LOCUS       NM_172373               3678 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens E74 like ETS transcription factor 1 (ELF1), transcript
            variant 1, mRNA.
ACCESSION   NM_172373
VERSION     NM_172373.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3678)
  AUTHORS   Zhu,P., Dou,C., Song,Z., Bi,X., Wu,X. and Miao,Y.
  TITLE     ELF1/PRR11/ARP2/3 promoted trophoblast cells proliferation and
            motility in early pregnancy
  JOURNAL   Am J Reprod Immunol 90 (3), e13758 (2023)
   PUBMED   37641376
  REMARK    GeneRIF: ELF1/PRR11/ARP2/3 promoted trophoblast cells proliferation
            and motility in early pregnancy.
REFERENCE   2  (bases 1 to 3678)
  AUTHORS   Zhao,L., Wu,X., Zhang,Z., Fang,L., Yang,B. and Li,Y.
  TITLE     ELF1 suppresses autophagy to reduce cisplatin resistance via the
            miR-152-3p/NCAM1/ERK axis in lung cancer cells
  JOURNAL   Cancer Sci 114 (6), 2650-2663 (2023)
   PUBMED   36846943
  REMARK    GeneRIF: ELF1 suppresses autophagy to reduce cisplatin resistance
            via the miR-152-3p/NCAM1/ERK axis in lung cancer cells.
REFERENCE   3  (bases 1 to 3678)
  AUTHORS   Han,D., Li,X. and Cheng,Y.
  TITLE     Transcription Factor ELF1 Modulates Cisplatin Sensitivity in
            Prostate Cancer by Targeting MEIS Homeobox 2
  JOURNAL   Chem Res Toxicol 36 (3), 360-368 (2023)
   PUBMED   36763086
  REMARK    GeneRIF: Transcription Factor ELF1 Modulates Cisplatin Sensitivity
            in Prostate Cancer by Targeting MEIS Homeobox 2.
REFERENCE   4  (bases 1 to 3678)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 3678)
  AUTHORS   Hu,M., Li,H., Xie,H., Fan,M., Wang,J., Zhang,N., Ma,J. and Che,S.
  TITLE     ELF1 Transcription Factor Enhances the Progression of Glioma via
            ATF5 promoter
  JOURNAL   ACS Chem Neurosci 12 (7), 1252-1261 (2021)
   PUBMED   33720698
  REMARK    GeneRIF: ELF1 Transcription Factor Enhances the Progression of
            Glioma via ATF5 promoter.
REFERENCE   6  (bases 1 to 3678)
  AUTHORS   Oettgen,P., Akbarali,Y., Boltax,J., Best,J., Kunsch,C. and
            Libermann,T.A.
  TITLE     Characterization of NERF, a novel transcription factor related to
            the Ets factor ELF-1
  JOURNAL   Mol Cell Biol 16 (9), 5091-5106 (1996)
   PUBMED   8756667
REFERENCE   7  (bases 1 to 3678)
  AUTHORS   John,S., Reeves,R.B., Lin,J.X., Child,R., Leiden,J.M.,
            Thompson,C.B. and Leonard,W.J.
  TITLE     Regulation of cell-type-specific interleukin-2 receptor alpha-chain
            gene expression: potential role of physical interactions between
            Elf-1, HMG-I(Y), and NF-kappa B family proteins
  JOURNAL   Mol Cell Biol 15 (3), 1786-1796 (1995)
   PUBMED   7862168
REFERENCE   8  (bases 1 to 3678)
  AUTHORS   Wang,C.Y., Petryniak,B., Thompson,C.B., Kaelin,W.G. and Leiden,J.M.
  TITLE     Regulation of the Ets-related transcription factor Elf-1 by binding
            to the retinoblastoma protein
  JOURNAL   Science 260 (5112), 1330-1335 (1993)
   PUBMED   8493578
REFERENCE   9  (bases 1 to 3678)
  AUTHORS   Leiden,J.M., Wang,C.Y., Petryniak,B., Markovitz,D.M., Nabel,G.J.
            and Thompson,C.B.
