and Taipale,J.
  TITLE     Impact of cytosine methylation on DNA binding specificities of
            human transcription factors
  JOURNAL   Science 356 (6337) (2017)
   PUBMED   28473536
REFERENCE   6  (bases 1 to 4003)
  AUTHORS   King,J.K., Yeh,S.H., Lin,M.W., Liu,C.J., Lai,M.Y., Kao,J.H.,
            Chen,D.S. and Chen,P.J.
  TITLE     Genetic polymorphisms in interferon pathway and response to
            interferon treatment in hepatitis B patients: A pilot study
  JOURNAL   Hepatology 36 (6), 1416-1424 (2002)
   PUBMED   12447867
  REMARK    GeneRIF: Observational study of gene-environment interaction. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 4003)
  AUTHORS   Christensen,R.A., Fujikawa,K., Madore,R., Oettgen,P. and
            Varticovski,L.
  TITLE     NERF2, a member of the Ets family of transcription factors, is
            increased in response to hypoxia and angiopoietin-1: a potential
            mechanism for Tie2 regulation during hypoxia
  JOURNAL   J Cell Biochem 85 (3), 505-515 (2002)
   PUBMED   11967990
  REMARK    GeneRIF: angiopoietin-1 regulates expression of NERF2 and its own
            receptor in hypoxic cells.
REFERENCE   8  (bases 1 to 4003)
  AUTHORS   Mao,S., Frank,R.C., Zhang,J., Miyazaki,Y. and Nimer,S.D.
  TITLE     Functional and physical interactions between AML1 proteins and an
            ETS protein, MEF: implications for the pathogenesis of
            t(8;21)-positive leukemias
  JOURNAL   Mol Cell Biol 19 (5), 3635-3644 (1999)
   PUBMED   10207087
REFERENCE   9  (bases 1 to 4003)
  AUTHORS   Wilkinson,D.A., Neale,G.A., Mao,S., Naeve,C.W. and Goorha,R.M.
  TITLE     Elf-2, a rhombotin-2 binding ets transcription factor: discovery
            and potential role in T cell leukemia
  JOURNAL   Leukemia 11 (1), 86-96 (1997)
   PUBMED   9001422
REFERENCE   10 (bases 1 to 4003)
  AUTHORS   Oettgen,P., Akbarali,Y., Boltax,J., Best,J., Kunsch,C. and
            Libermann,T.A.
  TITLE     Characterization of NERF, a novel transcription factor related to
            the Ets factor ELF-1
  JOURNAL   Mol Cell Biol 16 (9), 5091-5106 (1996)
   PUBMED   8756667
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA221737.1, AF256222.1, BC065025.1, U43188.1 and BU621268.1.
            
            On Aug 13, 2020 this sequence version replaced NM_001331036.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853558.19003.1,
                                           SRR18074967.4049441.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000686138.1/ ENSP00000510098.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-561               DA221737.1         1-561
            562-855             AF256222.1         241-534
            856-891             BC065025.1         326-361
            892-2995            AF256222.1         535-2638
            2996-3551           U43188.1           2665-3220
            3552-4003           BU621268.1         23-474              c
FEATURES             Location/Qualifiers
     source          1..4003
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q31.1"
     gene            1..4003
                     /gene="ELF2"
                     /gene_synonym="b; EU32; NERF; NERF-1a; NERF-1A; NERF-1B;
                     NERF-2"
                     /note="E74 like ETS transcription factor 2"