  TITLE     A novel Ets-related transcription factor, Elf-1, binds to human
            immunodeficiency virus type 2 regulatory elements that are required
            for inducible trans activation in T cells
  JOURNAL   J Virol 66 (10), 5890-5897 (1992)
   PUBMED   1527846
REFERENCE   10 (bases 1 to 3678)
  AUTHORS   Thompson,C.B., Wang,C.Y., Ho,I.C., Bohjanen,P.R., Petryniak,B.,
            June,C.H., Miesfeldt,S., Zhang,L., Nabel,G.J., Karpinski,B. et al.
  TITLE     cis-acting sequences required for inducible interleukin-2 enhancer
            function bind a novel Ets-related protein, Elf-1
  JOURNAL   Mol Cell Biol 12 (3), 1043-1053 (1992)
   PUBMED   1545787
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC418141.1, M82882.1,
            BC030507.2, AL157877.11 and BX640798.1.
            
            On Nov 23, 2018 this sequence version replaced NM_172373.3.
            
            Summary: This gene encodes an E26 transformation-specific related
            transcription factor. The encoded protein is primarily expressed in
            lymphoid cells and acts as both an enhancer and a repressor to
            regulate transcription of various genes. Alternative splicing
            results in multiple transcript variants. [provided by RefSeq, Feb
            2009].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M82882.1, SRR1803613.19928.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN03267775 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000239882.7/ ENSP00000239882.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 DC418141.1         57-58
            3-89                M82882.1           1-87
            90-1258             BC030507.2         1-1169
            1259-1259           AL157877.11        45938-45938         c
            1260-3423           BX640798.1         597-2760
            3424-3424           AL157877.11        36881-36881         c
            3425-3678           BX640798.1         2762-3015
FEATURES             Location/Qualifiers
     source          1..3678
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q14.11"
     gene            1..3678
                     /gene="ELF1"
                     /gene_synonym="EFTUD1; RIA1"
                     /note="E74 like ETS transcription factor 1"
                     /db_xref="GeneID:1997"
                     /db_xref="HGNC:HGNC:3316"
                     /db_xref="MIM:189973"
     exon            1..89
                     /gene="ELF1"
                     /gene_synonym="EFTUD1; RIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            90..389
                     /gene="ELF1"
                     /gene_synonym="EFTUD1; RIA1"
                     /inference="alignment:Splign:2.1.0"
     CDS             318..2177
                     /gene="ELF1"
                     /gene_synonym="EFTUD1; RIA1"
                     /note="isoform a is encoded by transcript variant 1;
                     ets-related transcription factor Elf-1; E74-like factor 1
                     (ets domain transcription factor)"
                     /codon_start=1
                     /product="ETS-related transcription factor Elf-1 isoform
                     a"
                     /protein_id="NP_758961.1"
                     /db_xref="CCDS:CCDS9374.1"
                     /db_xref="GeneID:1997"
                     /db_xref="HGNC:HGNC:3316"
                     /db_xref="MIM:189973"
                     /translation="MAAVVQQNDLVFEFASNVMEDERQLGDPAIFPAVIVEHVPGADI
                     LNSYAGLACVEEPNDMITESSLDVAEEEIIDDDDDDITLTVEASCHDGDETIETIEAA
                     EALLNMDSPGPMLDEKRINNNIFSSPEDDMVVAPVTHVSVTLDGIPEVMETQQVQEKY