                     /db_xref="GeneID:1998"
                     /db_xref="HGNC:HGNC:3317"
                     /db_xref="MIM:619798"
     exon            1..252
                     /gene="ELF2"
                     /gene_synonym="b; EU32; NERF; NERF-1a; NERF-1A; NERF-1B;
                     NERF-2"
                     /inference="alignment:Splign:2.1.0"
     exon            253..337
                     /gene="ELF2"
                     /gene_synonym="b; EU32; NERF; NERF-1a; NERF-1A; NERF-1B;
                     NERF-2"
                     /inference="alignment:Splign:2.1.0"
     exon            338..575
                     /gene="ELF2"
                     /gene_synonym="b; EU32; NERF; NERF-1a; NERF-1A; NERF-1B;
                     NERF-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             504..2285
                     /gene="ELF2"
                     /gene_synonym="b; EU32; NERF; NERF-1a; NERF-1A; NERF-1B;
                     NERF-2"
                     /note="isoform 6 is encoded by transcript variant 6; new
                     Ets-related factor; ETS-related transcription factor
                     Elf-2; ets family transcription factor ELF2C; E74-like
                     factor 2 (ets domain transcription factor)"
                     /codon_start=1
                     /product="ETS-related transcription factor Elf-2 isoform
                     6"
                     /protein_id="NP_001317965.1"
                     /db_xref="CCDS:CCDS82954.1"
                     /db_xref="GeneID:1998"
                     /db_xref="HGNC:HGNC:3317"
                     /db_xref="MIM:619798"
                     /translation="MTSAVVDSGGTILELSSNGVENQEESEKVSEYPAVIVEPVPSAR
                     LEQGYAAQVLVYDDETYMMQDVAEEQEVETENVETVEASVHSSNAHCTDKTIEAAEAL
                     LHMESPTCLRDSRSPVEVFVPPCVSTPEFIHAAMRPDVITETVVEVSTEESEPMDTSP
                     IPTSPDSHEPMKKKKVGRKPKTQQSPISNGSPELGIKKKPREGKGNTTYLWEFLLDLL
                     QDKNTCPRYIKWTQREKGIFKLVDSKAVSKLWGKHKNKPDMNYETMGRALRYYYQRGI
                     LAKVEGQRLVYQFKDMPKNIVVIDDDKSETCNEDLAGTTDEKSLERVSLSAESLLKAA
                     SSVRSGKNSSPINCSRAEKGVARVVNITSPGHDASSRSPTTTASVSATAAPRTVRVAM
                     QVPVVMTSLGQKISTVAVQSVNAGAPLITSTSPTTATSPKVVIQTIPTVMPASTENGD
                     KITMQPAKIITIPATQLAQCQLQTKSNLTGSGSINIVGTPLAVRALTPVSIAHGTPVM
                     RLSMPTQQASGQTPPRVISAVIKGPEVKSEAVAKKQEHDVKTLQLVEEKPADGNKTVT
                     HVVVVSAPSAIALPVTMKTEGLVTCEK"
     exon            576..741
                     /gene="ELF2"
                     /gene_synonym="b; EU32; NERF; NERF-1a; NERF-1A; NERF-1B;
                     NERF-2"
                     /inference="alignment:Splign:2.1.0"
     exon            742..855
                     /gene="ELF2"
                     /gene_synonym="b; EU32; NERF; NERF-1a; NERF-1A; NERF-1B;
                     NERF-2"
                     /inference="alignment:Splign:2.1.0"
     exon            856..1029
                     /gene="ELF2"
                     /gene_synonym="b; EU32; NERF; NERF-1a; NERF-1A; NERF-1B;
                     NERF-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1030..1116
                     /gene="ELF2"
                     /gene_synonym="b; EU32; NERF; NERF-1a; NERF-1A; NERF-1B;
                     NERF-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1117..1309
                     /gene="ELF2"
                     /gene_synonym="b; EU32; NERF; NERF-1a; NERF-1A; NERF-1B;
                     NERF-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1310..1660
                     /gene="ELF2"
                     /gene_synonym="b; EU32; NERF; NERF-1a; NERF-1A; NERF-1B;
                     NERF-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1661..4003
                     /gene="ELF2"
                     /gene_synonym="b; EU32; NERF; NERF-1a; NERF-1A; NERF-1B;
                     NERF-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3388..3393
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ELF2"
                     /gene_synonym="b; EU32; NERF; NERF-1a; NERF-1A; NERF-1B;
                     NERF-2"
                     /note="hexamer: AATATA"
     polyA_site      3406
                     /gene="ELF2"
                     /gene_synonym="b; EU32; NERF; NERF-1a; NERF-1A; NERF-1B;
                     NERF-2"
                     /note="major polyA site"
     regulatory      3976..3981
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ELF2"
                     /gene_synonym="b; EU32; NERF; NERF-1a; NERF-1A; NERF-1B;
                     NERF-2"
                     /note="hexamer: AATATA"
     polyA_site      4003
                     /gene="ELF2"
                     /gene_synonym="b; EU32; NERF; NERF-1a; NERF-1A; NERF-1B;
                     NERF-2"
ORIGIN      
        1 attgctccca gcgccaagct ctgtgtcgcc gccgtcgcct aggcggttgg gggtcggtgg
       61 ggcggcgcgg gcgggggtcg ctgcgcgggg cggcgagcct ctgttttgtc tccttctctc
      121 cctgtggagc ggctcgggct gctggggagg ccccggctcc ctccggacgc tcggccaacg
      181 gcggcggcta gtccgcggcc ctgctgagag ggaaaaggac gccgcggtct tcccaggcgt
      241 cgcggagagc agttccaaag aactactggt tcagatttta gctcttccca agttgtgaaa
      301 atagtgaagg atgcttagac tacttaacat acaaactgct ttctggttaa tcatctttag
      361 aagactggat ttctggatat ctactccact ccatctctat tgacttttaa aacatgataa
      421 tgcaaaccta taacactggc aaccatcagt gaacctttaa tttcattgat taatagcgtt
      481 tgaagcttcc tcagggaata acaatgacat cagcagtggt tgacagtgga ggtactattt
      541 tggagctttc cagcaatgga gtagaaaatc aagaggaaag tgaaaaggtt tctgaatatc
      601 cagcagtgat tgtggagcca gttccaagtg ccagattaga gcagggctat gcagcccagg
      661 ttctggttta tgatgatgag acttatatga tgcaagatgt ggcagaagaa caagaagttg
      721 agaccgagaa tgtggaaaca gtggaagcat cagttcacag cagtaatgca cactgtacag
      781 ataagacaat tgaagctgct gaagccctgc ttcatatgga atctcctacc tgcttgaggg
      841 attcaagaag tcctgtggaa gtgtttgttc ctccttgtgt atcaactcca gaattcatcc
      901 atgctgctat gaggccagat gtcattacag aaactgtagt ggaggtgtca actgaagagt
      961 ctgaacccat ggatacctct cctattccaa catcaccaga tagccatgaa ccaatgaaaa
     1021 agaaaaaagt tggccgtaaa ccaaagaccc agcaatcacc aatttccaat gggtctcctg
     1081 agttaggtat aaagaagaaa ccaagagaag gaaaaggaaa cacaacctat ttgtgggagt
     1141 ttcttttaga tctacttcaa gataaaaata cttgtcccag gtatattaaa tggactcaga
     1201 gagaaaaagg catattcaag ctggtggatt caaaggctgt ctctaagctt tggggaaagc
     1261 ataagaacaa accagacatg aactatgaaa ccatgggacg agctttgaga tactactacc
     1321 aaaggggaat tcttgcaaag gttgaaggac agaggcttgt atatcagttc aaggatatgc