                     ADSPGASSPEQPKRKKGRKTKPPRPDSPATTPNISVKKKNKDGKGNTIYLWEFLLALL
                     QDKATCPKYIKWTQREKGIFKLVDSKAVSRLWGKHKNKPDMNYETMGRALRYYYQRGI
                     LAKVEGQRLVYQFKEMPKDLIYINDEDPSSSIESSDPSLSSSATSNRNQTSRSRVSSS
                     PGVKGGATTVLKPGNSKAAKPKDPVEVAQPSEVLRTVQPTQSPYPTQLFRTVHVVQPV
                     QAVPEGEAARTSTMQDETLNSSVQSIRTIQAPTQVPVVVSPRNQQLHTVTLQTVPLTT
                     VIASTDPSAGTGSQKFILQAIPSSQPMTVLKENVMLQSQKAGSPPSIVLGPAQVQQVL
                     TSNVQTICNGTVSVASSPSFSATAPVVTFSPRSSQLVAHPPGTVITSVIKTQETKTLT
                     QEVEKKESEDHLKENTEKTEQQPQPYVMVVSSSNGFTSQVAMKQNELLEPNSF"
     exon            390..570
                     /gene="ELF1"
                     /gene_synonym="EFTUD1; RIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            571..678
                     /gene="ELF1"
                     /gene_synonym="EFTUD1; RIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            679..846
                     /gene="ELF1"
                     /gene_synonym="EFTUD1; RIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            847..930
                     /gene="ELF1"
                     /gene_synonym="EFTUD1; RIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            931..1123
                     /gene="ELF1"
                     /gene_synonym="EFTUD1; RIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1124..1573
                     /gene="ELF1"
                     /gene_synonym="EFTUD1; RIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1574..3678
                     /gene="ELF1"
                     /gene_synonym="EFTUD1; RIA1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3349..3354
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ELF1"
                     /gene_synonym="EFTUD1; RIA1"
                     /note="hexamer: AATAAT"
     polyA_site      3380
                     /gene="ELF1"
                     /gene_synonym="EFTUD1; RIA1"
                     /note="major polyA site"
     regulatory      3552..3557
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ELF1"
                     /gene_synonym="EFTUD1; RIA1"
                     /note="hexamer: AATAAA"
     polyA_site      3574
                     /gene="ELF1"
                     /gene_synonym="EFTUD1; RIA1"
                     /note="major polyA site"
     regulatory      3658..3663
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ELF1"
                     /gene_synonym="EFTUD1; RIA1"
                     /note="hexamer: AATAAA"
     polyA_site      3678
                     /gene="ELF1"
                     /gene_synonym="EFTUD1; RIA1"
ORIGIN      
        1 aatctacagg agccatttta acagctaaaa cttgtcggat tgctttttat tttcaagctc
       61 aaaagacgat agagaaagaa tacttgaagg ccaagaagct tgagagaaga aaaatttcag
      121 aaaaattgtc tcaatttgac tagaatatca atgaaccagg aaaactgaag caccttccct
      181 aaagaaaact tgggtataca attactccac agacagagct gagggttttt tacccaaatc
      241 agtcactgga ttttgctgcc tgatacgtga atcttcttgg aatttttctc atgtggatct
      301 aaggggaatg ctttattatg gctgctgttg tccaacagaa cgacctagta tttgaatttg
      361 ctagtaacgt catggaggat gaacgacagc ttggtgatcc agctattttt cctgccgtaa
      421 ttgtggaaca tgttcctggt gctgatattc tcaatagtta tgccggtcta gcctgtgtgg
      481 aagagcccaa tgacatgatt actgagagtt cactggatgt tgctgaagaa gaaatcatag
      541 acgatgatga tgatgacatc acccttacag ttgaagcttc ttgtcatgac ggggatgaaa
      601 caattgaaac tattgaggct gctgaggcac tcctcaatat ggattcccct ggccctatgc
      661 tggatgaaaa acgaataaat aataatatat ttagttcacc tgaagatgac atggttgttg
      721 ccccagtcac ccatgtgtcc gtcacattag atgggattcc tgaagtgatg gaaacacagc