     1381 cgaaaaacat agtggtcata gatgatgaca aaagtgaaac ctgtaatgaa gatttagcag
     1441 gaactactga tgaaaaatca ttagaacgag tgtcactgtc tgcagaaagt ctcctgaaag
     1501 cagcatcctc tgttcgcagt ggaaaaaatt catcccctat aaactgctcc agagcagaga
     1561 agggtgtagc tagagttgtg aatatcactt cccctgggca cgatgcttca tccaggtctc
     1621 ctactaccac tgcatctgtg tcagcaacag cagctccaag gacagttcgt gtggcaatgc
     1681 aggtacctgt tgtaatgaca tcattgggtc agaaaatttc aactgtggca gttcagtcag
     1741 ttaatgcagg tgcaccatta ataaccagca ctagtccaac aacagcgacc tctccaaagg
     1801 tagtcattca gacaatccct actgtgatgc cagcttctac tgaaaatgga gacaaaatca
     1861 ccatgcagcc tgccaaaatt attaccatcc cagctacaca gcttgcacag tgtcaactgc
     1921 agacaaagtc aaatctgact ggatcaggaa gcattaacat tgttggaacc ccattggctg
     1981 tgagagcact tacccctgtt tcaatagccc atggtacacc tgtaatgaga ctatcaatgc
     2041 ctactcagca ggcatctggc cagactcctc ctcgagttat cagtgcagtc ataaaggggc
     2101 cagaggttaa atcggaagca gtggcaaaaa agcaagaaca tgatgtgaaa actttgcagc
     2161 tagtagaaga aaaaccagca gatggaaata agacagtgac ccacgtagtg gttgtcagtg
     2221 cgccttcagc tattgccctt cctgtaacta tgaaaacaga aggactagtg acatgtgaga
     2281 aataaaatag cagctccacc atggacttca ggctgttagt ggcagtactg acataaacat
     2341 ttgcaaggga agtcatcaag aaaagtcaaa gaagacttta aaacattttt aatgcatata
     2401 caaaaacaat cagacttact ggaaataaat tacctatccc atgtttcagt gggaaatgaa
     2461 ctacatattg agatgctgac agaaaactgc ctcttacagt aggaaacaac tgaacccatc
     2521 aataagaaaa aggatcgaaa gggaccaagc agctcactac gatatcaagt tacactaaga
     2581 cttggaacac taacattctg taagaggtta tatagttttc agtgggaggg gttgggatgg
     2641 gtaatctcat tgttacatat agcaattttt gatgcatttt atatgcatac cagcaattat
     2701 tactgtgttc gcacagttct cacttaactg gtgctatgtg aagactctgc taatataggt
     2761 attttagaat gtgaattgaa gaatggatcc caaaaacttc agaaagagga tagcaaaaaa
     2821 agatctagtg cgattttata tatatatata tatatatata catacatata tatatatcat
     2881 atagcttaag ctgatttaaa acaaaggcct tagactaatt ttcgattttc tttcttgaaa
     2941 taagctaatg gcttgtttgt gtaaagcttt tttattaaaa gaaaaatttt aaaaatcttg
     3001 tacctagcac agtattgtta tagaatatac atgtaacatt ttatatggta gtttaagtct
     3061 gtcagtttct taattgtgga caaattaaca gttggctctg gccttttgct gtaacatgcc
     3121 tgtgtcactc acttagcctt ggcatttgtg cagacatacc attttcagtt ctgctgtcac
     3181 ttggaagttc aggctcagca tgaatttttg gcaggtagct ctaatacctg gagttttctt
     3241 tgtttttttt tctttttttt agttgaagtt tatgagggaa ataccagtgt tcagttttga
     3301 actataatag tttgtatatt caacatttga agtatattct attttgttgt actcttgttt
     3361 caaagtgtat tcaagtaggt tttctgaaat atagaaatga aatttatctt ctgttttggt
     3421 ctctggtgat attttaaaca atatttaaaa gtcagtatag aagtgtttta gttaggaagt
     3481 gataaaacat ctctcttctc cttcccaact actgcatgaa gaaattctac ttccattata
     3541 ttaatatttg gcaaatatct gcatgttgcc agtttctttc taattatgat gaactataat
     3601 gttctgctta acgtaatgaa tttagtattt tagttggctg cacttaaaga atttatattt
     3661 gtaaaacact ttaaaccatt tgtttcacaa tcagaccttt tgtggattaa aaagaacaat
     3721 tactcttcta gcccttttac agattaggaa gttaaggtat ctgaaggatt acataaacta
     3781 tgtaatttta ctactgtctg tcactccata tcttaatgct ctttctacta caaagaaaag
     3841 ttatctattt ttacatgttt tagaaatgta gatgaactca tacataatat tttttgtctt
     3901 ttaattgatc acatactact taggtcagaa attgtttata acagttccct ttgtaatctt
     3961 ttaaactttt ccataaatat attgatgata cttttataca aaa
//