      781 aggtgcaaga aaaatatgca gactcaccgg gagcctcatc accagaacag cctaagagga
      841 aaaaaggaag aaaaactaaa ccaccacgac cagattcccc agccactacg ccaaatatat
      901 ctgtgaagaa gaaaaacaaa gatggaaagg gaaacacaat ttatctttgg gagtttttac
      961 tggcactgct ccaggacaag gctacttgtc ctaaatacat caagtggacc cagcgagaga
     1021 aaggcatttt taaattggtg gattctaaag cagtgtccag gttgtggggg aagcacaaaa
     1081 acaaacctga tatgaattat gagaccatgg gaagagcact caggtactat taccaaaggg
     1141 gtattctggc aaaagtggaa ggtcagcgct tggtgtatca gtttaaagaa atgccaaaag
     1201 atcttatata tataaatgat gaggatccaa gttccagcat agagtcttca gatccatcgc
     1261 tatcttcatc agccacttca aataggaatc aaaccagccg gtcgagagta tcttcaagtc
     1321 caggggtaaa aggaggagcc actacagttc taaaaccagg gaattctaaa gctgcaaaac
     1381 ccaaagatcc tgtggaagtt gcacaaccat cagaagtttt gaggacagtg cagcccacgc
     1441 agtctccata tcctacccag ctcttccgga ctgttcatgt agtacagcca gtacaggctg
     1501 tcccagaggg agaagcagct agaaccagta ccatgcagga tgaaacatta aattcttccg
     1561 ttcagagtat taggactata caggctccaa cccaagttcc agtggttgtg tctcctagga
     1621 atcagcagtt gcatacagta acactccaaa cagtgccact cacaacagtt atagccagca
     1681 cagatccatc agcaggtact ggatctcaga agtttatttt acaagccatt ccatcatcac
     1741 agcccatgac agtactgaaa gaaaatgtca tgctgcagtc acaaaaggcg ggctctcctc
     1801 cttcaattgt cttgggccct gcccaggttc agcaggtcct tactagcaat gttcagacca
     1861 tttgcaatgg aaccgtcagt gtggcttcct ctccatcctt cagtgctact gcacctgtgg
     1921 tgaccttttc tcctcgcagt tcacagctgg ttgctcaccc acctggcact gtaatcactt
     1981 cagttatcaa aactcaagaa acaaaaactc ttacacagga agtagagaaa aaggaatctg
     2041 aagatcattt gaaagagaac actgagaaaa cggagcagca gccacagcct tatgtgatgg
     2101 tagtgtccag ttccaatgga tttacttctc aggtagctat gaaacaaaac gaactgctgg
     2161 aacccaactc tttttagtta atataccaaa gcttatgaat aattgtttgt taattgaaca
     2221 ttttcaatta tatgcagact gactgattct aagataaatt ctaaggaggt ttctaatttt
     2281 gtaattgtta aaaatagagt taattttgac tttgttagat gagggaggaa aactcaactg
     2341 tttctctttg ttatctaaat gtttcagaat tcaatcgtga aggaacaggc attttacact
     2401 atgaagacat tcttttgaga tttttatttc agttgctata tcataagcat ttttaaagtt
     2461 tcttttctaa ttttacattg tattagattt tctgattctt ttgtaaatac agaacttaaa
     2521 tagaaggcaa caggaaattt atataggaac tattttcatt ccacttgtgt aagttaagtc
     2581 ttgactcttt caaatgcaaa aaacctattt tatgctttgt taaaattatg gtgtcactta
     2641 gattgacttt agttgactgc actatataat atagaactat gaatatgtag aataacatga
     2701 aaaattggag gtgctggtgg tatggctgac cctgtttcag aagcaggata gtataaaagc
     2761 atcagcctaa gaatggcact cccactaact agctatgtaa tcttgacctc tttgggcttt
     2821 agttcctctc ataaaaggaa gagatgtatt ggattagact agatgatcac cactttctct
     2881 tctagttcta atttttttaa ttctaatacc tatattttca agttatgtca attaaatcat
     2941 tatcaggtta tttcctaatg taagaatagc taaaatgttg cagagaaata agtgacccaa
     3001 caaaatttat tcatctgtta tgggtaagat ctgccataaa ttcttcctaa ataatttgtt
     3061 tactaactct ttaggccact gtgctttgcg gtccattagt aaacttgtgt tgctaagtgc
     3121 taaacagaat actgctattt tgagagagtc aagactcttt cttaagggcc aagaaagcaa
     3181 cttgagcctt gggctaatct ggctgagtag tcagttataa aagcataatt gctttatatt
     3241 ttggatcatt ttttactggg ggcggacttg gggggggttg catacaaaga taacatatat
     3301 atccaacttt ctgaaatgaa atgtttttag attacttttt caactgtaaa taatgtacat
     3361 ttaatgtcac aagaaaaaaa tgtcttctgc aaattttcta gtataacaga aatttttgta
     3421 gatgaaaaaa atcattatgt ttagaggtct aatgctatgt tttcatatta cagagtgaat
     3481 ttgtatttaa acaaaaattt aaattttgga atcctctaaa catttttgta tctttaattg
     3541 gtttattatt aaataaatca tataaaaatt ctcagtgtct gttttcaggc aaaagtttct
     3601 taaagaataa gtgtgcagag aatattacta gaacatcagc attacttaat gtttataaat
     3661 aaatttcatt agtcagaa
//
